Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast ribosomal PPR-repeat containing protein 3, putative

Species:

Leishmania braziliensis

UniProt:

E9AIA5_LEIBR

TriTrypDb:

LbrM.20.4720 , LBRM2903_200061100

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.360
CLV_NRD_NRD_1	112	114	PF00675	0.327
CLV_NRD_NRD_1	300	302	PF00675	0.317
CLV_NRD_NRD_1	333	335	PF00675	0.481
CLV_NRD_NRD_1	67	69	PF00675	0.377
CLV_PCSK_KEX2_1	112	114	PF00082	0.333
CLV_PCSK_KEX2_1	119	121	PF00082	0.357
CLV_PCSK_KEX2_1	299	301	PF00082	0.334
CLV_PCSK_KEX2_1	67	69	PF00082	0.377
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.394
CLV_PCSK_SKI1_1	153	157	PF00082	0.342
CLV_PCSK_SKI1_1	160	164	PF00082	0.388
CLV_PCSK_SKI1_1	314	318	PF00082	0.330
CLV_PCSK_SKI1_1	348	352	PF00082	0.627
DEG_Nend_Nbox_1	1	3	PF02207	0.406
DEG_SPOP_SBC_1	142	146	PF00917	0.339
DOC_CKS1_1	234	239	PF01111	0.427
DOC_CKS1_1	99	104	PF01111	0.420
DOC_CYCLIN_RxL_1	149	159	PF00134	0.403
DOC_CYCLIN_RxL_1	311	319	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.334
DOC_MAPK_DCC_7	120	130	PF00069	0.328
DOC_PP2B_LxvP_1	197	200	PF13499	0.350
DOC_PP4_FxxP_1	122	125	PF00568	0.344
DOC_USP7_MATH_1	342	346	PF00917	0.330
DOC_USP7_MATH_1	87	91	PF00917	0.611
DOC_WW_Pin1_4	121	126	PF00397	0.350
DOC_WW_Pin1_4	19	24	PF00397	0.429
DOC_WW_Pin1_4	233	238	PF00397	0.369
DOC_WW_Pin1_4	98	103	PF00397	0.431
LIG_14-3-3_CanoR_1	112	122	PF00244	0.373
LIG_14-3-3_CanoR_1	167	176	PF00244	0.297
LIG_14-3-3_CanoR_1	189	197	PF00244	0.420
LIG_14-3-3_CanoR_1	289	297	PF00244	0.371
LIG_14-3-3_CanoR_1	320	325	PF00244	0.442
LIG_FAT_LD_1	130	138	PF03623	0.342
LIG_FHA_1	189	195	PF00498	0.498
LIG_FHA_1	205	211	PF00498	0.325
LIG_FHA_1	234	240	PF00498	0.336
LIG_FHA_1	243	249	PF00498	0.298
LIG_FHA_1	271	277	PF00498	0.268
LIG_FHA_1	289	295	PF00498	0.347
LIG_FHA_1	306	312	PF00498	0.363
LIG_FHA_1	78	84	PF00498	0.538
LIG_FHA_1	93	99	PF00498	0.409
LIG_FHA_2	99	105	PF00498	0.408
LIG_LIR_Gen_1	159	165	PF02991	0.343
LIG_LIR_Gen_1	257	267	PF02991	0.408
LIG_LIR_Gen_1	272	280	PF02991	0.284
LIG_LIR_Gen_1	284	295	PF02991	0.468
LIG_LIR_Nem_3	159	164	PF02991	0.352
LIG_LIR_Nem_3	168	173	PF02991	0.344
LIG_LIR_Nem_3	254	259	PF02991	0.267
LIG_LIR_Nem_3	272	277	PF02991	0.286
LIG_LIR_Nem_3	284	290	PF02991	0.411
LIG_NRBOX	15	21	PF00104	0.462
LIG_NRBOX	205	211	PF00104	0.299
LIG_NRBOX	242	248	PF00104	0.399
LIG_NRBOX	308	314	PF00104	0.275
LIG_PCNA_yPIPBox_3	303	317	PF02747	0.332
LIG_Pex3_1	313	324	PF04882	0.329
LIG_PTB_Apo_2	36	43	PF02174	0.333
LIG_PTB_Phospho_1	36	42	PF10480	0.327
LIG_SH2_CRK	274	278	PF00017	0.294
LIG_SH2_NCK_1	60	64	PF00017	0.378
LIG_SH2_STAP1	170	174	PF00017	0.264
LIG_SH2_STAP1	190	194	PF00017	0.498
LIG_SH2_STAP1	274	278	PF00017	0.378
LIG_SH2_STAP1	42	46	PF00017	0.399
LIG_SH2_STAT3	115	118	PF00017	0.301
LIG_SH2_STAT5	115	118	PF00017	0.391
LIG_SH2_STAT5	170	173	PF00017	0.409
LIG_SH2_STAT5	190	193	PF00017	0.478
LIG_SH2_STAT5	218	221	PF00017	0.336
LIG_SH2_STAT5	274	277	PF00017	0.390
LIG_SH3_1	335	341	PF00018	0.428
LIG_SH3_3	137	143	PF00018	0.366
LIG_SH3_3	159	165	PF00018	0.343
LIG_SH3_3	198	204	PF00018	0.335
LIG_SH3_3	231	237	PF00018	0.520
LIG_SH3_3	335	341	PF00018	0.428
LIG_SH3_3	96	102	PF00018	0.484
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.335
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.306
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.306
LIG_SUMO_SIM_par_1	126	131	PF11976	0.311
LIG_SUMO_SIM_par_1	244	250	PF11976	0.321
LIG_TRFH_1	161	165	PF08558	0.371
LIG_TYR_ITSM	169	176	PF00017	0.282
LIG_UBA3_1	205	211	PF00899	0.298
LIG_UBA3_1	276	283	PF00899	0.404
LIG_WRC_WIRS_1	321	326	PF05994	0.332
MOD_CK1_1	138	144	PF00069	0.428
MOD_CK1_1	242	248	PF00069	0.368
MOD_CK1_1	254	260	PF00069	0.285
MOD_CK1_1	266	272	PF00069	0.290
MOD_CK1_1	288	294	PF00069	0.532
MOD_CK1_1	61	67	PF00069	0.482
MOD_CK1_1	88	94	PF00069	0.542
MOD_CK2_1	266	272	PF00069	0.546
MOD_GlcNHglycan	215	218	PF01048	0.421
MOD_GlcNHglycan	269	272	PF01048	0.374
MOD_GlcNHglycan	344	347	PF01048	0.307
MOD_GlcNHglycan	90	93	PF01048	0.603
MOD_GSK3_1	138	145	PF00069	0.364
MOD_GSK3_1	168	175	PF00069	0.287
MOD_GSK3_1	242	249	PF00069	0.401
MOD_GSK3_1	262	269	PF00069	0.278
MOD_GSK3_1	281	288	PF00069	0.450
MOD_GSK3_1	88	95	PF00069	0.643
MOD_N-GLC_1	213	218	PF02516	0.316
MOD_N-GLC_1	239	244	PF02516	0.335
MOD_NEK2_1	135	140	PF00069	0.360
MOD_NEK2_1	213	218	PF00069	0.316
MOD_NEK2_1	262	267	PF00069	0.411
MOD_NEK2_1	328	333	PF00069	0.335
MOD_NEK2_1	58	63	PF00069	0.333
MOD_PIKK_1	281	287	PF00454	0.319
MOD_PKA_2	166	172	PF00069	0.303
MOD_PKA_2	188	194	PF00069	0.345
MOD_PKA_2	288	294	PF00069	0.384
MOD_PKA_2	88	94	PF00069	0.476
MOD_Plk_1	239	245	PF00069	0.314
MOD_Plk_1	305	311	PF00069	0.517
MOD_Plk_4	135	141	PF00069	0.414
MOD_Plk_4	242	248	PF00069	0.455
MOD_Plk_4	272	278	PF00069	0.338
MOD_Plk_4	328	334	PF00069	0.328
MOD_Plk_4	52	58	PF00069	0.390
MOD_Plk_4	61	67	PF00069	0.315
MOD_ProDKin_1	121	127	PF00069	0.348
MOD_ProDKin_1	19	25	PF00069	0.433
MOD_ProDKin_1	233	239	PF00069	0.362
MOD_ProDKin_1	98	104	PF00069	0.428
TRG_DiLeu_BaEn_1	221	226	PF01217	0.337
TRG_DiLeu_BaEn_1	272	277	PF01217	0.341
TRG_DiLeu_BaEn_1	54	59	PF01217	0.310
TRG_DiLeu_BaEn_2	31	37	PF01217	0.330
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.297
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.323
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.386
TRG_ENDOCYTIC_2	173	176	PF00928	0.260
TRG_ENDOCYTIC_2	259	262	PF00928	0.382
TRG_ENDOCYTIC_2	274	277	PF00928	0.296
TRG_ENDOCYTIC_2	329	332	PF00928	0.333
TRG_ER_diArg_1	111	113	PF00400	0.330
TRG_ER_diArg_1	299	301	PF00400	0.333
TRG_ER_diArg_1	66	68	PF00400	0.356
TRG_NLS_MonoExtC_3	333	338	PF00514	0.308
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NQ51	Trypanosomatidae	33%	71%
A0A3R7K7U1	Trypanosoma rangeli	54%	68%
A4HYR3	Leishmania infantum	91%	86%
C9ZI67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	67%
C9ZMB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	67%
V5BQU6	Trypanosoma cruzi	56%	69%