Tubulin delta chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tubulin delta chain

Gene product:

zeta tubulin, putative

Species:

Leishmania braziliensis

UniProt:

E9AIA4_LEIBR

TriTrypDb:

LbrM.20.4710 , LBRM2903_200061000

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	1
GO:0005814	centriole	5	11
GO:0005874	microtubule	6	11
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11

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Expansion

Sequence features

E9AIA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA4

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000278	mitotic cell cycle	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	11
GO:0007049	cell cycle	2	1
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0030030	cell projection organization	4	11
GO:0071840	cellular component organization or biogenesis	2	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005198	structural molecule activity	1	11
GO:0005200	structural constituent of cytoskeleton	2	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.483
CLV_NRD_NRD_1	146	148	PF00675	0.483
CLV_NRD_NRD_1	219	221	PF00675	0.295
CLV_PCSK_KEX2_1	107	109	PF00082	0.630
CLV_PCSK_KEX2_1	146	148	PF00082	0.542
CLV_PCSK_KEX2_1	219	221	PF00082	0.297
CLV_PCSK_KEX2_1	439	441	PF00082	0.433
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.433
CLV_PCSK_SKI1_1	286	290	PF00082	0.566
CLV_PCSK_SKI1_1	334	338	PF00082	0.542

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NWW5	Trypanosomatidae	46%	86%
A0A3S5H784	Leishmania donovani	85%	73%
A0A422NCE3	Trypanosoma rangeli	51%	92%
A4HYR4	Leishmania infantum	85%	73%
C9ZI66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	92%
D0A8V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	91%
E9AUJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	73%
P25295	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P32348	Microbotryum violaceum	25%	95%
P34786	Euplotoides octocarinatus	26%	96%

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