Tubulin delta chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tubulin delta chain

Gene product:

zeta tubulin, putative

Species:

Leishmania braziliensis

UniProt:

E9AIA4_LEIBR

TriTrypDb:

LbrM.20.4710 , LBRM2903_200061000

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005814	centriole	5	11
GO:0005874	microtubule	6	11
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AIA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA4

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0030030	cell projection organization	4	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000278	mitotic cell cycle	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007049	cell cycle	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005198	structural molecule activity	1	11
GO:0005200	structural constituent of cytoskeleton	2	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.483
CLV_NRD_NRD_1	146	148	PF00675	0.483
CLV_NRD_NRD_1	219	221	PF00675	0.295
CLV_PCSK_KEX2_1	107	109	PF00082	0.630
CLV_PCSK_KEX2_1	146	148	PF00082	0.542
CLV_PCSK_KEX2_1	219	221	PF00082	0.297
CLV_PCSK_KEX2_1	439	441	PF00082	0.433
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.433
CLV_PCSK_SKI1_1	286	290	PF00082	0.566
CLV_PCSK_SKI1_1	334	338	PF00082	0.542
CLV_PCSK_SKI1_1	355	359	PF00082	0.581
CLV_PCSK_SKI1_1	383	387	PF00082	0.547
CLV_PCSK_SKI1_1	56	60	PF00082	0.289
CLV_PCSK_SKI1_1	65	69	PF00082	0.289
DEG_APCC_DBOX_1	354	362	PF00400	0.322
DOC_MAPK_gen_1	219	229	PF00069	0.475
DOC_MAPK_HePTP_8	175	187	PF00069	0.561
DOC_MAPK_HePTP_8	217	229	PF00069	0.358
DOC_MAPK_MEF2A_6	178	187	PF00069	0.561
DOC_MAPK_MEF2A_6	220	229	PF00069	0.472
DOC_PP1_RVXF_1	182	188	PF00149	0.539
DOC_PP1_RVXF_1	284	291	PF00149	0.575
DOC_PP2B_LxvP_1	300	303	PF13499	0.410
DOC_PP2B_LxvP_1	339	342	PF13499	0.577
DOC_PP4_FxxP_1	187	190	PF00568	0.472
DOC_USP7_MATH_1	272	276	PF00917	0.683
DOC_USP7_MATH_1	293	297	PF00917	0.426
DOC_USP7_MATH_1	342	346	PF00917	0.612
DOC_USP7_MATH_1	406	410	PF00917	0.640
DOC_WW_Pin1_4	43	48	PF00397	0.545
LIG_14-3-3_CanoR_1	184	190	PF00244	0.567
LIG_14-3-3_CanoR_1	286	291	PF00244	0.565
LIG_14-3-3_CanoR_1	344	350	PF00244	0.538
LIG_14-3-3_CanoR_1	408	413	PF00244	0.545
LIG_14-3-3_CanoR_1	414	424	PF00244	0.464
LIG_BIR_II_1	1	5	PF00653	0.311
LIG_BRCT_BRCA1_1	154	158	PF00533	0.561
LIG_BRCT_BRCA1_1	45	49	PF00533	0.472
LIG_FHA_1	178	184	PF00498	0.499
LIG_FHA_1	237	243	PF00498	0.471
LIG_FHA_1	245	251	PF00498	0.464
LIG_FHA_1	283	289	PF00498	0.575
LIG_FHA_1	313	319	PF00498	0.506
LIG_FHA_1	372	378	PF00498	0.510
LIG_FHA_1	426	432	PF00498	0.625
LIG_FHA_2	287	293	PF00498	0.421
LIG_GBD_Chelix_1	175	183	PF00786	0.361
LIG_LIR_Gen_1	155	164	PF02991	0.469
LIG_LIR_Gen_1	17	25	PF02991	0.561
LIG_LIR_Gen_1	345	353	PF02991	0.577
LIG_LIR_Nem_3	155	161	PF02991	0.469
LIG_LIR_Nem_3	17	23	PF02991	0.472
LIG_MAD2	334	342	PF02301	0.571
LIG_MLH1_MIPbox_1	45	49	PF16413	0.472
LIG_NRBOX	296	302	PF00104	0.492
LIG_PCNA_yPIPBox_3	291	301	PF02747	0.480
LIG_Pex14_1	94	98	PF04695	0.459
LIG_PTB_Apo_2	204	211	PF02174	0.358
LIG_SH2_STAP1	200	204	PF00017	0.561
LIG_SH2_STAT3	215	218	PF00017	0.358
LIG_SH2_STAT3	435	438	PF00017	0.434
LIG_SH2_STAT5	186	189	PF00017	0.472
LIG_SH2_STAT5	326	329	PF00017	0.318
LIG_SH2_STAT5	371	374	PF00017	0.608
LIG_SH2_STAT5	426	429	PF00017	0.588
LIG_SH2_STAT5	435	438	PF00017	0.505
LIG_SH3_3	266	272	PF00018	0.641
LIG_SH3_3	370	376	PF00018	0.518
LIG_SH3_3	427	433	PF00018	0.503
LIG_SUMO_SIM_anti_2	159	166	PF11976	0.472
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.489
LIG_SUMO_SIM_anti_2	295	302	PF11976	0.210
LIG_SUMO_SIM_par_1	159	166	PF11976	0.472
LIG_TRAF2_2	192	197	PF00917	0.561
LIG_TYR_ITIM	96	101	PF00017	0.472
LIG_UBA3_1	357	362	PF00899	0.604
LIG_WW_1	323	326	PF00397	0.586
MOD_CK1_1	177	183	PF00069	0.534
MOD_CK1_1	273	279	PF00069	0.643
MOD_CK1_1	282	288	PF00069	0.559
MOD_CK1_1	29	35	PF00069	0.511
MOD_CK1_1	345	351	PF00069	0.535
MOD_CK1_1	400	406	PF00069	0.691
MOD_CK2_1	146	152	PF00069	0.593
MOD_CK2_1	286	292	PF00069	0.438
MOD_GlcNHglycan	152	157	PF01048	0.410
MOD_GlcNHglycan	172	175	PF01048	0.159
MOD_GlcNHglycan	271	275	PF01048	0.629
MOD_GlcNHglycan	278	281	PF01048	0.623
MOD_GlcNHglycan	28	31	PF01048	0.302
MOD_GlcNHglycan	388	391	PF01048	0.542
MOD_GlcNHglycan	392	395	PF01048	0.587
MOD_GlcNHglycan	408	411	PF01048	0.458
MOD_GlcNHglycan	87	90	PF01048	0.254
MOD_GSK3_1	142	149	PF00069	0.538
MOD_GSK3_1	170	177	PF00069	0.472
MOD_GSK3_1	25	32	PF00069	0.493
MOD_GSK3_1	272	279	PF00069	0.595
MOD_GSK3_1	282	289	PF00069	0.542
MOD_GSK3_1	322	329	PF00069	0.534
MOD_GSK3_1	38	45	PF00069	0.412
MOD_GSK3_1	386	393	PF00069	0.694
MOD_GSK3_1	400	407	PF00069	0.590
MOD_GSK3_1	434	441	PF00069	0.685
MOD_N-GLC_1	225	230	PF02516	0.329
MOD_N-GLC_1	242	247	PF02516	0.157
MOD_N-GLC_1	293	298	PF02516	0.205
MOD_N-GLC_1	43	48	PF02516	0.289
MOD_NEK2_1	242	247	PF00069	0.535
MOD_NEK2_1	25	30	PF00069	0.516
MOD_NEK2_1	327	332	PF00069	0.486
MOD_NEK2_1	381	386	PF00069	0.555
MOD_NEK2_1	415	420	PF00069	0.591
MOD_NEK2_2	392	397	PF00069	0.441
MOD_PIKK_1	18	24	PF00454	0.572
MOD_PIKK_1	236	242	PF00454	0.459
MOD_PIKK_1	434	440	PF00454	0.433
MOD_PKA_1	146	152	PF00069	0.557
MOD_PKA_1	416	422	PF00069	0.464
MOD_PKA_2	142	148	PF00069	0.452
MOD_PKA_2	422	428	PF00069	0.465
MOD_Plk_1	225	231	PF00069	0.471
MOD_Plk_1	242	248	PF00069	0.450
MOD_Plk_1	293	299	PF00069	0.381
MOD_Plk_4	163	169	PF00069	0.484
MOD_Plk_4	279	285	PF00069	0.617
MOD_Plk_4	293	299	PF00069	0.242
MOD_Plk_4	322	328	PF00069	0.475
MOD_Plk_4	334	340	PF00069	0.425
MOD_Plk_4	422	428	PF00069	0.742
MOD_ProDKin_1	43	49	PF00069	0.545
MOD_SUMO_for_1	101	104	PF00179	0.561
MOD_SUMO_rev_2	46	55	PF00179	0.532
MOD_SUMO_rev_2	61	67	PF00179	0.371
TRG_ENDOCYTIC_2	346	349	PF00928	0.478
TRG_ENDOCYTIC_2	98	101	PF00928	0.472
TRG_ER_diArg_1	182	185	PF00400	0.561
TRG_ER_diArg_1	219	222	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NWW5	Trypanosomatidae	46%	86%
A0A3S5H784	Leishmania donovani	85%	73%
A0A422NCE3	Trypanosoma rangeli	51%	92%
A4HYR4	Leishmania infantum	85%	73%
C9ZI66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	92%
D0A8V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	91%
E9AUJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	73%
P25295	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P32348	Microbotryum violaceum	25%	95%
P34786	Euplotoides octocarinatus	26%	96%
P53377	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	96%
P54402	Euplotes aediculatus	25%	96%
P90548	Euplotoides octocarinatus	26%	96%
Q4QCZ3	Leishmania major	85%	73%
Q4R7T7	Macaca fascicularis	25%	98%
Q75A43	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	94%
Q7Z9Z2	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	26%	98%
Q8HZV4	Canis lupus familiaris	26%	98%
Q9R1K7	Mus musculus	26%	98%
Q9UJT1	Homo sapiens	26%	98%
Q9Y882	Schizosaccharomyces japonicus	24%	100%
V5BAC4	Trypanosoma cruzi	51%	92%