Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AIG2-like family, putative

Species:

Leishmania braziliensis

UniProt:

E9AIA3_LEIBR

TriTrypDb:

LbrM.20.4690 , LBRM2903_200060700

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AIA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003839	gamma-glutamylcyclotransferase activity	5	7
GO:0016829	lyase activity	2	7
GO:0016840	carbon-nitrogen lyase activity	3	7
GO:0016842	amidine-lyase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.520
CLV_C14_Caspase3-7	259	263	PF00656	0.493
CLV_C14_Caspase3-7	404	408	PF00656	0.265
CLV_NRD_NRD_1	169	171	PF00675	0.458
CLV_NRD_NRD_1	336	338	PF00675	0.380
CLV_NRD_NRD_1	487	489	PF00675	0.744
CLV_PCSK_KEX2_1	336	338	PF00082	0.380
CLV_PCSK_KEX2_1	485	487	PF00082	0.738
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.618
CLV_PCSK_SKI1_1	105	109	PF00082	0.391
CLV_PCSK_SKI1_1	170	174	PF00082	0.472
CLV_PCSK_SKI1_1	337	341	PF00082	0.361
CLV_PCSK_SKI1_1	97	101	PF00082	0.603
DEG_APCC_DBOX_1	104	112	PF00400	0.385
DEG_Nend_UBRbox_2	1	3	PF02207	0.505
DEG_SCF_FBW7_1	470	477	PF00400	0.365
DOC_CYCLIN_RxL_1	411	422	PF00134	0.310
DOC_MAPK_gen_1	246	254	PF00069	0.519
DOC_MAPK_gen_1	336	347	PF00069	0.366
DOC_MAPK_MEF2A_6	249	256	PF00069	0.605
DOC_PP1_RVXF_1	177	183	PF00149	0.371
DOC_PP2B_LxvP_1	163	166	PF13499	0.427
DOC_PP4_FxxP_1	173	176	PF00568	0.390
DOC_USP7_MATH_1	261	265	PF00917	0.623
DOC_USP7_MATH_1	316	320	PF00917	0.425
DOC_USP7_MATH_1	474	478	PF00917	0.394
DOC_USP7_MATH_1	87	91	PF00917	0.545
DOC_USP7_UBL2_3	485	489	PF12436	0.630
DOC_WW_Pin1_4	146	151	PF00397	0.530
DOC_WW_Pin1_4	232	237	PF00397	0.427
DOC_WW_Pin1_4	32	37	PF00397	0.404
DOC_WW_Pin1_4	470	475	PF00397	0.435
DOC_WW_Pin1_4	477	482	PF00397	0.542
DOC_WW_Pin1_4	81	86	PF00397	0.755
DOC_WW_Pin1_4	89	94	PF00397	0.671
LIG_14-3-3_CanoR_1	301	307	PF00244	0.527
LIG_14-3-3_CanoR_1	384	388	PF00244	0.429
LIG_CaM_NSCaTE_8	225	232	PF13499	0.444
LIG_CSL_BTD_1	147	150	PF09270	0.442
LIG_CtBP_PxDLS_1	70	74	PF00389	0.537
LIG_FHA_1	310	316	PF00498	0.388
LIG_FHA_1	32	38	PF00498	0.492
LIG_FHA_2	14	20	PF00498	0.419
LIG_FHA_2	439	445	PF00498	0.325
LIG_FHA_2	90	96	PF00498	0.609
LIG_LIR_Gen_1	237	248	PF02991	0.576
LIG_LIR_Gen_1	250	258	PF02991	0.476
LIG_LIR_Gen_1	322	330	PF02991	0.458
LIG_LIR_Gen_1	343	352	PF02991	0.277
LIG_LIR_Gen_1	432	438	PF02991	0.321
LIG_LIR_Gen_1	7	17	PF02991	0.319
LIG_LIR_Nem_3	126	132	PF02991	0.434
LIG_LIR_Nem_3	217	223	PF02991	0.467
LIG_LIR_Nem_3	237	243	PF02991	0.580
LIG_LIR_Nem_3	245	251	PF02991	0.499
LIG_LIR_Nem_3	312	317	PF02991	0.392
LIG_LIR_Nem_3	322	326	PF02991	0.465
LIG_LIR_Nem_3	343	347	PF02991	0.272
LIG_LIR_Nem_3	359	364	PF02991	0.318
LIG_LIR_Nem_3	432	437	PF02991	0.321
LIG_LIR_Nem_3	7	12	PF02991	0.458
LIG_MYND_1	43	47	PF01753	0.578
LIG_MYND_3	165	169	PF01753	0.353
LIG_MYND_3	446	450	PF01753	0.231
LIG_Pex14_1	313	317	PF04695	0.350
LIG_SH2_CRK	132	136	PF00017	0.412
LIG_SH2_CRK	49	53	PF00017	0.460
LIG_SH2_GRB2like	363	366	PF00017	0.436
LIG_SH2_NCK_1	109	113	PF00017	0.303
LIG_SH2_PTP2	240	243	PF00017	0.448
LIG_SH2_PTP2	344	347	PF00017	0.344
LIG_SH2_SRC	17	20	PF00017	0.413
LIG_SH2_SRC	251	254	PF00017	0.562
LIG_SH2_SRC	396	399	PF00017	0.312
LIG_SH2_STAP1	132	136	PF00017	0.294
LIG_SH2_STAP1	288	292	PF00017	0.588
LIG_SH2_STAT3	436	439	PF00017	0.302
LIG_SH2_STAT5	11	14	PF00017	0.384
LIG_SH2_STAT5	17	20	PF00017	0.413
LIG_SH2_STAT5	240	243	PF00017	0.528
LIG_SH2_STAT5	251	254	PF00017	0.692
LIG_SH2_STAT5	314	317	PF00017	0.344
LIG_SH2_STAT5	344	347	PF00017	0.344
LIG_SH2_STAT5	390	393	PF00017	0.312
LIG_SH2_STAT5	436	439	PF00017	0.319
LIG_SH2_STAT5	451	454	PF00017	0.207
LIG_SH3_3	189	195	PF00018	0.522
LIG_SUMO_SIM_par_1	367	373	PF11976	0.408
LIG_TRAF2_1	441	444	PF00917	0.285
LIG_TYR_ITIM	342	347	PF00017	0.442
LIG_WW_1	93	96	PF00397	0.518
MOD_CDC14_SPxK_1	86	89	PF00782	0.697
MOD_CDK_SPK_2	477	482	PF00069	0.584
MOD_CDK_SPxK_1	83	89	PF00069	0.684
MOD_CK1_1	205	211	PF00069	0.619
MOD_CK1_1	263	269	PF00069	0.697
MOD_CK1_1	270	276	PF00069	0.683
MOD_CK1_1	277	283	PF00069	0.592
MOD_CK1_1	28	34	PF00069	0.476
MOD_CK1_1	287	293	PF00069	0.444
MOD_CK1_1	319	325	PF00069	0.506
MOD_CK1_1	477	483	PF00069	0.427
MOD_CK2_1	438	444	PF00069	0.296
MOD_CK2_1	89	95	PF00069	0.614
MOD_DYRK1A_RPxSP_1	89	93	PF00069	0.536
MOD_GlcNHglycan	204	207	PF01048	0.621
MOD_GlcNHglycan	230	233	PF01048	0.455
MOD_GlcNHglycan	27	30	PF01048	0.551
MOD_GlcNHglycan	276	279	PF01048	0.698
MOD_GlcNHglycan	39	42	PF01048	0.551
MOD_GlcNHglycan	56	59	PF01048	0.510
MOD_GSK3_1	201	208	PF00069	0.797
MOD_GSK3_1	228	235	PF00069	0.448
MOD_GSK3_1	263	270	PF00069	0.787
MOD_GSK3_1	28	35	PF00069	0.513
MOD_GSK3_1	470	477	PF00069	0.377
MOD_GSK3_1	77	84	PF00069	0.680
MOD_N-GLC_1	319	324	PF02516	0.329
MOD_NEK2_1	154	159	PF00069	0.471
MOD_PIKK_1	149	155	PF00454	0.514
MOD_PIKK_1	205	211	PF00454	0.516
MOD_PIKK_1	234	240	PF00454	0.554
MOD_PIKK_1	396	402	PF00454	0.388
MOD_PIKK_1	474	480	PF00454	0.400
MOD_PKA_2	270	276	PF00069	0.553
MOD_PKA_2	383	389	PF00069	0.352
MOD_Plk_1	215	221	PF00069	0.482
MOD_Plk_1	261	267	PF00069	0.503
MOD_Plk_1	319	325	PF00069	0.454
MOD_Plk_4	13	19	PF00069	0.392
MOD_Plk_4	154	160	PF00069	0.432
MOD_Plk_4	309	315	PF00069	0.440
MOD_ProDKin_1	146	152	PF00069	0.517
MOD_ProDKin_1	232	238	PF00069	0.433
MOD_ProDKin_1	32	38	PF00069	0.395
MOD_ProDKin_1	470	476	PF00069	0.435
MOD_ProDKin_1	477	483	PF00069	0.543
MOD_ProDKin_1	81	87	PF00069	0.753
MOD_ProDKin_1	89	95	PF00069	0.668
MOD_SUMO_rev_2	164	173	PF00179	0.416
MOD_SUMO_rev_2	306	312	PF00179	0.486
MOD_SUMO_rev_2	367	377	PF00179	0.389
MOD_SUMO_rev_2	90	99	PF00179	0.651
TRG_DiLeu_BaEn_2	168	174	PF01217	0.384
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.397
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.340
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.364
TRG_ENDOCYTIC_2	132	135	PF00928	0.403
TRG_ENDOCYTIC_2	240	243	PF00928	0.627
TRG_ENDOCYTIC_2	251	254	PF00928	0.618
TRG_ENDOCYTIC_2	344	347	PF00928	0.344
TRG_ENDOCYTIC_2	363	366	PF00928	0.360
TRG_ENDOCYTIC_2	414	417	PF00928	0.255
TRG_ENDOCYTIC_2	49	52	PF00928	0.452
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.231
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P468	Leptomonas seymouri	54%	96%
A0A3Q8IAR7	Leishmania donovani	73%	100%
A4HYM3	Leishmania infantum	73%	100%
E9AUI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QCZ6	Leishmania major	74%	99%