Glycerol-3-phosphate dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol-3-phosphate dehydrogenase-like protein

Species:

Leishmania braziliensis

UniProt:

E9AIA2_LEIBR

TriTrypDb:

LbrM.20.4680 , LBRM2903_200060600

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	10
GO:0032991	protein-containing complex	1	10
GO:1902494	catalytic complex	2	10
GO:1990204	oxidoreductase complex	3	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AIA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA2

Function

Biological processes
Term	Name	Level	Count
GO:0006072	glycerol-3-phosphate metabolic process	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019637	organophosphate metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0052646	alditol phosphate metabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901135	carbohydrate derivative metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	5	10
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	10
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	4	10
GO:0052590	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity	6	6
GO:0052591	sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity	7	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.502
CLV_C14_Caspase3-7	667	671	PF00656	0.318
CLV_C14_Caspase3-7	88	92	PF00656	0.247
CLV_NRD_NRD_1	168	170	PF00675	0.537
CLV_NRD_NRD_1	27	29	PF00675	0.686
CLV_NRD_NRD_1	3	5	PF00675	0.378
CLV_NRD_NRD_1	384	386	PF00675	0.247
CLV_NRD_NRD_1	57	59	PF00675	0.619
CLV_NRD_NRD_1	6	8	PF00675	0.376
CLV_NRD_NRD_1	645	647	PF00675	0.680
CLV_NRD_NRD_1	662	664	PF00675	0.494
CLV_NRD_NRD_1	737	739	PF00675	0.463
CLV_NRD_NRD_1	770	772	PF00675	0.476
CLV_PCSK_FUR_1	382	386	PF00082	0.189
CLV_PCSK_FUR_1	4	8	PF00082	0.333
CLV_PCSK_KEX2_1	168	170	PF00082	0.537
CLV_PCSK_KEX2_1	27	29	PF00082	0.686
CLV_PCSK_KEX2_1	3	5	PF00082	0.356
CLV_PCSK_KEX2_1	382	384	PF00082	0.247
CLV_PCSK_KEX2_1	57	59	PF00082	0.619
CLV_PCSK_KEX2_1	6	8	PF00082	0.348
CLV_PCSK_KEX2_1	645	647	PF00082	0.680
CLV_PCSK_KEX2_1	662	664	PF00082	0.518
CLV_PCSK_KEX2_1	737	739	PF00082	0.485
CLV_PCSK_KEX2_1	770	772	PF00082	0.476
CLV_PCSK_SKI1_1	220	224	PF00082	0.404
CLV_PCSK_SKI1_1	363	367	PF00082	0.335
CLV_PCSK_SKI1_1	683	687	PF00082	0.657
CLV_PCSK_SKI1_1	98	102	PF00082	0.465
DEG_SPOP_SBC_1	208	212	PF00917	0.210
DEG_SPOP_SBC_1	277	281	PF00917	0.389
DOC_CDC14_PxL_1	530	538	PF14671	0.392
DOC_CDC14_PxL_1	654	662	PF14671	0.271
DOC_CDC14_PxL_1	750	758	PF14671	0.330
DOC_CKS1_1	472	477	PF01111	0.441
DOC_CKS1_1	698	703	PF01111	0.365
DOC_CYCLIN_RxL_1	689	702	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.473
DOC_MAPK_DCC_7	645	653	PF00069	0.349
DOC_MAPK_gen_1	3	12	PF00069	0.616
DOC_MAPK_gen_1	645	653	PF00069	0.349
DOC_MAPK_gen_1	690	698	PF00069	0.368
DOC_MAPK_MEF2A_6	3	12	PF00069	0.625
DOC_MAPK_MEF2A_6	307	316	PF00069	0.502
DOC_MAPK_MEF2A_6	645	653	PF00069	0.349
DOC_MAPK_RevD_3	648	663	PF00069	0.364
DOC_PP1_RVXF_1	506	512	PF00149	0.400
DOC_PP2B_LxvP_1	459	462	PF13499	0.465
DOC_PP4_FxxP_1	250	253	PF00568	0.344
DOC_PP4_FxxP_1	504	507	PF00568	0.400
DOC_SPAK_OSR1_1	262	266	PF12202	0.389
DOC_USP7_MATH_1	208	212	PF00917	0.320
DOC_USP7_MATH_1	241	245	PF00917	0.461
DOC_USP7_MATH_1	278	282	PF00917	0.465
DOC_USP7_MATH_1	365	369	PF00917	0.550
DOC_USP7_MATH_1	56	60	PF00917	0.396
DOC_USP7_MATH_1	568	572	PF00917	0.395
DOC_USP7_MATH_1	630	634	PF00917	0.379
DOC_USP7_UBL2_3	683	687	PF12436	0.476
DOC_WW_Pin1_4	117	122	PF00397	0.273
DOC_WW_Pin1_4	366	371	PF00397	0.562
DOC_WW_Pin1_4	471	476	PF00397	0.549
DOC_WW_Pin1_4	488	493	PF00397	0.500
DOC_WW_Pin1_4	503	508	PF00397	0.392
DOC_WW_Pin1_4	51	56	PF00397	0.452
DOC_WW_Pin1_4	697	702	PF00397	0.369
DOC_WW_Pin1_4	742	747	PF00397	0.247
LIG_14-3-3_CanoR_1	140	146	PF00244	0.309
LIG_14-3-3_CanoR_1	158	163	PF00244	0.373
LIG_14-3-3_CanoR_1	168	174	PF00244	0.237
LIG_14-3-3_CanoR_1	209	214	PF00244	0.299
LIG_14-3-3_CanoR_1	220	226	PF00244	0.225
LIG_14-3-3_CanoR_1	32	38	PF00244	0.404
LIG_14-3-3_CanoR_1	344	352	PF00244	0.471
LIG_14-3-3_CanoR_1	353	357	PF00244	0.417
LIG_14-3-3_CanoR_1	508	512	PF00244	0.400
LIG_14-3-3_CanoR_1	558	563	PF00244	0.460
LIG_14-3-3_CanoR_1	57	65	PF00244	0.333
LIG_14-3-3_CanoR_1	576	585	PF00244	0.256
LIG_14-3-3_CanoR_1	67	74	PF00244	0.358
LIG_14-3-3_CanoR_1	737	743	PF00244	0.287
LIG_Actin_WH2_2	124	142	PF00022	0.257
LIG_Actin_WH2_2	83	100	PF00022	0.247
LIG_AP2alpha_2	72	74	PF02296	0.324
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	290	294	PF00533	0.411
LIG_BRCT_BRCA1_1	528	532	PF00533	0.269
LIG_Clathr_ClatBox_1	213	217	PF01394	0.284
LIG_eIF4E_1	674	680	PF01652	0.260
LIG_FHA_1	208	214	PF00498	0.362
LIG_FHA_1	217	223	PF00498	0.337
LIG_FHA_1	298	304	PF00498	0.595
LIG_FHA_1	394	400	PF00498	0.524
LIG_FHA_1	401	407	PF00498	0.463
LIG_FHA_1	413	419	PF00498	0.455
LIG_FHA_1	497	503	PF00498	0.389
LIG_FHA_1	635	641	PF00498	0.579
LIG_FHA_1	691	697	PF00498	0.339
LIG_FHA_1	742	748	PF00498	0.323
LIG_FHA_2	142	148	PF00498	0.308
LIG_FHA_2	306	312	PF00498	0.592
LIG_FHA_2	330	336	PF00498	0.458
LIG_FHA_2	412	418	PF00498	0.389
LIG_FHA_2	67	73	PF00498	0.305
LIG_FHA_2	724	730	PF00498	0.395
LIG_FHA_2	86	92	PF00498	0.247
LIG_LIR_Apic_2	248	253	PF02991	0.344
LIG_LIR_Gen_1	137	146	PF02991	0.354
LIG_LIR_Gen_1	149	160	PF02991	0.184
LIG_LIR_Gen_1	510	518	PF02991	0.314
LIG_LIR_Gen_1	59	70	PF02991	0.361
LIG_LIR_Gen_1	72	79	PF02991	0.250
LIG_LIR_Gen_1	84	93	PF02991	0.255
LIG_LIR_Nem_3	149	155	PF02991	0.270
LIG_LIR_Nem_3	318	322	PF02991	0.493
LIG_LIR_Nem_3	489	493	PF02991	0.462
LIG_LIR_Nem_3	510	514	PF02991	0.314
LIG_LIR_Nem_3	59	65	PF02991	0.364
LIG_LIR_Nem_3	72	77	PF02991	0.281
LIG_LIR_Nem_3	84	90	PF02991	0.255
LIG_PCNA_yPIPBox_3	716	730	PF02747	0.189
LIG_PDZ_Class_2	784	789	PF00595	0.390
LIG_Pex14_2	250	254	PF04695	0.209
LIG_SH2_CRK	456	460	PF00017	0.530
LIG_SH2_CRK	743	747	PF00017	0.290
LIG_SH2_NCK_1	87	91	PF00017	0.247
LIG_SH2_PTP2	319	322	PF00017	0.389
LIG_SH2_SRC	319	322	PF00017	0.530
LIG_SH2_SRC	458	461	PF00017	0.502
LIG_SH2_STAP1	419	423	PF00017	0.424
LIG_SH2_STAP1	438	442	PF00017	0.466
LIG_SH2_STAP1	456	460	PF00017	0.517
LIG_SH2_STAP1	605	609	PF00017	0.363
LIG_SH2_STAP1	727	731	PF00017	0.265
LIG_SH2_STAT3	554	557	PF00017	0.364
LIG_SH2_STAT5	126	129	PF00017	0.275
LIG_SH2_STAT5	237	240	PF00017	0.391
LIG_SH2_STAT5	319	322	PF00017	0.444
LIG_SH2_STAT5	458	461	PF00017	0.451
LIG_SH2_STAT5	743	746	PF00017	0.385
LIG_SH2_STAT5	87	90	PF00017	0.247
LIG_SH3_3	157	163	PF00018	0.365
LIG_SH3_3	250	256	PF00018	0.360
LIG_SH3_3	367	373	PF00018	0.535
LIG_SH3_3	466	472	PF00018	0.515
LIG_SH3_3	531	537	PF00018	0.384
LIG_SUMO_SIM_anti_2	513	518	PF11976	0.347
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.265
LIG_SUMO_SIM_par_1	210	219	PF11976	0.293
LIG_SUMO_SIM_par_1	299	304	PF11976	0.502
LIG_TRAF2_1	308	311	PF00917	0.502
LIG_TRAF2_1	324	327	PF00917	0.384
LIG_TYR_ITIM	317	322	PF00017	0.308
LIG_WRC_WIRS_1	487	492	PF05994	0.203
MOD_CDC14_SPxK_1	54	57	PF00782	0.354
MOD_CDK_SPK_2	503	508	PF00069	0.400
MOD_CDK_SPxK_1	51	57	PF00069	0.388
MOD_CDK_SPxxK_3	51	58	PF00069	0.574
MOD_CK1_1	111	117	PF00069	0.369
MOD_CK1_1	2	8	PF00069	0.585
MOD_CK1_1	212	218	PF00069	0.300
MOD_CK1_1	279	285	PF00069	0.382
MOD_CK1_1	329	335	PF00069	0.288
MOD_CK1_1	338	344	PF00069	0.348
MOD_CK1_1	369	375	PF00069	0.397
MOD_CK1_1	388	394	PF00069	0.447
MOD_CK1_1	402	408	PF00069	0.359
MOD_CK1_1	491	497	PF00069	0.262
MOD_CK1_1	510	516	PF00069	0.292
MOD_CK1_1	563	569	PF00069	0.496
MOD_CK1_1	579	585	PF00069	0.333
MOD_CK1_1	681	687	PF00069	0.427
MOD_CK1_1	703	709	PF00069	0.630
MOD_CK2_1	141	147	PF00069	0.279
MOD_CK2_1	179	185	PF00069	0.360
MOD_CK2_1	305	311	PF00069	0.397
MOD_CK2_1	321	327	PF00069	0.238
MOD_CK2_1	329	335	PF00069	0.318
MOD_CK2_1	723	729	PF00069	0.434
MOD_CK2_1	742	748	PF00069	0.165
MOD_CK2_1	770	776	PF00069	0.444
MOD_CMANNOS	170	173	PF00535	0.360
MOD_GlcNHglycan	160	163	PF01048	0.336
MOD_GlcNHglycan	327	331	PF01048	0.440
MOD_GlcNHglycan	34	37	PF01048	0.488
MOD_GlcNHglycan	43	46	PF01048	0.501
MOD_GlcNHglycan	566	569	PF01048	0.445
MOD_GlcNHglycan	632	635	PF01048	0.484
MOD_GSK3_1	111	118	PF00069	0.357
MOD_GSK3_1	158	165	PF00069	0.382
MOD_GSK3_1	175	182	PF00069	0.288
MOD_GSK3_1	190	197	PF00069	0.264
MOD_GSK3_1	208	215	PF00069	0.413
MOD_GSK3_1	216	223	PF00069	0.332
MOD_GSK3_1	241	248	PF00069	0.363
MOD_GSK3_1	272	279	PF00069	0.476
MOD_GSK3_1	297	304	PF00069	0.459
MOD_GSK3_1	331	338	PF00069	0.328
MOD_GSK3_1	339	346	PF00069	0.378
MOD_GSK3_1	365	372	PF00069	0.406
MOD_GSK3_1	37	44	PF00069	0.526
MOD_GSK3_1	385	392	PF00069	0.307
MOD_GSK3_1	503	510	PF00069	0.316
MOD_GSK3_1	560	567	PF00069	0.505
MOD_GSK3_1	568	575	PF00069	0.424
MOD_GSK3_1	630	637	PF00069	0.571
MOD_GSK3_1	699	706	PF00069	0.468
MOD_GSK3_1	81	88	PF00069	0.308
MOD_LATS_1	30	36	PF00433	0.396
MOD_N-GLC_1	297	302	PF02516	0.303
MOD_N-GLC_1	388	393	PF02516	0.251
MOD_N-GLC_1	424	429	PF02516	0.374
MOD_N-GLC_2	441	443	PF02516	0.203
MOD_NEK2_1	141	146	PF00069	0.360
MOD_NEK2_1	242	247	PF00069	0.358
MOD_NEK2_1	272	277	PF00069	0.358
MOD_NEK2_1	31	36	PF00069	0.488
MOD_NEK2_1	312	317	PF00069	0.427
MOD_NEK2_1	336	341	PF00069	0.498
MOD_NEK2_1	352	357	PF00069	0.344
MOD_NEK2_1	399	404	PF00069	0.365
MOD_NEK2_1	493	498	PF00069	0.344
MOD_NEK2_1	502	507	PF00069	0.275
MOD_NEK2_1	564	569	PF00069	0.459
MOD_NEK2_1	601	606	PF00069	0.497
MOD_NEK2_1	607	612	PF00069	0.452
MOD_NEK2_1	65	70	PF00069	0.390
MOD_NEK2_1	781	786	PF00069	0.390
MOD_NEK2_2	430	435	PF00069	0.360
MOD_PIKK_1	579	585	PF00454	0.429
MOD_PIKK_1	678	684	PF00454	0.308
MOD_PKA_1	57	63	PF00069	0.411
MOD_PKA_1	770	776	PF00069	0.436
MOD_PKA_2	2	8	PF00069	0.463
MOD_PKA_2	208	214	PF00069	0.209
MOD_PKA_2	31	37	PF00069	0.490
MOD_PKA_2	343	349	PF00069	0.321
MOD_PKA_2	352	358	PF00069	0.241
MOD_PKA_2	507	513	PF00069	0.443
MOD_PKA_2	56	62	PF00069	0.536
MOD_PKA_2	66	72	PF00069	0.457
MOD_PKA_2	736	742	PF00069	0.308
MOD_PKA_2	770	776	PF00069	0.456
MOD_PKB_1	383	391	PF00069	0.278
MOD_PKB_1	558	566	PF00069	0.476
MOD_Plk_1	147	153	PF00069	0.400
MOD_Plk_1	297	303	PF00069	0.249
MOD_Plk_1	572	578	PF00069	0.480
MOD_Plk_4	141	147	PF00069	0.358
MOD_Plk_4	162	168	PF00069	0.421
MOD_Plk_4	20	26	PF00069	0.203
MOD_Plk_4	209	215	PF00069	0.414
MOD_Plk_4	221	227	PF00069	0.265
MOD_Plk_4	242	248	PF00069	0.284
MOD_Plk_4	312	318	PF00069	0.360
MOD_Plk_4	454	460	PF00069	0.308
MOD_Plk_4	510	516	PF00069	0.316
MOD_Plk_4	560	566	PF00069	0.497
MOD_ProDKin_1	117	123	PF00069	0.320
MOD_ProDKin_1	366	372	PF00069	0.444
MOD_ProDKin_1	471	477	PF00069	0.426
MOD_ProDKin_1	488	494	PF00069	0.358
MOD_ProDKin_1	503	509	PF00069	0.392
MOD_ProDKin_1	51	57	PF00069	0.568
MOD_ProDKin_1	697	703	PF00069	0.453
MOD_ProDKin_1	742	748	PF00069	0.284
TRG_DiLeu_BaEn_1	777	782	PF01217	0.284
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.482
TRG_DiLeu_BaLyEn_6	646	651	PF01217	0.524
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.360
TRG_ENDOCYTIC_2	319	322	PF00928	0.284
TRG_ENDOCYTIC_2	456	459	PF00928	0.291
TRG_ENDOCYTIC_2	87	90	PF00928	0.284
TRG_ER_diArg_1	131	134	PF00400	0.286
TRG_ER_diArg_1	167	169	PF00400	0.387
TRG_ER_diArg_1	26	28	PF00400	0.601
TRG_ER_diArg_1	3	6	PF00400	0.435
TRG_ER_diArg_1	381	384	PF00400	0.328
TRG_ER_diArg_1	662	664	PF00400	0.429
TRG_ER_diArg_1	770	772	PF00400	0.439
TRG_NES_CRM1_1	310	326	PF08389	0.203
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	770	774	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L0	Leptomonas seymouri	47%	94%
A0A1X0NY01	Trypanosomatidae	32%	100%
A0A3Q8IDJ7	Leishmania donovani	76%	100%
A4HYM4	Leishmania infantum	75%	100%
C9ZI64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AUI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QCZ7	Leishmania major	75%	100%
V5BVH7	Trypanosoma cruzi	30%	100%