Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal RNA-processing protein 8, putative

Species:

Leishmania braziliensis

UniProt:

E9AIA1_LEIBR

TriTrypDb:

LbrM.20.4670 , LBRM2903_200060500

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AIA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AIA1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.518
CLV_NRD_NRD_1	203	205	PF00675	0.297
CLV_NRD_NRD_1	316	318	PF00675	0.316
CLV_NRD_NRD_1	50	52	PF00675	0.702
CLV_NRD_NRD_1	7	9	PF00675	0.594
CLV_NRD_NRD_1	76	78	PF00675	0.625
CLV_NRD_NRD_1	91	93	PF00675	0.500
CLV_PCSK_KEX2_1	123	125	PF00082	0.556
CLV_PCSK_KEX2_1	203	205	PF00082	0.284
CLV_PCSK_KEX2_1	21	23	PF00082	0.540
CLV_PCSK_KEX2_1	301	303	PF00082	0.306
CLV_PCSK_KEX2_1	50	52	PF00082	0.721
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.540
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.313
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.721
CLV_PCSK_SKI1_1	124	128	PF00082	0.565
CLV_PCSK_SKI1_1	18	22	PF00082	0.553
CLV_PCSK_SKI1_1	289	293	PF00082	0.320
CLV_PCSK_SKI1_1	296	300	PF00082	0.270
CLV_PCSK_SKI1_1	301	305	PF00082	0.257
DEG_COP1_1	361	370	PF00400	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.596
DOC_AGCK_PIF_2	340	345	PF00069	0.297
DOC_CYCLIN_RxL_1	286	293	PF00134	0.332
DOC_CYCLIN_RxL_1	296	308	PF00134	0.253
DOC_MAPK_gen_1	296	306	PF00069	0.297
DOC_USP7_MATH_1	115	119	PF00917	0.627
DOC_USP7_MATH_1	161	165	PF00917	0.248
DOC_USP7_MATH_1	60	64	PF00917	0.606
DOC_USP7_MATH_2	267	273	PF00917	0.212
DOC_USP7_UBL2_3	14	18	PF12436	0.533
DOC_USP7_UBL2_3	301	305	PF12436	0.313
DOC_USP7_UBL2_3	85	89	PF12436	0.656
DOC_USP7_UBL2_3	9	13	PF12436	0.567
LIG_14-3-3_CanoR_1	142	151	PF00244	0.320
LIG_14-3-3_CanoR_1	22	28	PF00244	0.597
LIG_Actin_WH2_2	291	307	PF00022	0.297
LIG_BRCT_BRCA1_1	247	251	PF00533	0.311
LIG_FHA_1	145	151	PF00498	0.297
LIG_FHA_1	191	197	PF00498	0.347
LIG_FHA_1	261	267	PF00498	0.382
LIG_FHA_1	283	289	PF00498	0.372
LIG_FHA_2	170	176	PF00498	0.297
LIG_FHA_2	257	263	PF00498	0.418
LIG_GBD_Chelix_1	322	330	PF00786	0.212
LIG_LIR_Apic_2	153	159	PF02991	0.332
LIG_LIR_Gen_1	248	257	PF02991	0.332
LIG_LIR_Gen_1	290	300	PF02991	0.302
LIG_LIR_Gen_1	329	340	PF02991	0.348
LIG_LIR_Nem_3	146	151	PF02991	0.300
LIG_LIR_Nem_3	170	176	PF02991	0.302
LIG_LIR_Nem_3	248	254	PF02991	0.332
LIG_LIR_Nem_3	290	295	PF02991	0.269
LIG_LIR_Nem_3	329	335	PF02991	0.311
LIG_LIR_Nem_3	338	343	PF02991	0.249
LIG_NRP_CendR_1	372	374	PF00754	0.297
LIG_Pex14_2	315	319	PF04695	0.446
LIG_SH2_CRK	100	104	PF00017	0.682
LIG_SH2_CRK	156	160	PF00017	0.332
LIG_SH2_NCK_1	156	160	PF00017	0.382
LIG_SH2_NCK_1	332	336	PF00017	0.384
LIG_SH2_STAP1	332	336	PF00017	0.418
LIG_SH2_STAT3	180	183	PF00017	0.297
LIG_SH2_STAT5	244	247	PF00017	0.313
LIG_SH2_STAT5	287	290	PF00017	0.306
LIG_SH2_STAT5	339	342	PF00017	0.311
LIG_SH2_STAT5	67	70	PF00017	0.469
LIG_SH3_3	182	188	PF00018	0.294
LIG_SH3_3	310	316	PF00018	0.339
LIG_SH3_3	362	368	PF00018	0.354
LIG_SUMO_SIM_anti_2	279	286	PF11976	0.297
LIG_SUMO_SIM_par_1	192	197	PF11976	0.347
LIG_SUMO_SIM_par_1	256	264	PF11976	0.420
LIG_SUMO_SIM_par_1	305	311	PF11976	0.297
LIG_TRFH_1	252	256	PF08558	0.327
LIG_WRC_WIRS_1	246	251	PF05994	0.297
MOD_CK1_1	34	40	PF00069	0.729
MOD_CK1_1	70	76	PF00069	0.620
MOD_CK2_1	287	293	PF00069	0.368
MOD_GlcNHglycan	118	121	PF01048	0.544
MOD_GlcNHglycan	33	36	PF01048	0.712
MOD_GlcNHglycan	38	41	PF01048	0.675
MOD_GlcNHglycan	72	75	PF01048	0.556
MOD_GSK3_1	157	164	PF00069	0.381
MOD_GSK3_1	256	263	PF00069	0.382
MOD_GSK3_1	27	34	PF00069	0.679
MOD_GSK3_1	278	285	PF00069	0.284
MOD_N-GLC_1	143	148	PF02516	0.384
MOD_NEK2_1	143	148	PF00069	0.295
MOD_NEK2_1	27	32	PF00069	0.720
MOD_NEK2_1	278	283	PF00069	0.305
MOD_NEK2_2	287	292	PF00069	0.390
MOD_PIKK_1	21	27	PF00454	0.664
MOD_PIKK_1	353	359	PF00454	0.418
MOD_PK_1	99	105	PF00069	0.564
MOD_PKA_1	21	27	PF00069	0.620
MOD_PKA_2	21	27	PF00069	0.570
MOD_PKA_2	70	76	PF00069	0.570
MOD_PKB_1	29	37	PF00069	0.502
MOD_Plk_1	143	149	PF00069	0.372
MOD_Plk_1	168	174	PF00069	0.416
MOD_Plk_1	261	267	PF00069	0.223
MOD_Plk_1	269	275	PF00069	0.197
MOD_Plk_2-3	169	175	PF00069	0.297
MOD_Plk_2-3	269	275	PF00069	0.186
MOD_Plk_4	190	196	PF00069	0.414
MOD_Plk_4	219	225	PF00069	0.313
MOD_Plk_4	278	284	PF00069	0.286
MOD_Plk_4	287	293	PF00069	0.279
MOD_Plk_4	366	372	PF00069	0.297
MOD_Plk_4	99	105	PF00069	0.670
MOD_SUMO_rev_2	83	90	PF00179	0.633
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.297
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.297
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.297
TRG_ENDOCYTIC_2	100	103	PF00928	0.686
TRG_ENDOCYTIC_2	332	335	PF00928	0.347
TRG_ER_diArg_1	123	125	PF00400	0.614
TRG_ER_diArg_1	139	142	PF00400	0.361
TRG_ER_diArg_1	203	206	PF00400	0.298
TRG_ER_diArg_1	28	31	PF00400	0.497
TRG_ER_diArg_1	309	312	PF00400	0.289
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD61	Leptomonas seymouri	82%	100%
A0A0S4J2L3	Bodo saltans	56%	71%
A0A1X0NWQ8	Trypanosomatidae	59%	100%
A0A3Q8IAH5	Leishmania donovani	89%	100%
A0A422NCI5	Trypanosoma rangeli	59%	100%
A4HYM5	Leishmania infantum	88%	100%
A8XI07	Caenorhabditis briggsae	35%	100%
C9ZI63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AUI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O44410	Caenorhabditis elegans	33%	100%
Q10257	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4QCZ8	Leishmania major	89%	100%
Q54CP1	Dictyostelium discoideum	36%	96%
Q5U4F0	Rattus norvegicus	34%	82%
Q84JC0	Arabidopsis thaliana	36%	100%
V5C0A6	Trypanosoma cruzi	64%	100%