TFIIH_basal_transcription_factor_subunit_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIH basal transcription factor subunit, putative

Species:

Leishmania braziliensis

UniProt:

E9AI99_LEIBR

TriTrypDb:

LbrM.20.4650 , LBRM2903_200060300

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.460
CLV_NRD_NRD_1	158	160	PF00675	0.585
CLV_NRD_NRD_1	261	263	PF00675	0.559
CLV_NRD_NRD_1	344	346	PF00675	0.637
CLV_NRD_NRD_1	562	564	PF00675	0.559
CLV_PCSK_FUR_1	342	346	PF00082	0.663
CLV_PCSK_FUR_1	560	564	PF00082	0.557
CLV_PCSK_KEX2_1	128	130	PF00082	0.492
CLV_PCSK_KEX2_1	158	160	PF00082	0.585
CLV_PCSK_KEX2_1	261	263	PF00082	0.559
CLV_PCSK_KEX2_1	344	346	PF00082	0.676
CLV_PCSK_KEX2_1	559	561	PF00082	0.577
CLV_PCSK_KEX2_1	562	564	PF00082	0.554
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.402
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.650
CLV_PCSK_PC7_1	257	263	PF00082	0.658
CLV_PCSK_SKI1_1	110	114	PF00082	0.544
CLV_PCSK_SKI1_1	257	261	PF00082	0.635
CLV_PCSK_SKI1_1	396	400	PF00082	0.509
CLV_PCSK_SKI1_1	438	442	PF00082	0.692
CLV_PCSK_SKI1_1	507	511	PF00082	0.578
CLV_PCSK_SKI1_1	519	523	PF00082	0.536
CLV_PCSK_SKI1_1	575	579	PF00082	0.670
DOC_CYCLIN_RxL_1	290	300	PF00134	0.530
DOC_MAPK_gen_1	342	350	PF00069	0.671
DOC_PP1_RVXF_1	300	306	PF00149	0.616
DOC_PP2B_LxvP_1	295	298	PF13499	0.633
DOC_PP4_FxxP_1	433	436	PF00568	0.683
DOC_PP4_FxxP_1	584	587	PF00568	0.685
DOC_SPAK_OSR1_1	275	279	PF12202	0.567
DOC_USP7_MATH_1	186	190	PF00917	0.739
DOC_USP7_MATH_1	195	199	PF00917	0.736
DOC_USP7_MATH_1	218	222	PF00917	0.617
DOC_USP7_MATH_1	349	353	PF00917	0.638
DOC_USP7_MATH_1	359	363	PF00917	0.680
DOC_USP7_MATH_1	436	440	PF00917	0.736
DOC_USP7_MATH_1	448	452	PF00917	0.649
DOC_USP7_MATH_1	455	459	PF00917	0.450
DOC_USP7_MATH_1	462	466	PF00917	0.625
DOC_USP7_MATH_1	468	472	PF00917	0.372
DOC_USP7_MATH_1	75	79	PF00917	0.613
DOC_USP7_MATH_1	93	97	PF00917	0.700
DOC_USP7_MATH_2	50	56	PF00917	0.366
DOC_USP7_UBL2_3	175	179	PF12436	0.710
DOC_WW_Pin1_4	129	134	PF00397	0.535
DOC_WW_Pin1_4	350	355	PF00397	0.680
DOC_WW_Pin1_4	357	362	PF00397	0.644
DOC_WW_Pin1_4	446	451	PF00397	0.678
DOC_WW_Pin1_4	497	502	PF00397	0.594
DOC_WW_Pin1_4	6	11	PF00397	0.607
DOC_WW_Pin1_4	94	99	PF00397	0.770
LIG_14-3-3_CanoR_1	523	531	PF00244	0.639
LIG_APCC_ABBA_1	143	148	PF00400	0.480
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_BRCT_BRCA1_1	584	588	PF00533	0.643
LIG_FHA_1	145	151	PF00498	0.462
LIG_FHA_1	152	158	PF00498	0.457
LIG_FHA_1	161	167	PF00498	0.459
LIG_FHA_1	217	223	PF00498	0.698
LIG_FHA_1	325	331	PF00498	0.777
LIG_FHA_1	351	357	PF00498	0.567
LIG_FHA_1	520	526	PF00498	0.600
LIG_FHA_2	102	108	PF00498	0.667
LIG_FHA_2	120	126	PF00498	0.363
LIG_FHA_2	133	139	PF00498	0.537
LIG_FHA_2	319	325	PF00498	0.693
LIG_LIR_Apic_2	268	273	PF02991	0.537
LIG_LIR_Apic_2	431	436	PF02991	0.729
LIG_LIR_Apic_2	449	455	PF02991	0.421
LIG_LIR_Apic_2	583	587	PF02991	0.688
LIG_LIR_Gen_1	14	23	PF02991	0.401
LIG_LIR_Gen_1	242	252	PF02991	0.578
LIG_LIR_Gen_1	485	494	PF02991	0.680
LIG_LIR_Gen_1	52	61	PF02991	0.483
LIG_LIR_Nem_3	14	20	PF02991	0.412
LIG_LIR_Nem_3	177	181	PF02991	0.684
LIG_LIR_Nem_3	242	248	PF02991	0.571
LIG_LIR_Nem_3	485	490	PF02991	0.689
LIG_LIR_Nem_3	52	57	PF02991	0.433
LIG_LIR_Nem_3	585	591	PF02991	0.474
LIG_PCNA_yPIPBox_3	384	398	PF02747	0.311
LIG_Pex14_1	452	456	PF04695	0.715
LIG_Pex14_2	49	53	PF04695	0.436
LIG_Pex14_2	580	584	PF04695	0.671
LIG_Rb_pABgroove_1	280	288	PF01858	0.533
LIG_SH2_CRK	270	274	PF00017	0.516
LIG_SH2_NCK_1	173	177	PF00017	0.580
LIG_SH2_NCK_1	270	274	PF00017	0.441
LIG_SH2_NCK_1	31	35	PF00017	0.460
LIG_SH2_PTP2	111	114	PF00017	0.570
LIG_SH2_PTP2	245	248	PF00017	0.577
LIG_SH2_STAP1	456	460	PF00017	0.712
LIG_SH2_STAP1	73	77	PF00017	0.515
LIG_SH2_STAT3	511	514	PF00017	0.671
LIG_SH2_STAT5	111	114	PF00017	0.528
LIG_SH2_STAT5	168	171	PF00017	0.487
LIG_SH2_STAT5	245	248	PF00017	0.558
LIG_SH2_STAT5	277	280	PF00017	0.579
LIG_SH2_STAT5	31	34	PF00017	0.453
LIG_SH3_2	337	342	PF14604	0.411
LIG_SH3_3	24	30	PF00018	0.617
LIG_SH3_3	243	249	PF00018	0.567
LIG_SH3_3	307	313	PF00018	0.503
LIG_SH3_3	334	340	PF00018	0.718
LIG_SH3_3	414	420	PF00018	0.518
LIG_SH3_3	488	494	PF00018	0.677
LIG_SUMO_SIM_par_1	421	427	PF11976	0.557
LIG_SUMO_SIM_par_1	502	508	PF11976	0.606
LIG_TRAF2_1	265	268	PF00917	0.632
LIG_WRC_WIRS_1	223	228	PF05994	0.543
LIG_WRC_WIRS_1	430	435	PF05994	0.733
MOD_CK1_1	132	138	PF00069	0.591
MOD_CK1_1	188	194	PF00069	0.738
MOD_CK1_1	207	213	PF00069	0.742
MOD_CK1_1	271	277	PF00069	0.550
MOD_CK1_1	362	368	PF00069	0.652
MOD_CK1_1	466	472	PF00069	0.660
MOD_CK1_1	527	533	PF00069	0.641
MOD_CK1_1	94	100	PF00069	0.780
MOD_CK2_1	101	107	PF00069	0.662
MOD_CK2_1	119	125	PF00069	0.394
MOD_CK2_1	195	201	PF00069	0.557
MOD_CK2_1	218	224	PF00069	0.715
MOD_CK2_1	318	324	PF00069	0.770
MOD_CK2_1	325	331	PF00069	0.777
MOD_CK2_1	431	437	PF00069	0.637
MOD_CK2_1	52	58	PF00069	0.474
MOD_Cter_Amidation	557	560	PF01082	0.718
MOD_GlcNHglycan	188	191	PF01048	0.705
MOD_GlcNHglycan	197	200	PF01048	0.763
MOD_GlcNHglycan	206	209	PF01048	0.723
MOD_GlcNHglycan	361	364	PF01048	0.654
MOD_GlcNHglycan	366	370	PF01048	0.652
MOD_GlcNHglycan	480	483	PF01048	0.602
MOD_GlcNHglycan	526	529	PF01048	0.622
MOD_GlcNHglycan	553	556	PF01048	0.498
MOD_GlcNHglycan	73	76	PF01048	0.616
MOD_GlcNHglycan	93	96	PF01048	0.625
MOD_GSK3_1	184	191	PF00069	0.712
MOD_GSK3_1	204	211	PF00069	0.762
MOD_GSK3_1	218	225	PF00069	0.677
MOD_GSK3_1	462	469	PF00069	0.678
MOD_GSK3_1	493	500	PF00069	0.606
MOD_GSK3_1	71	78	PF00069	0.639
MOD_LATS_1	255	261	PF00433	0.375
MOD_N-GLC_1	101	106	PF02516	0.434
MOD_N-GLC_1	357	362	PF02516	0.637
MOD_N-GLC_1	71	76	PF02516	0.560
MOD_NEK2_1	101	106	PF00069	0.577
MOD_NEK2_1	222	227	PF00069	0.706
MOD_NEK2_1	397	402	PF00069	0.524
MOD_NEK2_1	537	542	PF00069	0.420
MOD_NEK2_1	582	587	PF00069	0.621
MOD_PIKK_1	493	499	PF00454	0.645
MOD_PKA_2	318	324	PF00069	0.607
MOD_PKA_2	537	543	PF00069	0.552
MOD_Plk_1	303	309	PF00069	0.602
MOD_Plk_1	436	442	PF00069	0.628
MOD_Plk_1	507	513	PF00069	0.563
MOD_Plk_1	514	520	PF00069	0.557
MOD_Plk_1	582	588	PF00069	0.610
MOD_Plk_2-3	119	125	PF00069	0.504
MOD_Plk_2-3	431	437	PF00069	0.477
MOD_Plk_2-3	52	58	PF00069	0.359
MOD_Plk_4	132	138	PF00069	0.666
MOD_Plk_4	218	224	PF00069	0.710
MOD_Plk_4	35	41	PF00069	0.610
MOD_Plk_4	436	442	PF00069	0.654
MOD_Plk_4	455	461	PF00069	0.504
MOD_ProDKin_1	129	135	PF00069	0.534
MOD_ProDKin_1	350	356	PF00069	0.690
MOD_ProDKin_1	357	363	PF00069	0.645
MOD_ProDKin_1	446	452	PF00069	0.678
MOD_ProDKin_1	497	503	PF00069	0.588
MOD_ProDKin_1	6	12	PF00069	0.599
MOD_ProDKin_1	94	100	PF00069	0.764
MOD_SUMO_for_1	383	386	PF00179	0.528
MOD_SUMO_rev_2	171	181	PF00179	0.695
TRG_DiLeu_BaEn_1	52	57	PF01217	0.569
TRG_DiLeu_BaEn_2	17	23	PF01217	0.473
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.607
TRG_ENDOCYTIC_2	111	114	PF00928	0.570
TRG_ENDOCYTIC_2	17	20	PF00928	0.438
TRG_ENDOCYTIC_2	178	181	PF00928	0.618
TRG_ENDOCYTIC_2	245	248	PF00928	0.577
TRG_ENDOCYTIC_2	456	459	PF00928	0.713
TRG_ER_diArg_1	126	129	PF00400	0.475
TRG_ER_diArg_1	157	159	PF00400	0.583
TRG_ER_diArg_1	341	344	PF00400	0.593
TRG_ER_diArg_1	560	563	PF00400	0.540
TRG_NLS_MonoCore_2	558	563	PF00514	0.681
TRG_NLS_MonoExtC_3	558	563	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC36	Leptomonas seymouri	53%	95%
A0A1X0NWG5	Trypanosomatidae	32%	100%
A0A3R7MIM2	Trypanosoma rangeli	31%	100%
A0A3S7WVS1	Leishmania donovani	78%	100%
A4HYM7	Leishmania infantum	77%	100%
C9ZI60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AUI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QD00	Leishmania major	79%	96%