Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AI97_LEIBR

TriTrypDb:

LbrM.20.4630 , LBRM2903_200060100

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI97

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.404
CLV_NRD_NRD_1	137	139	PF00675	0.532
CLV_NRD_NRD_1	275	277	PF00675	0.445
CLV_NRD_NRD_1	31	33	PF00675	0.556
CLV_PCSK_KEX2_1	137	139	PF00082	0.532
CLV_PCSK_KEX2_1	275	277	PF00082	0.444
CLV_PCSK_KEX2_1	31	33	PF00082	0.775
CLV_PCSK_KEX2_1	50	52	PF00082	0.380
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.401
CLV_PCSK_SKI1_1	197	201	PF00082	0.420
CLV_PCSK_SKI1_1	95	99	PF00082	0.663
DEG_ODPH_VHL_1	286	299	PF01847	0.475
DEG_SPOP_SBC_1	339	343	PF00917	0.449
DOC_MAPK_MEF2A_6	383	390	PF00069	0.451
DOC_MAPK_MEF2A_6	40	48	PF00069	0.534
DOC_PP1_RVXF_1	347	354	PF00149	0.394
DOC_PP2B_LxvP_1	286	289	PF13499	0.392
DOC_PP4_FxxP_1	353	356	PF00568	0.462
DOC_USP7_MATH_1	106	110	PF00917	0.432
DOC_USP7_MATH_1	182	186	PF00917	0.356
DOC_USP7_MATH_1	215	219	PF00917	0.509
DOC_USP7_MATH_1	329	333	PF00917	0.531
DOC_USP7_UBL2_3	50	54	PF12436	0.423
DOC_WW_Pin1_4	171	176	PF00397	0.548
DOC_WW_Pin1_4	19	24	PF00397	0.352
DOC_WW_Pin1_4	192	197	PF00397	0.449
DOC_WW_Pin1_4	266	271	PF00397	0.406
DOC_WW_Pin1_4	313	318	PF00397	0.649
LIG_14-3-3_CanoR_1	11	19	PF00244	0.397
LIG_14-3-3_CanoR_1	162	168	PF00244	0.551
LIG_Actin_WH2_2	174	190	PF00022	0.414
LIG_BRCT_BRCA1_1	280	284	PF00533	0.458
LIG_eIF4E_1	206	212	PF01652	0.361
LIG_FHA_1	13	19	PF00498	0.377
LIG_FHA_1	130	136	PF00498	0.323
LIG_FHA_1	163	169	PF00498	0.567
LIG_FHA_1	288	294	PF00498	0.377
LIG_FHA_2	340	346	PF00498	0.661
LIG_LIR_Apic_2	177	182	PF02991	0.318
LIG_LIR_Apic_2	264	270	PF02991	0.385
LIG_LIR_Apic_2	352	356	PF02991	0.425
LIG_LIR_Apic_2	369	375	PF02991	0.616
LIG_LIR_Apic_2	60	65	PF02991	0.289
LIG_LIR_Gen_1	205	216	PF02991	0.388
LIG_LIR_Gen_1	290	299	PF02991	0.387
LIG_LIR_Gen_1	327	337	PF02991	0.432
LIG_LIR_Nem_3	205	211	PF02991	0.355
LIG_LIR_Nem_3	290	294	PF02991	0.378
LIG_LIR_Nem_3	327	333	PF02991	0.434
LIG_LIR_Nem_3	381	385	PF02991	0.422
LIG_LIR_Nem_3	404	410	PF02991	0.414
LIG_LIR_Nem_3	60	64	PF02991	0.373
LIG_Pex14_2	385	389	PF04695	0.558
LIG_Pex14_2	57	61	PF04695	0.333
LIG_Rb_LxCxE_1	331	346	PF01857	0.524
LIG_SH2_CRK	179	183	PF00017	0.374
LIG_SH2_CRK	208	212	PF00017	0.356
LIG_SH2_CRK	330	334	PF00017	0.427
LIG_SH2_NCK_1	179	183	PF00017	0.374
LIG_SH2_PTP2	407	410	PF00017	0.399
LIG_SH2_PTP2	62	65	PF00017	0.357
LIG_SH2_STAP1	203	207	PF00017	0.385
LIG_SH2_STAP1	208	212	PF00017	0.356
LIG_SH2_STAP1	330	334	PF00017	0.427
LIG_SH2_STAT5	206	209	PF00017	0.362
LIG_SH2_STAT5	291	294	PF00017	0.476
LIG_SH2_STAT5	359	362	PF00017	0.466
LIG_SH2_STAT5	372	375	PF00017	0.563
LIG_SH2_STAT5	407	410	PF00017	0.399
LIG_SH2_STAT5	62	65	PF00017	0.357
LIG_SH2_STAT5	80	83	PF00017	0.466
LIG_SH3_3	222	228	PF00018	0.580
LIG_SH3_3	311	317	PF00018	0.625
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.369
LIG_SUMO_SIM_par_1	174	180	PF11976	0.353
LIG_TRAF2_1	221	224	PF00917	0.523
LIG_TRAF2_1	249	252	PF00917	0.572
LIG_TRFH_1	284	288	PF08558	0.390
LIG_TYR_ITIM	328	333	PF00017	0.429
LIG_WRC_WIRS_1	58	63	PF05994	0.315
LIG_WW_1	288	291	PF00397	0.481
MOD_CDK_SPK_2	192	197	PF00069	0.448
MOD_CK1_1	164	170	PF00069	0.485
MOD_CK1_1	218	224	PF00069	0.498
MOD_CK1_1	230	236	PF00069	0.610
MOD_CK1_1	260	266	PF00069	0.588
MOD_CK1_1	341	347	PF00069	0.531
MOD_CK2_1	106	112	PF00069	0.550
MOD_CK2_1	218	224	PF00069	0.539
MOD_CK2_1	232	238	PF00069	0.737
MOD_CK2_1	266	272	PF00069	0.431
MOD_CK2_1	321	327	PF00069	0.536
MOD_CK2_1	339	345	PF00069	0.609
MOD_CK2_1	363	369	PF00069	0.482
MOD_CMANNOS	148	151	PF00535	0.593
MOD_GlcNHglycan	108	111	PF01048	0.572
MOD_GlcNHglycan	156	160	PF01048	0.456
MOD_GlcNHglycan	171	174	PF01048	0.481
MOD_GlcNHglycan	213	216	PF01048	0.572
MOD_GlcNHglycan	217	220	PF01048	0.591
MOD_GlcNHglycan	234	237	PF01048	0.689
MOD_GSK3_1	151	158	PF00069	0.502
MOD_GSK3_1	162	169	PF00069	0.578
MOD_GSK3_1	211	218	PF00069	0.557
MOD_GSK3_1	228	235	PF00069	0.772
MOD_GSK3_1	278	285	PF00069	0.458
MOD_GSK3_1	32	39	PF00069	0.540
MOD_N-GLC_1	36	41	PF02516	0.515
MOD_NEK2_1	101	106	PF00069	0.617
MOD_NEK2_1	12	17	PF00069	0.387
MOD_NEK2_1	211	216	PF00069	0.510
MOD_NEK2_1	360	365	PF00069	0.660
MOD_NEK2_2	183	188	PF00069	0.485
MOD_PIKK_1	228	234	PF00454	0.730
MOD_PIKK_1	25	31	PF00454	0.522
MOD_PIKK_1	95	101	PF00454	0.685
MOD_PKA_1	31	37	PF00069	0.752
MOD_PKA_1	50	56	PF00069	0.291
MOD_PKA_1	95	101	PF00069	0.646
MOD_PKA_2	161	167	PF00069	0.506
MOD_PKA_2	30	36	PF00069	0.543
MOD_PKA_2	50	56	PF00069	0.289
MOD_Plk_4	12	18	PF00069	0.371
MOD_Plk_4	174	180	PF00069	0.412
MOD_Plk_4	202	208	PF00069	0.395
MOD_Plk_4	287	293	PF00069	0.406
MOD_Plk_4	329	335	PF00069	0.507
MOD_Plk_4	57	63	PF00069	0.402
MOD_ProDKin_1	171	177	PF00069	0.534
MOD_ProDKin_1	19	25	PF00069	0.364
MOD_ProDKin_1	192	198	PF00069	0.455
MOD_ProDKin_1	266	272	PF00069	0.413
MOD_ProDKin_1	313	319	PF00069	0.655
MOD_SUMO_rev_2	91	98	PF00179	0.594
TRG_DiLeu_BaEn_1	261	266	PF01217	0.409
TRG_DiLeu_BaEn_1	369	374	PF01217	0.461
TRG_DiLeu_BaEn_2	380	386	PF01217	0.416
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.531
TRG_ENDOCYTIC_2	208	211	PF00928	0.357
TRG_ENDOCYTIC_2	291	294	PF00928	0.463
TRG_ENDOCYTIC_2	330	333	PF00928	0.433
TRG_ENDOCYTIC_2	382	385	PF00928	0.416
TRG_ENDOCYTIC_2	407	410	PF00928	0.399
TRG_ER_diArg_1	136	138	PF00400	0.508
TRG_ER_diArg_1	274	276	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ0	Leptomonas seymouri	49%	100%
A0A3S7WVU6	Leishmania donovani	73%	100%
A4HYN2	Leishmania infantum	72%	100%
E9AUI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QD02	Leishmania major	74%	100%