Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania braziliensis

UniProt:

E9AI94_LEIBR

TriTrypDb:

LbrM.20.4600 , LBRM2903_200059700

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 16, no: 2
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

E9AI94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.412
CLV_C14_Caspase3-7	277	281	PF00656	0.657
CLV_NRD_NRD_1	264	266	PF00675	0.420
CLV_NRD_NRD_1	267	269	PF00675	0.424
CLV_NRD_NRD_1	272	274	PF00675	0.446
CLV_PCSK_KEX2_1	264	266	PF00082	0.439
DEG_APCC_KENBOX_2	121	125	PF00400	0.247
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DEG_SCF_FBW7_1	199	205	PF00400	0.260
DOC_CKS1_1	199	204	PF01111	0.255
DOC_MAPK_gen_1	7	15	PF00069	0.452
DOC_MAPK_MEF2A_6	9	17	PF00069	0.487
DOC_USP7_MATH_1	241	245	PF00917	0.398
DOC_WW_Pin1_4	198	203	PF00397	0.333
DOC_WW_Pin1_4	293	298	PF00397	0.724
LIG_14-3-3_CanoR_1	7	15	PF00244	0.527
LIG_FHA_1	172	178	PF00498	0.297
LIG_FHA_1	21	27	PF00498	0.330
LIG_FHA_1	8	14	PF00498	0.492
LIG_FHA_1	80	86	PF00498	0.274
LIG_FHA_2	191	197	PF00498	0.361
LIG_FHA_2	275	281	PF00498	0.643
LIG_GBD_Chelix_1	238	246	PF00786	0.410
LIG_LIR_Gen_1	131	142	PF02991	0.423
LIG_LIR_Nem_3	114	120	PF02991	0.271
LIG_LIR_Nem_3	131	137	PF02991	0.415
LIG_LIR_Nem_3	179	183	PF02991	0.294
LIG_LIR_Nem_3	189	194	PF02991	0.365
LIG_NRBOX	13	19	PF00104	0.448
LIG_Pex14_1	176	180	PF04695	0.240
LIG_PTB_Apo_2	74	81	PF02174	0.176
LIG_SH2_CRK	117	121	PF00017	0.263
LIG_SH2_STAP1	181	185	PF00017	0.320
LIG_SH2_STAP1	29	33	PF00017	0.278
LIG_SH2_STAT3	172	175	PF00017	0.379
LIG_SH2_STAT3	181	184	PF00017	0.408
LIG_SH2_STAT3	50	53	PF00017	0.245
LIG_SH2_STAT5	172	175	PF00017	0.295
LIG_SH2_STAT5	50	53	PF00017	0.278
LIG_SH3_3	189	195	PF00018	0.422
LIG_SH3_3	196	202	PF00018	0.403
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.420
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.395
LIG_SUMO_SIM_par_1	238	244	PF11976	0.341
LIG_SUMO_SIM_par_1	248	254	PF11976	0.304
LIG_TYR_ITSM	112	119	PF00017	0.263
LIG_UBA3_1	17	24	PF00899	0.185
LIG_Vh1_VBS_1	240	258	PF01044	0.305
MOD_CK1_1	146	152	PF00069	0.298
MOD_CK1_1	186	192	PF00069	0.449
MOD_CK1_1	259	265	PF00069	0.325
MOD_CK1_1	56	62	PF00069	0.278
MOD_CK1_1	66	72	PF00069	0.204
MOD_CK1_1	89	95	PF00069	0.326
MOD_CK2_1	67	73	PF00069	0.319
MOD_GlcNHglycan	138	141	PF01048	0.591
MOD_GlcNHglycan	159	162	PF01048	0.518
MOD_GlcNHglycan	54	58	PF01048	0.534
MOD_GlcNHglycan	69	72	PF01048	0.522
MOD_GlcNHglycan	91	94	PF01048	0.659
MOD_GSK3_1	186	193	PF00069	0.374
MOD_GSK3_1	198	205	PF00069	0.419
MOD_GSK3_1	3	10	PF00069	0.519
MOD_GSK3_1	63	70	PF00069	0.298
MOD_N-GLC_1	146	151	PF02516	0.637
MOD_N-GLC_1	286	291	PF02516	0.362
MOD_N-GLC_1	97	102	PF02516	0.553
MOD_NEK2_1	20	25	PF00069	0.360
MOD_PIKK_1	171	177	PF00454	0.339
MOD_PIKK_1	216	222	PF00454	0.457
MOD_PIKK_1	286	292	PF00454	0.614
MOD_PKA_2	216	222	PF00069	0.430
MOD_PKA_2	89	95	PF00069	0.413
MOD_Plk_1	111	117	PF00069	0.259
MOD_Plk_1	146	152	PF00069	0.428
MOD_Plk_1	186	192	PF00069	0.428
MOD_Plk_1	286	292	PF00069	0.622
MOD_Plk_1	97	103	PF00069	0.398
MOD_Plk_4	146	152	PF00069	0.409
MOD_Plk_4	168	174	PF00069	0.290
MOD_Plk_4	186	192	PF00069	0.359
MOD_Plk_4	241	247	PF00069	0.277
MOD_Plk_4	56	62	PF00069	0.232
MOD_ProDKin_1	198	204	PF00069	0.340
MOD_ProDKin_1	293	299	PF00069	0.724
MOD_SUMO_rev_2	270	275	PF00179	0.607
TRG_ENDOCYTIC_2	116	119	PF00928	0.265
TRG_ENDOCYTIC_2	134	137	PF00928	0.326
TRG_NLS_MonoExtC_3	264	269	PF00514	0.498
TRG_NLS_MonoExtN_4	264	269	PF00514	0.498
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P471	Leptomonas seymouri	63%	94%
A0A0N1I022	Leptomonas seymouri	33%	89%
A0A1X0NWG4	Trypanosomatidae	31%	83%
A0A1X0NWG7	Trypanosomatidae	32%	83%
A0A1X0NWG9	Trypanosomatidae	33%	83%
A0A1X0NXT1	Trypanosomatidae	32%	83%
A0A1X0NY10	Trypanosomatidae	29%	100%
A0A3Q8IBH3	Leishmania donovani	74%	95%
A0A3S5H4S6	Leishmania donovani	35%	91%
A4H335	Leishmania braziliensis	34%	100%
A4HRC3	Leishmania infantum	35%	91%
A4HYN5	Leishmania infantum	74%	95%
E9ABZ0	Leishmania major	35%	100%
E9AJ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	91%
E9AUH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	95%
Q4QD05	Leishmania major	75%	100%
V5DS51	Trypanosoma cruzi	32%	85%