Major Facilitator Superfamily (MFS)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania braziliensis

UniProt:

E9AI92_LEIBR

TriTrypDb:

LbrM.20.4580 , LBRM2903_200059500

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AI92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI92

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	5
GO:0022857	transmembrane transporter activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.756
CLV_C14_Caspase3-7	484	488	PF00656	0.690
CLV_C14_Caspase3-7	50	54	PF00656	0.617
CLV_NRD_NRD_1	145	147	PF00675	0.461
CLV_NRD_NRD_1	16	18	PF00675	0.641
CLV_NRD_NRD_1	169	171	PF00675	0.408
CLV_NRD_NRD_1	441	443	PF00675	0.607
CLV_NRD_NRD_1	455	457	PF00675	0.493
CLV_NRD_NRD_1	67	69	PF00675	0.464
CLV_PCSK_KEX2_1	139	141	PF00082	0.442
CLV_PCSK_KEX2_1	145	147	PF00082	0.447
CLV_PCSK_KEX2_1	16	18	PF00082	0.631
CLV_PCSK_KEX2_1	168	170	PF00082	0.420
CLV_PCSK_KEX2_1	441	443	PF00082	0.607
CLV_PCSK_KEX2_1	67	69	PF00082	0.464
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.370
CLV_PCSK_SKI1_1	139	143	PF00082	0.482
CLV_PCSK_SKI1_1	457	461	PF00082	0.569
DEG_SPOP_SBC_1	332	336	PF00917	0.430
DOC_MAPK_gen_1	168	175	PF00069	0.594
DOC_MAPK_gen_1	233	241	PF00069	0.546
DOC_MAPK_MEF2A_6	236	243	PF00069	0.546
DOC_PP2B_LxvP_1	258	261	PF13499	0.444
DOC_USP7_MATH_1	261	265	PF00917	0.369
DOC_USP7_MATH_1	333	337	PF00917	0.391
DOC_WW_Pin1_4	101	106	PF00397	0.648
DOC_WW_Pin1_4	234	239	PF00397	0.470
LIG_14-3-3_CanoR_1	140	144	PF00244	0.581
LIG_14-3-3_CanoR_1	146	156	PF00244	0.545
LIG_14-3-3_CanoR_1	4	8	PF00244	0.666
LIG_14-3-3_CanoR_1	441	447	PF00244	0.648
LIG_14-3-3_CanoR_1	456	460	PF00244	0.619
LIG_APCC_ABBA_1	435	440	PF00400	0.645
LIG_APCC_ABBAyCdc20_2	456	462	PF00400	0.641
LIG_BRCT_BRCA1_1	417	421	PF00533	0.630
LIG_FHA_1	160	166	PF00498	0.665
LIG_FHA_1	412	418	PF00498	0.725
LIG_FHA_1	487	493	PF00498	0.757
LIG_FHA_2	126	132	PF00498	0.742
LIG_FHA_2	153	159	PF00498	0.619
LIG_FHA_2	98	104	PF00498	0.662
LIG_LIR_Apic_2	232	238	PF02991	0.598
LIG_LIR_Apic_2	295	301	PF02991	0.670
LIG_LIR_Gen_1	155	164	PF02991	0.646
LIG_LIR_Gen_1	171	179	PF02991	0.484
LIG_LIR_Gen_1	188	197	PF02991	0.317
LIG_LIR_Gen_1	272	281	PF02991	0.375
LIG_LIR_Nem_3	142	147	PF02991	0.647
LIG_LIR_Nem_3	155	159	PF02991	0.550
LIG_LIR_Nem_3	162	167	PF02991	0.427
LIG_LIR_Nem_3	171	175	PF02991	0.474
LIG_LIR_Nem_3	188	192	PF02991	0.263
LIG_LIR_Nem_3	272	276	PF02991	0.375
LIG_NRP_CendR_1	503	505	PF00754	0.586
LIG_Pex14_2	273	277	PF04695	0.411
LIG_SH2_CRK	235	239	PF00017	0.524
LIG_SH2_SRC	223	226	PF00017	0.244
LIG_SH2_STAP1	292	296	PF00017	0.453
LIG_SH2_STAT5	127	130	PF00017	0.815
LIG_SH2_STAT5	164	167	PF00017	0.595
LIG_SH2_STAT5	223	226	PF00017	0.411
LIG_SH2_STAT5	275	278	PF00017	0.411
LIG_SH3_1	68	74	PF00018	0.654
LIG_SH3_3	102	108	PF00018	0.769
LIG_SH3_3	116	122	PF00018	0.604
LIG_SH3_3	374	380	PF00018	0.633
LIG_SH3_3	414	420	PF00018	0.722
LIG_SH3_3	68	74	PF00018	0.757
LIG_SUMO_SIM_par_1	317	322	PF11976	0.411
LIG_SUMO_SIM_par_1	340	346	PF11976	0.411
LIG_SUMO_SIM_par_1	72	81	PF11976	0.655
LIG_TRAF2_1	43	46	PF00917	0.662
LIG_TRAF2_1	431	434	PF00917	0.712
LIG_UBA3_1	253	259	PF00899	0.411
LIG_WRC_WIRS_1	153	158	PF05994	0.622
LIG_WRC_WIRS_1	186	191	PF05994	0.244
LIG_WRC_WIRS_1	270	275	PF05994	0.411
MOD_CDC14_SPxK_1	104	107	PF00782	0.644
MOD_CDK_SPxK_1	101	107	PF00069	0.648
MOD_CK1_1	177	183	PF00069	0.381
MOD_CK1_1	185	191	PF00069	0.350
MOD_CK1_1	322	328	PF00069	0.411
MOD_CK1_1	397	403	PF00069	0.688
MOD_CK1_1	458	464	PF00069	0.639
MOD_CK2_1	152	158	PF00069	0.627
MOD_CK2_1	40	46	PF00069	0.831
MOD_CK2_1	441	447	PF00069	0.712
MOD_CK2_1	458	464	PF00069	0.602
MOD_CK2_1	97	103	PF00069	0.783
MOD_GlcNHglycan	121	125	PF01048	0.561
MOD_GlcNHglycan	176	179	PF01048	0.274
MOD_GlcNHglycan	324	327	PF01048	0.361
MOD_GlcNHglycan	335	338	PF01048	0.634
MOD_GlcNHglycan	407	410	PF01048	0.566
MOD_GlcNHglycan	411	414	PF01048	0.538
MOD_GlcNHglycan	421	424	PF01048	0.545
MOD_GlcNHglycan	449	452	PF01048	0.468
MOD_GlcNHglycan	489	492	PF01048	0.443
MOD_GlcNHglycan	7	10	PF01048	0.532
MOD_GSK3_1	259	266	PF00069	0.518
MOD_GSK3_1	28	35	PF00069	0.786
MOD_GSK3_1	290	297	PF00069	0.482
MOD_GSK3_1	394	401	PF00069	0.775
MOD_GSK3_1	405	412	PF00069	0.631
MOD_GSK3_1	415	422	PF00069	0.692
MOD_GSK3_1	97	104	PF00069	0.747
MOD_N-GLC_1	40	45	PF02516	0.465
MOD_N-GLC_1	87	92	PF02516	0.627
MOD_N-GLC_2	314	316	PF02516	0.411
MOD_NEK2_1	174	179	PF00069	0.349
MOD_NEK2_1	206	211	PF00069	0.389
MOD_NEK2_1	243	248	PF00069	0.411
MOD_NEK2_1	281	286	PF00069	0.400
MOD_NEK2_1	294	299	PF00069	0.522
MOD_NEK2_1	394	399	PF00069	0.656
MOD_NEK2_2	353	358	PF00069	0.244
MOD_PIKK_1	112	118	PF00454	0.674
MOD_PIKK_1	388	394	PF00454	0.667
MOD_PIKK_1	400	406	PF00454	0.624
MOD_PIKK_1	411	417	PF00454	0.676
MOD_PKA_1	139	145	PF00069	0.584
MOD_PKA_1	441	447	PF00069	0.810
MOD_PKA_2	131	137	PF00069	0.704
MOD_PKA_2	139	145	PF00069	0.682
MOD_PKA_2	147	153	PF00069	0.653
MOD_PKA_2	3	9	PF00069	0.666
MOD_PKA_2	41	47	PF00069	0.760
MOD_PKA_2	440	446	PF00069	0.810
MOD_PKA_2	455	461	PF00069	0.658
MOD_Plk_1	290	296	PF00069	0.578
MOD_Plk_4	139	145	PF00069	0.682
MOD_Plk_4	159	165	PF00069	0.436
MOD_Plk_4	182	188	PF00069	0.411
MOD_Plk_4	216	222	PF00069	0.410
MOD_Plk_4	243	249	PF00069	0.362
MOD_Plk_4	269	275	PF00069	0.377
MOD_Plk_4	314	320	PF00069	0.362
MOD_Plk_4	353	359	PF00069	0.388
MOD_Plk_4	455	461	PF00069	0.761
MOD_ProDKin_1	101	107	PF00069	0.648
MOD_ProDKin_1	234	240	PF00069	0.427
MOD_SUMO_for_1	429	432	PF00179	0.633
MOD_SUMO_rev_2	422	431	PF00179	0.636
TRG_ENDOCYTIC_2	164	167	PF00928	0.595
TRG_ER_diArg_1	144	146	PF00400	0.666
TRG_ER_diArg_1	167	170	PF00400	0.497
TRG_ER_diArg_1	502	505	PF00400	0.661
TRG_ER_diArg_1	67	69	PF00400	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I416	Leptomonas seymouri	52%	71%
A0A3Q8IBI9	Leishmania donovani	69%	69%
A4HYN7	Leishmania infantum	69%	69%
E9AUH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	70%
Q4QD06	Leishmania major	70%	100%