Acetyltransf_13 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ESCO acetyltransferase domain-containing protein

Species:

Leishmania braziliensis

UniProt:

E9AI91_LEIBR

TriTrypDb:

LbrM.20.4570 , LBRM2903_200059400

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI91

Function

Biological processes
Term	Name	Level	Count
GO:0000070	mitotic sister chromatid segregation	4	9
GO:0000819	sister chromatid segregation	4	9
GO:0006996	organelle organization	4	10
GO:0007059	chromosome segregation	2	10
GO:0007062	sister chromatid cohesion	3	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022402	cell cycle process	2	10
GO:0022414	reproductive process	1	10
GO:0045132	meiotic chromosome segregation	3	10
GO:0051276	chromosome organization	5	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0098813	nuclear chromosome segregation	3	10
GO:1903046	meiotic cell cycle process	2	10
GO:1903047	mitotic cell cycle process	3	10
GO:0007064	mitotic sister chromatid cohesion	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016407	acetyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0008080	N-acetyltransferase activity	6	1
GO:0016410	N-acyltransferase activity	5	1
GO:0034212	peptide N-acetyltransferase activity	7	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	300	302	PF00675	0.309
CLV_NRD_NRD_1	72	74	PF00675	0.728
CLV_PCSK_FUR_1	70	74	PF00082	0.455
CLV_PCSK_KEX2_1	300	302	PF00082	0.331
CLV_PCSK_KEX2_1	72	74	PF00082	0.667
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.655
CLV_PCSK_PC7_1	70	76	PF00082	0.715
CLV_PCSK_SKI1_1	29	33	PF00082	0.495
CLV_PCSK_SKI1_1	54	58	PF00082	0.559
DOC_CKS1_1	31	36	PF01111	0.310
DOC_MAPK_gen_1	112	121	PF00069	0.309
DOC_PP1_RVXF_1	248	254	PF00149	0.561
DOC_PP1_RVXF_1	259	266	PF00149	0.561
DOC_PP4_FxxP_1	279	282	PF00568	0.482
DOC_PP4_FxxP_1	288	291	PF00568	0.467
DOC_USP7_MATH_1	125	129	PF00917	0.533
DOC_USP7_MATH_1	197	201	PF00917	0.717
DOC_USP7_MATH_1	210	214	PF00917	0.681
DOC_USP7_MATH_1	293	297	PF00917	0.591
DOC_WW_Pin1_4	153	158	PF00397	0.671
DOC_WW_Pin1_4	186	191	PF00397	0.574
DOC_WW_Pin1_4	252	257	PF00397	0.465
DOC_WW_Pin1_4	30	35	PF00397	0.580
DOC_WW_Pin1_4	92	97	PF00397	0.649
LIG_14-3-3_CanoR_1	184	190	PF00244	0.575
LIG_14-3-3_CanoR_1	54	63	PF00244	0.421
LIG_BRCT_BRCA1_1	155	159	PF00533	0.604
LIG_FHA_1	204	210	PF00498	0.718
LIG_FHA_1	240	246	PF00498	0.509
LIG_FHA_1	58	64	PF00498	0.392
LIG_FHA_2	199	205	PF00498	0.724
LIG_LIR_Nem_3	180	186	PF02991	0.466
LIG_LIR_Nem_3	20	24	PF02991	0.583
LIG_LIR_Nem_3	244	249	PF02991	0.221
LIG_LIR_Nem_3	306	311	PF02991	0.467
LIG_LIR_Nem_3	42	48	PF02991	0.580
LIG_REV1ctd_RIR_1	64	74	PF16727	0.547
LIG_SH2_CRK	277	281	PF00017	0.597
LIG_SH2_SRC	169	172	PF00017	0.277
LIG_SH2_STAT5	169	172	PF00017	0.402
LIG_SH2_STAT5	36	39	PF00017	0.569
LIG_SH3_3	28	34	PF00018	0.549
LIG_SH3_3	45	51	PF00018	0.722
LIG_SH3_3	93	99	PF00018	0.531
LIG_SUMO_SIM_par_1	59	65	PF11976	0.474
LIG_TYR_ITIM	275	280	PF00017	0.571
MOD_CDK_SPxK_1	92	98	PF00069	0.667
MOD_CDK_SPxxK_3	153	160	PF00069	0.601
MOD_CDK_SPxxK_3	252	259	PF00069	0.591
MOD_CK1_1	101	107	PF00069	0.677
MOD_CK1_1	108	114	PF00069	0.516
MOD_CK1_1	128	134	PF00069	0.582
MOD_CK1_1	158	164	PF00069	0.553
MOD_CK1_1	20	26	PF00069	0.500
MOD_CK1_1	213	219	PF00069	0.691
MOD_CK1_1	239	245	PF00069	0.584
MOD_CK1_1	255	261	PF00069	0.553
MOD_CK1_1	289	295	PF00069	0.508
MOD_CK2_1	263	269	PF00069	0.522
MOD_CK2_1	84	90	PF00069	0.777
MOD_GlcNHglycan	115	118	PF01048	0.488
MOD_GlcNHglycan	130	133	PF01048	0.328
MOD_GlcNHglycan	215	218	PF01048	0.584
MOD_GlcNHglycan	295	298	PF01048	0.391
MOD_GlcNHglycan	90	93	PF01048	0.737
MOD_GSK3_1	101	108	PF00069	0.701
MOD_GSK3_1	151	158	PF00069	0.468
MOD_GSK3_1	186	193	PF00069	0.631
MOD_GSK3_1	195	202	PF00069	0.711
MOD_GSK3_1	212	219	PF00069	0.764
MOD_GSK3_1	289	296	PF00069	0.531
MOD_GSK3_1	84	91	PF00069	0.779
MOD_N-GLC_1	101	106	PF02516	0.427
MOD_N-GLC_1	213	218	PF02516	0.548
MOD_N-GLC_1	88	93	PF02516	0.525
MOD_NEK2_2	110	115	PF00069	0.475
MOD_NEK2_2	241	246	PF00069	0.468
MOD_PKA_2	105	111	PF00069	0.606
MOD_PKA_2	198	204	PF00069	0.723
MOD_Plk_1	101	107	PF00069	0.475
MOD_Plk_4	144	150	PF00069	0.351
MOD_Plk_4	241	247	PF00069	0.337
MOD_Plk_4	57	63	PF00069	0.463
MOD_ProDKin_1	153	159	PF00069	0.673
MOD_ProDKin_1	186	192	PF00069	0.583
MOD_ProDKin_1	252	258	PF00069	0.465
MOD_ProDKin_1	30	36	PF00069	0.580
MOD_ProDKin_1	92	98	PF00069	0.650
TRG_ENDOCYTIC_2	183	186	PF00928	0.554
TRG_ENDOCYTIC_2	277	280	PF00928	0.561
TRG_ER_diArg_1	300	302	PF00400	0.531
TRG_ER_diArg_1	70	73	PF00400	0.656
TRG_NLS_MonoExtC_3	72	77	PF00514	0.689
TRG_NLS_MonoExtN_4	70	77	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N8	Leptomonas seymouri	35%	100%
A0A1X0NWH5	Trypanosomatidae	32%	94%
A0A3S7WVV5	Leishmania donovani	70%	100%
A0A422MWP0	Trypanosoma rangeli	32%	100%
A4HYS2	Leishmania infantum	70%	100%
E9AUH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QD07	Leishmania major	71%	99%
V5DS57	Trypanosoma cruzi	33%	100%