Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI90_LEIBR

TriTrypDb:

LbrM.20.4560 , LBRM2903_200059300

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.514
CLV_NRD_NRD_1	213	215	PF00675	0.772
CLV_NRD_NRD_1	229	231	PF00675	0.535
CLV_NRD_NRD_1	364	366	PF00675	0.407
CLV_PCSK_FUR_1	211	215	PF00082	0.628
CLV_PCSK_KEX2_1	210	212	PF00082	0.667
CLV_PCSK_KEX2_1	213	215	PF00082	0.681
CLV_PCSK_KEX2_1	229	231	PF00082	0.584
CLV_PCSK_KEX2_1	364	366	PF00082	0.407
CLV_PCSK_KEX2_1	44	46	PF00082	0.579
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.630
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.579
CLV_PCSK_SKI1_1	235	239	PF00082	0.492
CLV_PCSK_SKI1_1	338	342	PF00082	0.554
CLV_PCSK_SKI1_1	344	348	PF00082	0.482
DEG_Nend_UBRbox_3	1	3	PF02207	0.450
DEG_SCF_FBW7_2	380	387	PF00400	0.466
DOC_CKS1_1	381	386	PF01111	0.622
DOC_CKS1_1	92	97	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.525
DOC_MAPK_DCC_7	372	381	PF00069	0.466
DOC_MAPK_gen_1	210	217	PF00069	0.657
DOC_MAPK_gen_1	239	246	PF00069	0.497
DOC_MAPK_gen_1	341	351	PF00069	0.537
DOC_MAPK_MEF2A_6	372	381	PF00069	0.466
DOC_PIKK_1	254	262	PF02985	0.472
DOC_PP1_RVXF_1	132	139	PF00149	0.383
DOC_PP1_RVXF_1	348	355	PF00149	0.326
DOC_PP1_RVXF_1	63	70	PF00149	0.491
DOC_PP2B_LxvP_1	329	332	PF13499	0.545
DOC_PP2B_LxvP_1	386	389	PF13499	0.514
DOC_USP7_MATH_1	162	166	PF00917	0.508
DOC_USP7_MATH_1	224	228	PF00917	0.658
DOC_USP7_MATH_1	371	375	PF00917	0.611
DOC_USP7_MATH_1	73	77	PF00917	0.458
DOC_USP7_UBL2_3	82	86	PF12436	0.363
DOC_WW_Pin1_4	230	235	PF00397	0.676
DOC_WW_Pin1_4	304	309	PF00397	0.411
DOC_WW_Pin1_4	380	385	PF00397	0.579
DOC_WW_Pin1_4	69	74	PF00397	0.435
DOC_WW_Pin1_4	91	96	PF00397	0.478
LIG_14-3-3_CanoR_1	364	373	PF00244	0.597
LIG_14-3-3_CanoR_1	45	53	PF00244	0.459
LIG_14-3-3_CanoR_1	99	108	PF00244	0.422
LIG_Actin_WH2_2	345	363	PF00022	0.510
LIG_CtBP_PxDLS_1	107	111	PF00389	0.394
LIG_FHA_1	164	170	PF00498	0.473
LIG_FHA_1	381	387	PF00498	0.622
LIG_FHA_2	101	107	PF00498	0.432
LIG_FHA_2	137	143	PF00498	0.525
LIG_FHA_2	190	196	PF00498	0.594
LIG_FHA_2	202	208	PF00498	0.615
LIG_IRF3_LxIS_1	53	60	PF10401	0.422
LIG_LIR_Apic_2	281	287	PF02991	0.270
LIG_LIR_Gen_1	84	95	PF02991	0.480
LIG_LIR_LC3C_4	132	137	PF02991	0.493
LIG_LIR_Nem_3	119	125	PF02991	0.446
LIG_LIR_Nem_3	84	90	PF02991	0.470
LIG_MYND_1	384	388	PF01753	0.546
LIG_SH2_CRK	284	288	PF00017	0.428
LIG_SH2_CRK	46	50	PF00017	0.558
LIG_SH2_NCK_1	46	50	PF00017	0.461
LIG_SH2_STAP1	140	144	PF00017	0.540
LIG_SH2_STAP1	46	50	PF00017	0.618
LIG_SH2_STAP1	96	100	PF00017	0.420
LIG_SH2_STAT3	353	356	PF00017	0.418
LIG_SH2_STAT5	353	356	PF00017	0.459
LIG_SH3_3	303	309	PF00018	0.458
LIG_SH3_3	325	331	PF00018	0.539
LIG_SH3_3	367	373	PF00018	0.592
LIG_SH3_3	382	388	PF00018	0.641
LIG_SH3_3	50	56	PF00018	0.466
LIG_SH3_3	89	95	PF00018	0.410
LIG_SUMO_SIM_par_1	287	292	PF11976	0.431
LIG_SUMO_SIM_par_1	75	81	PF11976	0.529
LIG_UBA3_1	77	82	PF00899	0.377
LIG_WRC_WIRS_1	268	273	PF05994	0.452
MOD_CDK_SPK_2	230	235	PF00069	0.512
MOD_CK1_1	199	205	PF00069	0.526
MOD_CK1_1	225	231	PF00069	0.618
MOD_CK1_1	233	239	PF00069	0.617
MOD_CK1_1	72	78	PF00069	0.525
MOD_CK2_1	100	106	PF00069	0.429
MOD_CK2_1	136	142	PF00069	0.526
MOD_CK2_1	201	207	PF00069	0.619
MOD_CK2_1	271	277	PF00069	0.340
MOD_CK2_1	331	337	PF00069	0.542
MOD_Cter_Amidation	41	44	PF01082	0.474
MOD_GlcNHglycan	183	186	PF01048	0.625
MOD_GlcNHglycan	198	201	PF01048	0.600
MOD_GlcNHglycan	314	317	PF01048	0.505
MOD_GlcNHglycan	366	369	PF01048	0.601
MOD_GlcNHglycan	46	49	PF01048	0.716
MOD_GlcNHglycan	59	62	PF01048	0.369
MOD_GSK3_1	267	274	PF00069	0.455
MOD_GSK3_1	287	294	PF00069	0.390
MOD_GSK3_1	360	367	PF00069	0.493
MOD_GSK3_1	69	76	PF00069	0.463
MOD_NEK2_1	271	276	PF00069	0.448
MOD_NEK2_1	278	283	PF00069	0.403
MOD_NEK2_1	289	294	PF00069	0.390
MOD_NEK2_1	360	365	PF00069	0.592
MOD_NEK2_1	57	62	PF00069	0.473
MOD_PIKK_1	278	284	PF00454	0.271
MOD_PKA_1	364	370	PF00069	0.431
MOD_PKA_1	44	50	PF00069	0.599
MOD_PKA_2	225	231	PF00069	0.660
MOD_PKA_2	28	34	PF00069	0.601
MOD_PKA_2	360	366	PF00069	0.537
MOD_PKA_2	44	50	PF00069	0.641
MOD_PKA_2	9	15	PF00069	0.686
MOD_Plk_1	271	277	PF00069	0.478
MOD_Plk_2-3	201	207	PF00069	0.516
MOD_Plk_4	73	79	PF00069	0.495
MOD_ProDKin_1	230	236	PF00069	0.671
MOD_ProDKin_1	304	310	PF00069	0.422
MOD_ProDKin_1	380	386	PF00069	0.578
MOD_ProDKin_1	69	75	PF00069	0.435
MOD_ProDKin_1	91	97	PF00069	0.486
MOD_SUMO_for_1	238	241	PF00179	0.520
MOD_SUMO_rev_2	254	259	PF00179	0.468
MOD_SUMO_rev_2	261	269	PF00179	0.490
MOD_SUMO_rev_2	334	343	PF00179	0.491
MOD_SUMO_rev_2	79	87	PF00179	0.362
TRG_DiLeu_BaEn_1	258	263	PF01217	0.463
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.447
TRG_ENDOCYTIC_2	46	49	PF00928	0.562
TRG_ER_diArg_1	211	214	PF00400	0.766
TRG_ER_diArg_1	229	231	PF00400	0.749
TRG_ER_diArg_1	364	366	PF00400	0.419
TRG_NLS_MonoCore_2	209	214	PF00514	0.581
TRG_NLS_MonoExtC_3	209	214	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWV5	Leptomonas seymouri	58%	96%
A0A3S7WVR4	Leishmania donovani	78%	100%
A4HYS0	Leishmania infantum	78%	100%
C9ZIA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AUH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QD09	Leishmania major	77%	100%
V5BVI5	Trypanosoma cruzi	34%	100%