Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 49, putative

Species:

Leishmania braziliensis

UniProt:

E9AI88_LEIBR

TriTrypDb:

LbrM.20.4540 , LBRM2903_200059100

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AI88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.452
CLV_NRD_NRD_1	159	161	PF00675	0.538
CLV_NRD_NRD_1	243	245	PF00675	0.714
CLV_NRD_NRD_1	287	289	PF00675	0.506
CLV_NRD_NRD_1	367	369	PF00675	0.411
CLV_NRD_NRD_1	422	424	PF00675	0.345
CLV_NRD_NRD_1	49	51	PF00675	0.289
CLV_NRD_NRD_1	520	522	PF00675	0.593
CLV_NRD_NRD_1	524	526	PF00675	0.591
CLV_NRD_NRD_1	558	560	PF00675	0.594
CLV_NRD_NRD_1	582	584	PF00675	0.689
CLV_PCSK_FUR_1	580	584	PF00082	0.547
CLV_PCSK_KEX2_1	10	12	PF00082	0.342
CLV_PCSK_KEX2_1	159	161	PF00082	0.538
CLV_PCSK_KEX2_1	242	244	PF00082	0.700
CLV_PCSK_KEX2_1	286	288	PF00082	0.614
CLV_PCSK_KEX2_1	367	369	PF00082	0.432
CLV_PCSK_KEX2_1	422	424	PF00082	0.345
CLV_PCSK_KEX2_1	524	526	PF00082	0.656
CLV_PCSK_KEX2_1	558	560	PF00082	0.594
CLV_PCSK_KEX2_1	582	584	PF00082	0.689
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.342
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.677
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.689
CLV_PCSK_SKI1_1	287	291	PF00082	0.456
CLV_PCSK_SKI1_1	321	325	PF00082	0.419
CLV_PCSK_SKI1_1	33	37	PF00082	0.395
CLV_PCSK_SKI1_1	422	426	PF00082	0.363
CLV_PCSK_SKI1_1	561	565	PF00082	0.602
DEG_APCC_DBOX_1	320	328	PF00400	0.395
DOC_CYCLIN_RxL_1	301	314	PF00134	0.372
DOC_CYCLIN_RxL_1	47	58	PF00134	0.336
DOC_CYCLIN_RxL_1	558	568	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.374
DOC_MAPK_gen_1	10	18	PF00069	0.397
DOC_MAPK_gen_1	286	292	PF00069	0.452
DOC_MAPK_gen_1	301	310	PF00069	0.451
DOC_MAPK_gen_1	558	566	PF00069	0.599
DOC_MAPK_MEF2A_6	11	20	PF00069	0.400
DOC_MAPK_MEF2A_6	558	566	PF00069	0.522
DOC_MAPK_NFAT4_5	559	567	PF00069	0.522
DOC_PP4_FxxP_1	36	39	PF00568	0.296
DOC_USP7_MATH_1	102	106	PF00917	0.333
DOC_USP7_MATH_1	257	261	PF00917	0.526
DOC_USP7_MATH_1	268	272	PF00917	0.496
DOC_USP7_MATH_1	37	41	PF00917	0.409
DOC_USP7_MATH_1	493	497	PF00917	0.542
DOC_USP7_MATH_1	571	575	PF00917	0.660
DOC_USP7_MATH_1	589	593	PF00917	0.510
DOC_WW_Pin1_4	127	132	PF00397	0.385
DOC_WW_Pin1_4	2	7	PF00397	0.489
DOC_WW_Pin1_4	274	279	PF00397	0.550
DOC_WW_Pin1_4	393	398	PF00397	0.457
DOC_WW_Pin1_4	405	410	PF00397	0.552
DOC_WW_Pin1_4	502	507	PF00397	0.590
DOC_WW_Pin1_4	585	590	PF00397	0.675
DOC_WW_Pin1_4	60	65	PF00397	0.289
LIG_14-3-3_CanoR_1	159	169	PF00244	0.570
LIG_14-3-3_CanoR_1	81	86	PF00244	0.350
LIG_14-3-3_CterR_2	610	615	PF00244	0.487
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_BRCT_BRCA1_1	270	274	PF00533	0.476
LIG_CtBP_PxDLS_1	155	159	PF00389	0.506
LIG_DLG_GKlike_1	81	88	PF00625	0.340
LIG_FHA_1	186	192	PF00498	0.344
LIG_FHA_1	201	207	PF00498	0.474
LIG_FHA_1	23	29	PF00498	0.439
LIG_FHA_1	406	412	PF00498	0.566
LIG_FHA_1	503	509	PF00498	0.534
LIG_FHA_1	514	520	PF00498	0.499
LIG_FHA_1	552	558	PF00498	0.514
LIG_FHA_1	601	607	PF00498	0.422
LIG_FHA_2	138	144	PF00498	0.555
LIG_FHA_2	22	28	PF00498	0.325
LIG_FHA_2	271	277	PF00498	0.458
LIG_FHA_2	394	400	PF00498	0.570
LIG_IRF3_LxIS_1	350	356	PF10401	0.350
LIG_IRF3_LxIS_1	93	99	PF10401	0.317
LIG_LIR_Gen_1	297	305	PF02991	0.378
LIG_LIR_Gen_1	99	106	PF02991	0.379
LIG_LIR_Nem_3	297	302	PF02991	0.375
LIG_LIR_Nem_3	99	103	PF02991	0.375
LIG_PCNA_PIPBox_1	421	430	PF02747	0.430
LIG_PCNA_yPIPBox_3	193	201	PF02747	0.394
LIG_PCNA_yPIPBox_3	421	432	PF02747	0.430
LIG_PCNA_yPIPBox_3	599	612	PF02747	0.580
LIG_PTB_Apo_2	354	361	PF02174	0.410
LIG_PTB_Apo_2	94	101	PF02174	0.371
LIG_SH2_CRK	177	181	PF00017	0.284
LIG_SH2_NCK_1	177	181	PF00017	0.284
LIG_SH2_STAT3	371	374	PF00017	0.392
LIG_SH2_STAT5	371	374	PF00017	0.422
LIG_SH2_STAT5	70	73	PF00017	0.306
LIG_SH3_3	394	400	PF00018	0.463
LIG_SH3_3	539	545	PF00018	0.596
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.328
LIG_SUMO_SIM_par_1	187	192	PF11976	0.345
LIG_SUMO_SIM_par_1	294	300	PF11976	0.366
LIG_SUMO_SIM_par_1	351	356	PF11976	0.367
LIG_UBA3_1	427	432	PF00899	0.419
LIG_WRC_WIRS_1	180	185	PF05994	0.375
MOD_CK1_1	161	167	PF00069	0.572
MOD_CK1_1	178	184	PF00069	0.339
MOD_CK1_1	192	198	PF00069	0.364
MOD_CK1_1	258	264	PF00069	0.500
MOD_CK1_1	362	368	PF00069	0.427
MOD_CK1_1	41	47	PF00069	0.515
MOD_CK1_1	410	416	PF00069	0.604
MOD_CK1_1	5	11	PF00069	0.423
MOD_CK1_1	502	508	PF00069	0.624
MOD_CK1_1	572	578	PF00069	0.537
MOD_CK2_1	21	27	PF00069	0.338
MOD_CK2_1	294	300	PF00069	0.366
MOD_CK2_1	308	314	PF00069	0.358
MOD_CK2_1	393	399	PF00069	0.555
MOD_CK2_1	475	481	PF00069	0.619
MOD_GlcNHglycan	165	168	PF01048	0.548
MOD_GlcNHglycan	310	313	PF01048	0.353
MOD_GlcNHglycan	413	416	PF01048	0.655
MOD_GlcNHglycan	455	458	PF01048	0.599
MOD_GlcNHglycan	501	504	PF01048	0.667
MOD_GlcNHglycan	571	574	PF01048	0.632
MOD_GlcNHglycan	88	91	PF01048	0.357
MOD_GSK3_1	1	8	PF00069	0.483
MOD_GSK3_1	154	161	PF00069	0.564
MOD_GSK3_1	175	182	PF00069	0.388
MOD_GSK3_1	185	192	PF00069	0.339
MOD_GSK3_1	226	233	PF00069	0.610
MOD_GSK3_1	257	264	PF00069	0.618
MOD_GSK3_1	268	275	PF00069	0.526
MOD_GSK3_1	37	44	PF00069	0.317
MOD_GSK3_1	407	414	PF00069	0.628
MOD_GSK3_1	484	491	PF00069	0.604
MOD_GSK3_1	53	60	PF00069	0.273
MOD_GSK3_1	544	551	PF00069	0.591
MOD_GSK3_1	565	572	PF00069	0.642
MOD_GSK3_1	585	592	PF00069	0.601
MOD_GSK3_1	606	613	PF00069	0.525
MOD_N-GLC_1	175	180	PF02516	0.289
MOD_N-GLC_1	96	101	PF02516	0.321
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	109	114	PF00069	0.367
MOD_NEK2_1	12	17	PF00069	0.453
MOD_NEK2_1	158	163	PF00069	0.539
MOD_NEK2_1	308	313	PF00069	0.349
MOD_NEK2_1	353	358	PF00069	0.351
MOD_NEK2_1	359	364	PF00069	0.402
MOD_NEK2_1	411	416	PF00069	0.457
MOD_NEK2_1	52	57	PF00069	0.289
MOD_NEK2_1	606	611	PF00069	0.523
MOD_NEK2_1	88	93	PF00069	0.441
MOD_NEK2_1	96	101	PF00069	0.305
MOD_PIKK_1	245	251	PF00454	0.548
MOD_PK_1	175	181	PF00069	0.290
MOD_PKA_1	159	165	PF00069	0.543
MOD_PKA_1	242	248	PF00069	0.635
MOD_PKA_1	306	312	PF00069	0.361
MOD_PKA_2	158	164	PF00069	0.586
MOD_PKA_2	192	198	PF00069	0.377
MOD_PKA_2	242	248	PF00069	0.644
MOD_PKA_2	28	34	PF00069	0.323
MOD_Plk_1	109	115	PF00069	0.308
MOD_Plk_1	175	181	PF00069	0.290
MOD_Plk_1	261	267	PF00069	0.492
MOD_Plk_1	96	102	PF00069	0.411
MOD_Plk_2-3	14	20	PF00069	0.416
MOD_Plk_2-3	226	232	PF00069	0.692
MOD_Plk_2-3	462	468	PF00069	0.464
MOD_Plk_4	175	181	PF00069	0.385
MOD_Plk_4	185	191	PF00069	0.339
MOD_Plk_4	261	267	PF00069	0.489
MOD_Plk_4	294	300	PF00069	0.380
MOD_Plk_4	359	365	PF00069	0.378
MOD_Plk_4	544	550	PF00069	0.590
MOD_Plk_4	91	97	PF00069	0.328
MOD_ProDKin_1	127	133	PF00069	0.391
MOD_ProDKin_1	2	8	PF00069	0.476
MOD_ProDKin_1	274	280	PF00069	0.545
MOD_ProDKin_1	393	399	PF00069	0.469
MOD_ProDKin_1	405	411	PF00069	0.552
MOD_ProDKin_1	502	508	PF00069	0.589
MOD_ProDKin_1	585	591	PF00069	0.672
MOD_ProDKin_1	60	66	PF00069	0.289
MOD_SUMO_rev_2	534	540	PF00179	0.559
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.445
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.475
TRG_ENDOCYTIC_2	177	180	PF00928	0.358
TRG_ER_diArg_1	158	160	PF00400	0.514
TRG_ER_diArg_1	286	288	PF00400	0.595
TRG_ER_diArg_1	366	368	PF00400	0.404
TRG_ER_diArg_1	422	424	PF00400	0.345
TRG_ER_diArg_1	524	526	PF00400	0.535
TRG_ER_diArg_1	557	559	PF00400	0.588
TRG_NES_CRM1_1	300	314	PF08389	0.375
TRG_NLS_MonoExtC_3	520	525	PF00514	0.659
TRG_NLS_MonoExtN_4	518	525	PF00514	0.653
TRG_NLS_MonoExtN_4	580	586	PF00514	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N9	Leptomonas seymouri	53%	96%
A0A3Q8IBM2	Leishmania donovani	73%	98%
A4HYR8	Leishmania infantum	70%	100%
E9AUH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
Q4QD11	Leishmania major	73%	100%