Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania braziliensis

UniProt:

E9AI86_LEIBR

TriTrypDb:

LbrM.20.4520 , LBRM2903_200058900

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AI86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.424
CLV_NRD_NRD_1	100	102	PF00675	0.303
CLV_NRD_NRD_1	229	231	PF00675	0.462
CLV_PCSK_KEX2_1	100	102	PF00082	0.303
CLV_PCSK_KEX2_1	146	148	PF00082	0.503
CLV_PCSK_KEX2_1	229	231	PF00082	0.602
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.363
CLV_PCSK_SKI1_1	178	182	PF00082	0.402
CLV_PCSK_SKI1_1	230	234	PF00082	0.349
CLV_PCSK_SKI1_1	51	55	PF00082	0.414
DEG_Nend_UBRbox_3	1	3	PF02207	0.440
DOC_MAPK_gen_1	146	153	PF00069	0.455
DOC_MAPK_MEF2A_6	146	153	PF00069	0.455
DOC_MAPK_MEF2A_6	250	258	PF00069	0.459
DOC_WW_Pin1_4	245	250	PF00397	0.640
LIG_14-3-3_CanoR_1	100	104	PF00244	0.289
LIG_14-3-3_CanoR_1	40	46	PF00244	0.587
LIG_14-3-3_CanoR_1	51	57	PF00244	0.338
LIG_14-3-3_CanoR_1	9	18	PF00244	0.516
LIG_Actin_WH2_2	103	118	PF00022	0.287
LIG_Actin_WH2_2	38	53	PF00022	0.437
LIG_APCC_ABBA_1	181	186	PF00400	0.419
LIG_Clathr_ClatBox_1	110	114	PF01394	0.407
LIG_eIF4E_1	36	42	PF01652	0.435
LIG_FHA_1	116	122	PF00498	0.344
LIG_FHA_1	148	154	PF00498	0.319
LIG_FHA_1	168	174	PF00498	0.245
LIG_FHA_1	18	24	PF00498	0.561
LIG_FHA_1	249	255	PF00498	0.411
LIG_FHA_2	10	16	PF00498	0.632
LIG_LIR_Gen_1	179	187	PF02991	0.282
LIG_LIR_Gen_1	210	219	PF02991	0.396
LIG_LIR_Nem_3	179	183	PF02991	0.261
LIG_LIR_Nem_3	210	215	PF02991	0.435
LIG_LIR_Nem_3	221	227	PF02991	0.360
LIG_LYPXL_yS_3	224	227	PF13949	0.411
LIG_PDZ_Class_2	253	258	PF00595	0.473
LIG_Pex14_2	107	111	PF04695	0.399
LIG_SH2_GRB2like	92	95	PF00017	0.427
LIG_SH2_SRC	185	188	PF00017	0.455
LIG_SH2_STAT3	211	214	PF00017	0.298
LIG_SH2_STAT5	109	112	PF00017	0.214
LIG_SH2_STAT5	141	144	PF00017	0.481
LIG_SH2_STAT5	207	210	PF00017	0.488
LIG_SH2_STAT5	211	214	PF00017	0.390
LIG_SH2_STAT5	36	39	PF00017	0.577
LIG_SH2_STAT5	62	65	PF00017	0.558
LIG_SH2_STAT5	92	95	PF00017	0.427
LIG_SH3_1	146	152	PF00018	0.462
LIG_SH3_2	225	230	PF14604	0.446
LIG_SH3_3	131	137	PF00018	0.331
LIG_SH3_3	146	152	PF00018	0.581
LIG_SH3_3	222	228	PF00018	0.448
LIG_SUMO_SIM_anti_2	156	161	PF11976	0.357
LIG_SUMO_SIM_par_1	158	164	PF11976	0.433
LIG_SUMO_SIM_par_1	19	24	PF11976	0.485
LIG_WRC_WIRS_1	177	182	PF05994	0.261
MOD_CDK_SPK_2	245	250	PF00069	0.409
MOD_CK1_1	135	141	PF00069	0.506
MOD_CK1_1	248	254	PF00069	0.469
MOD_CK1_1	73	79	PF00069	0.321
MOD_CK2_1	16	22	PF00069	0.426
MOD_CK2_1	9	15	PF00069	0.632
MOD_GlcNHglycan	75	78	PF01048	0.474
MOD_GSK3_1	245	252	PF00069	0.581
MOD_GSK3_1	5	12	PF00069	0.603
MOD_GSK3_1	67	74	PF00069	0.443
MOD_LATS_1	7	13	PF00433	0.518
MOD_NEK2_1	115	120	PF00069	0.328
MOD_NEK2_1	168	173	PF00069	0.283
MOD_NEK2_1	193	198	PF00069	0.423
MOD_NEK2_1	23	28	PF00069	0.590
MOD_NEK2_1	30	35	PF00069	0.528
MOD_NEK2_1	41	46	PF00069	0.311
MOD_NEK2_1	71	76	PF00069	0.477
MOD_NEK2_2	52	57	PF00069	0.424
MOD_PIKK_1	9	15	PF00454	0.516
MOD_PKA_2	132	138	PF00069	0.448
MOD_PKA_2	8	14	PF00069	0.548
MOD_PKA_2	99	105	PF00069	0.285
MOD_Plk_4	155	161	PF00069	0.362
MOD_Plk_4	188	194	PF00069	0.377
MOD_Plk_4	67	73	PF00069	0.446
MOD_Plk_4	80	86	PF00069	0.458
MOD_ProDKin_1	245	251	PF00069	0.640
TRG_ENDOCYTIC_2	224	227	PF00928	0.437
TRG_ER_diArg_1	228	230	PF00400	0.462
TRG_NES_CRM1_1	49	59	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKD6	Leishmania donovani	81%	83%
A4HYM2	Leishmania infantum	81%	83%
E9AUH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	83%
Q4QD13	Leishmania major	80%	100%