Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

developmentally regulated phosphoprotein-like protein

Species:

Leishmania braziliensis

UniProt:

E9AI84_LEIBR

TriTrypDb:

LbrM.20.4500 , LBRM2903_200058700

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AI84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI84

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0044237	cellular metabolic process	2	11
GO:0006109	regulation of carbohydrate metabolic process	5	1
GO:0006468	protein phosphorylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0010675	obsolete regulation of cellular carbohydrate metabolic process	5	1
GO:0010906	regulation of glucose metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.323
CLV_NRD_NRD_1	180	182	PF00675	0.324
CLV_NRD_NRD_1	2	4	PF00675	0.560
CLV_NRD_NRD_1	62	64	PF00675	0.536
CLV_PCSK_KEX2_1	146	148	PF00082	0.305
CLV_PCSK_KEX2_1	180	182	PF00082	0.336
CLV_PCSK_KEX2_1	2	4	PF00082	0.560
CLV_PCSK_KEX2_1	324	326	PF00082	0.454
CLV_PCSK_KEX2_1	71	73	PF00082	0.516
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.454
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.471
CLV_PCSK_SKI1_1	146	150	PF00082	0.337
CLV_PCSK_SKI1_1	159	163	PF00082	0.208
CLV_PCSK_SKI1_1	180	184	PF00082	0.291
CLV_PCSK_SKI1_1	231	235	PF00082	0.282
CLV_PCSK_SKI1_1	312	316	PF00082	0.310
CLV_PCSK_SKI1_1	38	42	PF00082	0.397
CLV_PCSK_SKI1_1	381	385	PF00082	0.352
CLV_PCSK_SKI1_1	63	67	PF00082	0.572
CLV_PCSK_SKI1_1	71	75	PF00082	0.537
DEG_APCC_DBOX_1	145	153	PF00400	0.521
DEG_APCC_DBOX_1	158	166	PF00400	0.418
DEG_APCC_DBOX_1	179	187	PF00400	0.560
DEG_APCC_DBOX_1	26	34	PF00400	0.341
DEG_APCC_DBOX_1	324	332	PF00400	0.201
DEG_Nend_UBRbox_1	1	4	PF02207	0.570
DOC_CYCLIN_RxL_1	156	164	PF00134	0.476
DOC_MAPK_FxFP_2	294	297	PF00069	0.541
DOC_MAPK_gen_1	180	186	PF00069	0.567
DOC_MAPK_gen_1	324	330	PF00069	0.201
DOC_MAPK_gen_1	38	46	PF00069	0.323
DOC_MAPK_gen_1	63	70	PF00069	0.554
DOC_MAPK_MEF2A_6	248	256	PF00069	0.512
DOC_PP4_FxxP_1	294	297	PF00568	0.554
DOC_USP7_MATH_1	112	116	PF00917	0.465
DOC_USP7_MATH_1	215	219	PF00917	0.560
DOC_USP7_MATH_1	297	301	PF00917	0.369
DOC_USP7_UBL2_3	41	45	PF12436	0.541
DOC_USP7_UBL2_3	67	71	PF12436	0.292
DOC_WW_Pin1_4	396	401	PF00397	0.342
LIG_14-3-3_CanoR_1	120	124	PF00244	0.470
LIG_14-3-3_CanoR_1	2	11	PF00244	0.525
LIG_14-3-3_CanoR_1	221	227	PF00244	0.565
LIG_14-3-3_CanoR_1	316	320	PF00244	0.310
LIG_APCC_ABBA_1	74	79	PF00400	0.531
LIG_BRCT_BRCA1_1	229	233	PF00533	0.560
LIG_BRCT_BRCA1_1	290	294	PF00533	0.534
LIG_EH1_1	304	312	PF00400	0.329
LIG_eIF4E_1	305	311	PF01652	0.310
LIG_FHA_1	12	18	PF00498	0.600
LIG_FHA_1	5	11	PF00498	0.616
LIG_FHA_1	89	95	PF00498	0.379
LIG_FHA_2	203	209	PF00498	0.528
LIG_FHA_2	281	287	PF00498	0.540
LIG_FHA_2	330	336	PF00498	0.454
LIG_FHA_2	99	105	PF00498	0.508
LIG_LIR_Apic_2	291	297	PF02991	0.598
LIG_LIR_Apic_2	79	85	PF02991	0.454
LIG_LIR_Gen_1	126	135	PF02991	0.565
LIG_LIR_Gen_1	190	198	PF02991	0.502
LIG_LIR_Gen_1	205	214	PF02991	0.427
LIG_LIR_Gen_1	225	234	PF02991	0.567
LIG_LIR_Gen_1	302	311	PF02991	0.310
LIG_LIR_Gen_1	375	384	PF02991	0.339
LIG_LIR_Nem_3	126	130	PF02991	0.459
LIG_LIR_Nem_3	164	170	PF02991	0.560
LIG_LIR_Nem_3	190	196	PF02991	0.502
LIG_LIR_Nem_3	205	209	PF02991	0.412
LIG_LIR_Nem_3	225	229	PF02991	0.559
LIG_LIR_Nem_3	302	308	PF02991	0.310
LIG_LIR_Nem_3	375	379	PF02991	0.339
LIG_LIR_Nem_3	432	438	PF02991	0.310
LIG_SH2_CRK	226	230	PF00017	0.456
LIG_SH2_CRK	376	380	PF00017	0.352
LIG_SH2_CRK	406	410	PF00017	0.454
LIG_SH2_CRK	82	86	PF00017	0.560
LIG_SH2_NCK_1	206	210	PF00017	0.560
LIG_SH2_NCK_1	376	380	PF00017	0.421
LIG_SH2_PTP2	305	308	PF00017	0.310
LIG_SH2_PTP2	437	440	PF00017	0.352
LIG_SH2_SRC	206	209	PF00017	0.536
LIG_SH2_STAP1	414	418	PF00017	0.310
LIG_SH2_STAT5	175	178	PF00017	0.527
LIG_SH2_STAT5	305	308	PF00017	0.310
LIG_SH2_STAT5	376	379	PF00017	0.331
LIG_SH2_STAT5	437	440	PF00017	0.297
LIG_SH3_3	376	382	PF00018	0.352
LIG_SH3_4	381	388	PF00018	0.454
LIG_SUMO_SIM_par_1	168	174	PF11976	0.476
LIG_SUMO_SIM_par_1	250	255	PF11976	0.513
LIG_TYR_ITIM	204	209	PF00017	0.555
LIG_TYR_ITIM	224	229	PF00017	0.456
LIG_TYR_ITIM	303	308	PF00017	0.310
LIG_UBA3_1	169	173	PF00899	0.487
LIG_UBA3_1	306	312	PF00899	0.421
LIG_WRC_WIRS_1	124	129	PF05994	0.470
MOD_CK1_1	115	121	PF00069	0.379
MOD_CK1_1	244	250	PF00069	0.541
MOD_CK1_1	375	381	PF00069	0.448
MOD_CK2_1	202	208	PF00069	0.523
MOD_CK2_1	22	28	PF00069	0.591
MOD_CK2_1	280	286	PF00069	0.524
MOD_GlcNHglycan	107	110	PF01048	0.360
MOD_GlcNHglycan	388	391	PF01048	0.425
MOD_GSK3_1	115	122	PF00069	0.474
MOD_GSK3_1	18	25	PF00069	0.660
MOD_GSK3_1	392	399	PF00069	0.454
MOD_N-GLC_2	220	222	PF02516	0.360
MOD_NEK2_1	10	15	PF00069	0.618
MOD_NEK2_1	123	128	PF00069	0.502
MOD_NEK2_1	161	166	PF00069	0.561
MOD_NEK2_1	19	24	PF00069	0.556
MOD_NEK2_1	241	246	PF00069	0.577
MOD_NEK2_1	299	304	PF00069	0.321
MOD_NEK2_1	372	377	PF00069	0.338
MOD_NEK2_1	393	398	PF00069	0.438
MOD_NEK2_1	4	9	PF00069	0.575
MOD_NEK2_1	47	52	PF00069	0.489
MOD_NEK2_1	59	64	PF00069	0.339
MOD_PK_1	192	198	PF00069	0.560
MOD_PKA_1	187	193	PF00069	0.553
MOD_PKA_2	119	125	PF00069	0.470
MOD_PKA_2	17	23	PF00069	0.530
MOD_PKA_2	315	321	PF00069	0.310
MOD_Plk_2-3	202	208	PF00069	0.379
MOD_Plk_4	112	118	PF00069	0.461
MOD_Plk_4	119	125	PF00069	0.450
MOD_ProDKin_1	396	402	PF00069	0.342
MOD_SUMO_rev_2	267	272	PF00179	0.402
MOD_SUMO_rev_2	284	294	PF00179	0.483
MOD_SUMO_rev_2	31	40	PF00179	0.551
MOD_SUMO_rev_2	48	53	PF00179	0.526
TRG_ENDOCYTIC_2	206	209	PF00928	0.501
TRG_ENDOCYTIC_2	226	229	PF00928	0.458
TRG_ENDOCYTIC_2	305	308	PF00928	0.310
TRG_ENDOCYTIC_2	376	379	PF00928	0.352
TRG_ENDOCYTIC_2	435	438	PF00928	0.310
TRG_ER_diArg_1	1	3	PF00400	0.562
TRG_ER_diArg_1	145	147	PF00400	0.532
TRG_NLS_MonoExtC_3	62	67	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JAB1	Bodo saltans	40%	99%
A0A0S4JGW0	Bodo saltans	22%	97%
A0A1X0NWS5	Trypanosomatidae	50%	100%
A0A3R7K9G7	Trypanosoma rangeli	47%	100%
A0A3S7WVX8	Leishmania donovani	91%	98%
A0A422MQ68	Trypanosoma rangeli	24%	100%
A4HYM0	Leishmania infantum	92%	98%
C9ZHT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AUG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	98%
O02623	Ascaris suum	29%	100%
O14874	Homo sapiens	26%	100%
O54937	Rattus norvegicus	29%	100%
O55028	Mus musculus	26%	100%
O70571	Mus musculus	29%	100%
O88345	Ictidomys tridecemlineatus	28%	100%
P91622	Drosophila melanogaster	29%	100%
Q00972	Rattus norvegicus	26%	100%
Q02332	Caenorhabditis elegans	30%	100%
Q15118	Homo sapiens	27%	100%
Q15119	Homo sapiens	29%	100%
Q15120	Homo sapiens	29%	100%
Q16654	Homo sapiens	28%	100%
Q1KMR4	Rhinolophus ferrumequinum	28%	100%
Q2KJG8	Bos taurus	26%	100%
Q4QD15	Leishmania major	92%	100%
Q63065	Rattus norvegicus	28%	100%
Q64536	Rattus norvegicus	29%	100%
Q8BFP9	Mus musculus	28%	100%
Q922H2	Mus musculus	29%	100%
Q9JK42	Mus musculus	29%	100%
Q9P6P9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q9SBJ1	Arabidopsis thaliana	29%	100%
V5BAE3	Trypanosoma cruzi	49%	100%
V5C0T8	Trypanosoma cruzi	26%	100%