Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enkuring domain-containig protein

Species:

Leishmania braziliensis

UniProt:

E9AI83_LEIBR

TriTrypDb:

LbrM.20.4490 , LBRM2903_200058600

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI83

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.648
CLV_C14_Caspase3-7	160	164	PF00656	0.624
CLV_NRD_NRD_1	101	103	PF00675	0.581
CLV_NRD_NRD_1	217	219	PF00675	0.482
CLV_NRD_NRD_1	251	253	PF00675	0.421
CLV_NRD_NRD_1	278	280	PF00675	0.344
CLV_NRD_NRD_1	299	301	PF00675	0.286
CLV_PCSK_KEX2_1	206	208	PF00082	0.494
CLV_PCSK_KEX2_1	277	279	PF00082	0.367
CLV_PCSK_KEX2_1	301	303	PF00082	0.278
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.512
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.319
CLV_PCSK_SKI1_1	186	190	PF00082	0.507
CLV_PCSK_SKI1_1	322	326	PF00082	0.456
CLV_PCSK_SKI1_1	59	63	PF00082	0.533
DOC_MAPK_gen_1	300	306	PF00069	0.398
DOC_MAPK_gen_1	318	327	PF00069	0.283
DOC_USP7_MATH_1	122	126	PF00917	0.600
DOC_USP7_MATH_1	137	141	PF00917	0.517
DOC_USP7_MATH_1	147	151	PF00917	0.533
DOC_USP7_MATH_1	157	161	PF00917	0.445
DOC_USP7_MATH_1	350	354	PF00917	0.539
DOC_USP7_UBL2_3	18	22	PF12436	0.685
DOC_USP7_UBL2_3	249	253	PF12436	0.298
DOC_USP7_UBL2_3	318	322	PF12436	0.183
DOC_USP7_UBL2_3	99	103	PF12436	0.472
DOC_WW_Pin1_4	22	27	PF00397	0.697
DOC_WW_Pin1_4	293	298	PF00397	0.350
LIG_14-3-3_CanoR_1	218	222	PF00244	0.505
LIG_Actin_WH2_2	69	85	PF00022	0.504
LIG_APCC_ABBA_1	325	330	PF00400	0.399
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BRCT_BRCA1_1	43	47	PF00533	0.519
LIG_BRCT_BRCA1_2	43	49	PF00533	0.518
LIG_FHA_2	307	313	PF00498	0.396
LIG_FHA_2	43	49	PF00498	0.544
LIG_FHA_2	93	99	PF00498	0.450
LIG_LIR_Apic_2	98	104	PF02991	0.534
LIG_LIR_Nem_3	25	30	PF02991	0.705
LIG_LIR_Nem_3	4	10	PF02991	0.502
LIG_MLH1_MIPbox_1	43	47	PF16413	0.519
LIG_REV1ctd_RIR_1	44	53	PF16727	0.500
LIG_REV1ctd_RIR_1	58	68	PF16727	0.629
LIG_SH2_CRK	101	105	PF00017	0.626
LIG_SH2_CRK	27	31	PF00017	0.538
LIG_SH2_PTP2	260	263	PF00017	0.408
LIG_SH2_PTP2	90	93	PF00017	0.446
LIG_SH2_STAP1	31	35	PF00017	0.536
LIG_SH2_STAP1	43	47	PF00017	0.485
LIG_SH2_STAT5	10	13	PF00017	0.596
LIG_SH2_STAT5	227	230	PF00017	0.258
LIG_SH2_STAT5	260	263	PF00017	0.355
LIG_SH2_STAT5	27	30	PF00017	0.542
LIG_SH2_STAT5	81	84	PF00017	0.614
LIG_SH2_STAT5	90	93	PF00017	0.605
LIG_SH3_3	35	41	PF00018	0.588
LIG_SUMO_SIM_par_1	195	201	PF11976	0.507
LIG_TRAF2_1	244	247	PF00917	0.374
LIG_TRAF2_1	265	268	PF00917	0.322
LIG_TRAF2_1	95	98	PF00917	0.505
LIG_UBA3_1	6	12	PF00899	0.477
LIG_WRC_WIRS_1	43	48	PF05994	0.501
MOD_CDK_SPxxK_3	293	300	PF00069	0.350
MOD_CK1_1	125	131	PF00069	0.625
MOD_CK1_1	168	174	PF00069	0.440
MOD_CK1_1	2	8	PF00069	0.477
MOD_CK1_1	217	223	PF00069	0.527
MOD_CK1_1	25	31	PF00069	0.618
MOD_CK1_1	293	299	PF00069	0.311
MOD_CK2_1	10	16	PF00069	0.479
MOD_CK2_1	217	223	PF00069	0.540
MOD_CK2_1	241	247	PF00069	0.357
MOD_CK2_1	42	48	PF00069	0.544
MOD_CK2_1	92	98	PF00069	0.431
MOD_GlcNHglycan	1	4	PF01048	0.525
MOD_GlcNHglycan	118	121	PF01048	0.662
MOD_GlcNHglycan	12	15	PF01048	0.503
MOD_GlcNHglycan	149	152	PF01048	0.730
MOD_GlcNHglycan	159	162	PF01048	0.611
MOD_GlcNHglycan	170	173	PF01048	0.550
MOD_GSK3_1	18	25	PF00069	0.643
MOD_GSK3_1	182	189	PF00069	0.613
MOD_GSK3_1	213	220	PF00069	0.493
MOD_GSK3_1	226	233	PF00069	0.376
MOD_N-GLC_1	107	112	PF02516	0.687
MOD_N-GLC_1	22	27	PF02516	0.427
MOD_NEK2_1	192	197	PF00069	0.434
MOD_NEK2_1	306	311	PF00069	0.321
MOD_NEK2_2	42	47	PF00069	0.492
MOD_PKA_2	217	223	PF00069	0.502
MOD_Plk_1	107	113	PF00069	0.494
MOD_Plk_1	306	312	PF00069	0.323
MOD_Plk_4	2	8	PF00069	0.481
MOD_Plk_4	42	48	PF00069	0.544
MOD_ProDKin_1	22	28	PF00069	0.697
MOD_ProDKin_1	293	299	PF00069	0.350
MOD_SUMO_for_1	231	234	PF00179	0.262
MOD_SUMO_rev_2	13	20	PF00179	0.499
MOD_SUMO_rev_2	244	250	PF00179	0.408
TRG_DiLeu_BaEn_1	268	273	PF01217	0.338
TRG_ENDOCYTIC_2	260	263	PF00928	0.408
TRG_ENDOCYTIC_2	27	30	PF00928	0.651
TRG_ENDOCYTIC_2	43	46	PF00928	0.422
TRG_ER_diArg_1	276	279	PF00400	0.402
TRG_NLS_MonoCore_2	299	304	PF00514	0.408
TRG_NLS_MonoExtC_3	299	305	PF00514	0.408
TRG_NLS_MonoExtN_4	205	210	PF00514	0.507
TRG_NLS_MonoExtN_4	297	304	PF00514	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA5	Leptomonas seymouri	55%	98%
A0A1X0NJ07	Trypanosomatidae	25%	100%
A0A1X0NWL2	Trypanosomatidae	39%	92%
A0A3R7MDK6	Trypanosoma rangeli	40%	90%
A0A3S5H782	Leishmania donovani	77%	96%
A0A3S7WY66	Leishmania donovani	25%	100%
A4HYL9	Leishmania infantum	77%	96%
C9ZHT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	95%
E9AH22	Leishmania infantum	25%	100%
E9AUG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	96%
Q4QD16	Leishmania major	76%	100%
V5BAW3	Trypanosoma cruzi	26%	100%
V5DS69	Trypanosoma cruzi	40%	90%