Midasin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Midasin

Gene product:

Midasin, putative

Species:

Leishmania braziliensis

UniProt:

E9AI81_LEIBR

TriTrypDb:

LbrM.20.4470 , LBRM2903_200058500

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI81

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.704
CLV_PCSK_KEX2_1	219	221	PF00082	0.549
CLV_PCSK_KEX2_1	223	225	PF00082	0.480
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.549
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.480
CLV_PCSK_SKI1_1	253	257	PF00082	0.549
CLV_PCSK_SKI1_1	326	330	PF00082	0.687
CLV_PCSK_SKI1_1	44	48	PF00082	0.449
CLV_PCSK_SKI1_1	63	67	PF00082	0.212
DEG_Nend_Nbox_1	1	3	PF02207	0.653
DEG_SCF_FBW7_2	1	8	PF00400	0.625
DOC_CKS1_1	2	7	PF01111	0.616
DOC_MAPK_HePTP_8	292	304	PF00069	0.652
DOC_MAPK_MEF2A_6	295	304	PF00069	0.650
DOC_MAPK_MEF2A_6	396	404	PF00069	0.748
DOC_MAPK_MEF2A_6	48	56	PF00069	0.650
DOC_MAPK_MEF2A_6	9	18	PF00069	0.610
DOC_PP1_RVXF_1	324	330	PF00149	0.708
DOC_PP2B_LxvP_1	120	123	PF13499	0.650
DOC_USP7_MATH_1	296	300	PF00917	0.640
DOC_USP7_MATH_1	345	349	PF00917	0.610
DOC_USP7_UBL2_3	219	223	PF12436	0.549
DOC_USP7_UBL2_3	44	48	PF12436	0.650
DOC_WW_Pin1_4	1	6	PF00397	0.630
DOC_WW_Pin1_4	198	203	PF00397	0.648
DOC_WW_Pin1_4	225	230	PF00397	0.549
DOC_WW_Pin1_4	236	241	PF00397	0.357
DOC_WW_Pin1_4	71	76	PF00397	0.650
LIG_14-3-3_CanoR_1	153	159	PF00244	0.688
LIG_14-3-3_CanoR_1	274	283	PF00244	0.549
LIG_BRCT_BRCA1_1	117	121	PF00533	0.650
LIG_FHA_1	117	123	PF00498	0.650
LIG_FHA_1	138	144	PF00498	0.676
LIG_FHA_1	195	201	PF00498	0.613
LIG_FHA_1	2	8	PF00498	0.619
LIG_FHA_1	226	232	PF00498	0.549
LIG_FHA_1	268	274	PF00498	0.549
LIG_FHA_1	299	305	PF00498	0.642
LIG_FHA_1	361	367	PF00498	0.650
LIG_FHA_1	374	380	PF00498	0.487
LIG_FHA_1	84	90	PF00498	0.650
LIG_FHA_2	171	177	PF00498	0.620
LIG_FHA_2	401	407	PF00498	0.663
LIG_GBD_Chelix_1	365	373	PF00786	0.449
LIG_Integrin_isoDGR_2	427	429	PF01839	0.786
LIG_LIR_Gen_1	104	112	PF02991	0.650
LIG_LIR_Gen_1	157	168	PF02991	0.632
LIG_LIR_Gen_1	184	193	PF02991	0.616
LIG_LIR_Gen_1	254	264	PF02991	0.549
LIG_LIR_Gen_1	348	357	PF02991	0.549
LIG_LIR_Gen_1	409	419	PF02991	0.668
LIG_LIR_LC3C_4	376	379	PF02991	0.650
LIG_LIR_Nem_3	104	108	PF02991	0.650
LIG_LIR_Nem_3	157	163	PF02991	0.645
LIG_LIR_Nem_3	184	188	PF02991	0.624
LIG_LIR_Nem_3	254	259	PF02991	0.549
LIG_LIR_Nem_3	348	354	PF02991	0.647
LIG_LIR_Nem_3	406	411	PF02991	0.653
LIG_NRBOX	110	116	PF00104	0.650
LIG_NRBOX	210	216	PF00104	0.549
LIG_Pex14_2	391	395	PF04695	0.650
LIG_Pex14_2	411	415	PF04695	0.309
LIG_PTB_Apo_2	179	186	PF02174	0.631
LIG_PTB_Phospho_1	179	185	PF10480	0.625
LIG_SH2_CRK	185	189	PF00017	0.618
LIG_SH2_NCK_1	185	189	PF00017	0.618
LIG_SH2_PTP2	351	354	PF00017	0.549
LIG_SH2_STAP1	160	164	PF00017	0.636
LIG_SH2_STAT5	351	354	PF00017	0.549
LIG_SH2_STAT5	368	371	PF00017	0.437
LIG_SH3_3	283	289	PF00018	0.622
LIG_SH3_3	307	313	PF00018	0.605
LIG_SH3_3	78	84	PF00018	0.650
LIG_SUMO_SIM_par_1	110	119	PF11976	0.650
LIG_SUMO_SIM_par_1	288	293	PF11976	0.634
LIG_SUMO_SIM_par_1	298	306	PF11976	0.462
LIG_TYR_ITIM	158	163	PF00017	0.638
LIG_WRC_WIRS_1	102	107	PF05994	0.650
MOD_CK1_1	195	201	PF00069	0.613
MOD_CK1_1	236	242	PF00069	0.549
MOD_CK1_1	244	250	PF00069	0.410
MOD_CK1_1	322	328	PF00069	0.729
MOD_CK1_1	409	415	PF00069	0.653
MOD_CK2_1	110	116	PF00069	0.650
MOD_CK2_1	334	340	PF00069	0.609
MOD_GlcNHglycan	145	148	PF01048	0.713
MOD_GlcNHglycan	34	37	PF01048	0.449
MOD_GlcNHglycan	408	411	PF01048	0.646
MOD_GlcNHglycan	69	72	PF01048	0.449
MOD_GSK3_1	110	117	PF00069	0.650
MOD_GSK3_1	188	195	PF00069	0.612
MOD_GSK3_1	200	207	PF00069	0.458
MOD_GSK3_1	215	222	PF00069	0.287
MOD_GSK3_1	330	337	PF00069	0.640
MOD_GSK3_1	67	74	PF00069	0.650
MOD_N-GLC_1	170	175	PF02516	0.633
MOD_N-GLC_1	181	186	PF02516	0.441
MOD_NEK2_1	114	119	PF00069	0.650
MOD_NEK2_1	137	142	PF00069	0.650
MOD_NEK2_1	143	148	PF00069	0.579
MOD_NEK2_1	163	168	PF00069	0.266
MOD_NEK2_1	18	23	PF00069	0.618
MOD_NEK2_1	215	220	PF00069	0.549
MOD_NEK2_1	242	247	PF00069	0.549
MOD_NEK2_1	314	319	PF00069	0.696
MOD_NEK2_1	373	378	PF00069	0.650
MOD_NEK2_1	414	419	PF00069	0.684
MOD_NEK2_1	69	74	PF00069	0.650
MOD_PIKK_1	137	143	PF00454	0.650
MOD_PIKK_1	69	75	PF00454	0.650
MOD_PK_1	154	160	PF00069	0.677
MOD_PK_1	34	40	PF00069	0.650
MOD_PKA_1	219	225	PF00069	0.549
MOD_PKA_2	152	158	PF00069	0.696
MOD_PKA_2	215	221	PF00069	0.549
MOD_PKA_2	223	229	PF00069	0.410
MOD_PKA_2	247	253	PF00069	0.549
MOD_PKA_2	322	328	PF00069	0.729
MOD_Plk_1	115	121	PF00069	0.650
MOD_Plk_1	181	187	PF00069	0.633
MOD_Plk_1	56	62	PF00069	0.650
MOD_Plk_2-3	101	107	PF00069	0.650
MOD_Plk_2-3	298	304	PF00069	0.651
MOD_Plk_4	110	116	PF00069	0.650
MOD_Plk_4	163	169	PF00069	0.610
MOD_Plk_4	176	182	PF00069	0.379
MOD_Plk_4	188	194	PF00069	0.400
MOD_Plk_4	195	201	PF00069	0.280
MOD_Plk_4	204	210	PF00069	0.269
MOD_Plk_4	247	253	PF00069	0.549
MOD_Plk_4	314	320	PF00069	0.704
MOD_Plk_4	334	340	PF00069	0.259
MOD_Plk_4	34	40	PF00069	0.650
MOD_Plk_4	360	366	PF00069	0.650
MOD_Plk_4	373	379	PF00069	0.487
MOD_Plk_4	47	53	PF00069	0.487
MOD_ProDKin_1	1	7	PF00069	0.623
MOD_ProDKin_1	198	204	PF00069	0.656
MOD_ProDKin_1	225	231	PF00069	0.549
MOD_ProDKin_1	236	242	PF00069	0.357
MOD_ProDKin_1	71	77	PF00069	0.650
MOD_SUMO_rev_2	57	65	PF00179	0.650
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.618
TRG_ENDOCYTIC_2	160	163	PF00928	0.648
TRG_ENDOCYTIC_2	185	188	PF00928	0.621
TRG_ENDOCYTIC_2	351	354	PF00928	0.549
TRG_ENDOCYTIC_2	408	411	PF00928	0.646
TRG_ENDOCYTIC_2	93	96	PF00928	0.650
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q51664	PARDP	30%	100%
Q9HHS9	HALSA	27%	100%
Q9HI16	HALSA	25%	100%