Putative deoxyhypusine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyhypusine synthase, putative

Species:

Leishmania braziliensis

UniProt:

E9AI79_LEIBR

TriTrypDb:

LbrM.20.4450 , LBRM2903_200058400

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI79

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	3	12
GO:0009058	biosynthetic process	2	12
GO:0018193	peptidyl-amino acid modification	5	12
GO:0018205	peptidyl-lysine modification	6	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0051604	protein maturation	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016740	transferase activity	2	6
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	6
GO:0034038	deoxyhypusine synthase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.528
CLV_NRD_NRD_1	102	104	PF00675	0.324
CLV_NRD_NRD_1	170	172	PF00675	0.330
CLV_NRD_NRD_1	19	21	PF00675	0.736
CLV_NRD_NRD_1	284	286	PF00675	0.425
CLV_PCSK_KEX2_1	102	104	PF00082	0.280
CLV_PCSK_KEX2_1	169	171	PF00082	0.367
CLV_PCSK_KEX2_1	19	21	PF00082	0.738
CLV_PCSK_KEX2_1	50	52	PF00082	0.441
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.441
CLV_PCSK_PC7_1	166	172	PF00082	0.429
CLV_PCSK_SKI1_1	108	112	PF00082	0.393
CLV_Separin_Metazoa	350	354	PF03568	0.254
DOC_CKS1_1	192	197	PF01111	0.455
DOC_MAPK_RevD_3	273	286	PF00069	0.455
DOC_PP2B_LxvP_1	15	18	PF13499	0.530
DOC_PP2B_LxvP_1	179	182	PF13499	0.308
DOC_PP4_FxxP_1	192	195	PF00568	0.324
DOC_USP7_MATH_1	112	116	PF00917	0.321
DOC_USP7_MATH_1	289	293	PF00917	0.242
DOC_USP7_MATH_1	3	7	PF00917	0.723
DOC_USP7_MATH_1	37	41	PF00917	0.762
DOC_USP7_MATH_1	74	78	PF00917	0.408
DOC_USP7_UBL2_3	286	290	PF12436	0.378
DOC_WW_Pin1_4	101	106	PF00397	0.464
DOC_WW_Pin1_4	191	196	PF00397	0.455
DOC_WW_Pin1_4	248	253	PF00397	0.324
DOC_WW_Pin1_4	44	49	PF00397	0.752
LIG_14-3-3_CanoR_1	208	215	PF00244	0.346
LIG_14-3-3_CanoR_1	244	250	PF00244	0.455
LIG_14-3-3_CanoR_1	311	316	PF00244	0.425
LIG_14-3-3_CanoR_1	73	82	PF00244	0.250
LIG_Actin_WH2_2	297	313	PF00022	0.429
LIG_Actin_WH2_2	57	75	PF00022	0.493
LIG_AP2alpha_1	189	193	PF02296	0.343
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BRCT_BRCA1_1	250	254	PF00533	0.393
LIG_FHA_1	192	198	PF00498	0.455
LIG_FHA_1	233	239	PF00498	0.424
LIG_FHA_1	320	326	PF00498	0.393
LIG_FHA_1	347	353	PF00498	0.455
LIG_FHA_1	79	85	PF00498	0.455
LIG_FHA_2	28	34	PF00498	0.700
LIG_FHA_2	321	327	PF00498	0.343
LIG_FHA_2	371	377	PF00498	0.527
LIG_FHA_2	64	70	PF00498	0.540
LIG_GBD_Chelix_1	296	304	PF00786	0.455
LIG_LIR_Apic_2	190	195	PF02991	0.308
LIG_LIR_Gen_1	124	134	PF02991	0.324
LIG_LIR_Gen_1	184	193	PF02991	0.324
LIG_LIR_Gen_1	59	64	PF02991	0.455
LIG_LIR_Nem_3	107	113	PF02991	0.321
LIG_LIR_Nem_3	124	129	PF02991	0.249
LIG_LIR_Nem_3	184	189	PF02991	0.308
LIG_LIR_Nem_3	190	196	PF02991	0.308
LIG_LIR_Nem_3	237	243	PF02991	0.324
LIG_LIR_Nem_3	59	63	PF02991	0.438
LIG_PCNA_yPIPBox_3	306	319	PF02747	0.455
LIG_Pex14_1	188	192	PF04695	0.429
LIG_Pex14_2	189	193	PF04695	0.308
LIG_Pex14_2	250	254	PF04695	0.393
LIG_PTB_Apo_2	180	187	PF02174	0.308
LIG_PTB_Phospho_1	180	186	PF10480	0.308
LIG_RPA_C_Fungi	88	100	PF08784	0.365
LIG_SH2_STAP1	113	117	PF00017	0.308
LIG_SH2_STAT5	113	116	PF00017	0.308
LIG_SH2_STAT5	128	131	PF00017	0.308
LIG_SH2_STAT5	186	189	PF00017	0.324
LIG_SH2_STAT5	264	267	PF00017	0.319
LIG_SH3_3	246	252	PF00018	0.343
LIG_SH3_3	271	277	PF00018	0.324
LIG_SH3_3	357	363	PF00018	0.455
LIG_SUMO_SIM_par_1	316	323	PF11976	0.395
LIG_SUMO_SIM_par_1	362	370	PF11976	0.356
LIG_TRAF2_1	66	69	PF00917	0.553
MOD_CDC14_SPxK_1	47	50	PF00782	0.474
MOD_CDK_SPxK_1	44	50	PF00069	0.487
MOD_CDK_SPxxK_3	101	108	PF00069	0.455
MOD_CDK_SPxxK_3	44	51	PF00069	0.482
MOD_CK1_1	22	28	PF00069	0.701
MOD_CK1_1	248	254	PF00069	0.455
MOD_CK1_1	35	41	PF00069	0.575
MOD_CK1_1	46	52	PF00069	0.469
MOD_CK1_1	78	84	PF00069	0.425
MOD_CK2_1	196	202	PF00069	0.392
MOD_CK2_1	320	326	PF00069	0.365
MOD_CK2_1	63	69	PF00069	0.534
MOD_GlcNHglycan	119	122	PF01048	0.204
MOD_GlcNHglycan	140	143	PF01048	0.393
MOD_GlcNHglycan	291	294	PF01048	0.370
MOD_GlcNHglycan	332	335	PF01048	0.405
MOD_GlcNHglycan	35	38	PF01048	0.749
MOD_GlcNHglycan	39	42	PF01048	0.697
MOD_GlcNHglycan	5	8	PF01048	0.745
MOD_GlcNHglycan	51	54	PF01048	0.456
MOD_GSK3_1	112	119	PF00069	0.300
MOD_GSK3_1	20	27	PF00069	0.731
MOD_GSK3_1	204	211	PF00069	0.324
MOD_GSK3_1	230	237	PF00069	0.389
MOD_GSK3_1	248	255	PF00069	0.159
MOD_GSK3_1	33	40	PF00069	0.582
MOD_GSK3_1	59	66	PF00069	0.458
MOD_GSK3_1	74	81	PF00069	0.433
MOD_N-GLC_1	266	271	PF02516	0.308
MOD_N-GLC_1	311	316	PF02516	0.455
MOD_N-GLC_1	33	38	PF02516	0.522
MOD_N-GLC_2	185	187	PF02516	0.324
MOD_NEK2_1	111	116	PF00069	0.308
MOD_NEK2_1	117	122	PF00069	0.308
MOD_NEK2_1	138	143	PF00069	0.260
MOD_NEK2_1	320	325	PF00069	0.423
MOD_NEK2_1	63	68	PF00069	0.380
MOD_NEK2_1	84	89	PF00069	0.375
MOD_PIKK_1	64	70	PF00454	0.520
MOD_PIKK_1	84	90	PF00454	0.417
MOD_PKA_1	19	25	PF00069	0.770
MOD_PKA_2	122	128	PF00069	0.308
MOD_PKA_2	19	25	PF00069	0.776
MOD_PKA_2	204	210	PF00069	0.308
MOD_Plk_1	311	317	PF00069	0.455
MOD_Plk_1	356	362	PF00069	0.308
MOD_Plk_1	68	74	PF00069	0.548
MOD_Plk_2-3	370	376	PF00069	0.468
MOD_Plk_4	122	128	PF00069	0.377
MOD_Plk_4	153	159	PF00069	0.295
MOD_Plk_4	234	240	PF00069	0.304
MOD_Plk_4	356	362	PF00069	0.315
MOD_Plk_4	59	65	PF00069	0.559
MOD_ProDKin_1	101	107	PF00069	0.464
MOD_ProDKin_1	191	197	PF00069	0.455
MOD_ProDKin_1	248	254	PF00069	0.324
MOD_ProDKin_1	44	50	PF00069	0.748
MOD_SUMO_for_1	11	14	PF00179	0.533
TRG_AP2beta_CARGO_1	124	133	PF09066	0.343
TRG_DiLeu_BaEn_2	105	111	PF01217	0.472
TRG_DiLeu_BaEn_4	369	375	PF01217	0.446
TRG_ENDOCYTIC_2	186	189	PF00928	0.297
TRG_ER_diArg_1	168	171	PF00400	0.356
TRG_ER_diArg_1	18	20	PF00400	0.628
TRG_ER_diArg_1	282	285	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N5	Leptomonas seymouri	75%	100%
A0A0S4JCE9	Bodo saltans	51%	100%
A0A0S4KFM4	Bodo saltans	27%	97%
A0A1X0NWI9	Trypanosomatidae	61%	100%
A0A3Q8IEQ5	Leishmania donovani	87%	100%
A0A422NEH6	Trypanosoma rangeli	61%	100%
A3MVC9	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	29%	100%
A4HYL6	Leishmania infantum	88%	100%
A4YHK6	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	25%	100%
A4ZZ93	Leishmania donovani	87%	100%
A6URC0	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	40%	100%
A8AA61	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	28%	100%
A9KDQ8	Coxiella burnetii (strain Dugway 5J108-111)	22%	100%
A9NCJ8	Coxiella burnetii (strain RSA 331 / Henzerling II)	22%	100%
B0R5L2	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	30%	100%
B2KER6	Elusimicrobium minutum (strain Pei191)	22%	100%
B3QLU4	Chlorobaculum parvum (strain DSM 263 / NCIMB 8327)	25%	100%
B6YVB1	Thermococcus onnurineus (strain NA1)	38%	100%
C3MPN8	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	26%	100%
C3MYN2	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	26%	100%
C3N5B4	Sulfolobus islandicus (strain M.16.27)	26%	100%
C3NDW8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	26%	100%
C3NHT5	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	26%	100%
C4KGY0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	26%	100%
C5A5L0	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	38%	100%
C9ZHW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AUG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O26230	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	24%	100%
O27984	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	22%	100%
O50105	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	37%	100%
O94337	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P38791	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	98%
P49365	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	100%
P49366	Homo sapiens	40%	100%
P59650	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	22%	100%
P60038	Senecio vernalis	38%	100%
Q3TXU5	Mus musculus	40%	100%
Q4GZD1	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	58%	100%
Q4J978	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	26%	100%
Q4QD19	Leishmania major	87%	100%
Q54MQ7	Dictyostelium discoideum	40%	100%
Q58224	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	39%	100%
Q5JEY0	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	37%	100%
Q6AY53	Rattus norvegicus	40%	100%
Q6BJH5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	36%	100%
Q6CG56	Yarrowia lipolytica (strain CLIB 122 / E 150)	39%	100%
Q6CNG7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	100%
Q6EWQ6	Bos taurus	40%	100%
Q6FRN2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	37%	98%
Q6KZL5	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	29%	100%
Q6RJS2	Brassica napus	35%	100%
Q75EW4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	99%
Q8KGF7	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	24%	100%
Q8PV89	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	22%	100%
Q8SQN2	Encephalitozoon cuniculi (strain GB-M1)	35%	100%
Q8TLM3	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	20%	100%
Q8TS38	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	22%	100%
Q8TXD7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	25%	100%
Q8U407	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	37%	100%
Q8YQL7	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	23%	99%
Q8ZT09	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	26%	100%
Q971T3	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	25%	100%
Q977X6	Methanosarcina thermophila	21%	100%
Q97BN6	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	28%	100%
Q97ZF1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	26%	100%
Q9AXQ8	Dianthus caryophyllus	36%	100%
Q9AXQ9	Musa acuminata	34%	100%
Q9AXR0	Solanum lycopersicum	38%	99%
Q9FI94	Arabidopsis thaliana	36%	100%
Q9HL74	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	31%	100%
Q9HPX2	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	30%	100%
Q9M4B0	Senecio vulgaris	38%	100%
Q9SC13	Senecio vernalis	38%	100%
Q9SC14	Senecio vernalis	38%	100%
Q9SC80	Nicotiana tabacum	38%	100%
Q9V0N5	Pyrococcus abyssi (strain GE5 / Orsay)	36%	100%
Q9VSF4	Drosophila melanogaster	41%	100%
Q9XXJ0	Caenorhabditis elegans	40%	100%
Q9YE72	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	100%
V5C0C4	Trypanosoma cruzi	61%	100%