ER membrane protein complex subunit 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane protein, putative

Species:

Leishmania braziliensis

UniProt:

E9AI78_LEIBR

TriTrypDb:

LbrM.20.4440 , LBRM2903_200058300

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 3
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AI78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.415
CLV_NRD_NRD_1	189	191	PF00675	0.577
CLV_NRD_NRD_1	34	36	PF00675	0.338
CLV_PCSK_KEX2_1	217	219	PF00082	0.729
CLV_PCSK_KEX2_1	34	36	PF00082	0.338
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.711
CLV_PCSK_SKI1_1	237	241	PF00082	0.483
DOC_CKS1_1	106	111	PF01111	0.393
DOC_CYCLIN_yCln2_LP_2	182	188	PF00134	0.546
DOC_MAPK_DCC_7	179	188	PF00069	0.496
DOC_MAPK_MEF2A_6	100	107	PF00069	0.393
DOC_MAPK_MEF2A_6	169	176	PF00069	0.437
DOC_MAPK_MEF2A_6	6	14	PF00069	0.508
DOC_PP4_FxxP_1	247	250	PF00568	0.407
DOC_USP7_MATH_1	118	122	PF00917	0.312
DOC_USP7_MATH_1	136	140	PF00917	0.396
DOC_USP7_UBL2_3	187	191	PF12436	0.671
DOC_USP7_UBL2_3	96	100	PF12436	0.473
DOC_WW_Pin1_4	105	110	PF00397	0.330
DOC_WW_Pin1_4	54	59	PF00397	0.354
LIG_14-3-3_CanoR_1	60	69	PF00244	0.463
LIG_14-3-3_CanoR_1	76	80	PF00244	0.445
LIG_Actin_WH2_2	173	189	PF00022	0.572
LIG_deltaCOP1_diTrp_1	39	48	PF00928	0.452
LIG_FHA_1	102	108	PF00498	0.478
LIG_FHA_1	121	127	PF00498	0.219
LIG_FHA_1	171	177	PF00498	0.480
LIG_FHA_1	5	11	PF00498	0.460
LIG_FHA_2	226	232	PF00498	0.540
LIG_LIR_Gen_1	39	50	PF02991	0.409
LIG_LIR_Nem_3	3	8	PF02991	0.525
LIG_LIR_Nem_3	39	45	PF02991	0.383
LIG_REV1ctd_RIR_1	149	159	PF16727	0.580
LIG_SH2_SRC	92	95	PF00017	0.424
LIG_SH2_STAT3	90	93	PF00017	0.490
LIG_SH2_STAT5	246	249	PF00017	0.473
LIG_SH2_STAT5	30	33	PF00017	0.356
LIG_SH3_3	103	109	PF00018	0.411
LIG_SH3_3	130	136	PF00018	0.385
LIG_SH3_3	227	233	PF00018	0.413
LIG_SH3_4	96	103	PF00018	0.462
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.522
LIG_SUMO_SIM_par_1	103	108	PF11976	0.460
LIG_SUMO_SIM_par_1	120	128	PF11976	0.248
LIG_TRAF2_1	72	75	PF00917	0.601
LIG_TRAF2_1	91	94	PF00917	0.431
LIG_TYR_ITIM	192	197	PF00017	0.604
LIG_WRC_WIRS_1	45	50	PF05994	0.377
MOD_CDK_SPxK_1	54	60	PF00069	0.444
MOD_CK1_1	146	152	PF00069	0.500
MOD_CK1_1	51	57	PF00069	0.431
MOD_CK2_1	218	224	PF00069	0.689
MOD_CK2_1	225	231	PF00069	0.508
MOD_CK2_1	35	41	PF00069	0.511
MOD_CK2_1	69	75	PF00069	0.499
MOD_GSK3_1	101	108	PF00069	0.374
MOD_GSK3_1	44	51	PF00069	0.328
MOD_GSK3_1	6	13	PF00069	0.469
MOD_N-GLC_1	136	141	PF02516	0.389
MOD_NEK2_1	10	15	PF00069	0.440
MOD_NEK2_1	151	156	PF00069	0.393
MOD_NEK2_1	17	22	PF00069	0.488
MOD_NEK2_1	4	9	PF00069	0.470
MOD_NEK2_1	48	53	PF00069	0.372
MOD_PIKK_1	24	30	PF00454	0.433
MOD_PIKK_1	52	58	PF00454	0.601
MOD_PIKK_1	60	66	PF00454	0.393
MOD_PKA_2	59	65	PF00069	0.433
MOD_PKA_2	75	81	PF00069	0.451
MOD_Plk_1	136	142	PF00069	0.353
MOD_Plk_1	162	168	PF00069	0.388
MOD_Plk_1	235	241	PF00069	0.468
MOD_Plk_1	67	73	PF00069	0.483
MOD_Plk_1	74	80	PF00069	0.435
MOD_Plk_4	101	107	PF00069	0.371
MOD_Plk_4	108	114	PF00069	0.305
MOD_Plk_4	120	126	PF00069	0.260
MOD_Plk_4	136	142	PF00069	0.317
MOD_Plk_4	251	257	PF00069	0.427
MOD_Plk_4	26	32	PF00069	0.238
MOD_Plk_4	6	12	PF00069	0.450
MOD_ProDKin_1	105	111	PF00069	0.332
MOD_ProDKin_1	54	60	PF00069	0.353
MOD_SUMO_rev_2	117	124	PF00179	0.443
TRG_ENDOCYTIC_2	194	197	PF00928	0.476
TRG_ENDOCYTIC_2	246	249	PF00928	0.449
TRG_ER_diArg_1	34	36	PF00400	0.338
TRG_NLS_MonoExtC_3	189	195	PF00514	0.555
TRG_NLS_MonoExtN_4	187	194	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK3	Leptomonas seymouri	66%	100%
A0A0S4J8Z8	Bodo saltans	31%	100%
A0A1X0NWH6	Trypanosomatidae	41%	96%
A0A3R7KYG2	Trypanosoma rangeli	34%	93%
A0A3S7WVR1	Leishmania donovani	78%	100%
A4HYL5	Leishmania infantum	78%	100%
C9ZHW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
E9AUG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QD20	Leishmania major	79%	100%
V5BQW5	Trypanosoma cruzi	37%	94%