Kelch domain-containing protein 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kelch domain-containing protein

Species:

Leishmania braziliensis

UniProt:

E9AI75_LEIBR

TriTrypDb:

LbrM.20.4400 , LBRM2903_200058000

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.551
CLV_NRD_NRD_1	147	149	PF00675	0.396
CLV_NRD_NRD_1	76	78	PF00675	0.456
CLV_NRD_NRD_1	79	81	PF00675	0.421
CLV_PCSK_KEX2_1	147	149	PF00082	0.396
CLV_PCSK_KEX2_1	76	78	PF00082	0.456
CLV_PCSK_SKI1_1	405	409	PF00082	0.472
DEG_APCC_DBOX_1	334	342	PF00400	0.357
DEG_MDM2_SWIB_1	297	305	PF02201	0.466
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DOC_CKS1_1	163	168	PF01111	0.546
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.339
DOC_PP4_FxxP_1	361	364	PF00568	0.455
DOC_PP4_MxPP_1	88	91	PF00568	0.562
DOC_USP7_MATH_1	288	292	PF00917	0.561
DOC_USP7_MATH_1	334	338	PF00917	0.409
DOC_USP7_MATH_1	83	87	PF00917	0.563
DOC_USP7_MATH_1	94	98	PF00917	0.425
DOC_WW_Pin1_4	111	116	PF00397	0.425
DOC_WW_Pin1_4	162	167	PF00397	0.518
DOC_WW_Pin1_4	169	174	PF00397	0.533
DOC_WW_Pin1_4	79	84	PF00397	0.335
LIG_14-3-3_CanoR_1	130	134	PF00244	0.461
LIG_14-3-3_CanoR_1	232	238	PF00244	0.373
LIG_14-3-3_CanoR_1	269	275	PF00244	0.228
LIG_14-3-3_CanoR_1	335	339	PF00244	0.452
LIG_BRCT_BRCA1_1	293	297	PF00533	0.531
LIG_eIF4E_1	48	54	PF01652	0.321
LIG_FHA_1	355	361	PF00498	0.303
LIG_FHA_1	370	376	PF00498	0.487
LIG_FHA_2	195	201	PF00498	0.653
LIG_LIR_Apic_2	359	364	PF02991	0.424
LIG_LIR_Gen_1	128	139	PF02991	0.406
LIG_LIR_Gen_1	294	305	PF02991	0.317
LIG_LIR_Gen_1	311	320	PF02991	0.464
LIG_LIR_Gen_1	50	56	PF02991	0.339
LIG_LIR_Nem_3	128	134	PF02991	0.392
LIG_LIR_Nem_3	181	187	PF02991	0.402
LIG_LIR_Nem_3	234	240	PF02991	0.343
LIG_LIR_Nem_3	294	300	PF02991	0.286
LIG_LIR_Nem_3	311	315	PF02991	0.422
LIG_LIR_Nem_3	50	55	PF02991	0.339
LIG_LYPXL_SIV_4	330	338	PF13949	0.414
LIG_MLH1_MIPbox_1	293	297	PF16413	0.531
LIG_PCNA_TLS_4	405	412	PF02747	0.370
LIG_Pex14_2	222	226	PF04695	0.352
LIG_Pex14_2	297	301	PF04695	0.363
LIG_Pex14_2	361	365	PF04695	0.233
LIG_PTB_Apo_2	154	161	PF02174	0.307
LIG_PTB_Apo_2	239	246	PF02174	0.321
LIG_PTB_Apo_2	63	70	PF02174	0.339
LIG_PTB_Phospho_1	154	160	PF10480	0.310
LIG_SH2_GRB2like	240	243	PF00017	0.339
LIG_SH2_SRC	118	121	PF00017	0.378
LIG_SH2_SRC	240	243	PF00017	0.354
LIG_SH2_STAP1	118	122	PF00017	0.425
LIG_SH2_STAP1	270	274	PF00017	0.327
LIG_SH2_STAP1	356	360	PF00017	0.316
LIG_SH2_STAT3	107	110	PF00017	0.362
LIG_SH2_STAT3	367	370	PF00017	0.626
LIG_SH2_STAT5	160	163	PF00017	0.358
LIG_SH2_STAT5	176	179	PF00017	0.338
LIG_SH2_STAT5	220	223	PF00017	0.313
LIG_SH2_STAT5	225	228	PF00017	0.306
LIG_SH2_STAT5	240	243	PF00017	0.452
LIG_SH2_STAT5	282	285	PF00017	0.340
LIG_SH2_STAT5	296	299	PF00017	0.305
LIG_SH2_STAT5	331	334	PF00017	0.385
LIG_SH2_STAT5	356	359	PF00017	0.404
LIG_SH2_STAT5	411	414	PF00017	0.404
LIG_SH2_STAT5	52	55	PF00017	0.429
LIG_SH3_1	258	264	PF00018	0.550
LIG_SH3_3	11	17	PF00018	0.504
LIG_SH3_3	138	144	PF00018	0.494
LIG_SH3_3	163	169	PF00018	0.556
LIG_SH3_3	258	264	PF00018	0.471
LIG_SH3_3	31	37	PF00018	0.408
LIG_SH3_3	347	353	PF00018	0.371
LIG_SH3_CIN85_PxpxPR_1	264	269	PF14604	0.261
LIG_SUMO_SIM_par_1	119	125	PF11976	0.427
LIG_TRFH_1	185	189	PF08558	0.282
LIG_TYR_ITIM	116	121	PF00017	0.425
LIG_TYR_ITIM	174	179	PF00017	0.489
LIG_WW_3	167	171	PF00397	0.353
LIG_WW_3	89	93	PF00397	0.452
MOD_CK1_1	192	198	PF00069	0.426
MOD_CK1_1	212	218	PF00069	0.396
MOD_CK1_1	233	239	PF00069	0.305
MOD_CK1_1	291	297	PF00069	0.552
MOD_CK1_1	324	330	PF00069	0.354
MOD_CK1_1	348	354	PF00069	0.458
MOD_CK1_1	44	50	PF00069	0.237
MOD_CK1_1	79	85	PF00069	0.418
MOD_CK2_1	194	200	PF00069	0.668
MOD_CK2_1	233	239	PF00069	0.399
MOD_CK2_1	240	246	PF00069	0.363
MOD_CK2_1	390	396	PF00069	0.609
MOD_GlcNHglycan	211	214	PF01048	0.321
MOD_GlcNHglycan	24	27	PF01048	0.614
MOD_GlcNHglycan	323	326	PF01048	0.339
MOD_GlcNHglycan	367	370	PF01048	0.629
MOD_GSK3_1	125	132	PF00069	0.324
MOD_GSK3_1	208	215	PF00069	0.392
MOD_GSK3_1	291	298	PF00069	0.532
MOD_GSK3_1	365	372	PF00069	0.521
MOD_GSK3_1	72	79	PF00069	0.324
MOD_N-GLC_1	288	293	PF02516	0.564
MOD_NEK2_1	365	370	PF00069	0.507
MOD_NEK2_1	93	98	PF00069	0.371
MOD_NEK2_2	240	245	PF00069	0.321
MOD_NEK2_2	334	339	PF00069	0.389
MOD_NEK2_2	369	374	PF00069	0.599
MOD_PKA_1	76	82	PF00069	0.458
MOD_PKA_2	129	135	PF00069	0.457
MOD_PKA_2	231	237	PF00069	0.199
MOD_PKA_2	27	33	PF00069	0.681
MOD_PKA_2	321	327	PF00069	0.340
MOD_PKA_2	334	340	PF00069	0.410
MOD_PKA_2	76	82	PF00069	0.390
MOD_Plk_1	230	236	PF00069	0.291
MOD_Plk_1	291	297	PF00069	0.515
MOD_Plk_1	348	354	PF00069	0.587
MOD_Plk_1	389	395	PF00069	0.395
MOD_Plk_2-3	390	396	PF00069	0.394
MOD_Plk_4	240	246	PF00069	0.332
MOD_Plk_4	291	297	PF00069	0.554
MOD_Plk_4	334	340	PF00069	0.370
MOD_Plk_4	41	47	PF00069	0.287
MOD_Plk_4	94	100	PF00069	0.286
MOD_ProDKin_1	111	117	PF00069	0.425
MOD_ProDKin_1	162	168	PF00069	0.526
MOD_ProDKin_1	169	175	PF00069	0.521
MOD_ProDKin_1	79	85	PF00069	0.331
TRG_ENDOCYTIC_2	118	121	PF00928	0.375
TRG_ENDOCYTIC_2	160	163	PF00928	0.358
TRG_ENDOCYTIC_2	176	179	PF00928	0.338
TRG_ENDOCYTIC_2	52	55	PF00928	0.452
TRG_ER_diArg_1	147	149	PF00400	0.396
TRG_ER_diArg_1	301	304	PF00400	0.371
TRG_ER_diArg_1	76	78	PF00400	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I272	Leptomonas seymouri	50%	100%
A0A0S4JFE6	Bodo saltans	34%	100%
A0A1X0NY29	Trypanosomatidae	40%	100%
A0A3S5H781	Leishmania donovani	83%	99%
A0A422NEH9	Trypanosoma rangeli	42%	100%
A0A422NWK7	Trypanosoma rangeli	20%	100%
A4HYL2	Leishmania infantum	83%	99%
C9ZHV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	97%
C9ZW92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9AUG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q0IIC2	Bos taurus	24%	94%
Q10AZ7	Oryza sativa subsp. japonica	24%	83%
Q4QD23	Leishmania major	83%	100%
Q58CV6	Bos taurus	25%	100%
Q5R8W1	Pongo abelii	27%	79%
Q5U3Y0	Rattus norvegicus	24%	100%
Q6AYI2	Rattus norvegicus	25%	100%
Q6PAR0	Mus musculus	24%	94%
Q6PID8	Homo sapiens	24%	94%
Q8VEM9	Mus musculus	25%	100%
Q9BQ90	Homo sapiens	25%	100%
V5BAH1	Trypanosoma cruzi	22%	100%
V5DS74	Trypanosoma cruzi	42%	100%