Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI74_LEIBR

TriTrypDb:

LbrM.20.4390 , LBRM2903_200057900

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.536
CLV_C14_Caspase3-7	721	725	PF00656	0.502
CLV_NRD_NRD_1	144	146	PF00675	0.655
CLV_NRD_NRD_1	403	405	PF00675	0.498
CLV_NRD_NRD_1	561	563	PF00675	0.558
CLV_NRD_NRD_1	578	580	PF00675	0.341
CLV_PCSK_KEX2_1	144	146	PF00082	0.655
CLV_PCSK_KEX2_1	561	563	PF00082	0.558
CLV_PCSK_KEX2_1	578	580	PF00082	0.341
CLV_PCSK_KEX2_1	75	77	PF00082	0.458
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.458
CLV_PCSK_SKI1_1	482	486	PF00082	0.480
CLV_PCSK_SKI1_1	76	80	PF00082	0.387
CLV_Separin_Metazoa	109	113	PF03568	0.490
DEG_APCC_DBOX_1	31	39	PF00400	0.308
DEG_SCF_TRCP1_1	147	153	PF00400	0.534
DEG_SPOP_SBC_1	428	432	PF00917	0.544
DEG_SPOP_SBC_1	612	616	PF00917	0.573
DOC_CKS1_1	448	453	PF01111	0.523
DOC_CKS1_1	683	688	PF01111	0.329
DOC_CYCLIN_RxL_1	669	680	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	477	483	PF00134	0.410
DOC_CYCLIN_yCln2_LP_2	511	517	PF00134	0.546
DOC_MAPK_DCC_7	446	456	PF00069	0.355
DOC_MAPK_gen_1	282	290	PF00069	0.372
DOC_MAPK_gen_1	4	14	PF00069	0.484
DOC_MAPK_gen_1	404	413	PF00069	0.407
DOC_MAPK_gen_1	75	81	PF00069	0.460
DOC_MAPK_MEF2A_6	228	236	PF00069	0.508
DOC_MAPK_MEF2A_6	4	12	PF00069	0.492
DOC_PP1_RVXF_1	337	344	PF00149	0.397
DOC_PP1_RVXF_1	480	487	PF00149	0.322
DOC_PP4_FxxP_1	224	227	PF00568	0.424
DOC_USP7_MATH_1	21	25	PF00917	0.410
DOC_USP7_MATH_1	255	259	PF00917	0.520
DOC_USP7_MATH_1	494	498	PF00917	0.451
DOC_USP7_MATH_1	548	552	PF00917	0.401
DOC_WW_Pin1_4	156	161	PF00397	0.709
DOC_WW_Pin1_4	251	256	PF00397	0.429
DOC_WW_Pin1_4	390	395	PF00397	0.372
DOC_WW_Pin1_4	429	434	PF00397	0.577
DOC_WW_Pin1_4	447	452	PF00397	0.319
DOC_WW_Pin1_4	682	687	PF00397	0.415
DOC_WW_Pin1_4	701	706	PF00397	0.433
LIG_14-3-3_CanoR_1	184	190	PF00244	0.439
LIG_14-3-3_CanoR_1	210	219	PF00244	0.410
LIG_14-3-3_CanoR_1	223	227	PF00244	0.415
LIG_14-3-3_CanoR_1	228	236	PF00244	0.529
LIG_14-3-3_CanoR_1	360	369	PF00244	0.382
LIG_14-3-3_CanoR_1	407	413	PF00244	0.307
LIG_14-3-3_CanoR_1	525	533	PF00244	0.398
LIG_14-3-3_CanoR_1	579	587	PF00244	0.416
LIG_14-3-3_CanoR_1	661	669	PF00244	0.472
LIG_14-3-3_CanoR_1	672	677	PF00244	0.337
LIG_14-3-3_CanoR_1	678	686	PF00244	0.332
LIG_14-3-3_CanoR_1	89	98	PF00244	0.410
LIG_Actin_WH2_2	196	212	PF00022	0.447
LIG_Actin_WH2_2	662	680	PF00022	0.313
LIG_BIR_II_1	1	5	PF00653	0.383
LIG_BRCT_BRCA1_1	150	154	PF00533	0.592
LIG_CSL_BTD_1	683	686	PF09270	0.419
LIG_deltaCOP1_diTrp_1	347	352	PF00928	0.409
LIG_DLG_GKlike_1	672	680	PF00625	0.473
LIG_EH1_1	266	274	PF00400	0.398
LIG_EH1_1	47	55	PF00400	0.282
LIG_EH1_1	690	698	PF00400	0.374
LIG_eIF4E_1	691	697	PF01652	0.373
LIG_FHA_1	164	170	PF00498	0.518
LIG_FHA_1	172	178	PF00498	0.476
LIG_FHA_1	255	261	PF00498	0.371
LIG_FHA_1	298	304	PF00498	0.453
LIG_FHA_1	322	328	PF00498	0.457
LIG_FHA_1	407	413	PF00498	0.429
LIG_FHA_1	419	425	PF00498	0.384
LIG_FHA_1	506	512	PF00498	0.457
LIG_FHA_1	57	63	PF00498	0.409
LIG_FHA_1	575	581	PF00498	0.419
LIG_FHA_1	587	593	PF00498	0.385
LIG_FHA_1	602	608	PF00498	0.400
LIG_FHA_1	617	623	PF00498	0.378
LIG_FHA_1	660	666	PF00498	0.330
LIG_FHA_1	678	684	PF00498	0.308
LIG_FHA_1	702	708	PF00498	0.510
LIG_FHA_1	91	97	PF00498	0.318
LIG_FHA_2	123	129	PF00498	0.652
LIG_FHA_2	186	192	PF00498	0.529
LIG_FHA_2	44	50	PF00498	0.457
LIG_FHA_2	597	603	PF00498	0.280
LIG_FHA_2	623	629	PF00498	0.359
LIG_FHA_2	638	644	PF00498	0.386
LIG_FHA_2	715	721	PF00498	0.495
LIG_GBD_Chelix_1	326	334	PF00786	0.308
LIG_LIR_Gen_1	321	330	PF02991	0.413
LIG_LIR_Gen_1	532	539	PF02991	0.364
LIG_LIR_Gen_1	569	580	PF02991	0.467
LIG_LIR_Nem_3	321	326	PF02991	0.534
LIG_LIR_Nem_3	532	537	PF02991	0.364
LIG_LIR_Nem_3	569	575	PF02991	0.447
LIG_LIR_Nem_3	681	687	PF02991	0.500
LIG_LYPXL_SIV_4	433	441	PF13949	0.467
LIG_NRBOX	181	187	PF00104	0.414
LIG_NRBOX	625	631	PF00104	0.367
LIG_PCNA_yPIPBox_3	262	273	PF02747	0.310
LIG_SH2_SRC	691	694	PF00017	0.370
LIG_SH2_STAP1	172	176	PF00017	0.479
LIG_SH2_STAP1	434	438	PF00017	0.448
LIG_SH2_STAT5	172	175	PF00017	0.447
LIG_SH2_STAT5	358	361	PF00017	0.376
LIG_SH2_STAT5	426	429	PF00017	0.529
LIG_SH2_STAT5	506	509	PF00017	0.382
LIG_SH2_STAT5	534	537	PF00017	0.437
LIG_SH2_STAT5	691	694	PF00017	0.370
LIG_SH3_3	140	146	PF00018	0.530
LIG_SH3_3	233	239	PF00018	0.498
LIG_SH3_3	278	284	PF00018	0.459
LIG_SH3_3	587	593	PF00018	0.461
LIG_Sin3_3	453	460	PF02671	0.352
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.361
LIG_SUMO_SIM_anti_2	435	443	PF11976	0.443
LIG_SUMO_SIM_anti_2	624	631	PF11976	0.357
LIG_SUMO_SIM_par_1	185	191	PF11976	0.517
LIG_SUMO_SIM_par_1	453	459	PF11976	0.361
LIG_SUMO_SIM_par_1	598	604	PF11976	0.282
LIG_SxIP_EBH_1	296	307	PF03271	0.413
LIG_TRAF2_1	640	643	PF00917	0.474
LIG_UBA3_1	460	469	PF00899	0.305
LIG_WW_1	394	397	PF00397	0.396
LIG_WW_3	393	397	PF00397	0.388
MOD_CDC14_SPxK_1	393	396	PF00782	0.387
MOD_CDK_SPxK_1	390	396	PF00069	0.383
MOD_CDK_SPxxK_3	682	689	PF00069	0.405
MOD_CK1_1	148	154	PF00069	0.767
MOD_CK1_1	156	162	PF00069	0.625
MOD_CK1_1	178	184	PF00069	0.613
MOD_CK1_1	254	260	PF00069	0.419
MOD_CK1_1	318	324	PF00069	0.517
MOD_CK1_1	376	382	PF00069	0.406
MOD_CK1_1	585	591	PF00069	0.325
MOD_CK1_1	88	94	PF00069	0.376
MOD_CK2_1	103	109	PF00069	0.489
MOD_CK2_1	123	129	PF00069	0.447
MOD_CK2_1	185	191	PF00069	0.517
MOD_CK2_1	596	602	PF00069	0.274
MOD_CK2_1	637	643	PF00069	0.420
MOD_CK2_1	714	720	PF00069	0.549
MOD_GlcNHglycan	138	141	PF01048	0.548
MOD_GlcNHglycan	147	150	PF01048	0.612
MOD_GlcNHglycan	277	280	PF01048	0.532
MOD_GlcNHglycan	311	314	PF01048	0.607
MOD_GlcNHglycan	315	320	PF01048	0.554
MOD_GlcNHglycan	334	337	PF01048	0.520
MOD_GlcNHglycan	362	365	PF01048	0.469
MOD_GlcNHglycan	464	467	PF01048	0.369
MOD_GlcNHglycan	496	499	PF01048	0.454
MOD_GlcNHglycan	546	549	PF01048	0.395
MOD_GlcNHglycan	662	665	PF01048	0.466
MOD_GSK3_1	118	125	PF00069	0.600
MOD_GSK3_1	150	157	PF00069	0.655
MOD_GSK3_1	159	166	PF00069	0.594
MOD_GSK3_1	171	178	PF00069	0.647
MOD_GSK3_1	205	212	PF00069	0.389
MOD_GSK3_1	251	258	PF00069	0.425
MOD_GSK3_1	330	337	PF00069	0.411
MOD_GSK3_1	373	380	PF00069	0.493
MOD_GSK3_1	418	425	PF00069	0.482
MOD_GSK3_1	429	436	PF00069	0.439
MOD_GSK3_1	490	497	PF00069	0.559
MOD_GSK3_1	544	551	PF00069	0.405
MOD_GSK3_1	582	589	PF00069	0.426
MOD_GSK3_1	607	614	PF00069	0.567
MOD_GSK3_1	617	624	PF00069	0.365
MOD_GSK3_1	672	679	PF00069	0.416
MOD_N-GLC_1	388	393	PF02516	0.367
MOD_NEK2_1	103	108	PF00069	0.459
MOD_NEK2_1	154	159	PF00069	0.702
MOD_NEK2_1	163	168	PF00069	0.524
MOD_NEK2_1	170	175	PF00069	0.371
MOD_NEK2_1	185	190	PF00069	0.435
MOD_NEK2_1	209	214	PF00069	0.470
MOD_NEK2_1	222	227	PF00069	0.389
MOD_NEK2_1	260	265	PF00069	0.388
MOD_NEK2_1	298	303	PF00069	0.396
MOD_NEK2_1	330	335	PF00069	0.440
MOD_NEK2_1	377	382	PF00069	0.470
MOD_NEK2_1	388	393	PF00069	0.517
MOD_NEK2_1	413	418	PF00069	0.317
MOD_NEK2_1	455	460	PF00069	0.335
MOD_NEK2_1	574	579	PF00069	0.384
MOD_NEK2_1	580	585	PF00069	0.445
MOD_NEK2_1	586	591	PF00069	0.398
MOD_NEK2_1	621	626	PF00069	0.324
MOD_NEK2_1	659	664	PF00069	0.505
MOD_NEK2_1	69	74	PF00069	0.361
MOD_NEK2_1	79	84	PF00069	0.403
MOD_NEK2_1	90	95	PF00069	0.347
MOD_NEK2_2	205	210	PF00069	0.424
MOD_PIKK_1	103	109	PF00454	0.489
MOD_PIKK_1	164	170	PF00454	0.518
MOD_PIKK_1	21	27	PF00454	0.434
MOD_PIKK_1	222	228	PF00454	0.561
MOD_PIKK_1	418	424	PF00454	0.400
MOD_PIKK_1	62	68	PF00454	0.506
MOD_PIKK_1	714	720	PF00454	0.644
MOD_PIKK_1	90	96	PF00454	0.350
MOD_PKA_2	118	124	PF00069	0.537
MOD_PKA_2	209	215	PF00069	0.411
MOD_PKA_2	222	228	PF00069	0.448
MOD_PKA_2	403	409	PF00069	0.481
MOD_PKA_2	524	530	PF00069	0.416
MOD_PKA_2	660	666	PF00069	0.581
MOD_PKA_2	677	683	PF00069	0.334
MOD_PKA_2	85	91	PF00069	0.431
MOD_Plk_1	122	128	PF00069	0.643
MOD_Plk_1	178	184	PF00069	0.430
MOD_Plk_1	255	261	PF00069	0.452
MOD_Plk_1	62	68	PF00069	0.348
MOD_Plk_2-3	123	129	PF00069	0.652
MOD_Plk_4	150	156	PF00069	0.641
MOD_Plk_4	178	184	PF00069	0.430
MOD_Plk_4	255	261	PF00069	0.452
MOD_Plk_4	298	304	PF00069	0.406
MOD_Plk_4	318	324	PF00069	0.608
MOD_Plk_4	456	462	PF00069	0.361
MOD_Plk_4	473	479	PF00069	0.347
MOD_Plk_4	49	55	PF00069	0.478
MOD_Plk_4	582	588	PF00069	0.503
MOD_Plk_4	596	602	PF00069	0.307
MOD_Plk_4	617	623	PF00069	0.419
MOD_Plk_4	672	678	PF00069	0.386
MOD_ProDKin_1	156	162	PF00069	0.702
MOD_ProDKin_1	251	257	PF00069	0.417
MOD_ProDKin_1	390	396	PF00069	0.383
MOD_ProDKin_1	429	435	PF00069	0.563
MOD_ProDKin_1	447	453	PF00069	0.327
MOD_ProDKin_1	682	688	PF00069	0.409
MOD_ProDKin_1	701	707	PF00069	0.428
TRG_AP2beta_CARGO_1	569	579	PF09066	0.457
TRG_DiLeu_BaEn_1	198	203	PF01217	0.510
TRG_DiLeu_BaEn_1	256	261	PF01217	0.444
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.412
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.326
TRG_ENDOCYTIC_2	534	537	PF00928	0.437
TRG_ER_diArg_1	143	145	PF00400	0.650
TRG_ER_diArg_1	561	563	PF00400	0.481
TRG_ER_diArg_1	578	580	PF00400	0.424
TRG_ER_diArg_1	6	9	PF00400	0.417
TRG_NES_CRM1_1	544	559	PF08389	0.308
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK8	Leptomonas seymouri	46%	84%
A0A3Q8IBG3	Leishmania donovani	74%	85%
A4HYL1	Leishmania infantum	74%	85%
E9AUG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	85%
Q4QD24	Leishmania major	74%	100%