Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI72_LEIBR

TriTrypDb:

LbrM.20.4370 , LBRM2903_200057600 , LBRM2903_200057700

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.391
CLV_C14_Caspase3-7	70	74	PF00656	0.536
CLV_NRD_NRD_1	432	434	PF00675	0.727
CLV_NRD_NRD_1	49	51	PF00675	0.499
CLV_NRD_NRD_1	521	523	PF00675	0.456
CLV_NRD_NRD_1	578	580	PF00675	0.458
CLV_NRD_NRD_1	739	741	PF00675	0.503
CLV_NRD_NRD_1	855	857	PF00675	0.462
CLV_NRD_NRD_1	97	99	PF00675	0.543
CLV_PCSK_KEX2_1	578	580	PF00082	0.409
CLV_PCSK_KEX2_1	620	622	PF00082	0.610
CLV_PCSK_KEX2_1	855	857	PF00082	0.462
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.508
CLV_PCSK_PC7_1	574	580	PF00082	0.339
CLV_PCSK_SKI1_1	446	450	PF00082	0.791
CLV_PCSK_SKI1_1	522	526	PF00082	0.454
CLV_PCSK_SKI1_1	599	603	PF00082	0.419
CLV_PCSK_SKI1_1	609	613	PF00082	0.457
DEG_SPOP_SBC_1	3	7	PF00917	0.463
DEG_SPOP_SBC_1	342	346	PF00917	0.569
DOC_ANK_TNKS_1	763	770	PF00023	0.334
DOC_CKS1_1	800	805	PF01111	0.642
DOC_MAPK_DCC_7	260	268	PF00069	0.461
DOC_MAPK_gen_1	351	359	PF00069	0.576
DOC_MAPK_gen_1	585	594	PF00069	0.352
DOC_MAPK_gen_1	740	750	PF00069	0.416
DOC_MAPK_MEF2A_6	351	359	PF00069	0.576
DOC_MAPK_MEF2A_6	414	423	PF00069	0.527
DOC_MAPK_MEF2A_6	743	752	PF00069	0.372
DOC_PP1_RVXF_1	471	478	PF00149	0.380
DOC_PP1_RVXF_1	520	527	PF00149	0.568
DOC_PP2B_LxvP_1	297	300	PF13499	0.579
DOC_PP2B_PxIxI_1	682	688	PF00149	0.334
DOC_PP4_FxxP_1	83	86	PF00568	0.535
DOC_USP7_MATH_1	122	126	PF00917	0.692
DOC_USP7_MATH_1	183	187	PF00917	0.616
DOC_USP7_MATH_1	3	7	PF00917	0.463
DOC_USP7_MATH_1	300	304	PF00917	0.760
DOC_USP7_MATH_1	328	332	PF00917	0.586
DOC_USP7_MATH_1	343	347	PF00917	0.674
DOC_USP7_MATH_1	383	387	PF00917	0.571
DOC_USP7_MATH_1	391	395	PF00917	0.552
DOC_USP7_MATH_1	404	408	PF00917	0.588
DOC_USP7_MATH_1	562	566	PF00917	0.513
DOC_USP7_MATH_1	690	694	PF00917	0.446
DOC_USP7_MATH_1	804	808	PF00917	0.389
DOC_WW_Pin1_4	142	147	PF00397	0.486
DOC_WW_Pin1_4	298	303	PF00397	0.721
DOC_WW_Pin1_4	308	313	PF00397	0.673
DOC_WW_Pin1_4	371	376	PF00397	0.580
DOC_WW_Pin1_4	399	404	PF00397	0.799
DOC_WW_Pin1_4	517	522	PF00397	0.674
DOC_WW_Pin1_4	706	711	PF00397	0.673
DOC_WW_Pin1_4	722	727	PF00397	0.552
DOC_WW_Pin1_4	799	804	PF00397	0.642
DOC_WW_Pin1_4	817	822	PF00397	0.387
LIG_14-3-3_CanoR_1	314	323	PF00244	0.574
LIG_14-3-3_CanoR_1	399	403	PF00244	0.679
LIG_14-3-3_CanoR_1	476	480	PF00244	0.524
LIG_14-3-3_CanoR_1	50	57	PF00244	0.446
LIG_14-3-3_CanoR_1	502	506	PF00244	0.637
LIG_14-3-3_CanoR_1	559	565	PF00244	0.633
LIG_14-3-3_CanoR_1	596	602	PF00244	0.372
LIG_14-3-3_CanoR_1	621	627	PF00244	0.317
LIG_14-3-3_CanoR_1	704	710	PF00244	0.435
LIG_14-3-3_CanoR_1	716	726	PF00244	0.519
LIG_14-3-3_CanoR_1	755	761	PF00244	0.637
LIG_Actin_WH2_2	543	561	PF00022	0.368
LIG_AP2alpha_1	485	489	PF02296	0.640
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	512	516	PF00533	0.325
LIG_Clathr_ClatBox_1	224	228	PF01394	0.393
LIG_deltaCOP1_diTrp_1	644	649	PF00928	0.331
LIG_FHA_1	196	202	PF00498	0.784
LIG_FHA_1	219	225	PF00498	0.448
LIG_FHA_1	270	276	PF00498	0.546
LIG_FHA_1	439	445	PF00498	0.736
LIG_FHA_1	571	577	PF00498	0.606
LIG_FHA_1	587	593	PF00498	0.354
LIG_FHA_1	676	682	PF00498	0.600
LIG_FHA_1	694	700	PF00498	0.416
LIG_FHA_1	757	763	PF00498	0.337
LIG_FHA_1	777	783	PF00498	0.533
LIG_FHA_1	831	837	PF00498	0.522
LIG_FHA_1	91	97	PF00498	0.671
LIG_FHA_2	121	127	PF00498	0.801
LIG_FHA_2	286	292	PF00498	0.585
LIG_FHA_2	360	366	PF00498	0.612
LIG_GBD_Chelix_1	507	515	PF00786	0.597
LIG_LIR_Apic_2	643	648	PF02991	0.342
LIG_LIR_Apic_2	80	86	PF02991	0.789
LIG_LIR_Gen_1	791	801	PF02991	0.365
LIG_LIR_Nem_3	487	492	PF02991	0.579
LIG_LIR_Nem_3	600	605	PF02991	0.580
LIG_LIR_Nem_3	807	812	PF02991	0.438
LIG_PCNA_yPIPBox_3	502	516	PF02747	0.341
LIG_Pex14_1	477	481	PF04695	0.385
LIG_Pex14_1	645	649	PF04695	0.325
LIG_Pex14_2	481	485	PF04695	0.665
LIG_Pex14_2	602	606	PF04695	0.326
LIG_Pex14_2	811	815	PF04695	0.455
LIG_REV1ctd_RIR_1	486	494	PF16727	0.635
LIG_SH2_CRK	572	576	PF00017	0.335
LIG_SH2_CRK	809	813	PF00017	0.317
LIG_SH2_STAP1	572	576	PF00017	0.335
LIG_SH2_STAT3	133	136	PF00017	0.443
LIG_SH2_STAT3	760	763	PF00017	0.576
LIG_SH2_STAT3	840	843	PF00017	0.557
LIG_SH2_STAT5	166	169	PF00017	0.724
LIG_SH2_STAT5	246	249	PF00017	0.723
LIG_SH2_STAT5	572	575	PF00017	0.343
LIG_SH3_3	174	180	PF00018	0.541
LIG_SH3_3	299	305	PF00018	0.754
LIG_SH3_3	684	690	PF00018	0.579
LIG_SH3_3	724	730	PF00018	0.592
LIG_SH3_3	797	803	PF00018	0.657
LIG_SUMO_SIM_anti_2	417	422	PF11976	0.527
LIG_SUMO_SIM_par_1	277	288	PF11976	0.634
LIG_SUMO_SIM_par_1	786	791	PF11976	0.356
LIG_TRAF2_1	186	189	PF00917	0.849
LIG_UBA3_1	15	21	PF00899	0.649
LIG_UBA3_1	274	282	PF00899	0.553
LIG_UBA3_1	44	51	PF00899	0.384
LIG_UBA3_1	515	523	PF00899	0.392
LIG_WRC_WIRS_1	580	585	PF05994	0.339
LIG_WRC_WIRS_1	700	705	PF05994	0.360
MOD_CDC14_SPxK_1	145	148	PF00782	0.499
MOD_CDC14_SPxK_1	520	523	PF00782	0.711
MOD_CDK_SPK_2	517	522	PF00069	0.407
MOD_CDK_SPK_2	706	711	PF00069	0.673
MOD_CDK_SPxK_1	142	148	PF00069	0.489
MOD_CDK_SPxK_1	308	314	PF00069	0.589
MOD_CDK_SPxK_1	517	523	PF00069	0.684
MOD_CDK_SPxxK_3	399	406	PF00069	0.800
MOD_CDK_SPxxK_3	799	806	PF00069	0.650
MOD_CK1_1	114	120	PF00069	0.615
MOD_CK1_1	2	8	PF00069	0.570
MOD_CK1_1	283	289	PF00069	0.583
MOD_CK1_1	344	350	PF00069	0.597
MOD_CK1_1	394	400	PF00069	0.588
MOD_CK1_1	426	432	PF00069	0.611
MOD_CK1_1	438	444	PF00069	0.747
MOD_CK1_1	640	646	PF00069	0.590
MOD_CK1_1	693	699	PF00069	0.347
MOD_CK1_1	705	711	PF00069	0.497
MOD_CK1_1	776	782	PF00069	0.614
MOD_CK2_1	120	126	PF00069	0.807
MOD_CK2_1	183	189	PF00069	0.722
MOD_CK2_1	285	291	PF00069	0.586
MOD_CK2_1	359	365	PF00069	0.610
MOD_CK2_1	4	10	PF00069	0.431
MOD_CK2_1	55	61	PF00069	0.541
MOD_CK2_1	755	761	PF00069	0.637
MOD_DYRK1A_RPxSP_1	399	403	PF00069	0.650
MOD_GlcNHglycan	1	4	PF01048	0.508
MOD_GlcNHglycan	113	116	PF01048	0.555
MOD_GlcNHglycan	213	216	PF01048	0.771
MOD_GlcNHglycan	302	305	PF01048	0.824
MOD_GlcNHglycan	328	331	PF01048	0.799
MOD_GlcNHglycan	336	339	PF01048	0.735
MOD_GlcNHglycan	385	388	PF01048	0.706
MOD_GlcNHglycan	393	396	PF01048	0.785
MOD_GlcNHglycan	430	433	PF01048	0.799
MOD_GlcNHglycan	512	515	PF01048	0.330
MOD_GlcNHglycan	560	563	PF01048	0.440
MOD_GlcNHglycan	717	720	PF01048	0.570
MOD_GlcNHglycan	806	809	PF01048	0.395
MOD_GlcNHglycan	83	86	PF01048	0.776
MOD_GSK3_1	188	195	PF00069	0.784
MOD_GSK3_1	2	9	PF00069	0.451
MOD_GSK3_1	280	287	PF00069	0.644
MOD_GSK3_1	300	307	PF00069	0.699
MOD_GSK3_1	328	335	PF00069	0.684
MOD_GSK3_1	341	348	PF00069	0.587
MOD_GSK3_1	355	362	PF00069	0.577
MOD_GSK3_1	390	397	PF00069	0.594
MOD_GSK3_1	404	411	PF00069	0.623
MOD_GSK3_1	434	441	PF00069	0.563
MOD_GSK3_1	558	565	PF00069	0.391
MOD_GSK3_1	579	586	PF00069	0.365
MOD_GSK3_1	61	68	PF00069	0.645
MOD_GSK3_1	689	696	PF00069	0.498
MOD_GSK3_1	698	705	PF00069	0.469
MOD_GSK3_1	717	724	PF00069	0.493
MOD_GSK3_1	826	833	PF00069	0.364
MOD_GSK3_1	90	97	PF00069	0.601
MOD_LATS_1	207	213	PF00433	0.562
MOD_N-GLC_1	25	30	PF02516	0.381
MOD_N-GLC_1	659	664	PF02516	0.393
MOD_NEK2_1	140	145	PF00069	0.635
MOD_NEK2_1	326	331	PF00069	0.563
MOD_NEK2_1	4	9	PF00069	0.540
MOD_NEK2_1	558	563	PF00069	0.405
MOD_NEK2_1	583	588	PF00069	0.462
MOD_NEK2_1	675	680	PF00069	0.622
MOD_NEK2_1	699	704	PF00069	0.348
MOD_NEK2_2	277	282	PF00069	0.558
MOD_NEK2_2	435	440	PF00069	0.565
MOD_NEK2_2	637	642	PF00069	0.639
MOD_PIKK_1	346	352	PF00454	0.703
MOD_PIKK_1	373	379	PF00454	0.794
MOD_PIKK_1	394	400	PF00454	0.588
MOD_PIKK_1	729	735	PF00454	0.823
MOD_PIKK_1	826	832	PF00454	0.403
MOD_PK_1	353	359	PF00069	0.579
MOD_PKA_1	316	322	PF00069	0.569
MOD_PKA_1	50	56	PF00069	0.468
MOD_PKA_2	359	365	PF00069	0.718
MOD_PKA_2	398	404	PF00069	0.575
MOD_PKA_2	439	445	PF00069	0.788
MOD_PKA_2	475	481	PF00069	0.547
MOD_PKA_2	501	507	PF00069	0.630
MOD_PKA_2	558	564	PF00069	0.396
MOD_PKA_2	65	71	PF00069	0.620
MOD_PKA_2	715	721	PF00069	0.573
MOD_PKA_2	754	760	PF00069	0.644
MOD_Plk_1	188	194	PF00069	0.832
MOD_Plk_1	25	31	PF00069	0.384
MOD_Plk_1	332	338	PF00069	0.564
MOD_Plk_1	467	473	PF00069	0.640
MOD_Plk_1	693	699	PF00069	0.331
MOD_Plk_4	404	410	PF00069	0.563
MOD_Plk_4	414	420	PF00069	0.494
MOD_Plk_4	507	513	PF00069	0.585
MOD_Plk_4	579	585	PF00069	0.512
MOD_ProDKin_1	142	148	PF00069	0.489
MOD_ProDKin_1	298	304	PF00069	0.722
MOD_ProDKin_1	308	314	PF00069	0.675
MOD_ProDKin_1	371	377	PF00069	0.580
MOD_ProDKin_1	399	405	PF00069	0.799
MOD_ProDKin_1	517	523	PF00069	0.684
MOD_ProDKin_1	706	712	PF00069	0.690
MOD_ProDKin_1	722	728	PF00069	0.552
MOD_ProDKin_1	799	805	PF00069	0.640
MOD_ProDKin_1	817	823	PF00069	0.377
MOD_SUMO_for_1	281	284	PF00179	0.738
MOD_SUMO_for_1	641	644	PF00179	0.637
MOD_SUMO_rev_2	791	800	PF00179	0.377
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.397
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.341
TRG_DiLeu_BaLyEn_6	680	685	PF01217	0.640
TRG_ENDOCYTIC_2	486	489	PF00928	0.642
TRG_ENDOCYTIC_2	528	531	PF00928	0.505
TRG_ENDOCYTIC_2	572	575	PF00928	0.399
TRG_ENDOCYTIC_2	809	812	PF00928	0.320
TRG_ER_diArg_1	201	204	PF00400	0.652
TRG_ER_diArg_1	577	579	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	36	41	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	458	463	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBL2	Leishmania donovani	59%	100%
A4HYK9	Leishmania infantum	58%	100%
E9AUF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4QD26	Leishmania major	57%	100%