Leucine-rich repeat-containing protein 34

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania braziliensis

UniProt:

E9AI71_LEIBR

TriTrypDb:

LbrM.20.4360 , LBRM2903_200057500

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

E9AI71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI71

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.409
CLV_C14_Caspase3-7	52	56	PF00656	0.271
CLV_NRD_NRD_1	167	169	PF00675	0.307
CLV_NRD_NRD_1	83	85	PF00675	0.286
CLV_PCSK_KEX2_1	181	183	PF00082	0.507
CLV_PCSK_KEX2_1	83	85	PF00082	0.284
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.547
CLV_PCSK_SKI1_1	194	198	PF00082	0.349
CLV_PCSK_SKI1_1	276	280	PF00082	0.341
CLV_Separin_Metazoa	220	224	PF03568	0.484
DEG_APCC_DBOX_1	36	44	PF00400	0.278
DEG_Nend_UBRbox_2	1	3	PF02207	0.522
DEG_SCF_FBW7_1	38	45	PF00400	0.501
DOC_CKS1_1	359	364	PF01111	0.526
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.598
DOC_MAPK_DCC_7	181	191	PF00069	0.282
DOC_MAPK_gen_1	83	93	PF00069	0.337
DOC_MAPK_HePTP_8	138	150	PF00069	0.388
DOC_MAPK_MEF2A_6	141	150	PF00069	0.390
DOC_USP7_MATH_1	42	46	PF00917	0.434
DOC_USP7_UBL2_3	237	241	PF12436	0.579
DOC_WW_Pin1_4	244	249	PF00397	0.535
DOC_WW_Pin1_4	358	363	PF00397	0.498
DOC_WW_Pin1_4	38	43	PF00397	0.370
LIG_14-3-3_CanoR_1	151	156	PF00244	0.292
LIG_14-3-3_CanoR_1	325	335	PF00244	0.431
LIG_14-3-3_CanoR_1	87	92	PF00244	0.485
LIG_Actin_WH2_2	23	41	PF00022	0.299
LIG_APCC_ABBA_1	231	236	PF00400	0.457
LIG_BRCT_BRCA1_1	89	93	PF00533	0.451
LIG_Clathr_ClatBox_1	259	263	PF01394	0.473
LIG_EH1_1	255	263	PF00400	0.458
LIG_FHA_1	226	232	PF00498	0.468
LIG_FHA_2	264	270	PF00498	0.439
LIG_FHA_2	31	37	PF00498	0.435
LIG_FHA_2	59	65	PF00498	0.428
LIG_FHA_2	90	96	PF00498	0.337
LIG_LIR_Gen_1	215	224	PF02991	0.412
LIG_LIR_Gen_1	236	246	PF02991	0.409
LIG_LIR_Gen_1	254	262	PF02991	0.211
LIG_LIR_Gen_1	29	38	PF02991	0.348
LIG_LIR_Gen_1	334	345	PF02991	0.310
LIG_LIR_Gen_1	55	65	PF02991	0.493
LIG_LIR_Nem_3	215	221	PF02991	0.519
LIG_LIR_Nem_3	236	242	PF02991	0.400
LIG_LIR_Nem_3	254	259	PF02991	0.207
LIG_LIR_Nem_3	29	34	PF02991	0.313
LIG_LIR_Nem_3	334	340	PF02991	0.298
LIG_LIR_Nem_3	55	60	PF02991	0.494
LIG_NRBOX	256	262	PF00104	0.466
LIG_SH2_CRK	31	35	PF00017	0.404
LIG_SH2_PTP2	147	150	PF00017	0.378
LIG_SH2_STAP1	267	271	PF00017	0.292
LIG_SH2_STAT3	105	108	PF00017	0.373
LIG_SH2_STAT5	105	108	PF00017	0.336
LIG_SH2_STAT5	126	129	PF00017	0.463
LIG_SH2_STAT5	13	16	PF00017	0.474
LIG_SH2_STAT5	147	150	PF00017	0.474
LIG_SH2_STAT5	192	195	PF00017	0.396
LIG_SH2_STAT5	238	241	PF00017	0.322
LIG_SH2_STAT5	296	299	PF00017	0.442
LIG_SH2_STAT5	342	345	PF00017	0.366
LIG_SH2_STAT5	69	72	PF00017	0.330
LIG_SH2_STAT5	97	100	PF00017	0.355
LIG_SH3_1	182	188	PF00018	0.444
LIG_SH3_3	182	188	PF00018	0.521
LIG_SH3_3	283	289	PF00018	0.437
LIG_SH3_3	343	349	PF00018	0.528
LIG_SH3_3	45	51	PF00018	0.403
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.252
LIG_SUMO_SIM_par_1	257	263	PF11976	0.446
LIG_TRAF2_1	336	339	PF00917	0.219
LIG_TYR_ITIM	145	150	PF00017	0.376
MOD_CK1_1	153	159	PF00069	0.424
MOD_CK1_1	225	231	PF00069	0.467
MOD_CK1_1	247	253	PF00069	0.461
MOD_CK1_1	312	318	PF00069	0.561
MOD_CK1_1	99	105	PF00069	0.460
MOD_CK2_1	119	125	PF00069	0.376
MOD_CK2_1	213	219	PF00069	0.440
MOD_CK2_1	23	29	PF00069	0.339
MOD_CK2_1	263	269	PF00069	0.526
MOD_CK2_1	333	339	PF00069	0.454
MOD_GlcNHglycan	120	124	PF01048	0.455
MOD_GlcNHglycan	129	132	PF01048	0.393
MOD_GlcNHglycan	155	158	PF01048	0.530
MOD_GlcNHglycan	209	212	PF01048	0.415
MOD_GlcNHglycan	215	218	PF01048	0.350
MOD_GlcNHglycan	224	227	PF01048	0.318
MOD_GSK3_1	209	216	PF00069	0.410
MOD_GSK3_1	263	270	PF00069	0.444
MOD_GSK3_1	326	333	PF00069	0.513
MOD_GSK3_1	38	45	PF00069	0.512
MOD_GSK3_1	59	66	PF00069	0.428
MOD_N-GLC_1	99	104	PF02516	0.325
MOD_NEK2_1	150	155	PF00069	0.404
MOD_NEK2_1	213	218	PF00069	0.478
MOD_NEK2_1	222	227	PF00069	0.509
MOD_NEK2_1	309	314	PF00069	0.414
MOD_NEK2_1	63	68	PF00069	0.355
MOD_PIKK_1	69	75	PF00454	0.461
MOD_PKA_2	150	156	PF00069	0.393
MOD_PKA_2	222	228	PF00069	0.515
MOD_PKA_2	312	318	PF00069	0.545
MOD_Plk_1	267	273	PF00069	0.550
MOD_Plk_1	330	336	PF00069	0.301
MOD_Plk_1	99	105	PF00069	0.327
MOD_Plk_2-3	263	269	PF00069	0.442
MOD_Plk_4	209	215	PF00069	0.412
MOD_Plk_4	267	273	PF00069	0.381
MOD_Plk_4	99	105	PF00069	0.232
MOD_ProDKin_1	244	250	PF00069	0.533
MOD_ProDKin_1	358	364	PF00069	0.500
MOD_ProDKin_1	38	44	PF00069	0.374
MOD_SUMO_rev_2	173	183	PF00179	0.341
TRG_DiLeu_BaEn_4	2	8	PF01217	0.386
TRG_ENDOCYTIC_2	147	150	PF00928	0.378
TRG_ENDOCYTIC_2	31	34	PF00928	0.282
TRG_ER_diArg_1	37	40	PF00400	0.424
TRG_ER_diArg_1	83	85	PF00400	0.286
TRG_NES_CRM1_1	269	285	PF08389	0.277
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI3	Leptomonas seymouri	60%	93%
A0A0S4JE69	Bodo saltans	38%	98%
A0A1X0NWJ3	Trypanosomatidae	41%	98%
A0A3S5H780	Leishmania donovani	82%	100%
A0A422MW34	Trypanosoma rangeli	37%	99%
A4HYK8	Leishmania infantum	82%	100%
C9ZHV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
E9AUF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QD27	Leishmania major	81%	100%
V5BQX0	Trypanosoma cruzi	38%	88%