Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI69_LEIBR

TriTrypDb:

LbrM.20.1860 , LBRM2903_200029300

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.545
CLV_C14_Caspase3-7	7	11	PF00656	0.478
CLV_MEL_PAP_1	214	220	PF00089	0.515
CLV_NRD_NRD_1	131	133	PF00675	0.430
CLV_NRD_NRD_1	138	140	PF00675	0.410
CLV_NRD_NRD_1	24	26	PF00675	0.486
CLV_NRD_NRD_1	310	312	PF00675	0.514
CLV_NRD_NRD_1	75	77	PF00675	0.520
CLV_PCSK_FUR_1	22	26	PF00082	0.491
CLV_PCSK_KEX2_1	103	105	PF00082	0.473
CLV_PCSK_KEX2_1	24	26	PF00082	0.497
CLV_PCSK_KEX2_1	259	261	PF00082	0.490
CLV_PCSK_KEX2_1	75	77	PF00082	0.519
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.385
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.490
CLV_PCSK_SKI1_1	103	107	PF00082	0.481
CLV_PCSK_SKI1_1	132	136	PF00082	0.411
CLV_PCSK_SKI1_1	354	358	PF00082	0.453
CLV_PCSK_SKI1_1	416	420	PF00082	0.528
CLV_PCSK_SKI1_1	57	61	PF00082	0.492
DEG_APCC_DBOX_1	365	373	PF00400	0.504
DEG_APCC_DBOX_1	415	423	PF00400	0.544
DEG_SCF_FBW7_1	249	256	PF00400	0.507
DEG_SCF_FBW7_1	292	297	PF00400	0.677
DEG_SPOP_SBC_1	171	175	PF00917	0.651
DEG_SPOP_SBC_1	390	394	PF00917	0.658
DOC_ANK_TNKS_1	166	173	PF00023	0.459
DOC_CKS1_1	250	255	PF01111	0.504
DOC_CYCLIN_RxL_1	129	136	PF00134	0.408
DOC_CYCLIN_RxL_1	412	421	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.608
DOC_MAPK_gen_1	152	160	PF00069	0.469
DOC_MAPK_gen_1	22	30	PF00069	0.491
DOC_MAPK_gen_1	311	318	PF00069	0.522
DOC_MAPK_MEF2A_6	152	160	PF00069	0.474
DOC_MIT_MIM_1	157	167	PF04212	0.486
DOC_PP2B_LxvP_1	245	248	PF13499	0.611
DOC_USP7_MATH_1	171	175	PF00917	0.530
DOC_USP7_MATH_1	294	298	PF00917	0.678
DOC_USP7_MATH_1	374	378	PF00917	0.464
DOC_USP7_MATH_1	381	385	PF00917	0.490
DOC_USP7_MATH_1	390	394	PF00917	0.644
DOC_USP7_MATH_1	6	10	PF00917	0.621
DOC_WW_Pin1_4	183	188	PF00397	0.686
DOC_WW_Pin1_4	208	213	PF00397	0.648
DOC_WW_Pin1_4	249	254	PF00397	0.576
DOC_WW_Pin1_4	283	288	PF00397	0.634
DOC_WW_Pin1_4	290	295	PF00397	0.685
DOC_WW_Pin1_4	377	382	PF00397	0.517
LIG_14-3-3_CanoR_1	109	119	PF00244	0.502
LIG_14-3-3_CanoR_1	139	148	PF00244	0.432
LIG_14-3-3_CanoR_1	217	223	PF00244	0.625
LIG_14-3-3_CanoR_1	280	284	PF00244	0.615
LIG_Actin_WH2_2	16	33	PF00022	0.494
LIG_BIR_III_2	238	242	PF00653	0.541
LIG_BRCT_BRCA1_1	277	281	PF00533	0.563
LIG_BRCT_BRCA1_1	394	398	PF00533	0.472
LIG_FHA_1	209	215	PF00498	0.532
LIG_FHA_1	241	247	PF00498	0.533
LIG_FHA_1	250	256	PF00498	0.682
LIG_FHA_1	336	342	PF00498	0.547
LIG_FHA_1	413	419	PF00498	0.489
LIG_FHA_1	96	102	PF00498	0.484
LIG_FHA_2	111	117	PF00498	0.501
LIG_FHA_2	140	146	PF00498	0.645
LIG_FHA_2	346	352	PF00498	0.441
LIG_FHA_2	36	42	PF00498	0.621
LIG_FHA_2	48	54	PF00498	0.495
LIG_LIR_Gen_1	124	130	PF02991	0.468
LIG_LIR_Gen_1	26	35	PF02991	0.474
LIG_LIR_Gen_1	380	390	PF02991	0.459
LIG_LIR_Gen_1	401	411	PF02991	0.410
LIG_LIR_Nem_3	26	30	PF02991	0.478
LIG_LIR_Nem_3	380	385	PF02991	0.457
LIG_LIR_Nem_3	401	406	PF02991	0.432
LIG_NRBOX	312	318	PF00104	0.470
LIG_PCNA_yPIPBox_3	106	119	PF02747	0.397
LIG_PTB_Apo_2	397	404	PF02174	0.446
LIG_PTB_Apo_2	68	75	PF02174	0.480
LIG_SH2_CRK	87	91	PF00017	0.528
LIG_SH2_PTP2	27	30	PF00017	0.478
LIG_SH2_SRC	155	158	PF00017	0.472
LIG_SH2_STAP1	35	39	PF00017	0.467
LIG_SH2_STAT5	125	128	PF00017	0.472
LIG_SH2_STAT5	155	158	PF00017	0.407
LIG_SH2_STAT5	27	30	PF00017	0.458
LIG_SH3_2	212	217	PF14604	0.511
LIG_SH3_3	198	204	PF00018	0.641
LIG_SH3_3	209	215	PF00018	0.543
LIG_SH3_3	247	253	PF00018	0.626
LIG_SH3_3	419	425	PF00018	0.573
LIG_SUMO_SIM_par_1	247	252	PF11976	0.574
LIG_SUMO_SIM_par_1	305	310	PF11976	0.426
LIG_TRAF2_1	234	237	PF00917	0.513
LIG_TRAF2_1	343	346	PF00917	0.481
LIG_TRAF2_1	38	41	PF00917	0.465
LIG_UBA3_1	126	133	PF00899	0.465
LIG_UBA3_1	134	141	PF00899	0.479
LIG_UBA3_1	73	82	PF00899	0.459
MOD_CDK_SPK_2	283	288	PF00069	0.621
MOD_CDK_SPK_2	290	295	PF00069	0.597
MOD_CK1_1	110	116	PF00069	0.502
MOD_CK1_1	174	180	PF00069	0.627
MOD_CK1_1	183	189	PF00069	0.667
MOD_CK1_1	227	233	PF00069	0.558
MOD_CK1_1	266	272	PF00069	0.626
MOD_CK1_1	282	288	PF00069	0.684
MOD_CK1_1	29	35	PF00069	0.471
MOD_CK1_1	296	302	PF00069	0.506
MOD_CK1_1	377	383	PF00069	0.529
MOD_CK1_1	392	398	PF00069	0.619
MOD_CK1_1	407	413	PF00069	0.378
MOD_CK2_1	110	116	PF00069	0.344
MOD_CK2_1	139	145	PF00069	0.430
MOD_CK2_1	170	176	PF00069	0.644
MOD_CK2_1	183	189	PF00069	0.531
MOD_CK2_1	325	331	PF00069	0.527
MOD_CK2_1	35	41	PF00069	0.464
MOD_CK2_1	407	413	PF00069	0.511
MOD_CK2_1	47	53	PF00069	0.412
MOD_CK2_1	93	99	PF00069	0.516
MOD_GlcNHglycan	229	232	PF01048	0.550
MOD_GlcNHglycan	277	280	PF01048	0.773
MOD_GlcNHglycan	288	291	PF01048	0.638
MOD_GlcNHglycan	327	330	PF01048	0.496
MOD_GSK3_1	170	177	PF00069	0.615
MOD_GSK3_1	199	206	PF00069	0.615
MOD_GSK3_1	249	256	PF00069	0.619
MOD_GSK3_1	26	33	PF00069	0.452
MOD_GSK3_1	265	272	PF00069	0.703
MOD_GSK3_1	275	282	PF00069	0.586
MOD_GSK3_1	286	293	PF00069	0.580
MOD_GSK3_1	35	42	PF00069	0.406
MOD_GSK3_1	377	384	PF00069	0.499
MOD_GSK3_1	388	395	PF00069	0.670
MOD_GSK3_1	93	100	PF00069	0.516
MOD_N-GLC_1	399	404	PF02516	0.607
MOD_N-GLC_1	407	412	PF02516	0.446
MOD_NEK2_1	265	270	PF00069	0.628
MOD_NEK2_1	281	286	PF00069	0.747
MOD_NEK2_1	30	35	PF00069	0.472
MOD_NEK2_1	324	329	PF00069	0.516
MOD_NEK2_1	389	394	PF00069	0.669
MOD_NEK2_1	398	403	PF00069	0.729
MOD_NEK2_1	418	423	PF00069	0.409
MOD_PIKK_1	107	113	PF00454	0.503
MOD_PK_1	52	58	PF00069	0.478
MOD_PKA_1	139	145	PF00069	0.489
MOD_PKA_2	279	285	PF00069	0.640
MOD_PKA_2	294	300	PF00069	0.515
MOD_PKA_2	325	331	PF00069	0.503
MOD_PKA_2	367	373	PF00069	0.508
MOD_Plk_1	16	22	PF00069	0.496
MOD_Plk_1	175	181	PF00069	0.612
MOD_Plk_1	199	205	PF00069	0.636
MOD_Plk_1	266	272	PF00069	0.509
MOD_Plk_1	345	351	PF00069	0.482
MOD_Plk_1	39	45	PF00069	0.424
MOD_Plk_1	398	404	PF00069	0.630
MOD_Plk_1	407	413	PF00069	0.439
MOD_Plk_1	52	58	PF00069	0.466
MOD_Plk_2-3	93	99	PF00069	0.510
MOD_Plk_4	241	247	PF00069	0.487
MOD_Plk_4	266	272	PF00069	0.534
MOD_Plk_4	345	351	PF00069	0.450
MOD_Plk_4	399	405	PF00069	0.668
MOD_Plk_4	86	92	PF00069	0.470
MOD_ProDKin_1	183	189	PF00069	0.688
MOD_ProDKin_1	208	214	PF00069	0.648
MOD_ProDKin_1	249	255	PF00069	0.574
MOD_ProDKin_1	283	289	PF00069	0.634
MOD_ProDKin_1	290	296	PF00069	0.680
MOD_ProDKin_1	377	383	PF00069	0.522
MOD_SUMO_for_1	358	361	PF00179	0.502
MOD_SUMO_rev_2	370	375	PF00179	0.513
TRG_DiLeu_BaEn_1	40	45	PF01217	0.477
TRG_DiLeu_BaEn_2	398	404	PF01217	0.447
TRG_ENDOCYTIC_2	125	128	PF00928	0.472
TRG_ENDOCYTIC_2	155	158	PF00928	0.407
TRG_ENDOCYTIC_2	27	30	PF00928	0.478
TRG_ENDOCYTIC_2	87	90	PF00928	0.521
TRG_ER_diArg_1	166	169	PF00400	0.566
TRG_ER_diArg_1	22	25	PF00400	0.491
TRG_ER_diArg_1	366	369	PF00400	0.537
TRG_ER_diArg_1	74	76	PF00400	0.515
TRG_NES_CRM1_1	10	21	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y4	Leptomonas seymouri	53%	98%
A0A0S4JG85	Bodo saltans	29%	82%
A0A3Q8IL47	Leishmania donovani	78%	99%
A4IA15	Leishmania infantum	78%	99%
E9B522	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q2W4	Leishmania major	77%	100%