Putative cardiolipin synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cardiolipin synthetase, putative

Species:

Leishmania braziliensis

UniProt:

E9AI68_LEIBR

TriTrypDb:

LbrM.20.1600 , LBRM2903_200026500

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI68

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016740	transferase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.762
CLV_C14_Caspase3-7	57	61	PF00656	0.640
CLV_NRD_NRD_1	156	158	PF00675	0.592
CLV_NRD_NRD_1	216	218	PF00675	0.496
CLV_NRD_NRD_1	224	226	PF00675	0.482
CLV_NRD_NRD_1	290	292	PF00675	0.580
CLV_NRD_NRD_1	302	304	PF00675	0.617
CLV_NRD_NRD_1	329	331	PF00675	0.592
CLV_NRD_NRD_1	344	346	PF00675	0.506
CLV_NRD_NRD_1	474	476	PF00675	0.626
CLV_NRD_NRD_1	481	483	PF00675	0.605
CLV_NRD_NRD_1	548	550	PF00675	0.465
CLV_NRD_NRD_1	553	555	PF00675	0.378
CLV_NRD_NRD_1	565	567	PF00675	0.321
CLV_NRD_NRD_1	577	579	PF00675	0.329
CLV_PCSK_KEX2_1	156	158	PF00082	0.592
CLV_PCSK_KEX2_1	216	218	PF00082	0.527
CLV_PCSK_KEX2_1	290	292	PF00082	0.580
CLV_PCSK_KEX2_1	302	304	PF00082	0.617
CLV_PCSK_KEX2_1	329	331	PF00082	0.592
CLV_PCSK_KEX2_1	343	345	PF00082	0.672
CLV_PCSK_KEX2_1	474	476	PF00082	0.626
CLV_PCSK_KEX2_1	481	483	PF00082	0.605
CLV_PCSK_KEX2_1	494	496	PF00082	0.622
CLV_PCSK_KEX2_1	553	555	PF00082	0.400
CLV_PCSK_KEX2_1	577	579	PF00082	0.443
CLV_PCSK_KEX2_1	83	85	PF00082	0.580
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.622
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.639
CLV_PCSK_PC7_1	549	555	PF00082	0.411
CLV_PCSK_SKI1_1	132	136	PF00082	0.599
CLV_PCSK_SKI1_1	14	18	PF00082	0.743
CLV_PCSK_SKI1_1	199	203	PF00082	0.507
CLV_PCSK_SKI1_1	225	229	PF00082	0.437
CLV_PCSK_SKI1_1	302	306	PF00082	0.722
CLV_PCSK_SKI1_1	475	479	PF00082	0.724
CLV_PCSK_SKI1_1	482	486	PF00082	0.574
CLV_PCSK_SKI1_1	566	570	PF00082	0.353
CLV_PCSK_SKI1_1	672	676	PF00082	0.337
CLV_PCSK_SKI1_1	80	84	PF00082	0.568
DEG_COP1_1	508	515	PF00400	0.607
DEG_MDM2_SWIB_1	124	131	PF02201	0.459
DEG_MDM2_SWIB_1	91	99	PF02201	0.486
DEG_Nend_UBRbox_3	1	3	PF02207	0.534
DOC_CDC14_PxL_1	501	509	PF14671	0.679
DOC_CKS1_1	557	562	PF01111	0.411
DOC_CYCLIN_RxL_1	222	232	PF00134	0.451
DOC_CYCLIN_RxL_1	563	570	PF00134	0.360
DOC_CYCLIN_RxL_1	685	696	PF00134	0.476
DOC_CYCLIN_yClb5_NLxxxL_5	646	655	PF00134	0.411
DOC_MAPK_gen_1	10	18	PF00069	0.529
DOC_MAPK_gen_1	107	117	PF00069	0.339
DOC_MAPK_gen_1	181	190	PF00069	0.361
DOC_MAPK_gen_1	222	230	PF00069	0.398
DOC_MAPK_gen_1	348	356	PF00069	0.637
DOC_MAPK_gen_1	361	370	PF00069	0.504
DOC_MAPK_gen_1	549	557	PF00069	0.411
DOC_MAPK_gen_1	577	584	PF00069	0.443
DOC_MAPK_gen_1	607	615	PF00069	0.513
DOC_MAPK_gen_1	686	694	PF00069	0.490
DOC_MAPK_MEF2A_6	577	584	PF00069	0.513
DOC_PP1_RVXF_1	135	141	PF00149	0.461
DOC_PP1_RVXF_1	209	216	PF00149	0.540
DOC_PP1_RVXF_1	688	695	PF00149	0.327
DOC_PP1_RVXF_1	706	712	PF00149	0.507
DOC_PP2B_LxvP_1	465	468	PF13499	0.547
DOC_USP7_MATH_1	123	127	PF00917	0.554
DOC_USP7_MATH_1	36	40	PF00917	0.526
DOC_USP7_MATH_1	430	434	PF00917	0.711
DOC_USP7_MATH_1	452	456	PF00917	0.717
DOC_USP7_MATH_1	457	461	PF00917	0.722
DOC_USP7_MATH_1	468	472	PF00917	0.565
DOC_USP7_MATH_1	56	60	PF00917	0.718
DOC_USP7_UBL2_3	406	410	PF12436	0.564
DOC_WW_Pin1_4	215	220	PF00397	0.513
DOC_WW_Pin1_4	34	39	PF00397	0.532
DOC_WW_Pin1_4	44	49	PF00397	0.696
DOC_WW_Pin1_4	453	458	PF00397	0.762
DOC_WW_Pin1_4	556	561	PF00397	0.411
DOC_WW_Pin1_4	86	91	PF00397	0.655
LIG_14-3-3_CanoR_1	203	209	PF00244	0.527
LIG_14-3-3_CanoR_1	361	370	PF00244	0.720
LIG_14-3-3_CanoR_1	376	384	PF00244	0.568
LIG_14-3-3_CanoR_1	495	504	PF00244	0.592
LIG_14-3-3_CanoR_1	554	560	PF00244	0.400
LIG_14-3-3_CanoR_1	693	698	PF00244	0.494
LIG_14-3-3_CanoR_1	708	712	PF00244	0.520
LIG_14-3-3_CanoR_1	84	90	PF00244	0.637
LIG_AP2alpha_2	593	595	PF02296	0.411
LIG_APCC_ABBA_1	114	119	PF00400	0.574
LIG_BRCT_BRCA1_1	695	699	PF00533	0.451
LIG_BRCT_BRCA1_1	87	91	PF00533	0.642
LIG_deltaCOP1_diTrp_1	593	598	PF00928	0.411
LIG_eIF4E_1	603	609	PF01652	0.411
LIG_eIF4E_1	700	706	PF01652	0.478
LIG_FHA_1	166	172	PF00498	0.448
LIG_FHA_1	183	189	PF00498	0.497
LIG_FHA_1	205	211	PF00498	0.532
LIG_FHA_1	299	305	PF00498	0.718
LIG_FHA_1	496	502	PF00498	0.556
LIG_FHA_1	507	513	PF00498	0.576
LIG_FHA_1	524	530	PF00498	0.319
LIG_FHA_1	563	569	PF00498	0.384
LIG_FHA_1	603	609	PF00498	0.357
LIG_FHA_1	626	632	PF00498	0.411
LIG_FHA_1	666	672	PF00498	0.411
LIG_FHA_1	673	679	PF00498	0.487
LIG_FHA_1	693	699	PF00498	0.424
LIG_FHA_2	494	500	PF00498	0.450
LIG_FHA_2	76	82	PF00498	0.603
LIG_FHA_2	87	93	PF00498	0.532
LIG_LIR_Apic_2	558	564	PF02991	0.411
LIG_LIR_Gen_1	125	134	PF02991	0.467
LIG_LIR_Gen_1	496	505	PF02991	0.446
LIG_LIR_Gen_1	632	641	PF02991	0.353
LIG_LIR_Gen_1	689	699	PF02991	0.472
LIG_LIR_Gen_1	92	103	PF02991	0.491
LIG_LIR_Nem_3	125	131	PF02991	0.463
LIG_LIR_Nem_3	22	27	PF02991	0.647
LIG_LIR_Nem_3	632	638	PF02991	0.353
LIG_LIR_Nem_3	689	694	PF02991	0.490
LIG_LIR_Nem_3	695	700	PF02991	0.452
LIG_LIR_Nem_3	710	714	PF02991	0.529
LIG_LIR_Nem_3	92	98	PF02991	0.489
LIG_PCNA_yPIPBox_3	146	159	PF02747	0.471
LIG_PCNA_yPIPBox_3	385	399	PF02747	0.603
LIG_Pex14_2	124	128	PF04695	0.456
LIG_Pex14_2	91	95	PF04695	0.488
LIG_PTB_Apo_2	529	536	PF02174	0.486
LIG_PTB_Apo_2	698	705	PF02174	0.471
LIG_PTB_Phospho_1	529	535	PF10480	0.480
LIG_REV1ctd_RIR_1	199	207	PF16727	0.529
LIG_RPA_C_Fungi	476	488	PF08784	0.608
LIG_RPA_C_Fungi	572	584	PF08784	0.513
LIG_SH2_CRK	700	704	PF00017	0.468
LIG_SH2_STAP1	497	501	PF00017	0.579
LIG_SH2_STAP1	538	542	PF00017	0.422
LIG_SH2_STAT3	538	541	PF00017	0.415
LIG_SH2_STAT5	143	146	PF00017	0.477
LIG_SH2_STAT5	208	211	PF00017	0.524
LIG_SH2_STAT5	246	249	PF00017	0.479
LIG_SH2_STAT5	497	500	PF00017	0.585
LIG_SH2_STAT5	518	521	PF00017	0.537
LIG_SH2_STAT5	562	565	PF00017	0.411
LIG_SH2_STAT5	603	606	PF00017	0.411
LIG_SH2_STAT5	71	74	PF00017	0.625
LIG_SH3_1	194	200	PF00018	0.485
LIG_SH3_1	451	457	PF00018	0.578
LIG_SH3_3	194	200	PF00018	0.485
LIG_SH3_3	261	267	PF00018	0.471
LIG_SH3_3	451	457	PF00018	0.578
LIG_SH3_3	717	723	PF00018	0.561
LIG_Sin3_3	569	576	PF02671	0.411
LIG_SUMO_SIM_anti_2	100	106	PF11976	0.501
LIG_SUMO_SIM_par_1	226	232	PF11976	0.447
LIG_SUMO_SIM_par_1	627	633	PF11976	0.411
LIG_TRAF2_1	319	322	PF00917	0.713
LIG_TRAF2_2	457	462	PF00917	0.566
LIG_TYR_ITIM	698	703	PF00017	0.465
LIG_WRC_WIRS_1	711	716	PF05994	0.552
LIG_WRPW_2	198	201	PF00400	0.469
MOD_CDK_SPxxK_3	215	222	PF00069	0.501
MOD_CK1_1	19	25	PF00069	0.683
MOD_CK1_1	204	210	PF00069	0.524
MOD_CK1_1	335	341	PF00069	0.503
MOD_CK1_1	404	410	PF00069	0.714
MOD_CK1_1	433	439	PF00069	0.733
MOD_CK1_1	44	50	PF00069	0.688
MOD_CK1_1	440	446	PF00069	0.658
MOD_CK1_1	58	64	PF00069	0.783
MOD_CK1_1	588	594	PF00069	0.411
MOD_CK1_1	633	639	PF00069	0.407
MOD_CK1_1	665	671	PF00069	0.513
MOD_CK2_1	75	81	PF00069	0.642
MOD_CMANNOS	289	292	PF00535	0.610
MOD_CMANNOS	595	598	PF00535	0.411
MOD_Cter_Amidation	327	330	PF01082	0.561
MOD_GlcNHglycan	119	122	PF01048	0.443
MOD_GlcNHglycan	178	181	PF01048	0.563
MOD_GlcNHglycan	18	21	PF01048	0.580
MOD_GlcNHglycan	326	329	PF01048	0.611
MOD_GlcNHglycan	335	338	PF01048	0.595
MOD_GlcNHglycan	43	46	PF01048	0.769
MOD_GlcNHglycan	430	433	PF01048	0.733
MOD_GlcNHglycan	442	445	PF01048	0.576
MOD_GlcNHglycan	470	473	PF01048	0.553
MOD_GlcNHglycan	5	8	PF01048	0.760
MOD_GlcNHglycan	569	572	PF01048	0.513
MOD_GlcNHglycan	60	63	PF01048	0.639
MOD_GSK3_1	16	23	PF00069	0.516
MOD_GSK3_1	294	301	PF00069	0.693
MOD_GSK3_1	375	382	PF00069	0.801
MOD_GSK3_1	426	433	PF00069	0.720
MOD_GSK3_1	44	51	PF00069	0.671
MOD_GSK3_1	453	460	PF00069	0.648
MOD_GSK3_1	523	530	PF00069	0.476
MOD_GSK3_1	585	592	PF00069	0.411
MOD_GSK3_1	598	605	PF00069	0.411
MOD_GSK3_1	630	637	PF00069	0.381
MOD_LATS_1	493	499	PF00433	0.601
MOD_N-GLC_1	176	181	PF02516	0.541
MOD_N-GLC_1	332	337	PF02516	0.509
MOD_N-GLC_1	588	593	PF02516	0.411
MOD_NEK2_1	117	122	PF00069	0.468
MOD_NEK2_1	201	206	PF00069	0.538
MOD_NEK2_1	229	234	PF00069	0.474
MOD_NEK2_1	257	262	PF00069	0.453
MOD_NEK2_1	3	8	PF00069	0.677
MOD_NEK2_1	357	362	PF00069	0.702
MOD_NEK2_1	41	46	PF00069	0.704
MOD_NEK2_1	439	444	PF00069	0.804
MOD_NEK2_1	585	590	PF00069	0.387
MOD_NEK2_1	692	697	PF00069	0.449
MOD_NEK2_1	75	80	PF00069	0.550
MOD_NEK2_2	151	156	PF00069	0.464
MOD_NEK2_2	430	435	PF00069	0.555
MOD_PIKK_1	294	300	PF00454	0.588
MOD_PIKK_1	375	381	PF00454	0.774
MOD_PIKK_1	523	529	PF00454	0.448
MOD_PIKK_1	665	671	PF00454	0.411
MOD_PIKK_1	672	678	PF00454	0.488
MOD_PK_1	536	542	PF00069	0.469
MOD_PKA_2	106	112	PF00069	0.617
MOD_PKA_2	182	188	PF00069	0.446
MOD_PKA_2	257	263	PF00069	0.448
MOD_PKA_2	276	282	PF00069	0.331
MOD_PKA_2	362	368	PF00069	0.625
MOD_PKA_2	375	381	PF00069	0.630
MOD_PKA_2	486	492	PF00069	0.533
MOD_PKA_2	692	698	PF00069	0.451
MOD_PKA_2	707	713	PF00069	0.519
MOD_PKB_1	361	369	PF00069	0.496
MOD_PKB_1	534	542	PF00069	0.481
MOD_Plk_1	536	542	PF00069	0.469
MOD_Plk_4	123	129	PF00069	0.527
MOD_Plk_4	139	145	PF00069	0.304
MOD_Plk_4	204	210	PF00069	0.488
MOD_Plk_4	352	358	PF00069	0.616
MOD_Plk_4	36	42	PF00069	0.622
MOD_Plk_4	394	400	PF00069	0.564
MOD_Plk_4	430	436	PF00069	0.609
MOD_Plk_4	625	631	PF00069	0.411
MOD_Plk_4	693	699	PF00069	0.460
MOD_ProDKin_1	215	221	PF00069	0.506
MOD_ProDKin_1	34	40	PF00069	0.535
MOD_ProDKin_1	44	50	PF00069	0.695
MOD_ProDKin_1	453	459	PF00069	0.763
MOD_ProDKin_1	556	562	PF00069	0.411
MOD_ProDKin_1	86	92	PF00069	0.651
MOD_SUMO_rev_2	274	282	PF00179	0.619
MOD_SUMO_rev_2	382	391	PF00179	0.564
MOD_SUMO_rev_2	456	465	PF00179	0.563
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.384
TRG_ENDOCYTIC_2	198	201	PF00928	0.498
TRG_ENDOCYTIC_2	24	27	PF00928	0.684
TRG_ENDOCYTIC_2	317	320	PF00928	0.619
TRG_ENDOCYTIC_2	497	500	PF00928	0.585
TRG_ENDOCYTIC_2	700	703	PF00928	0.467
TRG_ER_diArg_1	155	157	PF00400	0.592
TRG_ER_diArg_1	181	184	PF00400	0.500
TRG_ER_diArg_1	215	217	PF00400	0.410
TRG_ER_diArg_1	289	291	PF00400	0.591
TRG_ER_diArg_1	302	304	PF00400	0.617
TRG_ER_diArg_1	308	311	PF00400	0.628
TRG_ER_diArg_1	329	331	PF00400	0.594
TRG_ER_diArg_1	342	345	PF00400	0.657
TRG_ER_diArg_1	361	364	PF00400	0.641
TRG_ER_diArg_1	473	475	PF00400	0.626
TRG_ER_diArg_1	553	555	PF00400	0.397
TRG_ER_diArg_1	688	691	PF00400	0.342
TRG_NES_CRM1_1	669	684	PF08389	0.484
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	672	676	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC19	Leptomonas seymouri	66%	86%
A0A3Q8III3	Leishmania donovani	82%	97%
A4IAM8	Leishmania infantum	82%	97%
E9B4Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	97%
Q4Q2Z0	Leishmania major	82%	100%