Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised ACR, YggU family COG1872, putative

Species:

Leishmania braziliensis

UniProt:

E9AI65_LEIBR

TriTrypDb:

LbrM.20.1190 , LBRM2903_200020600

Length:

193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	12	16	PF00082	0.431
CLV_PCSK_SKI1_1	170	174	PF00082	0.502
CLV_PCSK_SKI1_1	69	73	PF00082	0.585
CLV_Separin_Metazoa	55	59	PF03568	0.428
DEG_APCC_DBOX_1	179	187	PF00400	0.497
DEG_SCF_FBW7_1	31	37	PF00400	0.428
DEG_SPOP_SBC_1	102	106	PF00917	0.518
DOC_CKS1_1	31	36	PF01111	0.428
DOC_MAPK_gen_1	168	176	PF00069	0.400
DOC_MAPK_MEF2A_6	168	176	PF00069	0.456
DOC_PP4_FxxP_1	28	31	PF00568	0.428
DOC_USP7_MATH_1	102	106	PF00917	0.687
DOC_USP7_MATH_1	135	139	PF00917	0.662
DOC_USP7_MATH_1	141	145	PF00917	0.752
DOC_USP7_MATH_1	23	27	PF00917	0.336
DOC_USP7_UBL2_3	115	119	PF12436	0.581
DOC_WW_Pin1_4	30	35	PF00397	0.438
LIG_14-3-3_CanoR_1	24	32	PF00244	0.324
LIG_14-3-3_CanoR_1	66	72	PF00244	0.493
LIG_FHA_1	169	175	PF00498	0.496
LIG_FHA_1	31	37	PF00498	0.481
LIG_FHA_1	74	80	PF00498	0.428
LIG_FHA_2	164	170	PF00498	0.514
LIG_FHA_2	35	41	PF00498	0.391
LIG_LIR_Apic_2	26	31	PF02991	0.428
LIG_LIR_Gen_1	81	92	PF02991	0.532
LIG_LIR_LC3C_4	171	175	PF02991	0.298
LIG_LIR_Nem_3	81	87	PF02991	0.523
LIG_PCNA_yPIPBox_3	53	66	PF02747	0.354
LIG_SH2_CRK	18	22	PF00017	0.229
LIG_SH2_CRK	84	88	PF00017	0.530
LIG_SH2_NCK_1	18	22	PF00017	0.229
LIG_SH2_STAP1	84	88	PF00017	0.519
LIG_SH2_STAT5	13	16	PF00017	0.468
LIG_SH2_STAT5	59	62	PF00017	0.468
LIG_SH2_STAT5	78	81	PF00017	0.376
LIG_SH3_3	171	177	PF00018	0.438
LIG_SH3_3	28	34	PF00018	0.388
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.541
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.495
LIG_TYR_ITSM	80	87	PF00017	0.533
MOD_CK1_1	125	131	PF00069	0.690
MOD_CK1_1	98	104	PF00069	0.562
MOD_CK2_1	163	169	PF00069	0.530
MOD_CK2_1	32	38	PF00069	0.265
MOD_CK2_1	67	73	PF00069	0.375
MOD_GlcNHglycan	100	103	PF01048	0.702
MOD_GlcNHglycan	105	108	PF01048	0.690
MOD_GlcNHglycan	132	135	PF01048	0.721
MOD_GlcNHglycan	25	28	PF01048	0.359
MOD_GSK3_1	121	128	PF00069	0.668
MOD_GSK3_1	135	142	PF00069	0.602
MOD_GSK3_1	164	171	PF00069	0.476
MOD_GSK3_1	30	37	PF00069	0.346
MOD_GSK3_1	69	76	PF00069	0.474
MOD_GSK3_1	91	98	PF00069	0.503
MOD_PIKK_1	135	141	PF00454	0.662
MOD_PIKK_1	96	102	PF00454	0.481
MOD_PKA_2	109	115	PF00069	0.516
MOD_PKA_2	23	29	PF00069	0.324
MOD_Plk_1	157	163	PF00069	0.512
MOD_Plk_1	168	174	PF00069	0.406
MOD_Plk_4	157	163	PF00069	0.429
MOD_Plk_4	168	174	PF00069	0.407
MOD_ProDKin_1	30	36	PF00069	0.438
TRG_DiLeu_BaEn_1	169	174	PF01217	0.437
TRG_ENDOCYTIC_2	84	87	PF00928	0.531
TRG_ER_diArg_1	129	132	PF00400	0.501
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK74	Leptomonas seymouri	55%	100%
A0A1X0P9D1	Trypanosomatidae	31%	100%
A0A3Q8IKV6	Leishmania donovani	73%	95%
A0A422NGS4	Trypanosoma rangeli	30%	100%
A4I9S6	Leishmania infantum	72%	95%
C9ZMV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B4T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	95%
Q4Q389	Leishmania major	75%	100%