Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI61_LEIBR

TriTrypDb:

LbrM.18.1590 , LBRM2903_180022100

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.666
CLV_NRD_NRD_1	115	117	PF00675	0.717
CLV_NRD_NRD_1	150	152	PF00675	0.546
CLV_NRD_NRD_1	177	179	PF00675	0.607
CLV_NRD_NRD_1	385	387	PF00675	0.456
CLV_NRD_NRD_1	464	466	PF00675	0.514
CLV_PCSK_FUR_1	112	116	PF00082	0.493
CLV_PCSK_KEX2_1	114	116	PF00082	0.497
CLV_PCSK_KEX2_1	150	152	PF00082	0.546
CLV_PCSK_KEX2_1	176	178	PF00082	0.616
CLV_PCSK_KEX2_1	23	25	PF00082	0.489
CLV_PCSK_KEX2_1	385	387	PF00082	0.456
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.489
CLV_PCSK_SKI1_1	178	182	PF00082	0.616
CLV_PCSK_SKI1_1	317	321	PF00082	0.477
CLV_PCSK_SKI1_1	39	43	PF00082	0.509
CLV_PCSK_SKI1_1	465	469	PF00082	0.396
CLV_PCSK_SKI1_1	506	510	PF00082	0.492
CLV_PCSK_SKI1_1	81	85	PF00082	0.348
DEG_APCC_DBOX_1	444	452	PF00400	0.430
DEG_MDM2_SWIB_1	526	533	PF02201	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.436
DOC_CDC14_PxL_1	27	35	PF14671	0.460
DOC_CKS1_1	452	457	PF01111	0.430
DOC_CYCLIN_RxL_1	292	305	PF00134	0.323
DOC_CYCLIN_RxL_1	460	472	PF00134	0.405
DOC_CYCLIN_RxL_1	85	96	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.532
DOC_MAPK_gen_1	120	129	PF00069	0.521
DOC_MAPK_gen_1	439	448	PF00069	0.446
DOC_MAPK_HePTP_8	438	450	PF00069	0.497
DOC_MAPK_MEF2A_6	123	131	PF00069	0.511
DOC_MAPK_MEF2A_6	298	306	PF00069	0.537
DOC_MAPK_MEF2A_6	441	450	PF00069	0.499
DOC_MAPK_MEF2A_6	81	89	PF00069	0.422
DOC_MAPK_NFAT4_5	445	453	PF00069	0.501
DOC_USP7_MATH_1	228	232	PF00917	0.636
DOC_USP7_MATH_1	281	285	PF00917	0.438
DOC_USP7_MATH_1	294	298	PF00917	0.588
DOC_USP7_MATH_1	332	336	PF00917	0.302
DOC_WW_Pin1_4	157	162	PF00397	0.485
DOC_WW_Pin1_4	181	186	PF00397	0.506
DOC_WW_Pin1_4	312	317	PF00397	0.461
DOC_WW_Pin1_4	439	444	PF00397	0.490
DOC_WW_Pin1_4	451	456	PF00397	0.528
LIG_14-3-3_CanoR_1	114	122	PF00244	0.665
LIG_14-3-3_CanoR_1	126	130	PF00244	0.323
LIG_14-3-3_CanoR_1	177	187	PF00244	0.531
LIG_14-3-3_CanoR_1	32	41	PF00244	0.428
LIG_14-3-3_CanoR_1	385	392	PF00244	0.454
LIG_APCC_ABBA_1	159	164	PF00400	0.536
LIG_Clathr_ClatBox_1	66	70	PF01394	0.291
LIG_deltaCOP1_diTrp_1	189	196	PF00928	0.483
LIG_FHA_1	11	17	PF00498	0.416
LIG_FHA_1	126	132	PF00498	0.529
LIG_FHA_1	137	143	PF00498	0.492
LIG_FHA_1	198	204	PF00498	0.493
LIG_FHA_1	264	270	PF00498	0.471
LIG_FHA_1	275	281	PF00498	0.350
LIG_FHA_1	404	410	PF00498	0.370
LIG_FHA_1	542	548	PF00498	0.378
LIG_FHA_1	73	79	PF00498	0.518
LIG_FHA_1	82	88	PF00498	0.280
LIG_FHA_2	442	448	PF00498	0.488
LIG_FHA_2	77	83	PF00498	0.517
LIG_FHA_2	95	101	PF00498	0.388
LIG_LIR_Gen_1	189	197	PF02991	0.477
LIG_LIR_Gen_1	434	443	PF02991	0.372
LIG_LIR_Gen_1	44	53	PF02991	0.441
LIG_LIR_Gen_1	520	531	PF02991	0.401
LIG_LIR_Gen_1	540	551	PF02991	0.295
LIG_LIR_Nem_3	189	194	PF02991	0.588
LIG_LIR_Nem_3	254	258	PF02991	0.384
LIG_LIR_Nem_3	434	440	PF02991	0.352
LIG_LIR_Nem_3	44	48	PF02991	0.434
LIG_LIR_Nem_3	520	526	PF02991	0.397
LIG_LIR_Nem_3	540	546	PF02991	0.301
LIG_LYPXL_yS_3	255	258	PF13949	0.448
LIG_NRBOX	239	245	PF00104	0.429
LIG_PCNA_TLS_4	408	415	PF02747	0.269
LIG_PCNA_TLS_4	506	513	PF02747	0.279
LIG_PCNA_yPIPBox_3	377	389	PF02747	0.555
LIG_Pex14_1	210	214	PF04695	0.302
LIG_Pex14_2	41	45	PF04695	0.413
LIG_Pex14_2	526	530	PF04695	0.350
LIG_SH2_CRK	22	26	PF00017	0.397
LIG_SH2_CRK	27	31	PF00017	0.414
LIG_SH2_CRK	398	402	PF00017	0.516
LIG_SH2_SRC	52	55	PF00017	0.571
LIG_SH2_STAP1	523	527	PF00017	0.353
LIG_SH2_STAT5	214	217	PF00017	0.489
LIG_SH2_STAT5	341	344	PF00017	0.368
LIG_SH2_STAT5	364	367	PF00017	0.466
LIG_SH2_STAT5	512	515	PF00017	0.415
LIG_SH2_STAT5	52	55	PF00017	0.568
LIG_SH2_STAT5	528	531	PF00017	0.337
LIG_SH3_2	455	460	PF14604	0.560
LIG_SH3_3	155	161	PF00018	0.514
LIG_SH3_3	452	458	PF00018	0.565
LIG_SH3_3	68	74	PF00018	0.505
LIG_SUMO_SIM_anti_2	444	450	PF11976	0.500
LIG_SUMO_SIM_anti_2	459	465	PF11976	0.289
LIG_SUMO_SIM_anti_2	82	87	PF11976	0.284
LIG_SUMO_SIM_par_1	127	133	PF11976	0.516
LIG_SUMO_SIM_par_1	163	171	PF11976	0.526
LIG_SUMO_SIM_par_1	264	273	PF11976	0.545
LIG_SUMO_SIM_par_1	277	284	PF11976	0.314
LIG_SUMO_SIM_par_1	300	305	PF11976	0.391
LIG_SUMO_SIM_par_1	428	434	PF11976	0.454
LIG_SUMO_SIM_par_1	447	454	PF11976	0.476
LIG_SUMO_SIM_par_1	65	70	PF11976	0.421
LIG_SUMO_SIM_par_1	88	97	PF11976	0.507
LIG_TRAF2_1	106	109	PF00917	0.642
LIG_TRAF2_1	152	155	PF00917	0.568
LIG_TRAF2_1	161	164	PF00917	0.531
LIG_TRAF2_1	180	183	PF00917	0.637
LIG_TRAF2_1	216	219	PF00917	0.676
LIG_TRFH_1	27	31	PF08558	0.409
LIG_TYR_ITIM	25	30	PF00017	0.489
LIG_UBA3_1	16	23	PF00899	0.428
LIG_UBA3_1	239	247	PF00899	0.271
LIG_UBA3_1	467	473	PF00899	0.325
LIG_WRC_WIRS_1	42	47	PF05994	0.554
LIG_WRC_WIRS_1	485	490	PF05994	0.406
MOD_CDC14_SPxK_1	442	445	PF00782	0.470
MOD_CDK_SPK_2	312	317	PF00069	0.500
MOD_CDK_SPxK_1	439	445	PF00069	0.487
MOD_CK1_1	10	16	PF00069	0.274
MOD_CK1_1	205	211	PF00069	0.426
MOD_CK1_1	3	9	PF00069	0.402
MOD_CK1_1	35	41	PF00069	0.519
MOD_CK1_1	44	50	PF00069	0.479
MOD_CK1_1	76	82	PF00069	0.453
MOD_CK2_1	103	109	PF00069	0.697
MOD_CK2_1	157	163	PF00069	0.553
MOD_CK2_1	201	207	PF00069	0.389
MOD_CK2_1	248	254	PF00069	0.295
MOD_CK2_1	281	287	PF00069	0.513
MOD_CK2_1	3	9	PF00069	0.411
MOD_CK2_1	343	349	PF00069	0.441
MOD_CK2_1	76	82	PF00069	0.429
MOD_CK2_1	94	100	PF00069	0.528
MOD_Cter_Amidation	112	115	PF01082	0.493
MOD_GlcNHglycan	155	158	PF01048	0.594
MOD_GlcNHglycan	398	401	PF01048	0.470
MOD_GlcNHglycan	427	430	PF01048	0.544
MOD_GlcNHglycan	475	478	PF01048	0.450
MOD_GlcNHglycan	533	536	PF01048	0.364
MOD_GlcNHglycan	9	12	PF01048	0.573
MOD_GSK3_1	136	143	PF00069	0.490
MOD_GSK3_1	153	160	PF00069	0.394
MOD_GSK3_1	197	204	PF00069	0.409
MOD_GSK3_1	224	231	PF00069	0.609
MOD_GSK3_1	281	288	PF00069	0.464
MOD_GSK3_1	3	10	PF00069	0.407
MOD_GSK3_1	321	328	PF00069	0.548
MOD_GSK3_1	364	371	PF00069	0.553
MOD_GSK3_1	72	79	PF00069	0.511
MOD_GSK3_1	99	106	PF00069	0.572
MOD_NEK2_1	197	202	PF00069	0.436
MOD_NEK2_1	243	248	PF00069	0.441
MOD_NEK2_1	274	279	PF00069	0.410
MOD_NEK2_1	384	389	PF00069	0.379
MOD_NEK2_1	484	489	PF00069	0.383
MOD_PIKK_1	140	146	PF00454	0.529
MOD_PKA_1	114	120	PF00069	0.460
MOD_PKA_1	343	349	PF00069	0.418
MOD_PKA_1	385	391	PF00069	0.346
MOD_PKA_2	114	120	PF00069	0.700
MOD_PKA_2	125	131	PF00069	0.336
MOD_PKA_2	384	390	PF00069	0.504
MOD_PKB_1	112	120	PF00069	0.719
MOD_PKB_1	176	184	PF00069	0.542
MOD_Plk_1	263	269	PF00069	0.539
MOD_Plk_1	81	87	PF00069	0.406
MOD_Plk_1	99	105	PF00069	0.623
MOD_Plk_2-3	345	351	PF00069	0.624
MOD_Plk_4	281	287	PF00069	0.539
MOD_Plk_4	368	374	PF00069	0.400
MOD_Plk_4	41	47	PF00069	0.486
MOD_Plk_4	500	506	PF00069	0.516
MOD_Plk_4	73	79	PF00069	0.485
MOD_Plk_4	81	87	PF00069	0.320
MOD_ProDKin_1	157	163	PF00069	0.477
MOD_ProDKin_1	181	187	PF00069	0.505
MOD_ProDKin_1	312	318	PF00069	0.460
MOD_ProDKin_1	439	445	PF00069	0.487
MOD_ProDKin_1	451	457	PF00069	0.525
TRG_DiLeu_BaEn_1	207	212	PF01217	0.454
TRG_DiLeu_BaEn_1	254	259	PF01217	0.487
TRG_DiLeu_BaEn_1	349	354	PF01217	0.305
TRG_DiLeu_BaEn_1	82	87	PF01217	0.425
TRG_DiLeu_BaEn_2	191	197	PF01217	0.563
TRG_DiLeu_BaEn_4	333	339	PF01217	0.547
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.417
TRG_ENDOCYTIC_2	22	25	PF00928	0.400
TRG_ENDOCYTIC_2	255	258	PF00928	0.462
TRG_ENDOCYTIC_2	27	30	PF00928	0.404
TRG_ENDOCYTIC_2	339	342	PF00928	0.506
TRG_ENDOCYTIC_2	398	401	PF00928	0.468
TRG_ENDOCYTIC_2	523	526	PF00928	0.408
TRG_ER_diArg_1	112	115	PF00400	0.729
TRG_ER_diArg_1	176	178	PF00400	0.619
TRG_ER_diArg_1	384	386	PF00400	0.436
TRG_NES_CRM1_1	425	436	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRD6	Leptomonas seymouri	56%	100%
A0A1X0P7Z6	Trypanosomatidae	30%	100%
A0A3R7M1T0	Trypanosoma rangeli	30%	100%
A0A3S7WV76	Leishmania donovani	79%	99%
D0A560	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AGQ6	Leishmania infantum	79%	99%
E9ARU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
Q4QDN3	Leishmania major	78%	100%
V5BDF3	Trypanosoma cruzi	30%	100%