UTP--glucose-1-phosphate uridylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-glucose pyrophosphorylase

Species:

Leishmania braziliensis

UniProt:

E9AI58_LEIBR

TriTrypDb:

LbrM.18.1050 , LBRM2903_180016200 , LBRM2903_180016300

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI58

PDB structure(s): 2oef_A , 2oeg_A , 4j18_A , 4m28_A , 4m2a_A , 4m2b_A , 5nzg_A , 5nzh_A , 5nzh_B , 5nzi_A , 5nzj_A , 5nzk_A , 5nzl_A , 5nzm_A

Function

Biological processes
Term	Name	Level	Count
GO:0006011	UDP-glucose metabolic process	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009225	nucleotide-sugar metabolic process	4	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0005975	carbohydrate metabolic process	3	1
GO:0005976	polysaccharide metabolic process	4	1
GO:0005977	glycogen metabolic process	6	1
GO:0006073	obsolete cellular glucan metabolic process	5	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006112	energy reserve metabolic process	5	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044042	glucan metabolic process	5	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044264	obsolete cellular polysaccharide metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity	7	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0051748	UTP-monosaccharide-1-phosphate uridylyltransferase activity	6	12
GO:0070569	uridylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.413
CLV_C14_Caspase3-7	271	275	PF00656	0.393
CLV_C14_Caspase3-7	46	50	PF00656	0.362
CLV_C14_Caspase3-7	99	103	PF00656	0.480
CLV_NRD_NRD_1	140	142	PF00675	0.254
CLV_NRD_NRD_1	248	250	PF00675	0.262
CLV_PCSK_KEX2_1	140	142	PF00082	0.159
CLV_PCSK_KEX2_1	229	231	PF00082	0.275
CLV_PCSK_KEX2_1	248	250	PF00082	0.262
CLV_PCSK_KEX2_1	443	445	PF00082	0.229
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.275
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.229
CLV_PCSK_SKI1_1	104	108	PF00082	0.213
CLV_PCSK_SKI1_1	126	130	PF00082	0.250
CLV_PCSK_SKI1_1	140	144	PF00082	0.256
CLV_PCSK_SKI1_1	20	24	PF00082	0.438
CLV_PCSK_SKI1_1	213	217	PF00082	0.220
CLV_PCSK_SKI1_1	229	233	PF00082	0.293
CLV_PCSK_SKI1_1	401	405	PF00082	0.213
CLV_PCSK_SKI1_1	95	99	PF00082	0.213
DEG_Nend_UBRbox_2	1	3	PF02207	0.494
DOC_CKS1_1	474	479	PF01111	0.261
DOC_CYCLIN_yClb5_NLxxxL_5	306	315	PF00134	0.424
DOC_MAPK_DCC_7	407	417	PF00069	0.427
DOC_MAPK_gen_1	101	109	PF00069	0.434
DOC_MAPK_MEF2A_6	324	333	PF00069	0.420
DOC_PP1_RVXF_1	122	128	PF00149	0.420
DOC_PP1_RVXF_1	236	243	PF00149	0.454
DOC_PP2B_LxvP_1	329	332	PF13499	0.413
DOC_PP2B_LxvP_1	370	373	PF13499	0.345
DOC_PP4_FxxP_1	474	477	PF00568	0.432
DOC_USP7_MATH_1	273	277	PF00917	0.345
DOC_USP7_MATH_1	388	392	PF00917	0.424
DOC_WW_Pin1_4	344	349	PF00397	0.523
DOC_WW_Pin1_4	473	478	PF00397	0.524
DOC_WW_Pin1_4	485	490	PF00397	0.562
LIG_14-3-3_CanoR_1	118	128	PF00244	0.438
LIG_DLG_GKlike_1	54	61	PF00625	0.345
LIG_FHA_1	275	281	PF00498	0.477
LIG_FHA_1	306	312	PF00498	0.413
LIG_FHA_1	326	332	PF00498	0.480
LIG_FHA_1	42	48	PF00498	0.351
LIG_FHA_1	453	459	PF00498	0.501
LIG_FHA_1	460	466	PF00498	0.512
LIG_FHA_1	74	80	PF00498	0.436
LIG_FHA_2	103	109	PF00498	0.409
LIG_FHA_2	175	181	PF00498	0.359
LIG_FHA_2	248	254	PF00498	0.413
LIG_FHA_2	380	386	PF00498	0.413
LIG_FHA_2	51	57	PF00498	0.483
LIG_FHA_2	64	70	PF00498	0.366
LIG_FHA_2	94	100	PF00498	0.463
LIG_GBD_Chelix_1	77	85	PF00786	0.224
LIG_LIR_Apic_2	185	189	PF02991	0.418
LIG_LIR_Apic_2	472	477	PF02991	0.499
LIG_LIR_Gen_1	105	114	PF02991	0.415
LIG_LIR_Gen_1	193	199	PF02991	0.413
LIG_LIR_LC3C_4	368	372	PF02991	0.345
LIG_LIR_Nem_3	105	109	PF02991	0.415
LIG_LIR_Nem_3	144	150	PF02991	0.405
LIG_LIR_Nem_3	193	198	PF02991	0.432
LIG_LIR_Nem_3	375	380	PF02991	0.413
LIG_LYPXL_yS_3	147	150	PF13949	0.438
LIG_MAD2	167	175	PF02301	0.480
LIG_PTB_Apo_2	206	213	PF02174	0.345
LIG_PTB_Apo_2	416	423	PF02174	0.381
LIG_PTB_Phospho_1	206	212	PF10480	0.345
LIG_PTB_Phospho_1	416	422	PF10480	0.381
LIG_SH2_CRK	195	199	PF00017	0.413
LIG_SH2_CRK	212	216	PF00017	0.413
LIG_SH2_PTP2	214	217	PF00017	0.345
LIG_SH2_STAP1	195	199	PF00017	0.422
LIG_SH2_STAT3	116	119	PF00017	0.455
LIG_SH2_STAT5	116	119	PF00017	0.472
LIG_SH2_STAT5	195	198	PF00017	0.424
LIG_SH2_STAT5	214	217	PF00017	0.424
LIG_SH2_STAT5	394	397	PF00017	0.460
LIG_SH3_3	173	179	PF00018	0.345
LIG_SH3_3	339	345	PF00018	0.363
LIG_SH3_3	484	490	PF00018	0.407
LIG_SUMO_SIM_anti_2	155	162	PF11976	0.415
LIG_SUMO_SIM_par_1	279	285	PF11976	0.492
LIG_SUMO_SIM_par_1	385	392	PF11976	0.414
LIG_SUMO_SIM_par_1	413	418	PF11976	0.438
LIG_SUMO_SIM_par_1	96	102	PF11976	0.480
LIG_UBA3_1	282	291	PF00899	0.345
LIG_UBA3_1	318	324	PF00899	0.484
LIG_WRC_WIRS_1	130	135	PF05994	0.413
LIG_WRC_WIRS_1	29	34	PF05994	0.308
MOD_CDK_SPK_2	344	349	PF00069	0.514
MOD_CK1_1	132	138	PF00069	0.421
MOD_CK1_1	268	274	PF00069	0.380
MOD_CK1_1	50	56	PF00069	0.406
MOD_CK2_1	153	159	PF00069	0.466
MOD_CK2_1	174	180	PF00069	0.359
MOD_CK2_1	37	43	PF00069	0.408
MOD_CK2_1	50	56	PF00069	0.315
MOD_GlcNHglycan	135	138	PF01048	0.278
MOD_GlcNHglycan	200	203	PF01048	0.213
MOD_GlcNHglycan	367	370	PF01048	0.221
MOD_GlcNHglycan	469	472	PF01048	0.560
MOD_GlcNHglycan	49	52	PF01048	0.292
MOD_GlcNHglycan	8	11	PF01048	0.379
MOD_GSK3_1	129	136	PF00069	0.435
MOD_GSK3_1	301	308	PF00069	0.494
MOD_GSK3_1	336	343	PF00069	0.456
MOD_GSK3_1	37	44	PF00069	0.394
MOD_GSK3_1	469	476	PF00069	0.416
MOD_GSK3_1	50	57	PF00069	0.366
MOD_N-GLC_1	133	138	PF02516	0.347
MOD_N-GLC_1	365	370	PF02516	0.220
MOD_N-GLC_1	397	402	PF02516	0.145
MOD_NEK2_1	107	112	PF00069	0.438
MOD_NEK2_1	129	134	PF00069	0.439
MOD_NEK2_1	198	203	PF00069	0.413
MOD_NEK2_1	305	310	PF00069	0.425
MOD_NEK2_1	459	464	PF00069	0.510
MOD_NEK2_1	482	487	PF00069	0.519
MOD_NEK2_1	73	78	PF00069	0.460
MOD_PIKK_1	268	274	PF00454	0.345
MOD_PKA_2	247	253	PF00069	0.456
MOD_Plk_1	107	113	PF00069	0.424
MOD_Plk_1	336	342	PF00069	0.490
MOD_Plk_1	365	371	PF00069	0.383
MOD_Plk_1	397	403	PF00069	0.345
MOD_Plk_1	483	489	PF00069	0.298
MOD_Plk_2-3	102	108	PF00069	0.429
MOD_Plk_2-3	174	180	PF00069	0.345
MOD_Plk_2-3	43	49	PF00069	0.405
MOD_Plk_2-3	93	99	PF00069	0.477
MOD_Plk_4	102	108	PF00069	0.413
MOD_Plk_4	301	307	PF00069	0.508
MOD_Plk_4	435	441	PF00069	0.480
MOD_Plk_4	73	79	PF00069	0.443
MOD_Plk_4	93	99	PF00069	0.315
MOD_ProDKin_1	344	350	PF00069	0.523
MOD_ProDKin_1	473	479	PF00069	0.526
MOD_SUMO_for_1	463	466	PF00179	0.351
MOD_SUMO_rev_2	2	8	PF00179	0.514
MOD_SUMO_rev_2	99	106	PF00179	0.443
TRG_DiLeu_BaEn_2	122	128	PF01217	0.550
TRG_DiLeu_BaLyEn_6	441	446	PF01217	0.345
TRG_ENDOCYTIC_2	147	150	PF00928	0.413
TRG_ENDOCYTIC_2	151	154	PF00928	0.413
TRG_ENDOCYTIC_2	195	198	PF00928	0.435
TRG_ENDOCYTIC_2	212	215	PF00928	0.435
TRG_ENDOCYTIC_2	422	425	PF00928	0.413
TRG_ER_diArg_1	124	127	PF00400	0.420
TRG_ER_diArg_1	140	142	PF00400	0.345
TRG_ER_diArg_1	373	376	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.145

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H7	Leptomonas seymouri	76%	99%
A0A0S4JER9	Bodo saltans	56%	100%
A0A1X0P7U0	Trypanosomatidae	65%	100%
A0A3S7WUZ9	Leishmania donovani	87%	99%
A0A422P1Z6	Trypanosoma rangeli	62%	100%
A4HXX2	Leishmania infantum	87%	99%
C9ZZT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ARN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
O35156	Cricetulus griseus	37%	96%
O59819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	98%
O64459	Pyrus pyrifolia	36%	100%
P08800	Dictyostelium discoideum	32%	96%
P19595	Solanum tuberosum	35%	100%
P32861	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	98%
P38709	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	99%
P57751	Arabidopsis thaliana	36%	100%
P78811	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	97%
P79303	Sus scrofa	36%	96%
Q07130	Bos taurus	37%	96%
Q16851	Homo sapiens	37%	96%
Q43772	Hordeum vulgare	37%	100%
Q4QDU3	Leishmania major	86%	100%
Q54YZ0	Dictyostelium discoideum	35%	98%
Q59KI0	Candida albicans (strain SC5314 / ATCC MYA-2876)	38%	98%
Q8SSC5	Encephalitozoon cuniculi (strain GB-M1)	38%	100%
Q91ZJ5	Mus musculus	37%	96%
Q9LKG7	Astragalus penduliflorus	37%	100%
Q9M9P3	Arabidopsis thaliana	35%	100%
Q9SDX3	Musa acuminata	37%	100%
V5B6M0	Trypanosoma cruzi	61%	100%