Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 29, putative

Species:

Leishmania braziliensis

UniProt:

E9AI57_LEIBR

TriTrypDb:

LbrM.18.0240 , LBRM2903_180007400

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AI57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI57

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006379	mRNA cleavage	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.640
CLV_NRD_NRD_1	357	359	PF00675	0.446
CLV_NRD_NRD_1	365	367	PF00675	0.520
CLV_NRD_NRD_1	402	404	PF00675	0.543
CLV_NRD_NRD_1	75	77	PF00675	0.282
CLV_PCSK_KEX2_1	396	398	PF00082	0.669
CLV_PCSK_KEX2_1	400	402	PF00082	0.704
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.669
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.704
CLV_PCSK_SKI1_1	134	138	PF00082	0.463
CLV_PCSK_SKI1_1	19	23	PF00082	0.279
CLV_PCSK_SKI1_1	27	31	PF00082	0.279
CLV_PCSK_SKI1_1	330	334	PF00082	0.518
CLV_PCSK_SKI1_1	64	68	PF00082	0.280
CLV_PCSK_SKI1_1	76	80	PF00082	0.279
CLV_Separin_Metazoa	355	359	PF03568	0.475
DEG_APCC_DBOX_1	133	141	PF00400	0.464
DEG_SCF_FBW7_1	1	8	PF00400	0.611
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.534
DOC_MAPK_gen_1	76	82	PF00069	0.479
DOC_PP2B_LxvP_1	203	206	PF13499	0.697
DOC_PP4_FxxP_1	333	336	PF00568	0.663
DOC_PP4_MxPP_1	265	268	PF00568	0.696
DOC_PP4_MxPP_1	285	288	PF00568	0.683
DOC_USP7_MATH_1	186	190	PF00917	0.570
DOC_USP7_MATH_1	302	306	PF00917	0.645
DOC_USP7_MATH_1	381	385	PF00917	0.643
DOC_USP7_UBL2_3	359	363	PF12436	0.445
DOC_USP7_UBL2_3	367	371	PF12436	0.508
DOC_USP7_UBL2_3	396	400	PF12436	0.621
DOC_WW_Pin1_4	1	6	PF00397	0.668
DOC_WW_Pin1_4	123	128	PF00397	0.588
DOC_WW_Pin1_4	148	153	PF00397	0.536
DOC_WW_Pin1_4	179	184	PF00397	0.725
DOC_WW_Pin1_4	198	203	PF00397	0.633
LIG_Actin_WH2_2	14	29	PF00022	0.481
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_eIF4E_1	68	74	PF01652	0.479
LIG_FHA_1	180	186	PF00498	0.626
LIG_FHA_2	174	180	PF00498	0.641
LIG_FHA_2	33	39	PF00498	0.482
LIG_FHA_2	56	62	PF00498	0.495
LIG_Integrin_isoDGR_2	42	44	PF01839	0.279
LIG_LIR_Apic_2	331	336	PF02991	0.527
LIG_LIR_Gen_1	351	361	PF02991	0.503
LIG_LIR_Nem_3	351	357	PF02991	0.503
LIG_LIR_Nem_3	8	13	PF02991	0.411
LIG_PCNA_PIPBox_1	155	164	PF02747	0.395
LIG_PCNA_yPIPBox_3	148	162	PF02747	0.399
LIG_SH2_STAP1	364	368	PF00017	0.501
LIG_SH2_STAT5	13	16	PF00017	0.479
LIG_SH2_STAT5	161	164	PF00017	0.417
LIG_SH3_3	199	205	PF00018	0.648
LIG_SH3_3	331	337	PF00018	0.490
LIG_SH3_3	84	90	PF00018	0.513
LIG_UBA3_1	136	144	PF00899	0.484
MOD_CK1_1	175	181	PF00069	0.748
MOD_CK1_1	323	329	PF00069	0.593
MOD_CK1_1	384	390	PF00069	0.622
MOD_Cter_Amidation	74	77	PF01082	0.279
MOD_GlcNHglycan	196	199	PF01048	0.811
MOD_GlcNHglycan	229	232	PF01048	0.693
MOD_GlcNHglycan	259	262	PF01048	0.617
MOD_GlcNHglycan	320	323	PF01048	0.674
MOD_GlcNHglycan	330	333	PF01048	0.672
MOD_GlcNHglycan	374	377	PF01048	0.610
MOD_GlcNHglycan	386	390	PF01048	0.640
MOD_GSK3_1	1	8	PF00069	0.611
MOD_GSK3_1	114	121	PF00069	0.580
MOD_GSK3_1	164	171	PF00069	0.598
MOD_GSK3_1	173	180	PF00069	0.708
MOD_GSK3_1	194	201	PF00069	0.815
MOD_GSK3_1	204	211	PF00069	0.654
MOD_GSK3_1	227	234	PF00069	0.607
MOD_GSK3_1	247	254	PF00069	0.558
MOD_GSK3_1	381	388	PF00069	0.788
MOD_N-GLC_1	171	176	PF02516	0.642
MOD_N-GLC_1	328	333	PF02516	0.556
MOD_NEK2_1	118	123	PF00069	0.610
MOD_NEK2_1	157	162	PF00069	0.482
MOD_NEK2_1	208	213	PF00069	0.592
MOD_NEK2_1	303	308	PF00069	0.557
MOD_PIKK_1	186	192	PF00454	0.539
MOD_PIKK_1	293	299	PF00454	0.550
MOD_PKA_1	396	402	PF00069	0.537
MOD_PKA_2	396	402	PF00069	0.537
MOD_Plk_1	17	23	PF00069	0.501
MOD_Plk_1	328	334	PF00069	0.523
MOD_Plk_1	37	43	PF00069	0.390
MOD_Plk_1	381	387	PF00069	0.535
MOD_Plk_2-3	55	61	PF00069	0.480
MOD_Plk_4	114	120	PF00069	0.569
MOD_Plk_4	251	257	PF00069	0.683
MOD_Plk_4	32	38	PF00069	0.479
MOD_ProDKin_1	1	7	PF00069	0.658
MOD_ProDKin_1	123	129	PF00069	0.581
MOD_ProDKin_1	148	154	PF00069	0.529
MOD_ProDKin_1	179	185	PF00069	0.726
MOD_ProDKin_1	198	204	PF00069	0.629
MOD_SUMO_rev_2	360	368	PF00179	0.488
MOD_SUMO_rev_2	388	398	PF00179	0.618
TRG_DiLeu_BaEn_1	132	137	PF01217	0.451
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.455
TRG_ENDOCYTIC_2	263	266	PF00928	0.645
TRG_ENDOCYTIC_2	68	71	PF00928	0.479
TRG_NLS_MonoExtC_3	399	404	PF00514	0.622
TRG_NLS_MonoExtN_4	397	404	PF00514	0.621
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P353	Leptomonas seymouri	51%	100%
A0A3Q8IE55	Leishmania donovani	86%	99%
A4HXP8	Leishmania infantum	85%	99%
E9ARF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QE20	Leishmania major	84%	100%