Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AI56_LEIBR

TriTrypDb:

LbrM.17.1300 , LBRM2903_170020100 , LBRM2903_170020200

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.531
CLV_C14_Caspase3-7	513	517	PF00656	0.502
CLV_C14_Caspase3-7	686	690	PF00656	0.568
CLV_NRD_NRD_1	149	151	PF00675	0.541
CLV_NRD_NRD_1	364	366	PF00675	0.646
CLV_NRD_NRD_1	471	473	PF00675	0.635
CLV_NRD_NRD_1	480	482	PF00675	0.540
CLV_NRD_NRD_1	581	583	PF00675	0.654
CLV_NRD_NRD_1	591	593	PF00675	0.595
CLV_NRD_NRD_1	598	600	PF00675	0.544
CLV_PCSK_FUR_1	146	150	PF00082	0.541
CLV_PCSK_KEX2_1	148	150	PF00082	0.541
CLV_PCSK_KEX2_1	364	366	PF00082	0.646
CLV_PCSK_KEX2_1	480	482	PF00082	0.561
CLV_PCSK_KEX2_1	591	593	PF00082	0.786
CLV_PCSK_KEX2_1	597	599	PF00082	0.714
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.776
CLV_PCSK_SKI1_1	547	551	PF00082	0.597
CLV_PCSK_SKI1_1	572	576	PF00082	0.715
CLV_PCSK_SKI1_1	591	595	PF00082	0.504
DEG_APCC_DBOX_1	149	157	PF00400	0.529
DEG_SIAH_1	616	624	PF03145	0.537
DEG_SPOP_SBC_1	194	198	PF00917	0.624
DEG_SPOP_SBC_1	303	307	PF00917	0.699
DEG_SPOP_SBC_1	330	334	PF00917	0.576
DEG_SPOP_SBC_1	510	514	PF00917	0.597
DEG_SPOP_SBC_1	628	632	PF00917	0.573
DEG_SPOP_SBC_1	680	684	PF00917	0.544
DOC_CDC14_PxL_1	489	497	PF14671	0.489
DOC_CKS1_1	324	329	PF01111	0.700
DOC_CYCLIN_yCln2_LP_2	419	425	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	490	496	PF00134	0.488
DOC_MAPK_MEF2A_6	564	573	PF00069	0.572
DOC_PP2B_LxvP_1	186	189	PF13499	0.544
DOC_PP2B_LxvP_1	451	454	PF13499	0.555
DOC_PP2B_LxvP_1	490	493	PF13499	0.484
DOC_PP2B_LxvP_1	95	98	PF13499	0.561
DOC_PP4_FxxP_1	390	393	PF00568	0.584
DOC_PP4_FxxP_1	620	623	PF00568	0.538
DOC_USP7_MATH_1	105	109	PF00917	0.552
DOC_USP7_MATH_1	12	16	PF00917	0.588
DOC_USP7_MATH_1	231	235	PF00917	0.523
DOC_USP7_MATH_1	242	246	PF00917	0.503
DOC_USP7_MATH_1	264	268	PF00917	0.572
DOC_USP7_MATH_1	281	285	PF00917	0.631
DOC_USP7_MATH_1	330	334	PF00917	0.640
DOC_USP7_MATH_1	340	344	PF00917	0.678
DOC_USP7_MATH_1	349	353	PF00917	0.568
DOC_USP7_MATH_1	356	360	PF00917	0.516
DOC_USP7_MATH_1	404	408	PF00917	0.737
DOC_USP7_MATH_1	427	431	PF00917	0.656
DOC_USP7_MATH_1	46	50	PF00917	0.528
DOC_USP7_MATH_1	463	467	PF00917	0.497
DOC_USP7_MATH_1	503	507	PF00917	0.628
DOC_USP7_MATH_1	510	514	PF00917	0.635
DOC_USP7_MATH_1	542	546	PF00917	0.607
DOC_USP7_MATH_1	64	68	PF00917	0.497
DOC_USP7_MATH_1	680	684	PF00917	0.560
DOC_USP7_MATH_1	713	717	PF00917	0.530
DOC_WW_Pin1_4	138	143	PF00397	0.563
DOC_WW_Pin1_4	18	23	PF00397	0.723
DOC_WW_Pin1_4	283	288	PF00397	0.597
DOC_WW_Pin1_4	323	328	PF00397	0.697
DOC_WW_Pin1_4	347	352	PF00397	0.633
DOC_WW_Pin1_4	396	401	PF00397	0.721
DOC_WW_Pin1_4	455	460	PF00397	0.613
DOC_WW_Pin1_4	629	634	PF00397	0.634
DOC_WW_Pin1_4	641	646	PF00397	0.562
DOC_WW_Pin1_4	689	694	PF00397	0.722
DOC_WW_Pin1_4	695	700	PF00397	0.642
LIG_14-3-3_CanoR_1	160	164	PF00244	0.627
LIG_14-3-3_CanoR_1	165	171	PF00244	0.645
LIG_14-3-3_CanoR_1	392	398	PF00244	0.553
LIG_14-3-3_CanoR_1	480	485	PF00244	0.619
LIG_14-3-3_CanoR_1	640	645	PF00244	0.653
LIG_14-3-3_CanoR_1	92	96	PF00244	0.574
LIG_Actin_WH2_2	359	375	PF00022	0.480
LIG_Actin_WH2_2	556	574	PF00022	0.568
LIG_APCC_ABBA_1	116	121	PF00400	0.549
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_4	134	138	PF00653	0.570
LIG_BRCT_BRCA1_1	485	489	PF00533	0.468
LIG_BRCT_BRCA1_1	50	54	PF00533	0.527
LIG_BRCT_BRCA1_1	529	533	PF00533	0.565
LIG_CSL_BTD_1	324	327	PF09270	0.698
LIG_deltaCOP1_diTrp_1	318	325	PF00928	0.536
LIG_deltaCOP1_diTrp_1	529	534	PF00928	0.463
LIG_deltaCOP1_diTrp_1	557	567	PF00928	0.553
LIG_eIF4E_1	568	574	PF01652	0.590
LIG_FHA_1	197	203	PF00498	0.537
LIG_FHA_1	212	218	PF00498	0.493
LIG_FHA_1	242	248	PF00498	0.688
LIG_FHA_1	292	298	PF00498	0.680
LIG_FHA_1	303	309	PF00498	0.573
LIG_FHA_1	324	330	PF00498	0.691
LIG_FHA_1	588	594	PF00498	0.531
LIG_FHA_1	616	622	PF00498	0.616
LIG_FHA_1	632	638	PF00498	0.508
LIG_FHA_1	668	674	PF00498	0.600
LIG_FHA_2	124	130	PF00498	0.662
LIG_FHA_2	326	332	PF00498	0.599
LIG_FHA_2	607	613	PF00498	0.599
LIG_FHA_2	9	15	PF00498	0.683
LIG_GBD_Chelix_1	380	388	PF00786	0.511
LIG_HP1_1	427	431	PF01393	0.528
LIG_LIR_Apic_2	389	393	PF02991	0.580
LIG_LIR_Apic_2	618	623	PF02991	0.539
LIG_LIR_Gen_1	486	496	PF02991	0.495
LIG_LIR_Gen_1	49	59	PF02991	0.695
LIG_LIR_Gen_1	502	511	PF02991	0.490
LIG_LIR_Gen_1	557	568	PF02991	0.556
LIG_LIR_Nem_3	168	174	PF02991	0.670
LIG_LIR_Nem_3	318	324	PF02991	0.535
LIG_LIR_Nem_3	486	492	PF02991	0.488
LIG_LIR_Nem_3	49	55	PF02991	0.695
LIG_LIR_Nem_3	502	507	PF02991	0.489
LIG_LIR_Nem_3	557	563	PF02991	0.553
LIG_LIR_Nem_3	636	642	PF02991	0.524
LIG_LYPXL_yS_3	568	571	PF13949	0.579
LIG_PDZ_Class_2	721	726	PF00595	0.617
LIG_PTB_Apo_2	562	569	PF02174	0.553
LIG_PTB_Phospho_1	562	568	PF10480	0.551
LIG_Rb_pABgroove_1	113	121	PF01858	0.708
LIG_SH2_STAP1	32	36	PF00017	0.536
LIG_SH2_STAT3	558	561	PF00017	0.561
LIG_SH2_STAT5	558	561	PF00017	0.561
LIG_SH3_3	185	191	PF00018	0.568
LIG_SH3_3	215	221	PF00018	0.527
LIG_SH3_3	252	258	PF00018	0.693
LIG_SH3_3	321	327	PF00018	0.697
LIG_SH3_3	490	496	PF00018	0.488
LIG_SH3_3	639	645	PF00018	0.592
LIG_SH3_3	690	696	PF00018	0.566
LIG_Sin3_3	711	718	PF02671	0.454
LIG_SUMO_SIM_par_1	182	187	PF11976	0.540
LIG_SUMO_SIM_par_1	299	307	PF11976	0.698
LIG_SUMO_SIM_par_1	427	433	PF11976	0.529
LIG_TRAF2_1	11	14	PF00917	0.661
LIG_TRAF2_1	440	443	PF00917	0.698
LIG_WW_2	693	696	PF00397	0.560
MOD_CDC14_SPxK_1	141	144	PF00782	0.537
MOD_CDK_SPK_2	396	401	PF00069	0.562
MOD_CDK_SPK_2	695	700	PF00069	0.547
MOD_CDK_SPxK_1	138	144	PF00069	0.548
MOD_CDK_SPxxK_3	18	25	PF00069	0.722
MOD_CK1_1	172	178	PF00069	0.630
MOD_CK1_1	249	255	PF00069	0.689
MOD_CK1_1	302	308	PF00069	0.678
MOD_CK1_1	333	339	PF00069	0.666
MOD_CK1_1	343	349	PF00069	0.673
MOD_CK1_1	458	464	PF00069	0.627
MOD_CK1_1	483	489	PF00069	0.460
MOD_CK1_1	506	512	PF00069	0.614
MOD_CK1_1	524	530	PF00069	0.513
MOD_CK1_1	587	593	PF00069	0.558
MOD_CK1_1	641	647	PF00069	0.610
MOD_CK1_1	67	73	PF00069	0.806
MOD_CK1_1	681	687	PF00069	0.697
MOD_CK1_1	688	694	PF00069	0.672
MOD_CK2_1	18	24	PF00069	0.619
MOD_CK2_1	209	215	PF00069	0.542
MOD_CK2_1	263	269	PF00069	0.665
MOD_CK2_1	307	313	PF00069	0.707
MOD_CK2_1	331	337	PF00069	0.544
MOD_CK2_1	383	389	PF00069	0.501
MOD_CK2_1	437	443	PF00069	0.693
MOD_CK2_1	47	53	PF00069	0.768
MOD_CK2_1	67	73	PF00069	0.734
MOD_CK2_1	8	14	PF00069	0.685
MOD_DYRK1A_RPxSP_1	283	287	PF00069	0.548
MOD_GlcNHglycan	1	4	PF01048	0.679
MOD_GlcNHglycan	107	110	PF01048	0.621
MOD_GlcNHglycan	131	134	PF01048	0.694
MOD_GlcNHglycan	211	214	PF01048	0.538
MOD_GlcNHglycan	237	240	PF01048	0.688
MOD_GlcNHglycan	283	286	PF01048	0.684
MOD_GlcNHglycan	406	409	PF01048	0.735
MOD_GlcNHglycan	415	419	PF01048	0.596
MOD_GlcNHglycan	460	463	PF01048	0.606
MOD_GlcNHglycan	518	521	PF01048	0.554
MOD_GlcNHglycan	542	545	PF01048	0.448
MOD_GlcNHglycan	579	582	PF01048	0.644
MOD_GlcNHglycan	599	602	PF01048	0.515
MOD_GlcNHglycan	604	607	PF01048	0.706
MOD_GlcNHglycan	66	69	PF01048	0.813
MOD_GlcNHglycan	715	718	PF01048	0.604
MOD_GSK3_1	101	108	PF00069	0.632
MOD_GSK3_1	123	130	PF00069	0.694
MOD_GSK3_1	165	172	PF00069	0.611
MOD_GSK3_1	173	180	PF00069	0.549
MOD_GSK3_1	193	200	PF00069	0.559
MOD_GSK3_1	209	216	PF00069	0.613
MOD_GSK3_1	231	238	PF00069	0.528
MOD_GSK3_1	242	249	PF00069	0.575
MOD_GSK3_1	275	282	PF00069	0.574
MOD_GSK3_1	283	290	PF00069	0.576
MOD_GSK3_1	299	306	PF00069	0.659
MOD_GSK3_1	325	332	PF00069	0.671
MOD_GSK3_1	340	347	PF00069	0.593
MOD_GSK3_1	388	395	PF00069	0.662
MOD_GSK3_1	4	11	PF00069	0.529
MOD_GSK3_1	476	483	PF00069	0.621
MOD_GSK3_1	495	502	PF00069	0.458
MOD_GSK3_1	506	513	PF00069	0.595
MOD_GSK3_1	524	531	PF00069	0.462
MOD_GSK3_1	602	609	PF00069	0.758
MOD_GSK3_1	611	618	PF00069	0.626
MOD_GSK3_1	627	634	PF00069	0.541
MOD_GSK3_1	652	659	PF00069	0.505
MOD_GSK3_1	678	685	PF00069	0.704
MOD_GSK3_1	69	76	PF00069	0.593
MOD_N-GLC_1	47	52	PF02516	0.689
MOD_NEK2_1	173	178	PF00069	0.601
MOD_NEK2_1	193	198	PF00069	0.502
MOD_NEK2_1	209	214	PF00069	0.542
MOD_NEK2_1	235	240	PF00069	0.693
MOD_NEK2_1	288	293	PF00069	0.544
MOD_NEK2_1	329	334	PF00069	0.600
MOD_NEK2_1	388	393	PF00069	0.599
MOD_NEK2_1	484	489	PF00069	0.615
MOD_NEK2_1	499	504	PF00069	0.518
MOD_NEK2_1	678	683	PF00069	0.699
MOD_NEK2_2	231	236	PF00069	0.525
MOD_NEK2_2	521	526	PF00069	0.648
MOD_NEK2_2	91	96	PF00069	0.567
MOD_OFUCOSY	434	441	PF10250	0.526
MOD_PIKK_1	175	181	PF00454	0.680
MOD_PIKK_1	349	355	PF00454	0.574
MOD_PIKK_1	383	389	PF00454	0.504
MOD_PIKK_1	532	538	PF00454	0.631
MOD_PIKK_1	542	548	PF00454	0.506
MOD_PKA_1	480	486	PF00069	0.620
MOD_PKA_1	597	603	PF00069	0.659
MOD_PKA_2	121	127	PF00069	0.742
MOD_PKA_2	159	165	PF00069	0.507
MOD_PKA_2	391	397	PF00069	0.553
MOD_PKA_2	480	486	PF00069	0.620
MOD_PKA_2	584	590	PF00069	0.614
MOD_PKA_2	597	603	PF00069	0.680
MOD_PKA_2	655	661	PF00069	0.630
MOD_PKA_2	91	97	PF00069	0.606
MOD_Plk_1	13	19	PF00069	0.643
MOD_Plk_1	272	278	PF00069	0.551
MOD_Plk_1	414	420	PF00069	0.531
MOD_Plk_1	47	53	PF00069	0.688
MOD_Plk_1	528	534	PF00069	0.622
MOD_Plk_4	166	172	PF00069	0.656
MOD_Plk_4	291	297	PF00069	0.540
MOD_Plk_4	480	486	PF00069	0.620
MOD_Plk_4	528	534	PF00069	0.566
MOD_Plk_4	73	79	PF00069	0.581
MOD_ProDKin_1	138	144	PF00069	0.563
MOD_ProDKin_1	18	24	PF00069	0.722
MOD_ProDKin_1	283	289	PF00069	0.595
MOD_ProDKin_1	323	329	PF00069	0.698
MOD_ProDKin_1	347	353	PF00069	0.635
MOD_ProDKin_1	396	402	PF00069	0.721
MOD_ProDKin_1	455	461	PF00069	0.609
MOD_ProDKin_1	629	635	PF00069	0.634
MOD_ProDKin_1	641	647	PF00069	0.562
MOD_ProDKin_1	689	695	PF00069	0.720
TRG_DiLeu_BaEn_1	415	420	PF01217	0.528
TRG_DiLeu_BaEn_1	73	78	PF01217	0.541
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.489
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.530
TRG_ENDOCYTIC_2	568	571	PF00928	0.645
TRG_ENDOCYTIC_2	706	709	PF00928	0.669
TRG_ER_diArg_1	146	149	PF00400	0.543
TRG_ER_diArg_1	363	365	PF00400	0.644
TRG_ER_diArg_1	480	482	PF00400	0.625
TRG_ER_diArg_1	591	593	PF00400	0.780
TRG_NLS_Bipartite_1	582	601	PF00514	0.531
TRG_NLS_MonoExtN_4	595	601	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	591	596	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUL3	Leishmania donovani	61%	100%
E9AR91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QE72	Leishmania major	60%	99%