Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

E9AI54_LEIBR

TriTrypDb:

LbrM.16.1640 , LBRM2903_160024400

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1

Expansion

Sequence features

E9AI54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI54

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0007018	microtubule-based movement	3	10
GO:0009987	cellular process	1	10
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003774	cytoskeletal motor activity	1	10
GO:0003777	microtubule motor activity	2	10
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0005524	ATP binding	5	10
GO:0008017	microtubule binding	5	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0015631	tubulin binding	4	10
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.451
CLV_C14_Caspase3-7	610	614	PF00656	0.773
CLV_C14_Caspase3-7	674	678	PF00656	0.511
CLV_C14_Caspase3-7	806	810	PF00656	0.535
CLV_NRD_NRD_1	118	120	PF00675	0.316
CLV_NRD_NRD_1	415	417	PF00675	0.516
CLV_NRD_NRD_1	423	425	PF00675	0.474
CLV_NRD_NRD_1	556	558	PF00675	0.740
CLV_NRD_NRD_1	568	570	PF00675	0.712
CLV_NRD_NRD_1	59	61	PF00675	0.419
CLV_NRD_NRD_1	603	605	PF00675	0.727
CLV_NRD_NRD_1	688	690	PF00675	0.564
CLV_NRD_NRD_1	716	718	PF00675	0.669
CLV_NRD_NRD_1	842	844	PF00675	0.587
CLV_NRD_NRD_1	848	850	PF00675	0.559
CLV_PCSK_FUR_1	840	844	PF00082	0.619
CLV_PCSK_KEX2_1	118	120	PF00082	0.380
CLV_PCSK_KEX2_1	415	417	PF00082	0.553
CLV_PCSK_KEX2_1	423	425	PF00082	0.478
CLV_PCSK_KEX2_1	568	570	PF00082	0.665
CLV_PCSK_KEX2_1	59	61	PF00082	0.394
CLV_PCSK_KEX2_1	602	604	PF00082	0.677
CLV_PCSK_KEX2_1	688	690	PF00082	0.564
CLV_PCSK_KEX2_1	842	844	PF00082	0.582
CLV_PCSK_KEX2_1	848	850	PF00082	0.533
CLV_PCSK_PC7_1	55	61	PF00082	0.441
CLV_PCSK_SKI1_1	12	16	PF00082	0.393
CLV_PCSK_SKI1_1	246	250	PF00082	0.435
CLV_PCSK_SKI1_1	305	309	PF00082	0.614
CLV_PCSK_SKI1_1	679	683	PF00082	0.511
CLV_PCSK_SKI1_1	688	692	PF00082	0.671
CLV_PCSK_SKI1_1	718	722	PF00082	0.646
CLV_PCSK_SKI1_1	746	750	PF00082	0.632
CLV_PCSK_SKI1_1	865	869	PF00082	0.431
DEG_APCC_DBOX_1	20	28	PF00400	0.283
DEG_APCC_DBOX_1	415	423	PF00400	0.593
DEG_APCC_DBOX_1	567	575	PF00400	0.691
DEG_SCF_FBW7_1	490	497	PF00400	0.707
DEG_SPOP_SBC_1	526	530	PF00917	0.757
DOC_CKS1_1	83	88	PF01111	0.453
DOC_CYCLIN_RxL_1	468	478	PF00134	0.432
DOC_MAPK_gen_1	200	208	PF00069	0.494
DOC_MAPK_gen_1	423	432	PF00069	0.538
DOC_MAPK_gen_1	565	574	PF00069	0.590
DOC_MAPK_MEF2A_6	216	225	PF00069	0.419
DOC_MAPK_MEF2A_6	874	882	PF00069	0.530
DOC_PP1_RVXF_1	744	751	PF00149	0.629
DOC_PP2B_LxvP_1	33	36	PF13499	0.494
DOC_PP2B_LxvP_1	487	490	PF13499	0.638
DOC_PP4_FxxP_1	212	215	PF00568	0.419
DOC_PP4_FxxP_1	312	315	PF00568	0.724
DOC_PP4_FxxP_1	638	641	PF00568	0.648
DOC_PP4_FxxP_1	83	86	PF00568	0.419
DOC_USP7_MATH_1	123	127	PF00917	0.507
DOC_USP7_MATH_1	252	256	PF00917	0.649
DOC_USP7_MATH_1	262	266	PF00917	0.694
DOC_USP7_MATH_1	300	304	PF00917	0.763
DOC_USP7_MATH_1	315	319	PF00917	0.615
DOC_USP7_MATH_1	405	409	PF00917	0.420
DOC_USP7_MATH_1	494	498	PF00917	0.801
DOC_USP7_MATH_1	618	622	PF00917	0.573
DOC_USP7_UBL2_3	558	562	PF12436	0.611
DOC_WW_Pin1_4	191	196	PF00397	0.535
DOC_WW_Pin1_4	223	228	PF00397	0.394
DOC_WW_Pin1_4	339	344	PF00397	0.745
DOC_WW_Pin1_4	490	495	PF00397	0.810
DOC_WW_Pin1_4	710	715	PF00397	0.554
DOC_WW_Pin1_4	82	87	PF00397	0.453
DOC_WW_Pin1_4	857	862	PF00397	0.501
DOC_WW_Pin1_4	91	96	PF00397	0.448
LIG_14-3-3_CanoR_1	468	472	PF00244	0.626
LIG_14-3-3_CanoR_1	511	521	PF00244	0.570
LIG_14-3-3_CanoR_1	569	575	PF00244	0.576
LIG_14-3-3_CanoR_1	633	639	PF00244	0.678
LIG_14-3-3_CanoR_1	851	859	PF00244	0.658
LIG_14-3-3_CanoR_1	874	882	PF00244	0.446
LIG_14-3-3_CanoR_1	915	920	PF00244	0.603
LIG_Actin_WH2_2	34	49	PF00022	0.389
LIG_Actin_WH2_2	733	751	PF00022	0.388
LIG_APCC_ABBA_1	4	9	PF00400	0.394
LIG_APCC_ABBA_1	880	885	PF00400	0.503
LIG_BRCT_BRCA1_1	125	129	PF00533	0.548
LIG_BRCT_BRCA1_1	237	241	PF00533	0.418
LIG_BRCT_BRCA1_1	712	716	PF00533	0.601
LIG_BRCT_BRCA1_1	73	77	PF00533	0.535
LIG_BRCT_BRCA1_2	712	718	PF00533	0.618
LIG_Clathr_ClatBox_1	657	661	PF01394	0.443
LIG_eIF4E_1	652	658	PF01652	0.604
LIG_FHA_1	137	143	PF00498	0.409
LIG_FHA_1	146	152	PF00498	0.497
LIG_FHA_1	192	198	PF00498	0.477
LIG_FHA_1	203	209	PF00498	0.350
LIG_FHA_1	30	36	PF00498	0.514
LIG_FHA_1	375	381	PF00498	0.489
LIG_FHA_1	407	413	PF00498	0.505
LIG_FHA_1	470	476	PF00498	0.530
LIG_FHA_1	761	767	PF00498	0.527
LIG_FHA_1	77	83	PF00498	0.451
LIG_FHA_1	821	827	PF00498	0.538
LIG_FHA_2	110	116	PF00498	0.520
LIG_FHA_2	148	154	PF00498	0.494
LIG_FHA_2	166	172	PF00498	0.494
LIG_FHA_2	229	235	PF00498	0.394
LIG_FHA_2	318	324	PF00498	0.693
LIG_FHA_2	376	382	PF00498	0.634
LIG_FHA_2	423	429	PF00498	0.588
LIG_FHA_2	43	49	PF00498	0.482
LIG_FHA_2	481	487	PF00498	0.508
LIG_FHA_2	498	504	PF00498	0.852
LIG_FHA_2	605	611	PF00498	0.554
LIG_FHA_2	866	872	PF00498	0.488
LIG_LIR_Apic_2	210	215	PF02991	0.419
LIG_LIR_Apic_2	636	641	PF02991	0.600
LIG_LIR_Apic_2	81	86	PF02991	0.416
LIG_LIR_Apic_2	829	834	PF02991	0.493
LIG_LIR_Gen_1	105	114	PF02991	0.283
LIG_LIR_Gen_1	168	178	PF02991	0.419
LIG_LIR_Gen_1	730	740	PF02991	0.410
LIG_LIR_Gen_1	876	883	PF02991	0.489
LIG_LIR_Nem_3	105	111	PF02991	0.471
LIG_LIR_Nem_3	168	173	PF02991	0.451
LIG_LIR_Nem_3	2	7	PF02991	0.283
LIG_LIR_Nem_3	713	719	PF02991	0.557
LIG_LIR_Nem_3	730	735	PF02991	0.372
LIG_LIR_Nem_3	74	80	PF02991	0.507
LIG_LIR_Nem_3	772	778	PF02991	0.361
LIG_LIR_Nem_3	876	882	PF02991	0.437
LIG_LIR_Nem_3	891	895	PF02991	0.557
LIG_MLH1_MIPbox_1	237	241	PF16413	0.451
LIG_MYND_1	910	914	PF01753	0.564
LIG_PCNA_PIPBox_1	326	335	PF02747	0.590
LIG_PCNA_yPIPBox_3	297	311	PF02747	0.509
LIG_PCNA_yPIPBox_3	758	771	PF02747	0.352
LIG_Pex14_1	879	883	PF04695	0.447
LIG_Pex14_2	308	312	PF04695	0.775
LIG_Pex14_2	731	735	PF04695	0.560
LIG_RPA_C_Fungi	388	400	PF08784	0.666
LIG_SH2_CRK	146	150	PF00017	0.426
LIG_SH2_NCK_1	53	57	PF00017	0.516
LIG_SH2_SRC	34	37	PF00017	0.283
LIG_SH2_STAP1	471	475	PF00017	0.467
LIG_SH2_STAP1	53	57	PF00017	0.535
LIG_SH2_STAP1	719	723	PF00017	0.576
LIG_SH2_STAT3	672	675	PF00017	0.572
LIG_SH2_STAT3	724	727	PF00017	0.487
LIG_SH2_STAT5	240	243	PF00017	0.419
LIG_SH2_STAT5	267	270	PF00017	0.595
LIG_SH2_STAT5	34	37	PF00017	0.420
LIG_SH2_STAT5	471	474	PF00017	0.435
LIG_SH2_STAT5	672	675	PF00017	0.472
LIG_SH2_STAT5	732	735	PF00017	0.365
LIG_SH2_STAT5	739	742	PF00017	0.393
LIG_SH2_STAT5	898	901	PF00017	0.558
LIG_SH3_2	195	200	PF14604	0.535
LIG_SH3_3	192	198	PF00018	0.535
LIG_SH3_3	20	26	PF00018	0.430
LIG_SH3_3	581	587	PF00018	0.620
LIG_SH3_3	750	756	PF00018	0.574
LIG_SH3_3	83	89	PF00018	0.479
LIG_SUMO_SIM_anti_2	483	489	PF11976	0.511
LIG_SUMO_SIM_par_1	147	153	PF11976	0.535
LIG_SUMO_SIM_par_1	570	575	PF11976	0.573
LIG_TRAF2_1	231	234	PF00917	0.494
LIG_TYR_ITIM	144	149	PF00017	0.451
LIG_WRC_WIRS_1	732	737	PF05994	0.439
LIG_WRC_WIRS_1	889	894	PF05994	0.416
MOD_CDK_SPxxK_3	339	346	PF00069	0.743
MOD_CDK_SPxxK_3	710	717	PF00069	0.606
MOD_CK1_1	147	153	PF00069	0.451
MOD_CK1_1	497	503	PF00069	0.807
MOD_CK1_1	519	525	PF00069	0.804
MOD_CK1_1	528	534	PF00069	0.763
MOD_CK1_1	582	588	PF00069	0.653
MOD_CK1_1	71	77	PF00069	0.408
MOD_CK1_1	900	906	PF00069	0.485
MOD_CK2_1	109	115	PF00069	0.458
MOD_CK2_1	228	234	PF00069	0.394
MOD_CK2_1	317	323	PF00069	0.505
MOD_CK2_1	346	352	PF00069	0.649
MOD_CK2_1	422	428	PF00069	0.570
MOD_CK2_1	480	486	PF00069	0.552
MOD_CK2_1	497	503	PF00069	0.852
MOD_CK2_1	604	610	PF00069	0.758
MOD_CK2_1	818	824	PF00069	0.620
MOD_CK2_1	857	863	PF00069	0.428
MOD_CK2_1	888	894	PF00069	0.541
MOD_GlcNHglycan	254	257	PF01048	0.642
MOD_GlcNHglycan	264	267	PF01048	0.669
MOD_GlcNHglycan	298	301	PF01048	0.511
MOD_GlcNHglycan	317	320	PF01048	0.443
MOD_GlcNHglycan	394	398	PF01048	0.651
MOD_GlcNHglycan	496	499	PF01048	0.755
MOD_GlcNHglycan	503	506	PF01048	0.731
MOD_GlcNHglycan	65	68	PF01048	0.388
MOD_GlcNHglycan	743	746	PF01048	0.467
MOD_GlcNHglycan	786	789	PF01048	0.792
MOD_GlcNHglycan	819	823	PF01048	0.410
MOD_GlcNHglycan	875	878	PF01048	0.431
MOD_GlcNHglycan	904	907	PF01048	0.753
MOD_GSK3_1	228	235	PF00069	0.394
MOD_GSK3_1	246	253	PF00069	0.579
MOD_GSK3_1	296	303	PF00069	0.730
MOD_GSK3_1	389	396	PF00069	0.520
MOD_GSK3_1	490	497	PF00069	0.742
MOD_GSK3_1	512	519	PF00069	0.750
MOD_GSK3_1	521	528	PF00069	0.667
MOD_GSK3_1	570	577	PF00069	0.653
MOD_GSK3_1	63	70	PF00069	0.426
MOD_GSK3_1	705	712	PF00069	0.625
MOD_GSK3_1	731	738	PF00069	0.498
MOD_GSK3_1	87	94	PF00069	0.472
MOD_GSK3_1	884	891	PF00069	0.608
MOD_N-GLC_1	176	181	PF02516	0.412
MOD_N-GLC_1	223	228	PF02516	0.394
MOD_N-GLC_1	511	516	PF02516	0.780
MOD_N-GLC_1	582	587	PF02516	0.763
MOD_N-GLC_1	67	72	PF02516	0.419
MOD_N-GLC_2	615	617	PF02516	0.589
MOD_NEK2_1	136	141	PF00069	0.513
MOD_NEK2_1	145	150	PF00069	0.521
MOD_NEK2_1	208	213	PF00069	0.394
MOD_NEK2_1	422	427	PF00069	0.630
MOD_NEK2_1	475	480	PF00069	0.573
MOD_NEK2_1	510	515	PF00069	0.695
MOD_NEK2_1	521	526	PF00069	0.734
MOD_NEK2_1	574	579	PF00069	0.769
MOD_NEK2_1	653	658	PF00069	0.581
MOD_NEK2_1	671	676	PF00069	0.409
MOD_NEK2_1	691	696	PF00069	0.585
MOD_NEK2_1	709	714	PF00069	0.528
MOD_NEK2_1	731	736	PF00069	0.514
MOD_NEK2_1	827	832	PF00069	0.621
MOD_NEK2_1	873	878	PF00069	0.432
MOD_NEK2_2	267	272	PF00069	0.644
MOD_NEK2_2	42	47	PF00069	0.330
MOD_NEK2_2	590	595	PF00069	0.512
MOD_OFUCOSY	509	516	PF10250	0.666
MOD_PIKK_1	300	306	PF00454	0.480
MOD_PIKK_1	364	370	PF00454	0.651
MOD_PIKK_1	475	481	PF00454	0.519
MOD_PIKK_1	671	677	PF00454	0.626
MOD_PK_1	532	538	PF00069	0.705
MOD_PK_1	884	890	PF00069	0.623
MOD_PKA_2	208	214	PF00069	0.409
MOD_PKA_2	29	35	PF00069	0.283
MOD_PKA_2	296	302	PF00069	0.512
MOD_PKA_2	422	428	PF00069	0.594
MOD_PKA_2	433	439	PF00069	0.409
MOD_PKA_2	467	473	PF00069	0.596
MOD_PKA_2	510	516	PF00069	0.819
MOD_PKA_2	564	570	PF00069	0.602
MOD_PKA_2	62	68	PF00069	0.407
MOD_PKA_2	634	640	PF00069	0.540
MOD_PKA_2	741	747	PF00069	0.554
MOD_PKA_2	873	879	PF00069	0.431
MOD_PKA_2	914	920	PF00069	0.542
MOD_PKB_1	602	610	PF00069	0.548
MOD_PKB_1	849	857	PF00069	0.656
MOD_Plk_1	176	182	PF00069	0.412
MOD_Plk_1	232	238	PF00069	0.394
MOD_Plk_1	393	399	PF00069	0.588
MOD_Plk_1	405	411	PF00069	0.565
MOD_Plk_1	475	481	PF00069	0.629
MOD_Plk_1	519	525	PF00069	0.784
MOD_Plk_1	626	632	PF00069	0.679
MOD_Plk_1	865	871	PF00069	0.369
MOD_Plk_1	900	906	PF00069	0.485
MOD_Plk_4	202	208	PF00069	0.416
MOD_Plk_4	235	241	PF00069	0.405
MOD_Plk_4	29	35	PF00069	0.332
MOD_Plk_4	346	352	PF00069	0.586
MOD_Plk_4	480	486	PF00069	0.607
MOD_Plk_4	653	659	PF00069	0.463
MOD_Plk_4	735	741	PF00069	0.340
MOD_Plk_4	760	766	PF00069	0.491
MOD_Plk_4	798	804	PF00069	0.573
MOD_Plk_4	834	840	PF00069	0.467
MOD_Plk_4	884	890	PF00069	0.574
MOD_ProDKin_1	191	197	PF00069	0.535
MOD_ProDKin_1	223	229	PF00069	0.394
MOD_ProDKin_1	339	345	PF00069	0.743
MOD_ProDKin_1	490	496	PF00069	0.812
MOD_ProDKin_1	710	716	PF00069	0.552
MOD_ProDKin_1	82	88	PF00069	0.453
MOD_ProDKin_1	857	863	PF00069	0.502
MOD_ProDKin_1	91	97	PF00069	0.448
MOD_SUMO_for_1	403	406	PF00179	0.650
TRG_DiLeu_BaEn_1	428	433	PF01217	0.557
TRG_DiLeu_BaEn_4	428	434	PF01217	0.434
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.601
TRG_ENDOCYTIC_2	146	149	PF00928	0.426
TRG_ENDOCYTIC_2	597	600	PF00928	0.752
TRG_ENDOCYTIC_2	732	735	PF00928	0.420
TRG_ER_diArg_1	422	424	PF00400	0.614
TRG_ER_diArg_1	59	61	PF00400	0.388
TRG_ER_diArg_1	601	604	PF00400	0.538
TRG_ER_diArg_1	688	690	PF00400	0.651
TRG_ER_diArg_1	839	842	PF00400	0.574
TRG_ER_diArg_1	848	851	PF00400	0.616
TRG_ER_diArg_1	856	859	PF00400	0.590
TRG_ER_FFAT_2	519	529	PF00635	0.574
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P672	Leptomonas seymouri	48%	87%
A0A0S4IXS6	Bodo saltans	30%	89%
A0A1X0NYU1	Trypanosomatidae	33%	91%
A0A3S7WU65	Leishmania donovani	69%	85%
A4HX56	Leishmania infantum	69%	85%
E9AQX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	87%
Q4QEK7	Leishmania major	68%	100%
V5BI80	Trypanosoma cruzi	33%	89%