Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI52_LEIBR

TriTrypDb:

LbrM.16.0190 , LBRM2903_160007100

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.796
CLV_PCSK_KEX2_1	155	157	PF00082	0.680
CLV_PCSK_KEX2_1	18	20	PF00082	0.796
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.680
CLV_PCSK_SKI1_1	126	130	PF00082	0.659
CLV_PCSK_SKI1_1	139	143	PF00082	0.602
CLV_PCSK_SKI1_1	158	162	PF00082	0.675
DOC_CKS1_1	45	50	PF01111	0.742
DOC_MAPK_gen_1	137	144	PF00069	0.696
DOC_USP7_MATH_1	149	153	PF00917	0.621
DOC_USP7_MATH_1	23	27	PF00917	0.524
DOC_WW_Pin1_4	161	166	PF00397	0.754
DOC_WW_Pin1_4	44	49	PF00397	0.614
LIG_14-3-3_CanoR_1	39	48	PF00244	0.742
LIG_BRCT_BRCA1_1	74	78	PF00533	0.744
LIG_FHA_2	45	51	PF00498	0.742
LIG_FHA_2	88	94	PF00498	0.599
LIG_LIR_Apic_2	43	48	PF02991	0.744
LIG_LIR_Gen_1	129	138	PF02991	0.539
LIG_LIR_Gen_1	95	105	PF02991	0.714
LIG_LIR_Nem_3	129	135	PF02991	0.539
LIG_LIR_Nem_3	95	100	PF02991	0.696
LIG_PCNA_yPIPBox_3	27	41	PF02747	0.512
LIG_SH2_CRK	97	101	PF00017	0.705
LIG_SH2_PTP2	45	48	PF00017	0.695
LIG_SH2_STAT5	45	48	PF00017	0.695
LIG_TRAF2_1	165	168	PF00917	0.616
MOD_CK1_1	121	127	PF00069	0.726
MOD_CK1_1	154	160	PF00069	0.571
MOD_CK1_1	44	50	PF00069	0.742
MOD_CK1_1	66	72	PF00069	0.642
MOD_CK2_1	161	167	PF00069	0.754
MOD_CK2_1	29	35	PF00069	0.532
MOD_CK2_1	66	72	PF00069	0.759
MOD_CK2_1	87	93	PF00069	0.593
MOD_GlcNHglycan	120	123	PF01048	0.738
MOD_GlcNHglycan	151	154	PF01048	0.526
MOD_GlcNHglycan	65	68	PF01048	0.683
MOD_GSK3_1	147	154	PF00069	0.536
MOD_GSK3_1	37	44	PF00069	0.739
MOD_GSK3_1	59	66	PF00069	0.669
MOD_GSK3_1	68	75	PF00069	0.655
MOD_GSK3_1	89	96	PF00069	0.585
MOD_N-GLC_1	21	26	PF02516	0.644
MOD_NEK2_1	100	105	PF00069	0.615
MOD_NEK2_1	29	34	PF00069	0.527
MOD_NEK2_1	77	82	PF00069	0.588
MOD_PKA_2	93	99	PF00069	0.708
MOD_Plk_2-3	163	169	PF00069	0.706
MOD_Plk_4	29	35	PF00069	0.575
MOD_Plk_4	41	47	PF00069	0.732
MOD_Plk_4	59	65	PF00069	0.503
MOD_Plk_4	72	78	PF00069	0.617
MOD_ProDKin_1	161	167	PF00069	0.754
MOD_ProDKin_1	44	50	PF00069	0.610
TRG_ENDOCYTIC_2	132	135	PF00928	0.699
TRG_ENDOCYTIC_2	97	100	PF00928	0.701
TRG_ER_diArg_1	156	159	PF00400	0.728
TRG_ER_diArg_1	17	19	PF00400	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTR1	Leishmania donovani	93%	100%
A0A422NDE0	Trypanosoma rangeli	35%	98%
A4HWR7	Leishmania infantum	93%	100%
C9ZW57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E9AQH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QF02	Leishmania major	89%	100%
V5AP83	Trypanosoma cruzi	37%	98%