VPS9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AI50_LEIBR

TriTrypDb:

LbrM.15.0520 , LBRM2903_150010600

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.695
CLV_NRD_NRD_1	221	223	PF00675	0.518
CLV_NRD_NRD_1	511	513	PF00675	0.733
CLV_PCSK_FUR_1	509	513	PF00082	0.728
CLV_PCSK_KEX2_1	212	214	PF00082	0.736
CLV_PCSK_KEX2_1	511	513	PF00082	0.733
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.736
CLV_PCSK_SKI1_1	223	227	PF00082	0.539
CLV_PCSK_SKI1_1	40	44	PF00082	0.598
CLV_PCSK_SKI1_1	410	414	PF00082	0.730
CLV_PCSK_SKI1_1	60	64	PF00082	0.693
DEG_COP1_1	313	323	PF00400	0.564
DEG_SCF_FBW7_1	21	28	PF00400	0.825
DEG_SPOP_SBC_1	127	131	PF00917	0.628
DEG_SPOP_SBC_1	304	308	PF00917	0.724
DOC_CKS1_1	203	208	PF01111	0.698
DOC_CKS1_1	22	27	PF01111	0.838
DOC_CKS1_1	346	351	PF01111	0.797
DOC_CYCLIN_RxL_1	57	66	PF00134	0.714
DOC_CYCLIN_yCln2_LP_2	274	280	PF00134	0.584
DOC_CYCLIN_yCln2_LP_2	398	401	PF00134	0.622
DOC_MAPK_MEF2A_6	40	48	PF00069	0.597
DOC_PP1_RVXF_1	58	64	PF00149	0.712
DOC_PP2B_LxvP_1	250	253	PF13499	0.639
DOC_PP2B_LxvP_1	398	401	PF13499	0.622
DOC_PP2B_LxvP_1	412	415	PF13499	0.649
DOC_PP4_MxPP_1	251	254	PF00568	0.776
DOC_PP4_MxPP_1	301	304	PF00568	0.826
DOC_USP7_MATH_1	198	202	PF00917	0.809
DOC_USP7_MATH_1	267	271	PF00917	0.726
DOC_USP7_MATH_1	304	308	PF00917	0.724
DOC_USP7_MATH_1	336	340	PF00917	0.673
DOC_USP7_MATH_1	386	390	PF00917	0.747
DOC_USP7_MATH_1	504	508	PF00917	0.550
DOC_USP7_MATH_1	514	518	PF00917	0.626
DOC_USP7_MATH_1	615	619	PF00917	0.837
DOC_USP7_MATH_1	673	677	PF00917	0.656
DOC_USP7_UBL2_3	219	223	PF12436	0.523
DOC_WW_Pin1_4	120	125	PF00397	0.720
DOC_WW_Pin1_4	138	143	PF00397	0.720
DOC_WW_Pin1_4	166	171	PF00397	0.773
DOC_WW_Pin1_4	17	22	PF00397	0.808
DOC_WW_Pin1_4	187	192	PF00397	0.765
DOC_WW_Pin1_4	202	207	PF00397	0.704
DOC_WW_Pin1_4	226	231	PF00397	0.712
DOC_WW_Pin1_4	235	240	PF00397	0.732
DOC_WW_Pin1_4	25	30	PF00397	0.711
DOC_WW_Pin1_4	254	259	PF00397	0.713
DOC_WW_Pin1_4	260	265	PF00397	0.729
DOC_WW_Pin1_4	273	278	PF00397	0.779
DOC_WW_Pin1_4	299	304	PF00397	0.679
DOC_WW_Pin1_4	329	334	PF00397	0.821
DOC_WW_Pin1_4	345	350	PF00397	0.697
DOC_WW_Pin1_4	357	362	PF00397	0.708
DOC_WW_Pin1_4	47	52	PF00397	0.841
DOC_WW_Pin1_4	69	74	PF00397	0.760
LIG_14-3-3_CanoR_1	16	20	PF00244	0.837
LIG_14-3-3_CanoR_1	305	314	PF00244	0.727
LIG_14-3-3_CanoR_1	410	415	PF00244	0.739
LIG_14-3-3_CanoR_1	60	66	PF00244	0.716
LIG_APCC_ABBA_1	370	375	PF00400	0.588
LIG_APCC_ABBA_1	646	651	PF00400	0.776
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BIR_III_2	570	574	PF00653	0.585
LIG_BRCT_BRCA1_1	434	438	PF00533	0.634
LIG_BRCT_BRCA1_1	642	646	PF00533	0.723
LIG_BRCT_BRCA1_1	651	655	PF00533	0.644
LIG_CtBP_PxDLS_1	253	257	PF00389	0.703
LIG_deltaCOP1_diTrp_1	651	655	PF00928	0.796
LIG_EVH1_1	139	143	PF00568	0.589
LIG_EVH1_1	399	403	PF00568	0.624
LIG_FHA_1	108	114	PF00498	0.824
LIG_FHA_1	346	352	PF00498	0.800
LIG_FHA_1	379	385	PF00498	0.666
LIG_FHA_1	484	490	PF00498	0.690
LIG_FHA_2	461	467	PF00498	0.764
LIG_FHA_2	471	477	PF00498	0.656
LIG_FHA_2	620	626	PF00498	0.581
LIG_IBAR_NPY_1	344	346	PF08397	0.679
LIG_IBAR_NPY_1	647	649	PF08397	0.670
LIG_Integrin_RGD_1	568	570	PF01839	0.586
LIG_IRF3_LxIS_1	151	156	PF10401	0.813
LIG_LIR_Gen_1	435	446	PF02991	0.764
LIG_LIR_Gen_1	476	484	PF02991	0.632
LIG_LIR_Nem_3	313	317	PF02991	0.782
LIG_LIR_Nem_3	435	441	PF02991	0.649
LIG_LIR_Nem_3	476	481	PF02991	0.619
LIG_LIR_Nem_3	64	68	PF02991	0.712
LIG_LIR_Nem_3	643	649	PF02991	0.675
LIG_MYND_1	254	258	PF01753	0.589
LIG_PAM2_1	644	656	PF00658	0.682
LIG_PROFILIN_1	400	406	PF00235	0.731
LIG_SH2_CRK	317	321	PF00017	0.711
LIG_SH2_CRK	346	350	PF00017	0.799
LIG_SH2_CRK	68	72	PF00017	0.724
LIG_SH2_SRC	649	652	PF00017	0.781
LIG_SH2_STAP1	471	475	PF00017	0.723
LIG_SH2_STAP1	613	617	PF00017	0.802
LIG_SH2_STAP1	649	653	PF00017	0.682
LIG_SH2_STAT3	527	530	PF00017	0.829
LIG_SH2_STAT5	224	227	PF00017	0.700
LIG_SH2_STAT5	428	431	PF00017	0.688
LIG_SH2_STAT5	678	681	PF00017	0.720
LIG_SH3_1	397	403	PF00018	0.628
LIG_SH3_3	137	143	PF00018	0.691
LIG_SH3_3	19	25	PF00018	0.608
LIG_SH3_3	203	209	PF00018	0.705
LIG_SH3_3	258	264	PF00018	0.723
LIG_SH3_3	330	336	PF00018	0.763
LIG_SH3_3	38	44	PF00018	0.643
LIG_SH3_3	397	403	PF00018	0.628
LIG_SH3_3	442	448	PF00018	0.641
LIG_SUMO_SIM_par_1	151	156	PF11976	0.711
LIG_SUMO_SIM_par_1	257	263	PF11976	0.573
LIG_SUMO_SIM_par_1	281	286	PF11976	0.707
LIG_TRAF2_1	463	466	PF00917	0.665
LIG_TRAF2_1	89	92	PF00917	0.804
LIG_TRAF2_2	372	377	PF00917	0.572
LIG_WW_2	403	406	PF00397	0.724
LIG_WW_3	302	306	PF00397	0.724
MOD_CDC14_SPxK_1	302	305	PF00782	0.723
MOD_CDK_SPxK_1	299	305	PF00069	0.726
MOD_CK1_1	108	114	PF00069	0.683
MOD_CK1_1	190	196	PF00069	0.723
MOD_CK1_1	2	8	PF00069	0.724
MOD_CK1_1	201	207	PF00069	0.790
MOD_CK1_1	257	263	PF00069	0.684
MOD_CK1_1	28	34	PF00069	0.752
MOD_CK1_1	306	312	PF00069	0.792
MOD_CK1_1	313	319	PF00069	0.712
MOD_CK1_1	327	333	PF00069	0.737
MOD_CK1_1	389	395	PF00069	0.697
MOD_CK1_1	450	456	PF00069	0.755
MOD_CK1_1	459	465	PF00069	0.783
MOD_CK1_1	507	513	PF00069	0.788
MOD_CK1_1	515	521	PF00069	0.723
MOD_CK1_1	562	568	PF00069	0.568
MOD_CK1_1	656	662	PF00069	0.716
MOD_CK1_1	74	80	PF00069	0.631
MOD_CK2_1	459	465	PF00069	0.682
MOD_Cter_Amidation	220	223	PF01082	0.520
MOD_GlcNHglycan	136	139	PF01048	0.712
MOD_GlcNHglycan	155	158	PF01048	0.723
MOD_GlcNHglycan	172	175	PF01048	0.618
MOD_GlcNHglycan	198	201	PF01048	0.699
MOD_GlcNHglycan	206	209	PF01048	0.754
MOD_GlcNHglycan	216	219	PF01048	0.704
MOD_GlcNHglycan	235	238	PF01048	0.788
MOD_GlcNHglycan	242	245	PF01048	0.552
MOD_GlcNHglycan	289	292	PF01048	0.560
MOD_GlcNHglycan	329	332	PF01048	0.828
MOD_GlcNHglycan	390	394	PF01048	0.736
MOD_GlcNHglycan	506	509	PF01048	0.706
MOD_GlcNHglycan	523	526	PF01048	0.747
MOD_GlcNHglycan	535	538	PF01048	0.741
MOD_GlcNHglycan	555	558	PF01048	0.471
MOD_GlcNHglycan	576	579	PF01048	0.620
MOD_GlcNHglycan	603	606	PF01048	0.737
MOD_GlcNHglycan	617	620	PF01048	0.802
MOD_GlcNHglycan	655	658	PF01048	0.701
MOD_GlcNHglycan	82	85	PF01048	0.608
MOD_GSK3_1	105	112	PF00069	0.721
MOD_GSK3_1	127	134	PF00069	0.716
MOD_GSK3_1	138	145	PF00069	0.728
MOD_GSK3_1	166	173	PF00069	0.797
MOD_GSK3_1	17	24	PF00069	0.793
MOD_GSK3_1	198	205	PF00069	0.710
MOD_GSK3_1	299	306	PF00069	0.751
MOD_GSK3_1	352	359	PF00069	0.720
MOD_GSK3_1	448	455	PF00069	0.706
MOD_GSK3_1	456	463	PF00069	0.702
MOD_GSK3_1	615	622	PF00069	0.745
MOD_GSK3_1	649	656	PF00069	0.689
MOD_GSK3_1	71	78	PF00069	0.734
MOD_LATS_1	572	578	PF00433	0.588
MOD_N-GLC_1	114	119	PF02516	0.710
MOD_N-GLC_1	134	139	PF02516	0.688
MOD_N-GLC_1	254	259	PF02516	0.713
MOD_N-GLC_1	287	292	PF02516	0.795
MOD_N-GLC_1	357	362	PF02516	0.567
MOD_N-GLC_1	378	383	PF02516	0.684
MOD_N-GLC_1	459	464	PF02516	0.783
MOD_N-GLC_1	562	567	PF02516	0.622
MOD_N-GLC_1	69	74	PF02516	0.829
MOD_NEK2_1	1	6	PF00069	0.831
MOD_NEK2_1	100	105	PF00069	0.568
MOD_NEK2_1	153	158	PF00069	0.711
MOD_NEK2_1	233	238	PF00069	0.707
MOD_NEK2_1	352	357	PF00069	0.720
MOD_NEK2_1	655	660	PF00069	0.809
MOD_NEK2_1	674	679	PF00069	0.724
MOD_PIKK_1	177	183	PF00454	0.803
MOD_PIKK_1	267	273	PF00454	0.820
MOD_PIKK_1	338	344	PF00454	0.564
MOD_PIKK_1	512	518	PF00454	0.845
MOD_PIKK_1	619	625	PF00454	0.581
MOD_PIKK_1	683	689	PF00454	0.728
MOD_PIKK_1	8	14	PF00454	0.828
MOD_PK_1	347	353	PF00069	0.704
MOD_PKA_2	131	137	PF00069	0.847
MOD_PKA_2	15	21	PF00069	0.830
MOD_PKA_2	304	310	PF00069	0.820
MOD_PKA_2	601	607	PF00069	0.811
MOD_PKA_2	682	688	PF00069	0.740
MOD_Plk_1	134	140	PF00069	0.595
MOD_Plk_1	465	471	PF00069	0.491
MOD_Plk_4	324	330	PF00069	0.714
MOD_Plk_4	347	353	PF00069	0.675
MOD_Plk_4	674	680	PF00069	0.629
MOD_ProDKin_1	120	126	PF00069	0.720
MOD_ProDKin_1	138	144	PF00069	0.719
MOD_ProDKin_1	166	172	PF00069	0.776
MOD_ProDKin_1	17	23	PF00069	0.808
MOD_ProDKin_1	187	193	PF00069	0.765
MOD_ProDKin_1	202	208	PF00069	0.703
MOD_ProDKin_1	226	232	PF00069	0.710
MOD_ProDKin_1	235	241	PF00069	0.731
MOD_ProDKin_1	25	31	PF00069	0.715
MOD_ProDKin_1	254	260	PF00069	0.714
MOD_ProDKin_1	273	279	PF00069	0.777
MOD_ProDKin_1	299	305	PF00069	0.680
MOD_ProDKin_1	329	335	PF00069	0.816
MOD_ProDKin_1	345	351	PF00069	0.696
MOD_ProDKin_1	357	363	PF00069	0.711
MOD_ProDKin_1	47	53	PF00069	0.839
MOD_ProDKin_1	69	75	PF00069	0.761
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.635
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.712
TRG_ENDOCYTIC_2	317	320	PF00928	0.717
TRG_ENDOCYTIC_2	68	71	PF00928	0.724
TRG_ENDOCYTIC_2	696	699	PF00928	0.830
TRG_ER_diArg_1	509	512	PF00400	0.710
TRG_ER_diArg_1	538	541	PF00400	0.829

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J0	Leptomonas seymouri	38%	97%
A0A3S5H6U8	Leishmania donovani	78%	100%
A4HWG3	Leishmania infantum	78%	100%
E9AQ63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
Q4QFC0	Leishmania major	75%	96%