LeishMANIAdb
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Na_H_Exchanger domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Na_H_Exchanger domain-containing protein
Gene product:
sodium/hydrogen exchanger, putative
Species:
Leishmania braziliensis
UniProt:
E9AI47_LEIBR
TriTrypDb:
LbrM.14.0960 , LBRM2903_140015300 *
Length:
785

Annotations

LeishMANIAdb annotations

Homologous to animal Na+ / H+ exchangers.. Interestingly most heavily expanded in Strigomonas species and the non-parazitic Bodo saltans

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 17

Expansion

Sequence features

E9AI47
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI47

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 14
GO:0005451 obsolete monoatomic cation:proton antiporter activity 5 14
GO:0008324 monoatomic cation transmembrane transporter activity 4 14
GO:0015075 monoatomic ion transmembrane transporter activity 3 14
GO:0015078 proton transmembrane transporter activity 5 14
GO:0015291 secondary active transmembrane transporter activity 4 14
GO:0015297 antiporter activity 5 14
GO:0015298 obsolete solute:monoatomic cation antiporter activity 5 14
GO:0015299 obsolete solute:proton antiporter activity 6 14
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 14
GO:0022804 active transmembrane transporter activity 3 14
GO:0022853 active monoatomic ion transmembrane transporter activity 4 14
GO:0022857 transmembrane transporter activity 2 14
GO:0022890 inorganic cation transmembrane transporter activity 4 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 745 749 PF00656 0.751
CLV_NRD_NRD_1 252 254 PF00675 0.370
CLV_NRD_NRD_1 571 573 PF00675 0.292
CLV_NRD_NRD_1 734 736 PF00675 0.482
CLV_PCSK_FUR_1 569 573 PF00082 0.197
CLV_PCSK_KEX2_1 252 254 PF00082 0.381
CLV_PCSK_KEX2_1 571 573 PF00082 0.326
CLV_PCSK_KEX2_1 727 729 PF00082 0.383
CLV_PCSK_KEX2_1 734 736 PF00082 0.493
CLV_PCSK_PC1ET2_1 727 729 PF00082 0.403
CLV_PCSK_PC1ET2_1 734 736 PF00082 0.511
CLV_PCSK_SKI1_1 333 337 PF00082 0.560
CLV_PCSK_SKI1_1 609 613 PF00082 0.535
DEG_COP1_1 24 34 PF00400 0.623
DEG_SCF_SKP2-CKS1_1 727 734 PF00560 0.570
DEG_SPOP_SBC_1 53 57 PF00917 0.621
DOC_CKS1_1 137 142 PF01111 0.612
DOC_MAPK_DCC_7 309 319 PF00069 0.504
DOC_MAPK_gen_1 647 654 PF00069 0.543
DOC_MAPK_HePTP_8 261 273 PF00069 0.393
DOC_MAPK_MEF2A_6 242 249 PF00069 0.560
DOC_MAPK_MEF2A_6 257 265 PF00069 0.434
DOC_MAPK_MEF2A_6 349 356 PF00069 0.334
DOC_MAPK_MEF2A_6 471 478 PF00069 0.315
DOC_MAPK_MEF2A_6 647 654 PF00069 0.543
DOC_PP1_RVXF_1 262 268 PF00149 0.432
DOC_PP2B_LxvP_1 122 125 PF13499 0.605
DOC_PP2B_LxvP_1 311 314 PF13499 0.359
DOC_PP4_FxxP_1 50 53 PF00568 0.777
DOC_SPAK_OSR1_1 631 635 PF12202 0.452
DOC_USP7_MATH_1 11 15 PF00917 0.789
DOC_USP7_MATH_1 132 136 PF00917 0.617
DOC_USP7_MATH_1 662 666 PF00917 0.359
DOC_USP7_MATH_1 749 753 PF00917 0.719
DOC_USP7_MATH_1 89 93 PF00917 0.709
DOC_USP7_UBL2_3 362 366 PF12436 0.560
DOC_USP7_UBL2_3 605 609 PF12436 0.364
DOC_WW_Pin1_4 100 105 PF00397 0.703
DOC_WW_Pin1_4 136 141 PF00397 0.709
DOC_WW_Pin1_4 415 420 PF00397 0.335
DOC_WW_Pin1_4 728 733 PF00397 0.568
DOC_WW_Pin1_4 94 99 PF00397 0.747
LIG_14-3-3_CanoR_1 54 59 PF00244 0.781
LIG_14-3-3_CanoR_1 631 637 PF00244 0.356
LIG_BIR_II_1 1 5 PF00653 0.608
LIG_BRCT_BRCA1_1 162 166 PF00533 0.578
LIG_BRCT_BRCA1_1 217 221 PF00533 0.596
LIG_BRCT_BRCA1_1 613 617 PF00533 0.260
LIG_BRCT_BRCA1_1 96 100 PF00533 0.746
LIG_Clathr_ClatBox_1 503 507 PF01394 0.397
LIG_CtBP_PxDLS_1 140 144 PF00389 0.615
LIG_deltaCOP1_diTrp_1 232 241 PF00928 0.617
LIG_EH1_1 497 505 PF00400 0.411
LIG_FHA_1 334 340 PF00498 0.259
LIG_FHA_1 351 357 PF00498 0.299
LIG_FHA_1 373 379 PF00498 0.531
LIG_FHA_1 528 534 PF00498 0.418
LIG_FHA_1 633 639 PF00498 0.354
LIG_FHA_2 689 695 PF00498 0.329
LIG_FHA_2 760 766 PF00498 0.772
LIG_GBD_Chelix_1 270 278 PF00786 0.224
LIG_GBD_Chelix_1 298 306 PF00786 0.452
LIG_GBD_Chelix_1 669 677 PF00786 0.452
LIG_LIR_Apic_2 218 223 PF02991 0.556
LIG_LIR_Apic_2 48 53 PF02991 0.615
LIG_LIR_Gen_1 208 215 PF02991 0.572
LIG_LIR_Gen_1 526 537 PF02991 0.342
LIG_LIR_Gen_1 584 593 PF02991 0.478
LIG_LIR_Gen_1 703 714 PF02991 0.394
LIG_LIR_Nem_3 208 213 PF02991 0.575
LIG_LIR_Nem_3 218 224 PF02991 0.534
LIG_LIR_Nem_3 526 532 PF02991 0.363
LIG_LIR_Nem_3 589 593 PF02991 0.344
LIG_LIR_Nem_3 703 709 PF02991 0.394
LIG_LIR_Nem_3 715 719 PF02991 0.369
LIG_MLH1_MIPbox_1 613 617 PF16413 0.285
LIG_MYND_1 177 181 PF01753 0.492
LIG_PALB2_WD40_1 216 224 PF16756 0.481
LIG_Pex14_1 235 239 PF04695 0.546
LIG_Pex14_1 457 461 PF04695 0.346
LIG_Pex14_2 612 616 PF04695 0.264
LIG_Pex14_2 632 636 PF04695 0.457
LIG_Pex14_2 96 100 PF04695 0.758
LIG_PTB_Apo_2 165 172 PF02174 0.615
LIG_PTB_Apo_2 392 399 PF02174 0.373
LIG_PTB_Apo_2 510 517 PF02174 0.485
LIG_PTB_Apo_2 610 617 PF02174 0.277
LIG_PTB_Phospho_1 165 171 PF10480 0.493
LIG_PTB_Phospho_1 510 516 PF10480 0.494
LIG_REV1ctd_RIR_1 539 549 PF16727 0.452
LIG_SH2_CRK 210 214 PF00017 0.583
LIG_SH2_CRK 537 541 PF00017 0.445
LIG_SH2_GRB2like 695 698 PF00017 0.321
LIG_SH2_NCK_1 537 541 PF00017 0.452
LIG_SH2_SRC 41 44 PF00017 0.612
LIG_SH2_STAP1 162 166 PF00017 0.491
LIG_SH2_STAP1 537 541 PF00017 0.381
LIG_SH2_STAP1 695 699 PF00017 0.285
LIG_SH2_STAT5 171 174 PF00017 0.620
LIG_SH2_STAT5 196 199 PF00017 0.631
LIG_SH2_STAT5 215 218 PF00017 0.448
LIG_SH2_STAT5 239 242 PF00017 0.559
LIG_SH2_STAT5 289 292 PF00017 0.268
LIG_SH2_STAT5 334 337 PF00017 0.270
LIG_SH2_STAT5 428 431 PF00017 0.504
LIG_SH2_STAT5 499 502 PF00017 0.310
LIG_SH2_STAT5 516 519 PF00017 0.451
LIG_SH2_STAT5 581 584 PF00017 0.486
LIG_SH2_STAT5 656 659 PF00017 0.515
LIG_SH2_STAT5 706 709 PF00017 0.346
LIG_SH3_2 71 76 PF14604 0.606
LIG_SH3_3 134 140 PF00018 0.726
LIG_SH3_3 26 32 PF00018 0.724
LIG_SH3_3 287 293 PF00018 0.294
LIG_SH3_3 418 424 PF00018 0.325
LIG_SH3_3 474 480 PF00018 0.276
LIG_SH3_3 590 596 PF00018 0.388
LIG_SH3_3 65 71 PF00018 0.627
LIG_SH3_3 766 772 PF00018 0.622
LIG_SH3_3 92 98 PF00018 0.717
LIG_Sin3_3 294 301 PF02671 0.224
LIG_SUMO_SIM_par_1 294 300 PF11976 0.409
LIG_TRFH_1 210 214 PF08558 0.496
LIG_TYR_ITIM 535 540 PF00017 0.224
LIG_UBA3_1 462 471 PF00899 0.407
LIG_UBA3_1 598 605 PF00899 0.373
LIG_UBA3_1 677 686 PF00899 0.476
LIG_WRC_WIRS_1 633 638 PF05994 0.346
LIG_WRC_WIRS_1 713 718 PF05994 0.397
MOD_CDK_SPxK_1 728 734 PF00069 0.472
MOD_CDK_SPxxK_3 728 735 PF00069 0.482
MOD_CDK_SPxxK_3 94 101 PF00069 0.507
MOD_CK1_1 115 121 PF00069 0.751
MOD_CK1_1 152 158 PF00069 0.622
MOD_CK1_1 24 30 PF00069 0.648
MOD_CK1_1 3 9 PF00069 0.537
MOD_CK1_1 35 41 PF00069 0.585
MOD_CK1_1 415 421 PF00069 0.357
MOD_CK1_1 62 68 PF00069 0.766
MOD_CK1_1 688 694 PF00069 0.408
MOD_CK1_1 741 747 PF00069 0.733
MOD_CK2_1 688 694 PF00069 0.393
MOD_CK2_1 759 765 PF00069 0.767
MOD_Cter_Amidation 250 253 PF01082 0.508
MOD_DYRK1A_RPxSP_1 94 98 PF00069 0.509
MOD_GlcNHglycan 152 155 PF01048 0.599
MOD_GlcNHglycan 299 302 PF01048 0.371
MOD_GlcNHglycan 445 448 PF01048 0.349
MOD_GlcNHglycan 559 562 PF01048 0.383
MOD_GlcNHglycan 641 644 PF01048 0.379
MOD_GlcNHglycan 660 663 PF01048 0.382
MOD_GlcNHglycan 702 705 PF01048 0.422
MOD_GlcNHglycan 740 743 PF01048 0.746
MOD_GlcNHglycan 745 748 PF01048 0.700
MOD_GlcNHglycan 751 754 PF01048 0.669
MOD_GlcNHglycan 79 82 PF01048 0.672
MOD_GlcNHglycan 8 12 PF01048 0.740
MOD_GlcNHglycan 84 87 PF01048 0.671
MOD_GSK3_1 120 127 PF00069 0.677
MOD_GSK3_1 132 139 PF00069 0.676
MOD_GSK3_1 150 157 PF00069 0.624
MOD_GSK3_1 3 10 PF00069 0.787
MOD_GSK3_1 439 446 PF00069 0.333
MOD_GSK3_1 658 665 PF00069 0.339
MOD_GSK3_1 708 715 PF00069 0.404
MOD_GSK3_1 738 745 PF00069 0.675
MOD_GSK3_1 759 766 PF00069 0.659
MOD_N-GLC_1 167 172 PF02516 0.455
MOD_N-GLC_1 612 617 PF02516 0.411
MOD_N-GLC_1 780 785 PF02516 0.729
MOD_N-GLC_2 522 524 PF02516 0.457
MOD_NEK2_1 156 161 PF00069 0.619
MOD_NEK2_1 245 250 PF00069 0.338
MOD_NEK2_1 350 355 PF00069 0.306
MOD_NEK2_1 377 382 PF00069 0.385
MOD_NEK2_1 412 417 PF00069 0.353
MOD_NEK2_1 443 448 PF00069 0.322
MOD_NEK2_1 527 532 PF00069 0.280
MOD_NEK2_1 559 564 PF00069 0.340
MOD_NEK2_1 586 591 PF00069 0.381
MOD_NEK2_1 598 603 PF00069 0.380
MOD_NEK2_1 612 617 PF00069 0.330
MOD_NEK2_1 624 629 PF00069 0.210
MOD_NEK2_1 632 637 PF00069 0.305
MOD_NEK2_1 708 713 PF00069 0.377
MOD_NEK2_2 89 94 PF00069 0.742
MOD_PIKK_1 132 138 PF00454 0.528
MOD_PK_1 252 258 PF00069 0.545
MOD_PKA_1 252 258 PF00069 0.545
MOD_PKA_2 252 258 PF00069 0.500
MOD_PKA_2 3 9 PF00069 0.773
MOD_PKA_2 53 59 PF00069 0.757
MOD_PKA_2 738 744 PF00069 0.733
MOD_Plk_1 120 126 PF00069 0.634
MOD_Plk_1 167 173 PF00069 0.493
MOD_Plk_1 612 618 PF00069 0.428
MOD_Plk_2-3 685 691 PF00069 0.397
MOD_Plk_4 162 168 PF00069 0.484
MOD_Plk_4 208 214 PF00069 0.481
MOD_Plk_4 350 356 PF00069 0.351
MOD_Plk_4 388 394 PF00069 0.420
MOD_Plk_4 412 418 PF00069 0.362
MOD_Plk_4 423 429 PF00069 0.336
MOD_Plk_4 439 445 PF00069 0.232
MOD_Plk_4 45 51 PF00069 0.777
MOD_Plk_4 581 587 PF00069 0.365
MOD_Plk_4 612 618 PF00069 0.373
MOD_Plk_4 625 631 PF00069 0.403
MOD_Plk_4 708 714 PF00069 0.323
MOD_Plk_4 79 85 PF00069 0.537
MOD_ProDKin_1 136 142 PF00069 0.662
MOD_ProDKin_1 415 421 PF00069 0.335
MOD_ProDKin_1 728 734 PF00069 0.472
MOD_ProDKin_1 94 100 PF00069 0.713
MOD_SUMO_for_1 504 507 PF00179 0.359
MOD_SUMO_for_1 726 729 PF00179 0.408
TRG_DiLeu_BaLyEn_6 220 225 PF01217 0.331
TRG_ENDOCYTIC_2 210 213 PF00928 0.486
TRG_ENDOCYTIC_2 537 540 PF00928 0.416
TRG_ENDOCYTIC_2 706 709 PF00928 0.336
TRG_ER_diArg_1 252 254 PF00400 0.482
TRG_ER_diArg_1 569 572 PF00400 0.224
TRG_Pf-PMV_PEXEL_1 13 17 PF00026 0.553
TRG_Pf-PMV_PEXEL_1 281 285 PF00026 0.533

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1I3 Leptomonas seymouri 76% 97%
A0A0S4IUH4 Bodo saltans 40% 100%
A0A0S4IYS7 Bodo saltans 46% 100%
A0A0S4J2L9 Bodo saltans 49% 100%
A0A1X0NSQ8 Trypanosomatidae 64% 100%
A0A1X0P4B5 Trypanosomatidae 26% 98%
A0A3Q8I9W9 Leishmania donovani 86% 100%
A0A422N0A8 Trypanosoma rangeli 59% 100%
A4HW40 Leishmania infantum 86% 100%
C9ZP87 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
D0A5M2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 98%
E9APU3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QFN7 Leishmania major 86% 100%
V5BES3 Trypanosoma cruzi 62% 100%
V5BN48 Trypanosoma cruzi 26% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS