Guanine nucleotide-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanine nucleotide-binding protein-like protein

Species:

Leishmania braziliensis

UniProt:

E9AI46_LEIBR

TriTrypDb:

LbrM.14.0740 , LBRM2903_140013000

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI46

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.505
CLV_NRD_NRD_1	196	198	PF00675	0.291
CLV_NRD_NRD_1	291	293	PF00675	0.476
CLV_NRD_NRD_1	304	306	PF00675	0.578
CLV_PCSK_KEX2_1	196	198	PF00082	0.291
CLV_PCSK_KEX2_1	291	293	PF00082	0.476
CLV_PCSK_KEX2_1	304	306	PF00082	0.578
CLV_PCSK_SKI1_1	270	274	PF00082	0.361
CLV_PCSK_SKI1_1	386	390	PF00082	0.519
DEG_APCC_DBOX_1	196	204	PF00400	0.265
DEG_COP1_1	37	46	PF00400	0.508
DEG_Nend_UBRbox_3	1	3	PF02207	0.523
DEG_SPOP_SBC_1	232	236	PF00917	0.344
DEG_SPOP_SBC_1	30	34	PF00917	0.632
DEG_SPOP_SBC_1	73	77	PF00917	0.583
DOC_CKS1_1	19	24	PF01111	0.629
DOC_MAPK_gen_1	196	203	PF00069	0.291
DOC_PP2B_LxvP_1	201	204	PF13499	0.285
DOC_USP7_MATH_1	133	137	PF00917	0.364
DOC_USP7_MATH_1	232	236	PF00917	0.402
DOC_USP7_MATH_1	290	294	PF00917	0.546
DOC_USP7_MATH_1	30	34	PF00917	0.675
DOC_USP7_MATH_1	362	366	PF00917	0.650
DOC_USP7_MATH_1	47	51	PF00917	0.529
DOC_WW_Pin1_4	18	23	PF00397	0.629
DOC_WW_Pin1_4	326	331	PF00397	0.518
DOC_WW_Pin1_4	350	355	PF00397	0.601
DOC_WW_Pin1_4	358	363	PF00397	0.688
DOC_WW_Pin1_4	36	41	PF00397	0.538
DOC_WW_Pin1_4	402	407	PF00397	0.749
DOC_WW_Pin1_4	67	72	PF00397	0.629
LIG_14-3-3_CanoR_1	252	259	PF00244	0.439
LIG_14-3-3_CanoR_1	357	362	PF00244	0.718
LIG_14-3-3_CanoR_1	82	92	PF00244	0.491
LIG_BRCT_BRCA1_1	177	181	PF00533	0.312
LIG_eIF4E_1	85	91	PF01652	0.487
LIG_FHA_1	103	109	PF00498	0.380
LIG_FHA_1	135	141	PF00498	0.312
LIG_FHA_1	155	161	PF00498	0.183
LIG_FHA_1	19	25	PF00498	0.625
LIG_FHA_1	262	268	PF00498	0.402
LIG_FHA_1	275	281	PF00498	0.242
LIG_FHA_2	372	378	PF00498	0.549
LIG_FHA_2	51	57	PF00498	0.645
LIG_LIR_Gen_1	274	283	PF02991	0.312
LIG_LIR_Nem_3	274	279	PF02991	0.312
LIG_PTB_Apo_2	176	183	PF02174	0.312
LIG_PTB_Phospho_1	176	182	PF10480	0.312
LIG_SH2_SRC	23	26	PF00017	0.507
LIG_SH2_STAT5	125	128	PF00017	0.312
LIG_SH2_STAT5	23	26	PF00017	0.507
LIG_SH2_STAT5	404	407	PF00017	0.505
LIG_SH2_STAT5	67	70	PF00017	0.503
LIG_SH2_STAT5	85	88	PF00017	0.671
LIG_SH3_3	129	135	PF00018	0.312
LIG_SH3_3	144	150	PF00018	0.312
LIG_SH3_3	16	22	PF00018	0.568
LIG_SH3_3	324	330	PF00018	0.510
LIG_SH3_3	41	47	PF00018	0.622
LIG_SH3_3	65	71	PF00018	0.583
LIG_SUMO_SIM_par_1	107	113	PF11976	0.312
LIG_SUMO_SIM_par_1	279	284	PF11976	0.312
LIG_SUMO_SIM_par_1	39	45	PF11976	0.505
LIG_TRAF2_1	168	171	PF00917	0.312
LIG_TRAF2_1	313	316	PF00917	0.526
MOD_CDK_SPxxK_3	350	357	PF00069	0.523
MOD_CK1_1	235	241	PF00069	0.282
MOD_CK1_1	242	248	PF00069	0.265
MOD_CK1_1	265	271	PF00069	0.313
MOD_CK1_1	31	37	PF00069	0.562
MOD_CK1_1	353	359	PF00069	0.635
MOD_CK1_1	365	371	PF00069	0.613
MOD_CK1_1	50	56	PF00069	0.547
MOD_CK2_1	238	244	PF00069	0.229
MOD_CK2_1	371	377	PF00069	0.542
MOD_GlcNHglycan	264	267	PF01048	0.334
MOD_GlcNHglycan	305	308	PF01048	0.559
MOD_GlcNHglycan	310	313	PF01048	0.667
MOD_GlcNHglycan	86	89	PF01048	0.581
MOD_GlcNHglycan	93	96	PF01048	0.582
MOD_GSK3_1	231	238	PF00069	0.339
MOD_GSK3_1	24	31	PF00069	0.663
MOD_GSK3_1	261	268	PF00069	0.437
MOD_GSK3_1	290	297	PF00069	0.661
MOD_GSK3_1	349	356	PF00069	0.715
MOD_GSK3_1	358	365	PF00069	0.562
MOD_GSK3_1	402	409	PF00069	0.656
MOD_GSK3_1	47	54	PF00069	0.602
MOD_GSK3_1	86	93	PF00069	0.523
MOD_N-GLC_2	299	301	PF02516	0.539
MOD_NEK2_1	102	107	PF00069	0.513
MOD_NEK2_1	164	169	PF00069	0.388
MOD_NEK2_1	262	267	PF00069	0.330
MOD_NEK2_1	48	53	PF00069	0.618
MOD_NEK2_1	74	79	PF00069	0.692
MOD_NEK2_1	84	89	PF00069	0.523
MOD_NEK2_1	90	95	PF00069	0.555
MOD_NEK2_2	362	367	PF00069	0.535
MOD_PKA_1	196	202	PF00069	0.291
MOD_PKA_2	196	202	PF00069	0.318
MOD_PKA_2	208	214	PF00069	0.231
MOD_PKA_2	251	257	PF00069	0.388
MOD_PKA_2	290	296	PF00069	0.476
MOD_PKA_2	303	309	PF00069	0.644
MOD_PKA_2	54	60	PF00069	0.534
MOD_Plk_4	156	162	PF00069	0.348
MOD_Plk_4	196	202	PF00069	0.312
MOD_Plk_4	62	68	PF00069	0.546
MOD_Plk_4	86	92	PF00069	0.564
MOD_ProDKin_1	18	24	PF00069	0.629
MOD_ProDKin_1	326	332	PF00069	0.519
MOD_ProDKin_1	350	356	PF00069	0.600
MOD_ProDKin_1	358	364	PF00069	0.690
MOD_ProDKin_1	36	42	PF00069	0.537
MOD_ProDKin_1	402	408	PF00069	0.746
MOD_ProDKin_1	67	73	PF00069	0.627
MOD_SUMO_rev_2	383	388	PF00179	0.522
TRG_ER_diArg_1	290	292	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	379	384	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKL4	Leptomonas seymouri	51%	100%
A0A3S7WT13	Leishmania donovani	66%	100%
A4HW20	Leishmania infantum	66%	100%
E9APS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4QFQ7	Leishmania major	67%	100%