AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania braziliensis

UniProt:

E9AI45_LEIBR

TriTrypDb:

LbrM.13.1280 , LBRM2903_130019400

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	492	496	PF00656	0.659
CLV_C14_Caspase3-7	79	83	PF00656	0.582
CLV_NRD_NRD_1	301	303	PF00675	0.658
CLV_NRD_NRD_1	374	376	PF00675	0.751
CLV_NRD_NRD_1	426	428	PF00675	0.862
CLV_NRD_NRD_1	432	434	PF00675	0.764
CLV_NRD_NRD_1	490	492	PF00675	0.675
CLV_NRD_NRD_1	505	507	PF00675	0.394
CLV_NRD_NRD_1	73	75	PF00675	0.597
CLV_PCSK_KEX2_1	265	267	PF00082	0.645
CLV_PCSK_KEX2_1	325	327	PF00082	0.703
CLV_PCSK_KEX2_1	374	376	PF00082	0.751
CLV_PCSK_KEX2_1	426	428	PF00082	0.862
CLV_PCSK_KEX2_1	431	433	PF00082	0.783
CLV_PCSK_KEX2_1	490	492	PF00082	0.675
CLV_PCSK_KEX2_1	505	507	PF00082	0.394
CLV_PCSK_KEX2_1	73	75	PF00082	0.597
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.645
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.703
CLV_PCSK_PC7_1	427	433	PF00082	0.864
CLV_PCSK_SKI1_1	187	191	PF00082	0.812
CLV_PCSK_SKI1_1	249	253	PF00082	0.649
CLV_PCSK_SKI1_1	256	260	PF00082	0.516
CLV_PCSK_SKI1_1	265	269	PF00082	0.367
CLV_PCSK_SKI1_1	322	326	PF00082	0.687
CLV_PCSK_SKI1_1	78	82	PF00082	0.592
DOC_ANK_TNKS_1	430	437	PF00023	0.859
DOC_CYCLIN_yClb5_NLxxxL_5	514	523	PF00134	0.668
DOC_MAPK_gen_1	215	225	PF00069	0.661
DOC_MAPK_gen_1	352	360	PF00069	0.729
DOC_MAPK_gen_1	53	63	PF00069	0.572
DOC_MAPK_MEF2A_6	218	227	PF00069	0.663
DOC_MAPK_NFAT4_5	220	228	PF00069	0.661
DOC_PP2B_LxvP_1	119	122	PF13499	0.648
DOC_PP2B_LxvP_1	30	33	PF13499	0.627
DOC_USP7_MATH_1	164	168	PF00917	0.707
DOC_USP7_MATH_1	240	244	PF00917	0.708
DOC_USP7_MATH_1	285	289	PF00917	0.709
DOC_USP7_MATH_1	388	392	PF00917	0.839
DOC_WW_Pin1_4	112	117	PF00397	0.663
LIG_14-3-3_CanoR_1	218	227	PF00244	0.663
LIG_14-3-3_CanoR_1	461	466	PF00244	0.648
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_CaM_IQ_9	205	221	PF13499	0.663
LIG_Clathr_ClatBox_1	511	515	PF01394	0.649
LIG_EVH1_2	447	451	PF00568	0.687
LIG_FHA_1	123	129	PF00498	0.637
LIG_FHA_1	174	180	PF00498	0.743
LIG_FHA_1	183	189	PF00498	0.649
LIG_FHA_1	220	226	PF00498	0.664
LIG_FHA_1	281	287	PF00498	0.701
LIG_FHA_1	330	336	PF00498	0.668
LIG_FHA_1	366	372	PF00498	0.675
LIG_FHA_1	462	468	PF00498	0.656
LIG_FHA_2	106	112	PF00498	0.647
LIG_FHA_2	150	156	PF00498	0.722
LIG_FHA_2	188	194	PF00498	0.809
LIG_FHA_2	243	249	PF00498	0.681
LIG_FHA_2	420	426	PF00498	0.857
LIG_FHA_2	471	477	PF00498	0.718
LIG_FHA_2	77	83	PF00498	0.584
LIG_Integrin_RGD_1	433	435	PF01839	0.864
LIG_LIR_Gen_1	101	109	PF02991	0.445
LIG_LIR_Gen_1	528	538	PF02991	0.768
LIG_LIR_Gen_1	90	97	PF02991	0.590
LIG_LIR_Nem_3	101	105	PF02991	0.449
LIG_LIR_Nem_3	90	96	PF02991	0.584
LIG_Pex14_1	466	470	PF04695	0.654
LIG_Pex14_1	47	51	PF04695	0.555
LIG_SH2_CRK	10	14	PF00017	0.587
LIG_SH2_NCK_1	93	97	PF00017	0.596
LIG_SH2_PTP2	102	105	PF00017	0.640
LIG_SH2_SRC	484	487	PF00017	0.670
LIG_SH2_STAP1	43	47	PF00017	0.587
LIG_SH2_STAP1	484	488	PF00017	0.662
LIG_SH2_STAT3	261	264	PF00017	0.639
LIG_SH2_STAT3	42	45	PF00017	0.586
LIG_SH2_STAT3	6	9	PF00017	0.599
LIG_SH2_STAT5	102	105	PF00017	0.640
LIG_SH2_STAT5	126	129	PF00017	0.638
LIG_SH2_STAT5	141	144	PF00017	0.377
LIG_SH2_STAT5	26	29	PF00017	0.629
LIG_SH2_STAT5	261	264	PF00017	0.639
LIG_SH2_STAT5	51	54	PF00017	0.561
LIG_SH3_3	118	124	PF00018	0.647
LIG_SH3_3	441	447	PF00018	0.743
LIG_SH3_3	560	566	PF00018	0.781
LIG_SUMO_SIM_anti_2	332	339	PF11976	0.659
LIG_SUMO_SIM_anti_2	368	373	PF11976	0.692
LIG_TRAF2_1	108	111	PF00917	0.641
LIG_TRAF2_1	200	203	PF00917	0.687
LIG_TRFH_1	562	566	PF08558	0.782
LIG_TYR_ITIM	52	57	PF00017	0.564
LIG_WRC_WIRS_1	381	386	PF05994	0.845
LIG_WW_2	121	124	PF00397	0.639
MOD_CK1_1	2	8	PF00069	0.617
MOD_CK1_1	404	410	PF00069	0.849
MOD_CK2_1	105	111	PF00069	0.400
MOD_CK2_1	112	118	PF00069	0.541
MOD_CK2_1	149	155	PF00069	0.712
MOD_CK2_1	454	460	PF00069	0.649
MOD_CK2_1	470	476	PF00069	0.422
MOD_CK2_1	91	97	PF00069	0.590
MOD_Cter_Amidation	372	375	PF01082	0.731
MOD_GlcNHglycan	166	169	PF01048	0.708
MOD_GlcNHglycan	193	198	PF01048	0.783
MOD_GlcNHglycan	384	387	PF01048	0.852
MOD_GlcNHglycan	391	394	PF01048	0.712
MOD_GlcNHglycan	403	406	PF01048	0.523
MOD_GlcNHglycan	542	545	PF01048	0.820
MOD_GSK3_1	314	321	PF00069	0.659
MOD_GSK3_1	417	424	PF00069	0.855
MOD_GSK3_1	76	83	PF00069	0.584
MOD_N-GLC_1	540	545	PF02516	0.818
MOD_NEK2_1	182	187	PF00069	0.807
MOD_NEK2_1	278	283	PF00069	0.687
MOD_NEK2_1	318	323	PF00069	0.669
MOD_NEK2_1	470	475	PF00069	0.694
MOD_NEK2_1	80	85	PF00069	0.567
MOD_PKA_1	426	432	PF00069	0.862
MOD_PKA_2	219	225	PF00069	0.663
MOD_PKA_2	373	379	PF00069	0.772
MOD_PKA_2	426	432	PF00069	0.862
MOD_PKA_2	91	97	PF00069	0.590
MOD_Plk_1	105	111	PF00069	0.645
MOD_Plk_2-3	76	82	PF00069	0.587
MOD_Plk_4	122	128	PF00069	0.634
MOD_Plk_4	249	255	PF00069	0.650
MOD_Plk_4	446	452	PF00069	0.677
MOD_Plk_4	461	467	PF00069	0.387
MOD_Plk_4	91	97	PF00069	0.590
MOD_ProDKin_1	112	118	PF00069	0.663
MOD_SUMO_rev_2	106	115	PF00179	0.651
MOD_SUMO_rev_2	300	304	PF00179	0.667
MOD_SUMO_rev_2	34	38	PF00179	0.642
TRG_DiLeu_BaEn_3	202	208	PF01217	0.675
TRG_DiLeu_BaLyEn_6	560	565	PF01217	0.782
TRG_ENDOCYTIC_2	10	13	PF00928	0.592
TRG_ENDOCYTIC_2	102	105	PF00928	0.483
TRG_ENDOCYTIC_2	233	236	PF00928	0.681
TRG_ENDOCYTIC_2	346	349	PF00928	0.698
TRG_ENDOCYTIC_2	531	534	PF00928	0.777
TRG_ENDOCYTIC_2	54	57	PF00928	0.560
TRG_ENDOCYTIC_2	93	96	PF00928	0.587
TRG_ER_diArg_1	374	377	PF00400	0.767
TRG_ER_diArg_1	431	433	PF00400	0.871
TRG_ER_diArg_1	472	475	PF00400	0.703
TRG_ER_diArg_1	489	491	PF00400	0.364
TRG_ER_diArg_1	504	506	PF00400	0.384
TRG_NES_CRM1_1	502	515	PF08389	0.647
TRG_Pf-PMV_PEXEL_1	322	327	PF00026	0.689
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A6H690	Mus musculus	25%	69%
Q9CUL5	Mus musculus	23%	66%