Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI41_LEIBR

TriTrypDb:

LbrM.10.0730 , LBRM2903_100015400

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.516
CLV_PCSK_SKI1_1	20	24	PF00082	0.673
CLV_PCSK_SKI1_1	48	52	PF00082	0.571
DEG_APCC_DBOX_1	138	146	PF00400	0.371
DOC_MAPK_gen_1	139	147	PF00069	0.379
DOC_MAPK_MEF2A_6	141	149	PF00069	0.371
DOC_PP1_RVXF_1	238	245	PF00149	0.414
DOC_USP7_MATH_1	230	234	PF00917	0.451
DOC_USP7_MATH_1	5	9	PF00917	0.651
DOC_USP7_UBL2_3	15	19	PF12436	0.573
DOC_USP7_UBL2_3	44	48	PF12436	0.403
DOC_USP7_UBL2_3	6	10	PF12436	0.679
DOC_WW_Pin1_4	232	237	PF00397	0.473
DOC_WW_Pin1_4	68	73	PF00397	0.495
LIG_14-3-3_CanoR_1	168	176	PF00244	0.431
LIG_FHA_1	105	111	PF00498	0.463
LIG_FHA_1	150	156	PF00498	0.393
LIG_FHA_1	168	174	PF00498	0.337
LIG_FHA_1	207	213	PF00498	0.381
LIG_FHA_1	229	235	PF00498	0.627
LIG_FHA_1	37	43	PF00498	0.561
LIG_FHA_1	64	70	PF00498	0.496
LIG_FHA_2	179	185	PF00498	0.531
LIG_FHA_2	189	195	PF00498	0.536
LIG_FHA_2	233	239	PF00498	0.448
LIG_LIR_Gen_1	187	195	PF02991	0.399
LIG_LIR_Nem_3	187	192	PF02991	0.419
LIG_LIR_Nem_3	238	242	PF02991	0.449
LIG_NRBOX	141	147	PF00104	0.420
LIG_NRBOX	216	222	PF00104	0.479
LIG_Pex14_2	189	193	PF04695	0.358
LIG_Pex14_2	259	263	PF04695	0.483
LIG_REV1ctd_RIR_1	242	251	PF16727	0.423
LIG_SH2_STAT3	157	160	PF00017	0.478
LIG_SH2_STAT3	32	35	PF00017	0.505
LIG_SH2_STAT5	41	44	PF00017	0.473
LIG_SH3_3	22	28	PF00018	0.574
LIG_SH3_3	37	43	PF00018	0.370
LIG_SH3_3	66	72	PF00018	0.467
LIG_SH3_4	6	13	PF00018	0.631
LIG_SUMO_SIM_par_1	198	203	PF11976	0.330
LIG_SUMO_SIM_par_1	65	71	PF11976	0.476
MOD_CDC14_SPxK_1	71	74	PF00782	0.505
MOD_CDK_SPK_2	232	237	PF00069	0.380
MOD_CDK_SPxK_1	68	74	PF00069	0.497
MOD_CK1_1	228	234	PF00069	0.597
MOD_CK2_1	176	182	PF00069	0.507
MOD_CK2_1	188	194	PF00069	0.397
MOD_CK2_1	232	238	PF00069	0.487
MOD_Cter_Amidation	12	15	PF01082	0.663
MOD_Cter_Amidation	17	20	PF01082	0.622
MOD_GlcNHglycan	178	181	PF01048	0.534
MOD_GlcNHglycan	194	198	PF01048	0.271
MOD_GlcNHglycan	227	230	PF01048	0.567
MOD_GSK3_1	167	174	PF00069	0.517
MOD_GSK3_1	184	191	PF00069	0.409
MOD_GSK3_1	200	207	PF00069	0.558
MOD_GSK3_1	219	226	PF00069	0.391
MOD_GSK3_1	228	235	PF00069	0.644
MOD_GSK3_1	63	70	PF00069	0.660
MOD_N-GLC_1	120	125	PF02516	0.479
MOD_N-GLC_1	204	209	PF02516	0.440
MOD_NEK2_1	149	154	PF00069	0.446
MOD_NEK2_1	36	41	PF00069	0.555
MOD_PIKK_1	115	121	PF00454	0.637
MOD_PIKK_1	228	234	PF00454	0.434
MOD_PIKK_1	5	11	PF00454	0.652
MOD_PK_1	172	178	PF00069	0.455
MOD_PKA_2	167	173	PF00069	0.525
MOD_Plk_1	120	126	PF00069	0.482
MOD_Plk_1	36	42	PF00069	0.536
MOD_Plk_4	120	126	PF00069	0.592
MOD_Plk_4	172	178	PF00069	0.431
MOD_Plk_4	188	194	PF00069	0.412
MOD_Plk_4	36	42	PF00069	0.536
MOD_ProDKin_1	232	238	PF00069	0.467
MOD_ProDKin_1	68	74	PF00069	0.497
TRG_NLS_MonoExtC_3	46	52	PF00514	0.384
TRG_NLS_MonoExtN_4	12	18	PF00514	0.591
TRG_NLS_MonoExtN_4	44	51	PF00514	0.395
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKR2	Leptomonas seymouri	45%	100%
A0A3Q8I8T9	Leishmania donovani	75%	100%
A0A3R7KUI1	Trypanosoma rangeli	27%	87%
A4H651	Leishmania braziliensis	98%	100%
A4HUH1	Leishmania infantum	74%	100%
C9ZVJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	92%
E9AN69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QHF6	Leishmania major	73%	100%
V5B6H6	Trypanosoma cruzi	25%	86%