Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania braziliensis

UniProt:

E9AI40_LEIBR

TriTrypDb:

LbrM.10.0370 , LBRM2903_100008700

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AI40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI40

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.482
CLV_C14_Caspase3-7	303	307	PF00656	0.535
CLV_NRD_NRD_1	272	274	PF00675	0.344
CLV_NRD_NRD_1	48	50	PF00675	0.421
CLV_NRD_NRD_1	638	640	PF00675	0.281
CLV_PCSK_KEX2_1	133	135	PF00082	0.300
CLV_PCSK_KEX2_1	272	274	PF00082	0.301
CLV_PCSK_KEX2_1	295	297	PF00082	0.385
CLV_PCSK_KEX2_1	48	50	PF00082	0.453
CLV_PCSK_KEX2_1	481	483	PF00082	0.214
CLV_PCSK_KEX2_1	507	509	PF00082	0.529
CLV_PCSK_KEX2_1	676	678	PF00082	0.472
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.300
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.385
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.214
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.529
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.498
CLV_PCSK_SKI1_1	116	120	PF00082	0.360
CLV_PCSK_SKI1_1	81	85	PF00082	0.371
DEG_COP1_1	301	313	PF00400	0.388
DOC_CDC14_PxL_1	597	605	PF14671	0.338
DOC_CYCLIN_yCln2_LP_2	614	620	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	654	660	PF00134	0.577
DOC_MAPK_gen_1	133	139	PF00069	0.507
DOC_MAPK_gen_1	257	267	PF00069	0.555
DOC_MAPK_gen_1	272	280	PF00069	0.547
DOC_MAPK_gen_1	481	488	PF00069	0.448
DOC_MAPK_gen_1	507	515	PF00069	0.330
DOC_MAPK_gen_1	624	633	PF00069	0.591
DOC_MAPK_MEF2A_6	227	234	PF00069	0.336
DOC_MAPK_MEF2A_6	507	515	PF00069	0.363
DOC_MAPK_RevD_3	467	482	PF00069	0.353
DOC_PP1_RVXF_1	483	489	PF00149	0.513
DOC_PP2B_LxvP_1	614	617	PF13499	0.366
DOC_PP2B_LxvP_1	620	623	PF13499	0.335
DOC_PP2B_PxIxI_1	227	233	PF00149	0.288
DOC_USP7_MATH_1	107	111	PF00917	0.596
DOC_USP7_MATH_1	156	160	PF00917	0.272
DOC_USP7_MATH_1	199	203	PF00917	0.333
DOC_USP7_MATH_1	298	302	PF00917	0.565
DOC_USP7_MATH_1	42	46	PF00917	0.651
DOC_USP7_MATH_1	526	530	PF00917	0.325
DOC_USP7_MATH_1	549	553	PF00917	0.493
DOC_USP7_UBL2_3	636	640	PF12436	0.449
DOC_WW_Pin1_4	103	108	PF00397	0.413
DOC_WW_Pin1_4	294	299	PF00397	0.593
DOC_WW_Pin1_4	429	434	PF00397	0.342
DOC_WW_Pin1_4	653	658	PF00397	0.630
LIG_14-3-3_CanoR_1	257	267	PF00244	0.589
LIG_14-3-3_CanoR_1	485	489	PF00244	0.498
LIG_APCC_ABBA_1	50	55	PF00400	0.641
LIG_APCC_ABBAyCdc20_2	30	36	PF00400	0.535
LIG_APCC_ABBAyCdc20_2	49	55	PF00400	0.507
LIG_BRCT_BRCA1_1	451	455	PF00533	0.325
LIG_FHA_1	117	123	PF00498	0.575
LIG_FHA_1	208	214	PF00498	0.347
LIG_FHA_1	240	246	PF00498	0.404
LIG_FHA_1	353	359	PF00498	0.594
LIG_FHA_1	370	376	PF00498	0.360
LIG_FHA_1	385	391	PF00498	0.261
LIG_FHA_1	485	491	PF00498	0.494
LIG_FHA_1	498	504	PF00498	0.359
LIG_FHA_2	269	275	PF00498	0.562
LIG_GBD_Chelix_1	384	392	PF00786	0.473
LIG_HP1_1	539	543	PF01393	0.409
LIG_LIR_Apic_2	336	342	PF02991	0.537
LIG_LIR_Apic_2	404	410	PF02991	0.411
LIG_LIR_Apic_2	580	584	PF02991	0.310
LIG_LIR_Gen_1	124	131	PF02991	0.527
LIG_LIR_Gen_1	183	194	PF02991	0.526
LIG_LIR_Gen_1	202	209	PF02991	0.502
LIG_LIR_Gen_1	454	463	PF02991	0.331
LIG_LIR_Gen_1	473	479	PF02991	0.391
LIG_LIR_Gen_1	491	497	PF02991	0.300
LIG_LIR_Gen_1	554	564	PF02991	0.518
LIG_LIR_Gen_1	87	95	PF02991	0.546
LIG_LIR_Nem_3	124	129	PF02991	0.502
LIG_LIR_Nem_3	132	138	PF02991	0.502
LIG_LIR_Nem_3	183	189	PF02991	0.532
LIG_LIR_Nem_3	202	208	PF02991	0.302
LIG_LIR_Nem_3	359	365	PF02991	0.506
LIG_LIR_Nem_3	404	409	PF02991	0.378
LIG_LIR_Nem_3	452	456	PF02991	0.304
LIG_LIR_Nem_3	473	478	PF02991	0.352
LIG_LIR_Nem_3	491	496	PF02991	0.330
LIG_Pex14_2	169	173	PF04695	0.376
LIG_Pex14_2	451	455	PF04695	0.313
LIG_Pex14_2	475	479	PF04695	0.375
LIG_PTB_Apo_2	447	454	PF02174	0.377
LIG_PTB_Phospho_1	447	453	PF10480	0.408
LIG_SH2_CRK	102	106	PF00017	0.520
LIG_SH2_CRK	136	140	PF00017	0.378
LIG_SH2_CRK	151	155	PF00017	0.332
LIG_SH2_CRK	186	190	PF00017	0.522
LIG_SH2_CRK	339	343	PF00017	0.620
LIG_SH2_CRK	367	371	PF00017	0.357
LIG_SH2_CRK	456	460	PF00017	0.306
LIG_SH2_CRK	581	585	PF00017	0.332
LIG_SH2_GRB2like	427	430	PF00017	0.415
LIG_SH2_GRB2like	438	441	PF00017	0.363
LIG_SH2_NCK_1	456	460	PF00017	0.308
LIG_SH2_PTP2	427	430	PF00017	0.360
LIG_SH2_PTP2	512	515	PF00017	0.402
LIG_SH2_SRC	427	430	PF00017	0.486
LIG_SH2_SRC	438	441	PF00017	0.352
LIG_SH2_STAP1	131	135	PF00017	0.508
LIG_SH2_STAP1	186	190	PF00017	0.494
LIG_SH2_STAP1	367	371	PF00017	0.404
LIG_SH2_STAP1	557	561	PF00017	0.350
LIG_SH2_STAP1	88	92	PF00017	0.544
LIG_SH2_STAT3	421	424	PF00017	0.208
LIG_SH2_STAT5	131	134	PF00017	0.506
LIG_SH2_STAT5	246	249	PF00017	0.448
LIG_SH2_STAT5	266	269	PF00017	0.457
LIG_SH2_STAT5	421	424	PF00017	0.361
LIG_SH2_STAT5	427	430	PF00017	0.351
LIG_SH2_STAT5	438	441	PF00017	0.287
LIG_SH2_STAT5	477	480	PF00017	0.457
LIG_SH2_STAT5	512	515	PF00017	0.310
LIG_SH2_STAT5	521	524	PF00017	0.302
LIG_SH2_STAT5	72	75	PF00017	0.530
LIG_SH3_1	339	345	PF00018	0.589
LIG_SH3_3	339	345	PF00018	0.599
LIG_SH3_3	606	612	PF00018	0.351
LIG_SUMO_SIM_par_1	539	545	PF11976	0.340
LIG_TRFH_1	151	155	PF08558	0.372
LIG_TYR_ITIM	149	154	PF00017	0.388
LIG_UBA3_1	149	157	PF00899	0.359
LIG_UBA3_1	167	175	PF00899	0.195
LIG_Vh1_VBS_1	365	383	PF01044	0.418
LIG_Vh1_VBS_1	455	473	PF01044	0.397
LIG_WRC_WIRS_1	490	495	PF05994	0.316
MOD_CK1_1	106	112	PF00069	0.364
MOD_CK1_1	480	486	PF00069	0.363
MOD_CK2_1	268	274	PF00069	0.423
MOD_Cter_Amidation	293	296	PF01082	0.476
MOD_GlcNHglycan	158	162	PF01048	0.362
MOD_GlcNHglycan	234	237	PF01048	0.382
MOD_GlcNHglycan	281	284	PF01048	0.347
MOD_GlcNHglycan	367	370	PF01048	0.204
MOD_GlcNHglycan	570	573	PF01048	0.402
MOD_GlcNHglycan	660	663	PF01048	0.680
MOD_GSK3_1	103	110	PF00069	0.417
MOD_GSK3_1	228	235	PF00069	0.450
MOD_GSK3_1	294	301	PF00069	0.430
MOD_GSK3_1	352	359	PF00069	0.478
MOD_GSK3_1	36	43	PF00069	0.408
MOD_GSK3_1	365	372	PF00069	0.371
MOD_GSK3_1	451	458	PF00069	0.380
MOD_GSK3_1	480	487	PF00069	0.374
MOD_GSK3_1	562	569	PF00069	0.386
MOD_N-GLC_1	449	454	PF02516	0.366
MOD_N-GLC_2	442	444	PF02516	0.200
MOD_N-GLC_2	608	610	PF02516	0.492
MOD_NEK2_1	111	116	PF00069	0.387
MOD_NEK2_1	129	134	PF00069	0.292
MOD_NEK2_1	137	142	PF00069	0.349
MOD_NEK2_1	169	174	PF00069	0.356
MOD_NEK2_1	213	218	PF00069	0.337
MOD_NEK2_1	268	273	PF00069	0.420
MOD_NEK2_1	313	318	PF00069	0.375
MOD_NEK2_1	365	370	PF00069	0.376
MOD_NEK2_1	384	389	PF00069	0.307
MOD_NEK2_1	40	45	PF00069	0.405
MOD_NEK2_1	451	456	PF00069	0.366
MOD_NEK2_1	488	493	PF00069	0.374
MOD_NEK2_1	566	571	PF00069	0.364
MOD_NEK2_2	228	233	PF00069	0.474
MOD_NEK2_2	29	34	PF00069	0.381
MOD_PKA_2	484	490	PF00069	0.360
MOD_PKA_2	549	555	PF00069	0.346
MOD_Plk_1	13	19	PF00069	0.476
MOD_Plk_1	449	455	PF00069	0.384
MOD_Plk_4	199	205	PF00069	0.349
MOD_Plk_4	213	219	PF00069	0.336
MOD_Plk_4	36	42	PF00069	0.526
MOD_Plk_4	402	408	PF00069	0.402
MOD_Plk_4	451	457	PF00069	0.445
MOD_Plk_4	551	557	PF00069	0.382
MOD_Plk_4	616	622	PF00069	0.379
MOD_ProDKin_1	103	109	PF00069	0.227
MOD_ProDKin_1	294	300	PF00069	0.480
MOD_ProDKin_1	429	435	PF00069	0.342
MOD_ProDKin_1	653	659	PF00069	0.528
MOD_SUMO_rev_2	629	638	PF00179	0.418
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.392
TRG_ENDOCYTIC_2	102	105	PF00928	0.332
TRG_ENDOCYTIC_2	136	139	PF00928	0.357
TRG_ENDOCYTIC_2	151	154	PF00928	0.347
TRG_ENDOCYTIC_2	186	189	PF00928	0.348
TRG_ENDOCYTIC_2	367	370	PF00928	0.358
TRG_ENDOCYTIC_2	427	430	PF00928	0.362
TRG_ENDOCYTIC_2	456	459	PF00928	0.362
TRG_ENDOCYTIC_2	512	515	PF00928	0.486
TRG_ENDOCYTIC_2	537	540	PF00928	0.315
TRG_ENDOCYTIC_2	557	560	PF00928	0.351
TRG_ENDOCYTIC_2	88	91	PF00928	0.361
TRG_ER_diArg_1	275	278	PF00400	0.329
TRG_ER_diArg_1	47	49	PF00400	0.582
TRG_NLS_MonoExtC_3	638	644	PF00514	0.330
TRG_NLS_MonoExtN_4	636	643	PF00514	0.183
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.205

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	48%	97%
A0A0N1HY49	Leptomonas seymouri	45%	100%
A0A0N1HZ06	Leptomonas seymouri	38%	100%
A0A0N1IHL1	Leptomonas seymouri	40%	95%
A0A0N1PAY4	Leptomonas seymouri	47%	77%
A0A0N1PB77	Leptomonas seymouri	35%	100%
A0A0N1PBZ2	Leptomonas seymouri	65%	100%
A0A0N1PCC1	Leptomonas seymouri	43%	100%
A0A0S4INN8	Bodo saltans	29%	100%
A0A381MBI0	Leishmania infantum	46%	100%
A0A3Q8I8X7	Leishmania donovani	46%	100%
A0A3Q8IAZ0	Leishmania donovani	77%	97%
A0A3Q8IH50	Leishmania donovani	60%	94%
A0A3Q8IVN0	Leishmania donovani	38%	100%
A0A3R7M4J1	Trypanosoma rangeli	42%	100%
A0A3S5H5P4	Leishmania donovani	43%	100%
A0A3S5H5V2	Leishmania donovani	45%	100%
A0A3S5H6F6	Leishmania donovani	77%	97%
A0A3S5H763	Leishmania donovani	52%	100%
A0A3S7WR10	Leishmania donovani	44%	91%
A0A3S7WR14	Leishmania donovani	74%	99%
A0A3S7WR15	Leishmania donovani	77%	80%
A0A3S7WR24	Leishmania donovani	76%	97%
A4H4T8	Leishmania braziliensis	42%	96%
A4H5Y4	Leishmania braziliensis	46%	100%
A4H617	Leishmania braziliensis	84%	100%
A4H618	Leishmania braziliensis	83%	100%
A4H619	Leishmania braziliensis	83%	100%
A4H620	Leishmania braziliensis	62%	100%
A4H6C3	Leishmania braziliensis	47%	100%
A4HNH7	Leishmania braziliensis	35%	97%
A4HSS2	Leishmania infantum	43%	100%
A4HUE4	Leishmania infantum	44%	91%
A4HUE5	Leishmania infantum	77%	98%
A4HUE6	Leishmania infantum	74%	99%
A4HUE7	Leishmania infantum	77%	97%
A4HUE8	Leishmania infantum	76%	97%
A4HUF4	Leishmania infantum	76%	97%
A4HUF5	Leishmania infantum	60%	100%
A4HYA9	Leishmania infantum	52%	100%
A4IC33	Leishmania infantum	38%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
E9AG72	Leishmania infantum	44%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	91%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	96%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4QDC4	Leishmania major	53%	100%
Q4QH81	Leishmania major	46%	100%
Q4QHH7	Leishmania major	58%	100%
Q4QHH8	Leishmania major	72%	100%
Q4QHH9	Leishmania major	72%	100%
Q4QHI0	Leishmania major	74%	100%
Q4QHI1	Leishmania major	74%	100%
Q4QHI2	Leishmania major	79%	100%
Q4QIU9	Leishmania major	43%	100%
Q4QJ48	Leishmania major	44%	100%
Q7KIP2	Leishmania major	36%	100%