MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI39_LEIBR

TriTrypDb:

LbrM.10.0191 , LBRM2903_100006900

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AI39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.439
CLV_NRD_NRD_1	36	38	PF00675	0.472
CLV_PCSK_KEX2_1	36	38	PF00082	0.472
CLV_PCSK_SKI1_1	6	10	PF00082	0.702
DEG_SPOP_SBC_1	195	199	PF00917	0.461
DOC_ANK_TNKS_1	154	161	PF00023	0.441
DOC_CDC14_PxL_1	183	191	PF14671	0.524
DOC_MAPK_gen_1	4	16	PF00069	0.599
DOC_USP7_MATH_1	195	199	PF00917	0.722
DOC_USP7_MATH_1	208	212	PF00917	0.584
DOC_USP7_MATH_1	51	55	PF00917	0.738
DOC_USP7_MATH_1	78	82	PF00917	0.713
DOC_USP7_UBL2_3	5	9	PF12436	0.609
DOC_WW_Pin1_4	196	201	PF00397	0.760
DOC_WW_Pin1_4	47	52	PF00397	0.588
DOC_WW_Pin1_4	59	64	PF00397	0.772
DOC_WW_Pin1_4	67	72	PF00397	0.782
LIG_14-3-3_CanoR_1	56	63	PF00244	0.644
LIG_14-3-3_CanoR_1	90	96	PF00244	0.417
LIG_BIR_III_4	164	168	PF00653	0.210
LIG_FHA_1	75	81	PF00498	0.456
LIG_LYPXL_S_1	185	189	PF13949	0.641
LIG_LYPXL_yS_3	186	189	PF13949	0.655
LIG_Pex14_1	170	174	PF04695	0.429
LIG_Pex14_2	129	133	PF04695	0.193
LIG_SH2_CRK	38	42	PF00017	0.544
LIG_SH2_CRK	93	97	PF00017	0.408
LIG_SH2_GRB2like	174	177	PF00017	0.507
LIG_SH2_NCK_1	162	166	PF00017	0.344
LIG_SH2_NCK_1	38	42	PF00017	0.661
LIG_SH2_NCK_1	93	97	PF00017	0.399
LIG_SH2_STAT5	100	103	PF00017	0.396
LIG_SH2_STAT5	147	150	PF00017	0.341
LIG_SH2_STAT5	162	165	PF00017	0.288
LIG_SH2_STAT5	22	25	PF00017	0.524
LIG_SH2_STAT5	93	96	PF00017	0.401
MOD_CDC14_SPxK_1	50	53	PF00782	0.701
MOD_CDC14_SPxK_1	62	65	PF00782	0.623
MOD_CDK_SPxK_1	47	53	PF00069	0.694
MOD_CDK_SPxK_1	59	65	PF00069	0.626
MOD_CK1_1	206	212	PF00069	0.468
MOD_CK1_1	54	60	PF00069	0.751
MOD_CK1_1	70	76	PF00069	0.605
MOD_GlcNHglycan	111	114	PF01048	0.336
MOD_GlcNHglycan	119	122	PF01048	0.434
MOD_GlcNHglycan	133	136	PF01048	0.313
MOD_GlcNHglycan	205	208	PF01048	0.624
MOD_GlcNHglycan	210	213	PF01048	0.575
MOD_GlcNHglycan	58	61	PF01048	0.678
MOD_GSK3_1	131	138	PF00069	0.329
MOD_GSK3_1	196	203	PF00069	0.720
MOD_GSK3_1	47	54	PF00069	0.721
MOD_GSK3_1	66	73	PF00069	0.766
MOD_GSK3_1	74	81	PF00069	0.683
MOD_GSK3_1	94	101	PF00069	0.344
MOD_N-GLC_1	175	180	PF02516	0.509
MOD_NEK2_1	109	114	PF00069	0.427
MOD_NEK2_1	117	122	PF00069	0.486
MOD_ProDKin_1	196	202	PF00069	0.755
MOD_ProDKin_1	47	53	PF00069	0.592
MOD_ProDKin_1	59	65	PF00069	0.775
MOD_ProDKin_1	67	73	PF00069	0.779
MOD_SUMO_for_1	8	11	PF00179	0.650
TRG_DiLeu_BaEn_2	10	16	PF01217	0.514
TRG_ENDOCYTIC_2	186	189	PF00928	0.645
TRG_ER_diArg_1	35	37	PF00400	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I749	Leptomonas seymouri	59%	84%
A0A0N1IB90	Leptomonas seymouri	34%	100%
A0A1X0NQ66	Trypanosomatidae	44%	100%
A0A1X0NSQ0	Trypanosomatidae	33%	100%
A0A3Q8IQ71	Leishmania donovani	34%	100%
A0A3R7KKB6	Trypanosoma rangeli	47%	100%
A0A3S5H6F3	Leishmania donovani	75%	97%
A0A422NAN4	Trypanosoma rangeli	36%	100%
A4HUC7	Leishmania infantum	76%	97%
A4I327	Leishmania infantum	34%	100%
C9ZJK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZVG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ACU8	Leishmania major	36%	97%
E9AN27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	97%
E9AZD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	97%
Q4QHJ9	Leishmania major	80%	100%
V5BCY8	Trypanosoma cruzi	35%	100%