PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania braziliensis

UniProt:

E9AI38_LEIBR

TriTrypDb:

LbrM.10.0120 , LBRM2903_100006100

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AI38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.620
CLV_NRD_NRD_1	105	107	PF00675	0.706
CLV_NRD_NRD_1	307	309	PF00675	0.259
CLV_NRD_NRD_1	355	357	PF00675	0.577
CLV_NRD_NRD_1	374	376	PF00675	0.675
CLV_PCSK_FUR_1	353	357	PF00082	0.527
CLV_PCSK_KEX2_1	105	107	PF00082	0.696
CLV_PCSK_KEX2_1	352	354	PF00082	0.544
CLV_PCSK_KEX2_1	355	357	PF00082	0.571
CLV_PCSK_KEX2_1	37	39	PF00082	0.539
CLV_PCSK_KEX2_1	373	375	PF00082	0.458
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.551
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.575
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.603
CLV_PCSK_PC7_1	369	375	PF00082	0.602
CLV_PCSK_SKI1_1	106	110	PF00082	0.640
CLV_PCSK_SKI1_1	253	257	PF00082	0.484
CLV_PCSK_SKI1_1	270	274	PF00082	0.228
CLV_PCSK_SKI1_1	309	313	PF00082	0.347
CLV_PCSK_SKI1_1	32	36	PF00082	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.473
DEG_SCF_FBW7_1	86	92	PF00400	0.517
DOC_CKS1_1	86	91	PF01111	0.668
DOC_CYCLIN_RxL_1	103	113	PF00134	0.681
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.318
DOC_MAPK_gen_1	150	158	PF00069	0.594
DOC_MAPK_gen_1	257	267	PF00069	0.329
DOC_MAPK_MEF2A_6	199	208	PF00069	0.510
DOC_PP2B_LxvP_1	163	166	PF13499	0.358
DOC_PP2B_LxvP_1	293	296	PF13499	0.353
DOC_PP2B_LxvP_1	46	49	PF13499	0.557
DOC_PP4_FxxP_1	183	186	PF00568	0.514
DOC_PP4_FxxP_1	59	62	PF00568	0.654
DOC_USP7_MATH_1	141	145	PF00917	0.559
DOC_USP7_MATH_1	248	252	PF00917	0.716
DOC_USP7_MATH_1	30	34	PF00917	0.706
DOC_USP7_MATH_1	41	45	PF00917	0.591
DOC_USP7_MATH_1	49	53	PF00917	0.520
DOC_USP7_MATH_1	62	66	PF00917	0.583
DOC_USP7_UBL2_3	151	155	PF12436	0.606
DOC_USP7_UBL2_3	253	257	PF12436	0.582
DOC_WW_Pin1_4	117	122	PF00397	0.659
DOC_WW_Pin1_4	149	154	PF00397	0.450
DOC_WW_Pin1_4	232	237	PF00397	0.744
DOC_WW_Pin1_4	244	249	PF00397	0.720
DOC_WW_Pin1_4	58	63	PF00397	0.648
DOC_WW_Pin1_4	65	70	PF00397	0.652
DOC_WW_Pin1_4	85	90	PF00397	0.620
LIG_14-3-3_CanoR_1	105	109	PF00244	0.693
LIG_14-3-3_CanoR_1	177	185	PF00244	0.450
LIG_14-3-3_CanoR_1	260	266	PF00244	0.387
LIG_14-3-3_CanoR_1	308	314	PF00244	0.262
LIG_APCC_ABBAyCdc20_2	105	111	PF00400	0.680
LIG_Clathr_ClatBox_1	191	195	PF01394	0.570
LIG_FHA_1	111	117	PF00498	0.577
LIG_FHA_1	171	177	PF00498	0.511
LIG_FHA_1	180	186	PF00498	0.499
LIG_FHA_1	2	8	PF00498	0.504
LIG_FHA_1	325	331	PF00498	0.408
LIG_FHA_1	86	92	PF00498	0.610
LIG_FHA_2	236	242	PF00498	0.770
LIG_IBAR_NPY_1	40	42	PF08397	0.480
LIG_LIR_Apic_2	180	186	PF02991	0.482
LIG_LIR_Apic_2	57	62	PF02991	0.602
LIG_LIR_Gen_1	187	194	PF02991	0.563
LIG_LIR_Gen_1	317	326	PF02991	0.342
LIG_LIR_Gen_1	52	63	PF02991	0.703
LIG_LIR_Nem_3	214	219	PF02991	0.519
LIG_LIR_Nem_3	317	323	PF02991	0.318
LIG_LIR_Nem_3	80	86	PF02991	0.606
LIG_SH2_CRK	83	87	PF00017	0.526
LIG_SH2_STAP1	189	193	PF00017	0.561
LIG_SH2_STAP1	315	319	PF00017	0.405
LIG_SH2_STAP1	42	46	PF00017	0.640
LIG_SH2_STAT3	90	93	PF00017	0.672
LIG_SH2_STAT5	157	160	PF00017	0.447
LIG_SH2_STAT5	283	286	PF00017	0.406
LIG_SH2_STAT5	315	318	PF00017	0.309
LIG_SH2_STAT5	320	323	PF00017	0.268
LIG_SH2_STAT5	90	93	PF00017	0.632
LIG_SH3_3	142	148	PF00018	0.607
LIG_SH3_3	199	205	PF00018	0.587
LIG_SH3_4	253	260	PF00018	0.373
LIG_SUMO_SIM_par_1	204	209	PF11976	0.513
LIG_SUMO_SIM_par_1	294	300	PF11976	0.415
LIG_TRAF2_1	193	196	PF00917	0.595
LIG_TYR_ITIM	81	86	PF00017	0.423
MOD_CDK_SPK_2	232	237	PF00069	0.534
MOD_CDK_SPxK_1	149	155	PF00069	0.458
MOD_CK1_1	122	128	PF00069	0.682
MOD_CK1_1	179	185	PF00069	0.358
MOD_CK1_1	235	241	PF00069	0.694
MOD_CK1_1	61	67	PF00069	0.714
MOD_CK1_1	84	90	PF00069	0.608
MOD_CK1_1	94	100	PF00069	0.660
MOD_CK2_1	260	266	PF00069	0.313
MOD_Cter_Amidation	360	363	PF01082	0.589
MOD_GlcNHglycan	121	124	PF01048	0.631
MOD_GlcNHglycan	219	222	PF01048	0.438
MOD_GlcNHglycan	250	253	PF01048	0.534
MOD_GlcNHglycan	28	31	PF01048	0.633
MOD_GlcNHglycan	32	35	PF01048	0.599
MOD_GlcNHglycan	358	362	PF01048	0.525
MOD_GlcNHglycan	83	86	PF01048	0.559
MOD_GSK3_1	119	126	PF00069	0.656
MOD_GSK3_1	22	29	PF00069	0.642
MOD_GSK3_1	228	235	PF00069	0.650
MOD_GSK3_1	244	251	PF00069	0.452
MOD_GSK3_1	291	298	PF00069	0.472
MOD_GSK3_1	309	316	PF00069	0.303
MOD_GSK3_1	347	354	PF00069	0.573
MOD_GSK3_1	54	61	PF00069	0.611
MOD_GSK3_1	77	84	PF00069	0.614
MOD_GSK3_1	85	92	PF00069	0.532
MOD_NEK2_1	1	6	PF00069	0.504
MOD_NEK2_1	109	114	PF00069	0.626
MOD_NEK2_1	128	133	PF00069	0.499
MOD_NEK2_1	91	96	PF00069	0.532
MOD_PIKK_1	89	95	PF00454	0.604
MOD_PKA_1	309	315	PF00069	0.307
MOD_PKA_2	104	110	PF00069	0.501
MOD_PKA_2	11	17	PF00069	0.356
MOD_PKA_2	176	182	PF00069	0.515
MOD_PKA_2	313	319	PF00069	0.434
MOD_PKA_2	344	350	PF00069	0.531
MOD_Plk_1	170	176	PF00069	0.460
MOD_Plk_1	179	185	PF00069	0.476
MOD_Plk_1	324	330	PF00069	0.405
MOD_Plk_1	49	55	PF00069	0.675
MOD_Plk_4	179	185	PF00069	0.497
MOD_Plk_4	187	193	PF00069	0.549
MOD_Plk_4	54	60	PF00069	0.641
MOD_Plk_4	77	83	PF00069	0.666
MOD_ProDKin_1	117	123	PF00069	0.662
MOD_ProDKin_1	149	155	PF00069	0.448
MOD_ProDKin_1	232	238	PF00069	0.746
MOD_ProDKin_1	244	250	PF00069	0.694
MOD_ProDKin_1	58	64	PF00069	0.646
MOD_ProDKin_1	65	71	PF00069	0.648
MOD_ProDKin_1	85	91	PF00069	0.622
MOD_SUMO_for_1	223	226	PF00179	0.612
MOD_SUMO_for_1	236	239	PF00179	0.710
TRG_DiLeu_BaEn_3	196	202	PF01217	0.346
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.423
TRG_ENDOCYTIC_2	189	192	PF00928	0.529
TRG_ENDOCYTIC_2	320	323	PF00928	0.285
TRG_ENDOCYTIC_2	55	58	PF00928	0.642
TRG_ENDOCYTIC_2	83	86	PF00928	0.658
TRG_ER_diArg_1	104	106	PF00400	0.694
TRG_ER_diArg_1	353	356	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	61%	99%
A0A0S4JEW1	Bodo saltans	26%	100%
A0A0S4JSN3	Bodo saltans	23%	73%
A0A1X0NQL8	Trypanosomatidae	31%	94%
A0A1X0NWX9	Trypanosomatidae	28%	100%
A0A3Q8IC14	Leishmania donovani	83%	100%
A0A3R7KIC4	Trypanosoma rangeli	30%	96%
A4HUB9	Leishmania infantum	83%	100%
C9ZVH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	97%
E9AFX3	Leishmania major	29%	100%
E9AN18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QHK8	Leishmania major	83%	100%
V5DA19	Trypanosoma cruzi	30%	96%