Glucosidase 2 subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glucosidase II beta subunit-like, putative

Species:

Leishmania braziliensis

UniProt:

E9AI37_LEIBR

TriTrypDb:

LbrM.09.0690 , LBRM2903_090011800

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0017177	glucosidase II complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AI37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI37

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009100	glycoprotein metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	593	597	PF00656	0.497
CLV_C14_Caspase3-7	92	96	PF00656	0.430
CLV_NRD_NRD_1	152	154	PF00675	0.641
CLV_NRD_NRD_1	245	247	PF00675	0.639
CLV_NRD_NRD_1	38	40	PF00675	0.511
CLV_NRD_NRD_1	413	415	PF00675	0.496
CLV_NRD_NRD_1	452	454	PF00675	0.550
CLV_NRD_NRD_1	562	564	PF00675	0.499
CLV_PCSK_KEX2_1	152	154	PF00082	0.606
CLV_PCSK_KEX2_1	245	247	PF00082	0.643
CLV_PCSK_KEX2_1	38	40	PF00082	0.700
CLV_PCSK_KEX2_1	413	415	PF00082	0.496
CLV_PCSK_KEX2_1	452	454	PF00082	0.550
CLV_PCSK_KEX2_1	562	564	PF00082	0.501
CLV_PCSK_SKI1_1	253	257	PF00082	0.528
CLV_PCSK_SKI1_1	272	276	PF00082	0.553
CLV_PCSK_SKI1_1	443	447	PF00082	0.585
CLV_PCSK_SKI1_1	57	61	PF00082	0.598
CLV_PCSK_SKI1_1	698	702	PF00082	0.552
CLV_PCSK_SKI1_1	709	713	PF00082	0.629
DEG_APCC_DBOX_1	79	87	PF00400	0.533
DEG_SCF_FBW7_1	566	571	PF00400	0.436
DEG_SPOP_SBC_1	426	430	PF00917	0.491
DOC_ANK_TNKS_1	648	655	PF00023	0.442
DOC_CKS1_1	1	6	PF01111	0.540
DOC_CKS1_1	110	115	PF01111	0.663
DOC_CKS1_1	205	210	PF01111	0.625
DOC_CKS1_1	254	259	PF01111	0.430
DOC_CKS1_1	444	449	PF01111	0.711
DOC_CKS1_1	59	64	PF01111	0.642
DOC_CKS1_1	686	691	PF01111	0.382
DOC_MAPK_DCC_7	66	76	PF00069	0.431
DOC_MAPK_gen_1	676	686	PF00069	0.329
DOC_MAPK_MEF2A_6	330	337	PF00069	0.474
DOC_MAPK_NFAT4_5	330	338	PF00069	0.475
DOC_PP1_RVXF_1	576	582	PF00149	0.540
DOC_PP1_RVXF_1	61	68	PF00149	0.420
DOC_PP2B_LxvP_1	182	185	PF13499	0.588
DOC_USP7_MATH_1	426	430	PF00917	0.495
DOC_USP7_MATH_1	533	537	PF00917	0.495
DOC_USP7_MATH_1	539	543	PF00917	0.504
DOC_USP7_MATH_1	617	621	PF00917	0.636
DOC_USP7_UBL2_3	601	605	PF12436	0.607
DOC_USP7_UBL2_3	705	709	PF12436	0.544
DOC_WW_Pin1_4	109	114	PF00397	0.610
DOC_WW_Pin1_4	204	209	PF00397	0.679
DOC_WW_Pin1_4	210	215	PF00397	0.697
DOC_WW_Pin1_4	253	258	PF00397	0.601
DOC_WW_Pin1_4	443	448	PF00397	0.572
DOC_WW_Pin1_4	512	517	PF00397	0.618
DOC_WW_Pin1_4	521	526	PF00397	0.537
DOC_WW_Pin1_4	564	569	PF00397	0.513
DOC_WW_Pin1_4	58	63	PF00397	0.647
DOC_WW_Pin1_4	600	605	PF00397	0.391
DOC_WW_Pin1_4	627	632	PF00397	0.509
DOC_WW_Pin1_4	685	690	PF00397	0.363
LIG_14-3-3_CanoR_1	118	123	PF00244	0.608
LIG_14-3-3_CanoR_1	161	171	PF00244	0.645
LIG_14-3-3_CanoR_1	245	254	PF00244	0.665
LIG_14-3-3_CanoR_1	521	525	PF00244	0.490
LIG_14-3-3_CanoR_1	66	74	PF00244	0.518
LIG_APCC_ABBAyCdc20_2	413	419	PF00400	0.323
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_BRCT_BRCA1_1	569	573	PF00533	0.616
LIG_EVH1_2	4	8	PF00568	0.408
LIG_FHA_1	10	16	PF00498	0.584
LIG_FHA_1	164	170	PF00498	0.456
LIG_FHA_1	178	184	PF00498	0.476
LIG_FHA_1	339	345	PF00498	0.515
LIG_FHA_1	385	391	PF00498	0.441
LIG_FHA_1	513	519	PF00498	0.489
LIG_FHA_1	53	59	PF00498	0.557
LIG_FHA_1	614	620	PF00498	0.611
LIG_FHA_1	628	634	PF00498	0.456
LIG_FHA_1	638	644	PF00498	0.582
LIG_FHA_1	654	660	PF00498	0.391
LIG_FHA_1	699	705	PF00498	0.330
LIG_FHA_1	95	101	PF00498	0.476
LIG_FHA_2	205	211	PF00498	0.465
LIG_FHA_2	283	289	PF00498	0.621
LIG_FHA_2	428	434	PF00498	0.633
LIG_FHA_2	444	450	PF00498	0.524
LIG_FHA_2	59	65	PF00498	0.591
LIG_FHA_2	601	607	PF00498	0.620
LIG_LIR_Gen_1	282	289	PF02991	0.603
LIG_LIR_Gen_1	316	327	PF02991	0.333
LIG_LIR_Nem_3	117	122	PF02991	0.605
LIG_LIR_Nem_3	277	283	PF02991	0.538
LIG_LIR_Nem_3	316	322	PF02991	0.374
LIG_LIR_Nem_3	348	353	PF02991	0.474
LIG_LIR_Nem_3	404	409	PF02991	0.404
LIG_LIR_Nem_3	50	56	PF02991	0.490
LIG_LIR_Nem_3	536	540	PF02991	0.473
LIG_Pex14_1	581	585	PF04695	0.457
LIG_SH2_SRC	122	125	PF00017	0.447
LIG_SH2_SRC	304	307	PF00017	0.450
LIG_SH2_SRC	623	626	PF00017	0.406
LIG_SH2_STAP1	260	264	PF00017	0.617
LIG_SH2_STAT3	148	151	PF00017	0.771
LIG_SH2_STAT3	458	461	PF00017	0.571
LIG_SH2_STAT5	122	125	PF00017	0.531
LIG_SH2_STAT5	163	166	PF00017	0.663
LIG_SH2_STAT5	284	287	PF00017	0.658
LIG_SH2_STAT5	350	353	PF00017	0.477
LIG_SH2_STAT5	514	517	PF00017	0.627
LIG_SH2_STAT5	623	626	PF00017	0.695
LIG_SH2_STAT5	639	642	PF00017	0.409
LIG_SH2_STAT5	663	666	PF00017	0.389
LIG_SH2_STAT5	90	93	PF00017	0.427
LIG_SH3_3	107	113	PF00018	0.608
LIG_SH3_3	165	171	PF00018	0.476
LIG_SH3_3	460	466	PF00018	0.584
LIG_SH3_3	527	533	PF00018	0.493
LIG_SH3_3	56	62	PF00018	0.653
LIG_SH3_3	583	589	PF00018	0.757
LIG_SUMO_SIM_anti_2	546	553	PF11976	0.443
LIG_SUMO_SIM_par_1	12	20	PF11976	0.650
LIG_TRAF2_1	346	349	PF00917	0.465
LIG_UBA3_1	238	243	PF00899	0.389
MOD_CDC14_SPxK_1	213	216	PF00782	0.637
MOD_CDK_SPK_2	58	63	PF00069	0.426
MOD_CDK_SPK_2	600	605	PF00069	0.391
MOD_CDK_SPxK_1	210	216	PF00069	0.638
MOD_CDK_SPxxK_3	521	528	PF00069	0.482
MOD_CDK_SPxxK_3	600	607	PF00069	0.388
MOD_CK1_1	282	288	PF00069	0.504
MOD_CK1_1	338	344	PF00069	0.425
MOD_CK1_1	394	400	PF00069	0.493
MOD_CK1_1	42	48	PF00069	0.534
MOD_CK1_1	427	433	PF00069	0.506
MOD_CK1_1	512	518	PF00069	0.559
MOD_CK1_1	690	696	PF00069	0.421
MOD_CK1_1	9	15	PF00069	0.610
MOD_CK2_1	282	288	PF00069	0.635
MOD_CK2_1	343	349	PF00069	0.545
MOD_CK2_1	42	48	PF00069	0.663
MOD_CK2_1	443	449	PF00069	0.592
MOD_CK2_1	58	64	PF00069	0.518
MOD_CK2_1	609	615	PF00069	0.564
MOD_GlcNHglycan	107	110	PF01048	0.538
MOD_GlcNHglycan	217	220	PF01048	0.459
MOD_GlcNHglycan	247	250	PF01048	0.580
MOD_GlcNHglycan	269	272	PF01048	0.544
MOD_GlcNHglycan	41	44	PF01048	0.596
MOD_GlcNHglycan	510	514	PF01048	0.584
MOD_GlcNHglycan	611	614	PF01048	0.630
MOD_GlcNHglycan	689	692	PF01048	0.338
MOD_GSK3_1	114	121	PF00069	0.546
MOD_GSK3_1	279	286	PF00069	0.540
MOD_GSK3_1	42	49	PF00069	0.568
MOD_GSK3_1	424	431	PF00069	0.553
MOD_GSK3_1	505	512	PF00069	0.385
MOD_GSK3_1	539	546	PF00069	0.412
MOD_GSK3_1	564	571	PF00069	0.612
MOD_GSK3_1	609	616	PF00069	0.620
MOD_GSK3_1	625	632	PF00069	0.487
MOD_GSK3_1	99	106	PF00069	0.475
MOD_N-GLC_1	328	333	PF02516	0.505
MOD_N-GLC_1	338	343	PF02516	0.436
MOD_N-GLC_1	470	475	PF02516	0.482
MOD_N-GLC_1	519	524	PF02516	0.444
MOD_N-GLC_2	103	105	PF02516	0.516
MOD_NEK2_1	162	167	PF00069	0.684
MOD_NEK2_1	172	177	PF00069	0.629
MOD_NEK2_1	335	340	PF00069	0.533
MOD_NEK2_1	418	423	PF00069	0.633
MOD_NEK2_1	519	524	PF00069	0.596
MOD_NEK2_2	279	284	PF00069	0.594
MOD_NEK2_2	568	573	PF00069	0.612
MOD_PIKK_1	177	183	PF00454	0.655
MOD_PIKK_1	247	253	PF00454	0.496
MOD_PIKK_1	328	334	PF00454	0.573
MOD_PIKK_1	617	623	PF00454	0.508
MOD_PIKK_1	75	81	PF00454	0.624
MOD_PKA_1	245	251	PF00069	0.606
MOD_PKA_1	452	458	PF00069	0.396
MOD_PKA_2	215	221	PF00069	0.683
MOD_PKA_2	245	251	PF00069	0.634
MOD_PKA_2	37	43	PF00069	0.473
MOD_PKA_2	452	458	PF00069	0.653
MOD_PKA_2	46	52	PF00069	0.454
MOD_PKA_2	520	526	PF00069	0.509
MOD_PKA_2	543	549	PF00069	0.416
MOD_Plk_1	328	334	PF00069	0.389
MOD_Plk_1	418	424	PF00069	0.640
MOD_Plk_1	470	476	PF00069	0.456
MOD_Plk_1	509	515	PF00069	0.565
MOD_Plk_2-3	343	349	PF00069	0.460
MOD_Plk_2-3	470	476	PF00069	0.521
MOD_Plk_4	118	124	PF00069	0.653
MOD_Plk_4	183	189	PF00069	0.520
MOD_Plk_4	279	285	PF00069	0.482
MOD_Plk_4	48	54	PF00069	0.598
MOD_Plk_4	568	574	PF00069	0.705
MOD_Plk_4	629	635	PF00069	0.576
MOD_ProDKin_1	109	115	PF00069	0.610
MOD_ProDKin_1	204	210	PF00069	0.681
MOD_ProDKin_1	253	259	PF00069	0.601
MOD_ProDKin_1	443	449	PF00069	0.563
MOD_ProDKin_1	512	518	PF00069	0.613
MOD_ProDKin_1	521	527	PF00069	0.540
MOD_ProDKin_1	564	570	PF00069	0.519
MOD_ProDKin_1	58	64	PF00069	0.642
MOD_ProDKin_1	600	606	PF00069	0.389
MOD_ProDKin_1	627	633	PF00069	0.506
MOD_ProDKin_1	685	691	PF00069	0.364
MOD_SUMO_rev_2	593	603	PF00179	0.567
TRG_DiLeu_BaEn_1	419	424	PF01217	0.546
TRG_ENDOCYTIC_2	280	283	PF00928	0.607
TRG_ENDOCYTIC_2	284	287	PF00928	0.562
TRG_ENDOCYTIC_2	408	411	PF00928	0.366
TRG_ER_diArg_1	245	247	PF00400	0.599
TRG_ER_diArg_1	37	39	PF00400	0.471
TRG_ER_diArg_1	413	415	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	679	683	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC1	Leptomonas seymouri	55%	76%
A0A1X0NMP0	Trypanosomatidae	29%	84%
A0A3Q8I8J4	Leishmania donovani	81%	85%
A0A422NV59	Trypanosoma rangeli	30%	88%
A4HTY2	Leishmania infantum	81%	74%
D0A9D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	94%
E9AMR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	85%
Q4QHW3	Leishmania major	80%	100%
V5B314	Trypanosoma cruzi	30%	88%