Ubiquitin-60S ribosomal protein L40

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-fusion protein

Species:

Leishmania braziliensis

UniProt:

E9AI36_LEIBR

TriTrypDb:

LbrM.09.0640 , LBRM2903_310031200

Length:

115

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0005634	nucleus	5	8
GO:0005737	cytoplasm	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

E9AI36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI36

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0043043	peptide biosynthetic process	5	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0043604	amide biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006508	proteolysis	4	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0016567	protein ubiquitination	7	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044248	cellular catabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	10
GO:0005198	structural molecule activity	1	10
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031386	protein tag	1	1
GO:0031625	ubiquitin protein ligase binding	5	1
GO:0044389	ubiquitin-like protein ligase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	39	41	PF00675	0.486
CLV_NRD_NRD_1	50	52	PF00675	0.548
CLV_NRD_NRD_1	97	99	PF00675	0.285
CLV_PCSK_KEX2_1	39	41	PF00082	0.685
CLV_PCSK_KEX2_1	50	52	PF00082	0.548
CLV_PCSK_SKI1_1	2	6	PF00082	0.323
DEG_Nend_UBRbox_1	1	4	PF02207	0.198
DEG_SCF_FBW7_1	32	37	PF00400	0.393
DOC_USP7_MATH_1	34	38	PF00917	0.592
DOC_USP7_UBL2_3	25	29	PF12436	0.523
DOC_WW_Pin1_4	30	35	PF00397	0.446
DOC_WW_Pin1_4	49	54	PF00397	0.387
LIG_14-3-3_CanoR_1	43	53	PF00244	0.485
LIG_FHA_1	6	12	PF00498	0.523
LIG_NRP_CendR_1	112	115	PF00754	0.362
LIG_SH2_CRK	87	91	PF00017	0.523
LIG_SUMO_SIM_par_1	7	12	PF11976	0.522
LIG_UBA3_1	69	75	PF00899	0.441
MOD_CK1_1	103	109	PF00069	0.393
MOD_CK1_1	44	50	PF00069	0.444
MOD_GSK3_1	30	37	PF00069	0.446
MOD_GSK3_1	41	48	PF00069	0.605
MOD_GSK3_1	49	56	PF00069	0.380
MOD_OFUCOSY	97	102	PF10250	0.193
MOD_PKA_1	98	104	PF00069	0.393
MOD_PKA_2	44	50	PF00069	0.492
MOD_PKA_2	92	98	PF00069	0.523
MOD_PKB_1	43	51	PF00069	0.441
MOD_Plk_4	65	71	PF00069	0.608
MOD_ProDKin_1	30	36	PF00069	0.446
MOD_ProDKin_1	49	55	PF00069	0.381
TRG_ENDOCYTIC_2	87	90	PF00928	0.523
TRG_ER_diArg_1	38	40	PF00400	0.747
TRG_ER_diLys_1	111	115	PF00400	0.562
TRG_NLS_Bipartite_1	80	102	PF00514	0.523
TRG_NLS_MonoExtC_3	110	115	PF00514	0.562
TRG_NLS_MonoExtN_4	109	115	PF00514	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NP39	Trypanosomatidae	63%	90%
A0A3Q8ISR1	Leishmania donovani	65%	90%
A0A3R7JQP6	Trypanosoma rangeli	63%	88%
A4HJH0	Leishmania braziliensis	62%	100%
B9DHA6	Arabidopsis thaliana	48%	90%
E9AHL5	Leishmania infantum	65%	90%
E9AMU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	90%
E9B1Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	90%
P0C224	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	50%	90%
P0C273	Macaca fascicularis	52%	90%
P0C275	Pongo pygmaeus	52%	90%
P0C276	Ovis aries	52%	90%
P0CH06	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	90%
P0CH07	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	90%
P0CH08	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	90%
P0CH09	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	90%
P0CH10	Chlamydomonas reinhardtii	52%	90%
P0CH11	Chlamydomonas reinhardtii	52%	90%
P0CH34	Oryza sativa subsp. japonica	49%	89%
P0CH35	Oryza sativa subsp. japonica	49%	89%
P0DJ25	Tetrahymena thermophila (strain SB210)	55%	89%
P14794	Dictyostelium discoideum	48%	90%
P14795	Trypanosoma cruzi	64%	90%
P18101	Drosophila melanogaster	53%	90%
P21899	Trypanosoma brucei brucei	64%	90%
P33190	Tetrahymena pyriformis	55%	89%
P40909	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	51%	89%
P46575	Eimeria bovis	55%	89%
P49632	Caenorhabditis elegans	52%	90%
P49633	Acanthamoeba castellanii	49%	90%
P49636	Nicotiana sylvestris	48%	90%
P51423	Brassica rapa subsp. pekinensis	49%	90%
P62984	Mus musculus	52%	90%
P62986	Rattus norvegicus	52%	90%
P62987	Homo sapiens	52%	90%
P63048	Bos taurus	52%	90%
P63050	Canis lupus familiaris	52%	90%
P63052	Felis catus	52%	90%
P63053	Sus scrofa	52%	90%
P68205	Ophiophagus hannah	52%	90%
P69200	Leishmania tarentolae	65%	90%
P69201	Leishmania major	62%	100%
Q42202	Arabidopsis thaliana	48%	90%