DUF3480 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E9AI35_LEIBR

TriTrypDb:

LbrM.09.0331 , LBRM2903_090008800

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.521
CLV_NRD_NRD_1	139	141	PF00675	0.618
CLV_NRD_NRD_1	148	150	PF00675	0.634
CLV_NRD_NRD_1	212	214	PF00675	0.628
CLV_PCSK_KEX2_1	139	141	PF00082	0.611
CLV_PCSK_KEX2_1	148	150	PF00082	0.600
CLV_PCSK_KEX2_1	211	213	PF00082	0.637
CLV_PCSK_KEX2_1	7	9	PF00082	0.537
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.662
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.537
CLV_PCSK_PC7_1	3	9	PF00082	0.538
CLV_PCSK_SKI1_1	45	49	PF00082	0.492
DOC_MAPK_gen_1	211	221	PF00069	0.518
DOC_MAPK_gen_1	7	16	PF00069	0.516
DOC_MAPK_JIP1_4	10	16	PF00069	0.565
DOC_MAPK_MEF2A_6	10	18	PF00069	0.497
DOC_USP7_MATH_1	130	134	PF00917	0.579
DOC_USP7_MATH_1	38	42	PF00917	0.522
DOC_WW_Pin1_4	114	119	PF00397	0.706
DOC_WW_Pin1_4	40	45	PF00397	0.611
DOC_WW_Pin1_4	96	101	PF00397	0.512
LIG_14-3-3_CanoR_1	142	152	PF00244	0.545
LIG_FHA_1	126	132	PF00498	0.709
LIG_FHA_1	148	154	PF00498	0.476
LIG_FHA_1	53	59	PF00498	0.563
LIG_FHA_2	198	204	PF00498	0.545
LIG_LIR_Nem_3	89	95	PF02991	0.627
LIG_NRP_CendR_1	245	248	PF00754	0.658
LIG_PCNA_PIPBox_1	64	73	PF02747	0.420
LIG_SH2_STAP1	59	63	PF00017	0.517
LIG_SH3_3	115	121	PF00018	0.552
LIG_SH3_3	182	188	PF00018	0.566
MOD_CDK_SPK_2	40	45	PF00069	0.630
MOD_CK1_1	116	122	PF00069	0.611
MOD_CK2_1	40	46	PF00069	0.651
MOD_GlcNHglycan	110	113	PF01048	0.695
MOD_GlcNHglycan	123	126	PF01048	0.709
MOD_GlcNHglycan	143	146	PF01048	0.637
MOD_GlcNHglycan	213	216	PF01048	0.562
MOD_GlcNHglycan	40	43	PF01048	0.529
MOD_GlcNHglycan	52	55	PF01048	0.555
MOD_GlcNHglycan	88	91	PF01048	0.548
MOD_GSK3_1	116	123	PF00069	0.694
MOD_GSK3_1	143	150	PF00069	0.566
MOD_NEK2_1	159	164	PF00069	0.577
MOD_PIKK_1	143	149	PF00454	0.503
MOD_PIKK_1	178	184	PF00454	0.544
MOD_PIKK_1	187	193	PF00454	0.603
MOD_PKA_1	211	217	PF00069	0.579
MOD_PKA_2	141	147	PF00069	0.614
MOD_PKA_2	211	217	PF00069	0.579
MOD_Plk_4	197	203	PF00069	0.513
MOD_ProDKin_1	114	120	PF00069	0.702
MOD_ProDKin_1	40	46	PF00069	0.610
MOD_ProDKin_1	96	102	PF00069	0.510
MOD_SUMO_for_1	6	9	PF00179	0.530
TRG_ENDOCYTIC_2	70	73	PF00928	0.584
TRG_ER_diArg_1	131	134	PF00400	0.630
TRG_ER_diArg_1	139	142	PF00400	0.616
TRG_ER_diArg_1	245	248	PF00400	0.732
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I643	Leptomonas seymouri	49%	100%
A0A3S7WQK0	Leishmania donovani	68%	99%
A4HTU7	Leishmania infantum	68%	99%
E9AMN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QHZ1	Leishmania major	71%	100%