EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Repeat of unknown function (DUF1126), putative

Species:

Leishmania braziliensis

UniProt:

E9AI34_LEIBR

TriTrypDb:

LbrM.08.0890 , LBRM2903_080016700

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 29
NetGPI	no	yes: 0, no: 30

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Cellular components
Term	Name	Level	Count
GO:0005819	spindle	5	3
GO:0005930	axoneme	2	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0072686	mitotic spindle	6	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

E9AI34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI34

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0000281	mitotic cytokinesis	4	3
GO:0000910	cytokinesis	3	3
GO:0001539	cilium or flagellum-dependent cell motility	3	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	3
GO:0007051	spindle organization	3	3
GO:0007052	mitotic spindle organization	4	3
GO:0009987	cellular process	1	3

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	20
GO:0005509	calcium ion binding	5	19
GO:0005515	protein binding	2	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0043014	alpha-tubulin binding	5	3
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.553
CLV_C14_Caspase3-7	290	294	PF00656	0.428
CLV_C14_Caspase3-7	448	452	PF00656	0.756
CLV_C14_Caspase3-7	738	742	PF00656	0.546
CLV_MEL_PAP_1	30	36	PF00089	0.606
CLV_NRD_NRD_1	100	102	PF00675	0.633
CLV_NRD_NRD_1	139	141	PF00675	0.284
CLV_NRD_NRD_1	301	303	PF00675	0.278
CLV_NRD_NRD_1	423	425	PF00675	0.535
CLV_NRD_NRD_1	495	497	PF00675	0.271

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H4	Leptomonas seymouri	69%	100%
A0A0N1HZ98	Leptomonas seymouri	23%	100%
A0A0N1I3M2	Leptomonas seymouri	21%	100%
A0A0S4IJW8	Bodo saltans	35%	100%
A0A0S4IQM0	Bodo saltans	25%	100%
A0A0S4J8J7	Bodo saltans	24%	94%
A0A1X0NEV8	Trypanosomatidae	46%	100%
A0A1X0P419	Trypanosomatidae	23%	100%
A0A3Q8IDH4	Leishmania donovani	24%	100%
A0A3Q8IPU3	Leishmania donovani	23%	100%

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