Putative histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone deacetylase, putative

Species:

Leishmania braziliensis

UniProt:

E9AI33_LEIBR

TriTrypDb:

LbrM.08.0840 , LBRM2903_080016000

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AI33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI33

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006476	protein deacetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016570	histone modification	5	1
GO:0016575	histone deacetylation	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035601	protein deacylation	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0098732	macromolecule deacylation	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004407	histone deacetylase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0019213	deacetylase activity	3	1
GO:0033558	protein lysine deacetylase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	52	58	PF00089	0.424
CLV_NRD_NRD_1	27	29	PF00675	0.422
CLV_NRD_NRD_1	40	42	PF00675	0.530
CLV_NRD_NRD_1	438	440	PF00675	0.157
CLV_NRD_NRD_1	545	547	PF00675	0.427
CLV_NRD_NRD_1	554	556	PF00675	0.468
CLV_NRD_NRD_1	595	597	PF00675	0.343
CLV_PCSK_FUR_1	593	597	PF00082	0.453
CLV_PCSK_KEX2_1	27	29	PF00082	0.497
CLV_PCSK_KEX2_1	438	440	PF00082	0.234
CLV_PCSK_KEX2_1	545	547	PF00082	0.434
CLV_PCSK_KEX2_1	554	556	PF00082	0.480
CLV_PCSK_KEX2_1	595	597	PF00082	0.461
CLV_PCSK_SKI1_1	138	142	PF00082	0.392
CLV_PCSK_SKI1_1	212	216	PF00082	0.329
DEG_APCC_DBOX_1	443	451	PF00400	0.491
DEG_APCC_DBOX_1	45	53	PF00400	0.286
DEG_Nend_UBRbox_4	1	3	PF02207	0.441
DOC_CKS1_1	150	155	PF01111	0.395
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.499
DOC_MAPK_DCC_7	168	177	PF00069	0.372
DOC_MAPK_FxFP_2	29	32	PF00069	0.353
DOC_MAPK_MEF2A_6	168	177	PF00069	0.372
DOC_MAPK_MEF2A_6	340	348	PF00069	0.415
DOC_MAPK_MEF2A_6	444	452	PF00069	0.408
DOC_MAPK_MEF2A_6	487	495	PF00069	0.474
DOC_PP2B_LxvP_1	177	180	PF13499	0.410
DOC_PP2B_LxvP_1	515	518	PF13499	0.412
DOC_PP2B_PxIxI_1	126	132	PF00149	0.384
DOC_PP2B_PxIxI_1	338	344	PF00149	0.415
DOC_PP4_FxxP_1	222	225	PF00568	0.427
DOC_PP4_FxxP_1	29	32	PF00568	0.440
DOC_PP4_MxPP_1	573	576	PF00568	0.470
DOC_USP7_MATH_1	276	280	PF00917	0.469
DOC_USP7_MATH_1	291	295	PF00917	0.375
DOC_USP7_MATH_1	382	386	PF00917	0.406
DOC_USP7_MATH_1	51	55	PF00917	0.538
DOC_USP7_MATH_1	60	64	PF00917	0.553
DOC_WW_Pin1_4	103	108	PF00397	0.630
DOC_WW_Pin1_4	146	151	PF00397	0.458
DOC_WW_Pin1_4	5	10	PF00397	0.537
LIG_14-3-3_CanoR_1	212	217	PF00244	0.336
LIG_14-3-3_CanoR_1	257	264	PF00244	0.471
LIG_14-3-3_CanoR_1	329	334	PF00244	0.542
LIG_14-3-3_CanoR_1	396	404	PF00244	0.400
LIG_14-3-3_CanoR_1	59	68	PF00244	0.533
LIG_APCC_ABBA_1	181	186	PF00400	0.528
LIG_BRCT_BRCA1_1	450	454	PF00533	0.415
LIG_EVH1_2	11	15	PF00568	0.566
LIG_FHA_1	117	123	PF00498	0.506
LIG_FHA_1	21	27	PF00498	0.416
LIG_FHA_1	284	290	PF00498	0.452
LIG_FHA_1	363	369	PF00498	0.549
LIG_FHA_1	387	393	PF00498	0.459
LIG_FHA_1	518	524	PF00498	0.449
LIG_FHA_2	213	219	PF00498	0.325
LIG_FHA_2	415	421	PF00498	0.357
LIG_FHA_2	95	101	PF00498	0.481
LIG_Integrin_RGD_1	386	388	PF01839	0.246
LIG_LIR_Apic_2	221	225	PF02991	0.381
LIG_LIR_Apic_2	455	461	PF02991	0.428
LIG_LIR_Gen_1	215	222	PF02991	0.476
LIG_LIR_Gen_1	294	301	PF02991	0.477
LIG_LIR_Gen_1	311	321	PF02991	0.511
LIG_LIR_Gen_1	366	375	PF02991	0.509
LIG_LIR_Gen_1	468	478	PF02991	0.471
LIG_LIR_Gen_1	549	558	PF02991	0.566
LIG_LIR_Gen_1	67	74	PF02991	0.330
LIG_LIR_LC3C_4	488	493	PF02991	0.469
LIG_LIR_Nem_3	215	219	PF02991	0.370
LIG_LIR_Nem_3	294	298	PF02991	0.477
LIG_LIR_Nem_3	311	316	PF02991	0.511
LIG_LIR_Nem_3	366	372	PF02991	0.500
LIG_LIR_Nem_3	379	383	PF02991	0.379
LIG_LIR_Nem_3	468	474	PF02991	0.471
LIG_LIR_Nem_3	549	553	PF02991	0.488
LIG_LIR_Nem_3	67	71	PF02991	0.621
LIG_NRBOX	523	529	PF00104	0.261
LIG_SH2_SRC	216	219	PF00017	0.376
LIG_SH2_STAT5	246	249	PF00017	0.446
LIG_SH2_STAT5	369	372	PF00017	0.438
LIG_SH2_STAT5	391	394	PF00017	0.428
LIG_SH2_STAT5	92	95	PF00017	0.552
LIG_SH3_1	6	12	PF00018	0.434
LIG_SH3_2	150	155	PF14604	0.391
LIG_SH3_2	335	340	PF14604	0.426
LIG_SH3_2	9	14	PF14604	0.438
LIG_SH3_3	121	127	PF00018	0.469
LIG_SH3_3	147	153	PF00018	0.422
LIG_SH3_3	295	301	PF00018	0.428
LIG_SH3_3	332	338	PF00018	0.426
LIG_SH3_3	526	532	PF00018	0.318
LIG_SH3_3	578	584	PF00018	0.524
LIG_SH3_3	6	12	PF00018	0.535
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.463
LIG_SUMO_SIM_par_1	237	244	PF11976	0.428
LIG_SUMO_SIM_par_1	342	347	PF11976	0.415
LIG_SUMO_SIM_par_1	446	451	PF11976	0.415
LIG_SUMO_SIM_par_1	491	496	PF11976	0.429
LIG_TRAF2_1	577	580	PF00917	0.644
LIG_TYR_ITIM	367	372	PF00017	0.428
LIG_UBA3_1	79	84	PF00899	0.554
LIG_WRC_WIRS_1	219	224	PF05994	0.418
LIG_WRC_WIRS_1	292	297	PF05994	0.469
LIG_WW_3	337	341	PF00397	0.471
MOD_CDK_SPK_2	103	108	PF00069	0.495
MOD_CDK_SPxK_1	149	155	PF00069	0.418
MOD_CK1_1	106	112	PF00069	0.607
MOD_CK1_1	149	155	PF00069	0.557
MOD_CK1_1	20	26	PF00069	0.419
MOD_CK1_1	234	240	PF00069	0.357
MOD_CK1_1	279	285	PF00069	0.374
MOD_CK1_1	308	314	PF00069	0.498
MOD_CK1_1	395	401	PF00069	0.430
MOD_CK1_1	473	479	PF00069	0.536
MOD_CK2_1	212	218	PF00069	0.324
MOD_CK2_1	353	359	PF00069	0.451
MOD_CK2_1	414	420	PF00069	0.492
MOD_CK2_1	427	433	PF00069	0.461
MOD_CK2_1	96	102	PF00069	0.692
MOD_GlcNHglycan	116	119	PF01048	0.602
MOD_GlcNHglycan	19	23	PF01048	0.523
MOD_GlcNHglycan	200	203	PF01048	0.493
MOD_GlcNHglycan	233	236	PF01048	0.269
MOD_GlcNHglycan	258	261	PF01048	0.343
MOD_GlcNHglycan	278	281	PF01048	0.329
MOD_GlcNHglycan	283	286	PF01048	0.340
MOD_GlcNHglycan	310	313	PF01048	0.273
MOD_GlcNHglycan	335	338	PF01048	0.274
MOD_GSK3_1	103	110	PF00069	0.642
MOD_GSK3_1	245	252	PF00069	0.367
MOD_GSK3_1	276	283	PF00069	0.448
MOD_GSK3_1	325	332	PF00069	0.439
MOD_GSK3_1	382	389	PF00069	0.357
MOD_GSK3_1	513	520	PF00069	0.428
MOD_GSK3_1	60	67	PF00069	0.528
MOD_N-GLC_1	146	151	PF02516	0.474
MOD_NEK2_1	231	236	PF00069	0.479
MOD_NEK2_1	368	373	PF00069	0.428
MOD_NEK2_1	427	432	PF00069	0.509
MOD_NEK2_1	513	518	PF00069	0.412
MOD_PIKK_1	305	311	PF00454	0.509
MOD_PIKK_1	414	420	PF00454	0.417
MOD_PK_1	329	335	PF00069	0.357
MOD_PKA_2	107	113	PF00069	0.598
MOD_PKA_2	256	262	PF00069	0.471
MOD_PKA_2	395	401	PF00069	0.512
MOD_PKA_2	60	66	PF00069	0.661
MOD_PKB_1	327	335	PF00069	0.469
MOD_PKB_1	59	67	PF00069	0.531
MOD_Plk_1	127	133	PF00069	0.352
MOD_Plk_1	249	255	PF00069	0.496
MOD_Plk_1	264	270	PF00069	0.534
MOD_Plk_1	387	393	PF00069	0.430
MOD_Plk_2-3	218	224	PF00069	0.362
MOD_Plk_4	110	116	PF00069	0.533
MOD_Plk_4	20	26	PF00069	0.280
MOD_Plk_4	234	240	PF00069	0.481
MOD_Plk_4	329	335	PF00069	0.357
MOD_Plk_4	353	359	PF00069	0.428
MOD_Plk_4	363	369	PF00069	0.428
MOD_Plk_4	376	382	PF00069	0.351
MOD_Plk_4	387	393	PF00069	0.364
MOD_Plk_4	427	433	PF00069	0.509
MOD_Plk_4	470	476	PF00069	0.516
MOD_ProDKin_1	103	109	PF00069	0.628
MOD_ProDKin_1	146	152	PF00069	0.451
MOD_ProDKin_1	5	11	PF00069	0.537
MOD_SUMO_rev_2	371	380	PF00179	0.357
MOD_SUMO_rev_2	570	576	PF00179	0.596
TRG_DiLeu_BaEn_1	586	591	PF01217	0.404
TRG_DiLeu_BaLyEn_6	519	524	PF01217	0.397
TRG_ENDOCYTIC_2	216	219	PF00928	0.397
TRG_ENDOCYTIC_2	228	231	PF00928	0.256
TRG_ENDOCYTIC_2	369	372	PF00928	0.451
TRG_ER_diArg_1	26	28	PF00400	0.410
TRG_ER_diArg_1	326	329	PF00400	0.469
TRG_ER_diArg_1	437	439	PF00400	0.428
TRG_ER_diArg_1	539	542	PF00400	0.384
TRG_ER_diArg_1	545	548	PF00400	0.397
TRG_ER_diArg_1	553	555	PF00400	0.410
TRG_ER_diArg_1	58	61	PF00400	0.635
TRG_ER_diArg_1	593	596	PF00400	0.341
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD56	Leptomonas seymouri	63%	100%
A0A0S4J6F0	Bodo saltans	37%	91%
A0A1X0NP71	Trypanosomatidae	42%	99%
A0A3S5H686	Leishmania donovani	81%	100%
A0A422NJU7	Trypanosoma rangeli	43%	100%
A4HTP2	Leishmania infantum	81%	94%
E9AMH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P53973	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	87%
Q4QI60	Leishmania major	81%	100%
Q5A960	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	74%
V5BR24	Trypanosoma cruzi	43%	100%