LeishMANIAdb
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Hexosyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hexosyltransferase
Gene product:
phosphoglycan beta 1,3 galactosyltransferase 4
Species:
Leishmania braziliensis
UniProt:
E9AI30_LEIBR
TriTrypDb:
LbrM.35.0010 * , LBRM2903_350005100 *
Length:
349

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 18
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 17
GO:0016020 membrane 2 18
GO:0031090 organelle membrane 3 17
GO:0098588 bounding membrane of organelle 4 17
GO:0110165 cellular anatomical entity 1 18

Expansion

Sequence features

E9AI30
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI30

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 18
GO:0006807 nitrogen compound metabolic process 2 18
GO:0008152 metabolic process 1 18
GO:0019538 protein metabolic process 3 18
GO:0036211 protein modification process 4 18
GO:0043170 macromolecule metabolic process 3 18
GO:0043412 macromolecule modification 4 18
GO:0043413 macromolecule glycosylation 3 18
GO:0044238 primary metabolic process 2 18
GO:0070085 glycosylation 2 18
GO:0071704 organic substance metabolic process 2 18
GO:1901564 organonitrogen compound metabolic process 3 18
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 19
GO:0016740 transferase activity 2 19
GO:0016757 glycosyltransferase activity 3 19
GO:0016758 hexosyltransferase activity 4 18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 148 150 PF00675 0.465
CLV_NRD_NRD_1 211 213 PF00675 0.452
CLV_NRD_NRD_1 219 221 PF00675 0.471
CLV_PCSK_FUR_1 333 337 PF00082 0.256
CLV_PCSK_KEX2_1 148 150 PF00082 0.461
CLV_PCSK_KEX2_1 211 213 PF00082 0.436
CLV_PCSK_KEX2_1 219 221 PF00082 0.462
CLV_PCSK_KEX2_1 267 269 PF00082 0.301
CLV_PCSK_KEX2_1 335 337 PF00082 0.261
CLV_PCSK_PC1ET2_1 267 269 PF00082 0.373
CLV_PCSK_PC1ET2_1 335 337 PF00082 0.261
CLV_PCSK_SKI1_1 167 171 PF00082 0.334
CLV_PCSK_SKI1_1 195 199 PF00082 0.383
CLV_PCSK_SKI1_1 335 339 PF00082 0.273
DEG_Nend_UBRbox_4 1 3 PF02207 0.345
DOC_CDC14_PxL_1 64 72 PF14671 0.226
DOC_MAPK_MEF2A_6 16 23 PF00069 0.331
DOC_MAPK_MEF2A_6 72 81 PF00069 0.224
DOC_MAPK_NFAT4_5 16 24 PF00069 0.286
DOC_PP1_RVXF_1 231 237 PF00149 0.444
DOC_PP1_RVXF_1 50 57 PF00149 0.349
DOC_PP2B_LxvP_1 79 82 PF13499 0.216
DOC_PP4_FxxP_1 243 246 PF00568 0.247
DOC_USP7_MATH_1 157 161 PF00917 0.533
DOC_USP7_MATH_1 172 176 PF00917 0.332
DOC_USP7_MATH_1 229 233 PF00917 0.453
DOC_USP7_UBL2_3 257 261 PF12436 0.370
LIG_14-3-3_CanoR_1 16 20 PF00244 0.376
LIG_14-3-3_CanoR_1 233 237 PF00244 0.331
LIG_14-3-3_CanoR_1 316 320 PF00244 0.321
LIG_14-3-3_CanoR_1 89 96 PF00244 0.389
LIG_14-3-3_CanoR_1 98 103 PF00244 0.319
LIG_Actin_WH2_2 245 263 PF00022 0.406
LIG_Actin_WH2_2 74 91 PF00022 0.405
LIG_EH_1 155 159 PF12763 0.224
LIG_FHA_1 113 119 PF00498 0.288
LIG_FHA_1 290 296 PF00498 0.243
LIG_FHA_1 315 321 PF00498 0.327
LIG_LIR_Apic_2 241 246 PF02991 0.231
LIG_LIR_Apic_2 38 44 PF02991 0.516
LIG_LIR_Apic_2 95 99 PF02991 0.551
LIG_LIR_Gen_1 18 24 PF02991 0.329
LIG_LIR_Gen_1 180 188 PF02991 0.342
LIG_LIR_Gen_1 235 243 PF02991 0.298
LIG_LIR_Gen_1 75 85 PF02991 0.247
LIG_LIR_Nem_3 18 23 PF02991 0.333
LIG_LIR_Nem_3 180 184 PF02991 0.300
LIG_LIR_Nem_3 235 239 PF02991 0.289
LIG_LIR_Nem_3 62 67 PF02991 0.488
LIG_LIR_Nem_3 75 81 PF02991 0.323
LIG_NRBOX 164 170 PF00104 0.229
LIG_Pex14_1 129 133 PF04695 0.456
LIG_RPA_C_Fungi 215 227 PF08784 0.239
LIG_SH2_SRC 188 191 PF00017 0.309
LIG_SH2_STAP1 188 192 PF00017 0.315
LIG_SH2_STAP1 330 334 PF00017 0.295
LIG_SH2_STAP1 59 63 PF00017 0.457
LIG_SH2_STAT3 90 93 PF00017 0.269
LIG_SH2_STAT5 144 147 PF00017 0.201
LIG_SH2_STAT5 181 184 PF00017 0.275
LIG_SH2_STAT5 251 254 PF00017 0.456
LIG_SH2_STAT5 319 322 PF00017 0.267
LIG_SH2_STAT5 61 64 PF00017 0.261
LIG_SH2_STAT5 69 72 PF00017 0.208
LIG_SH2_STAT5 78 81 PF00017 0.243
LIG_SH2_STAT5 84 87 PF00017 0.276
LIG_SH2_STAT5 90 93 PF00017 0.362
LIG_SH3_3 243 249 PF00018 0.506
LIG_SH3_3 62 68 PF00018 0.243
LIG_SUMO_SIM_anti_2 180 186 PF11976 0.369
LIG_SUMO_SIM_par_1 304 309 PF11976 0.271
LIG_TYR_ITIM 131 136 PF00017 0.254
MOD_CK1_1 232 238 PF00069 0.371
MOD_Cter_Amidation 209 212 PF01082 0.495
MOD_GSK3_1 98 105 PF00069 0.547
MOD_N-GLC_1 173 178 PF02516 0.318
MOD_N-GLC_1 281 286 PF02516 0.375
MOD_NEK2_1 102 107 PF00069 0.419
MOD_NEK2_1 158 163 PF00069 0.381
MOD_NEK2_1 306 311 PF00069 0.258
MOD_NEK2_1 35 40 PF00069 0.609
MOD_NEK2_1 88 93 PF00069 0.300
MOD_NEK2_2 173 178 PF00069 0.431
MOD_PIKK_1 290 296 PF00454 0.243
MOD_PIKK_1 47 53 PF00454 0.242
MOD_PIKK_1 88 94 PF00454 0.264
MOD_PKA_2 15 21 PF00069 0.475
MOD_PKA_2 218 224 PF00069 0.369
MOD_PKA_2 232 238 PF00069 0.255
MOD_PKA_2 315 321 PF00069 0.285
MOD_PKA_2 88 94 PF00069 0.536
MOD_Plk_1 173 179 PF00069 0.416
MOD_Plk_1 306 312 PF00069 0.221
MOD_Plk_4 15 21 PF00069 0.413
MOD_Plk_4 180 186 PF00069 0.443
MOD_Plk_4 235 241 PF00069 0.296
MOD_Plk_4 295 301 PF00069 0.249
MOD_Plk_4 306 312 PF00069 0.192
MOD_Plk_4 315 321 PF00069 0.266
MOD_SUMO_rev_2 259 269 PF00179 0.370
TRG_DiLeu_BaEn_1 180 185 PF01217 0.212
TRG_DiLeu_BaEn_1 265 270 PF01217 0.452
TRG_DiLeu_LyEn_5 265 270 PF01217 0.242
TRG_ENDOCYTIC_2 133 136 PF00928 0.381
TRG_ENDOCYTIC_2 181 184 PF00928 0.392
TRG_ENDOCYTIC_2 188 191 PF00928 0.355
TRG_ENDOCYTIC_2 61 64 PF00928 0.332
TRG_ENDOCYTIC_2 78 81 PF00928 0.490
TRG_ER_diArg_1 148 150 PF00400 0.394
TRG_ER_diArg_1 211 213 PF00400 0.438
TRG_ER_diArg_1 219 222 PF00400 0.436
TRG_NLS_MonoExtN_4 333 339 PF00514 0.265
TRG_Pf-PMV_PEXEL_1 148 152 PF00026 0.343
TRG_Pf-PMV_PEXEL_1 167 171 PF00026 0.200
TRG_Pf-PMV_PEXEL_1 267 271 PF00026 0.259

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NJF0 Trypanosomatidae 27% 100%
A0A1X0NJG9 Trypanosomatidae 26% 100%
A0A1X0NJQ2 Trypanosomatidae 29% 90%
A0A1X0NJS8 Trypanosomatidae 29% 91%
A0A1X0NPR7 Trypanosomatidae 29% 98%
A0A1X0NPV0 Trypanosomatidae 30% 91%
A0A1X0NPW4 Trypanosomatidae 32% 93%
A0A1X0NQ61 Trypanosomatidae 31% 91%
A0A1X0NQ97 Trypanosomatidae 28% 93%
A0A1X0NQX6 Trypanosomatidae 28% 100%
A0A1X0NRK5 Trypanosomatidae 29% 100%
A0A1X0NVK8 Trypanosomatidae 25% 78%
A0A1X0P6H4 Trypanosomatidae 30% 93%
A0A3R7KQD7 Trypanosoma rangeli 28% 87%
A4H3B5 Leishmania braziliensis 37% 66%
A4H3H1 Leishmania braziliensis 26% 100%
C9ZPC0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 91%
E8NHL6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS