Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

E9AI28_LEIBR

TriTrypDb:

LbrM.07.0920.B , LBRM2903_070017600

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AI28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.616
CLV_C14_Caspase3-7	392	396	PF00656	0.796
CLV_C14_Caspase3-7	77	81	PF00656	0.575
CLV_NRD_NRD_1	193	195	PF00675	0.631
CLV_NRD_NRD_1	272	274	PF00675	0.794
CLV_NRD_NRD_1	320	322	PF00675	0.818
CLV_NRD_NRD_1	325	327	PF00675	0.705
CLV_NRD_NRD_1	360	362	PF00675	0.754
CLV_NRD_NRD_1	490	492	PF00675	0.649
CLV_NRD_NRD_1	91	93	PF00675	0.585
CLV_PCSK_KEX2_1	193	195	PF00082	0.631
CLV_PCSK_KEX2_1	272	274	PF00082	0.794
CLV_PCSK_KEX2_1	320	322	PF00082	0.818
CLV_PCSK_KEX2_1	325	327	PF00082	0.705
CLV_PCSK_KEX2_1	480	482	PF00082	0.667
CLV_PCSK_KEX2_1	490	492	PF00082	0.484
CLV_PCSK_KEX2_1	91	93	PF00082	0.585
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.667
CLV_PCSK_PC7_1	321	327	PF00082	0.663
CLV_PCSK_SKI1_1	480	484	PF00082	0.660
CLV_Separin_Metazoa	317	321	PF03568	0.657
DEG_APCC_DBOX_1	24	32	PF00400	0.451
DEG_APCC_DBOX_1	271	279	PF00400	0.794
DEG_SPOP_SBC_1	515	519	PF00917	0.542
DOC_MAPK_gen_1	144	153	PF00069	0.467
DOC_MAPK_gen_1	259	267	PF00069	0.613
DOC_MAPK_gen_1	65	75	PF00069	0.584
DOC_MAPK_MEF2A_6	144	153	PF00069	0.467
DOC_PP1_RVXF_1	148	154	PF00149	0.462
DOC_PP2B_LxvP_1	391	394	PF13499	0.794
DOC_PP4_FxxP_1	232	235	PF00568	0.801
DOC_PP4_FxxP_1	327	330	PF00568	0.838
DOC_PP4_FxxP_1	448	451	PF00568	0.636
DOC_USP7_MATH_1	195	199	PF00917	0.643
DOC_USP7_MATH_1	2	6	PF00917	0.530
DOC_USP7_MATH_1	246	250	PF00917	0.785
DOC_USP7_MATH_1	277	281	PF00917	0.798
DOC_USP7_MATH_1	330	334	PF00917	0.798
DOC_USP7_MATH_1	418	422	PF00917	0.688
DOC_USP7_MATH_1	515	519	PF00917	0.702
DOC_USP7_MATH_1	7	11	PF00917	0.489
DOC_USP7_MATH_1	99	103	PF00917	0.599
DOC_WW_Pin1_4	273	278	PF00397	0.797
DOC_WW_Pin1_4	349	354	PF00397	0.825
DOC_WW_Pin1_4	373	378	PF00397	0.813
DOC_WW_Pin1_4	423	428	PF00397	0.807
DOC_WW_Pin1_4	447	452	PF00397	0.649
LIG_14-3-3_CanoR_1	104	110	PF00244	0.643
LIG_14-3-3_CanoR_1	150	154	PF00244	0.461
LIG_14-3-3_CanoR_1	405	412	PF00244	0.849
LIG_14-3-3_CanoR_1	447	451	PF00244	0.806
LIG_14-3-3_CanoR_1	580	585	PF00244	0.785
LIG_BIR_III_4	170	174	PF00653	0.540
LIG_BRCT_BRCA1_1	419	423	PF00533	0.824
LIG_EVH1_1	575	579	PF00568	0.779
LIG_FHA_1	250	256	PF00498	0.612
LIG_FHA_1	296	302	PF00498	0.626
LIG_FHA_1	374	380	PF00498	0.748
LIG_FHA_1	453	459	PF00498	0.646
LIG_FHA_2	1	7	PF00498	0.581
LIG_FHA_2	204	210	PF00498	0.651
LIG_FHA_2	354	360	PF00498	0.684
LIG_FHA_2	554	560	PF00498	0.637
LIG_LIR_Apic_2	229	235	PF02991	0.651
LIG_LIR_Nem_3	112	118	PF02991	0.653
LIG_MYND_1	573	577	PF01753	0.778
LIG_NRBOX	42	48	PF00104	0.427
LIG_PDZ_Class_1	586	591	PF00595	0.609
LIG_Pex14_1	48	52	PF04695	0.428
LIG_SH2_CRK	115	119	PF00017	0.651
LIG_SH2_CRK	221	225	PF00017	0.655
LIG_SH2_CRK	513	517	PF00017	0.675
LIG_SH2_STAT5	389	392	PF00017	0.805
LIG_SH2_STAT5	588	591	PF00017	0.657
LIG_SH2_STAT5	87	90	PF00017	0.604
LIG_SH3_2	566	571	PF14604	0.636
LIG_SH3_3	336	342	PF00018	0.662
LIG_SH3_3	421	427	PF00018	0.646
LIG_SH3_3	559	565	PF00018	0.755
LIG_SH3_3	570	576	PF00018	0.649
LIG_SH3_3	70	76	PF00018	0.595
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.637
LIG_SUMO_SIM_par_1	158	164	PF11976	0.484
LIG_SUMO_SIM_par_1	297	304	PF11976	0.634
LIG_SUMO_SIM_par_1	30	36	PF11976	0.427
LIG_SUMO_SIM_par_1	389	395	PF11976	0.805
LIG_TRAF2_1	139	142	PF00917	0.494
LIG_TRAF2_2	308	313	PF00917	0.679
LIG_TYR_ITIM	113	118	PF00017	0.603
LIG_UBA3_1	159	165	PF00899	0.487
LIG_WRC_WIRS_1	467	472	PF05994	0.723
LIG_WW_3	306	310	PF00397	0.669
LIG_WW_3	317	321	PF00397	0.507
LIG_WW_3	564	568	PF00397	0.628
MOD_CDK_SPxxK_3	373	380	PF00069	0.661
MOD_CK1_1	198	204	PF00069	0.659
MOD_CK1_1	24	30	PF00069	0.457
MOD_CK1_1	249	255	PF00069	0.603
MOD_CK1_1	266	272	PF00069	0.658
MOD_CK1_1	332	338	PF00069	0.828
MOD_CK1_1	460	466	PF00069	0.797
MOD_CK1_1	469	475	PF00069	0.567
MOD_CK1_1	531	537	PF00069	0.743
MOD_CK2_1	149	155	PF00069	0.461
MOD_CK2_1	203	209	PF00069	0.649
MOD_CK2_1	273	279	PF00069	0.796
MOD_CMANNOS	48	51	PF00535	0.430
MOD_Cter_Amidation	488	491	PF01082	0.634
MOD_GlcNHglycan	101	104	PF01048	0.610
MOD_GlcNHglycan	109	112	PF01048	0.555
MOD_GlcNHglycan	118	121	PF01048	0.498
MOD_GlcNHglycan	268	271	PF01048	0.777
MOD_GlcNHglycan	343	346	PF01048	0.810
MOD_GlcNHglycan	400	403	PF01048	0.684
MOD_GlcNHglycan	518	521	PF01048	0.712
MOD_GlcNHglycan	585	588	PF01048	0.620
MOD_GSK3_1	105	112	PF00069	0.643
MOD_GSK3_1	114	121	PF00069	0.527
MOD_GSK3_1	173	180	PF00069	0.562
MOD_GSK3_1	249	256	PF00069	0.640
MOD_GSK3_1	273	280	PF00069	0.806
MOD_GSK3_1	328	335	PF00069	0.803
MOD_GSK3_1	337	344	PF00069	0.657
MOD_GSK3_1	345	352	PF00069	0.689
MOD_GSK3_1	414	421	PF00069	0.789
MOD_GSK3_1	466	473	PF00069	0.727
MOD_GSK3_1	523	530	PF00069	0.810
MOD_GSK3_1	583	590	PF00069	0.661
MOD_GSK3_1	7	14	PF00069	0.617
MOD_N-GLC_1	11	16	PF02516	0.583
MOD_N-GLC_1	174	179	PF02516	0.714
MOD_N-GLC_1	246	251	PF02516	0.765
MOD_N-GLC_1	398	403	PF02516	0.804
MOD_N-GLC_1	527	532	PF02516	0.799
MOD_N-GLC_1	536	541	PF02516	0.675
MOD_NEK2_1	105	110	PF00069	0.594
MOD_NEK2_1	174	179	PF00069	0.714
MOD_NEK2_1	343	348	PF00069	0.798
MOD_NEK2_1	468	473	PF00069	0.738
MOD_NEK2_1	47	52	PF00069	0.462
MOD_NEK2_1	514	519	PF00069	0.688
MOD_NEK2_1	8	13	PF00069	0.583
MOD_NEK2_2	418	423	PF00069	0.650
MOD_OFUCOSY	274	281	PF10250	0.796
MOD_PIKK_1	330	336	PF00454	0.643
MOD_PIKK_1	470	476	PF00454	0.743
MOD_PK_1	263	269	PF00069	0.777
MOD_PKA_2	149	155	PF00069	0.496
MOD_PKA_2	24	30	PF00069	0.507
MOD_PKA_2	446	452	PF00069	0.773
MOD_Plk_1	246	252	PF00069	0.697
MOD_Plk_1	418	424	PF00069	0.647
MOD_Plk_2-3	203	209	PF00069	0.649
MOD_Plk_4	195	201	PF00069	0.682
MOD_Plk_4	203	209	PF00069	0.688
MOD_Plk_4	24	30	PF00069	0.497
MOD_Plk_4	295	301	PF00069	0.640
MOD_Plk_4	33	39	PF00069	0.355
MOD_Plk_4	41	47	PF00069	0.372
MOD_Plk_4	418	424	PF00069	0.673
MOD_ProDKin_1	273	279	PF00069	0.796
MOD_ProDKin_1	349	355	PF00069	0.827
MOD_ProDKin_1	373	379	PF00069	0.811
MOD_ProDKin_1	423	429	PF00069	0.807
MOD_ProDKin_1	447	453	PF00069	0.649
TRG_DiLeu_BaEn_1	155	160	PF01217	0.468
TRG_DiLeu_BaEn_1	479	484	PF01217	0.512
TRG_DiLeu_BaEn_4	500	506	PF01217	0.646
TRG_ENDOCYTIC_2	115	118	PF00928	0.651
TRG_ENDOCYTIC_2	513	516	PF00928	0.671
TRG_ER_diArg_1	144	147	PF00400	0.470
TRG_ER_diArg_1	271	273	PF00400	0.723
TRG_ER_diArg_1	319	321	PF00400	0.813
TRG_ER_diArg_1	324	326	PF00400	0.737
TRG_ER_diArg_1	490	493	PF00400	0.653
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HTE3	Leishmania infantum	67%	100%