Peroxisomal biogenesis factor 11

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peripherally associated ATOM36

Species:

Leishmania braziliensis

UniProt:

E9AI25_LEIBR

TriTrypDb:

LbrM.06.1080 , LBRM2903_060018100

Length:

302

Annotations

LeishMANIAdb annotations

These proteins have some structural similarity to Mitochondrial fission process protein (MTFP) of animals.. Has a transit peptide-like sequence on its N-terminus.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	6
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

E9AI25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI25

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.502
CLV_MEL_PAP_1	161	167	PF00089	0.302
CLV_NRD_NRD_1	176	178	PF00675	0.330
CLV_NRD_NRD_1	196	198	PF00675	0.247
CLV_NRD_NRD_1	258	260	PF00675	0.290
CLV_NRD_NRD_1	267	269	PF00675	0.430
CLV_NRD_NRD_1	30	32	PF00675	0.330
CLV_PCSK_FUR_1	265	269	PF00082	0.480
CLV_PCSK_KEX2_1	176	178	PF00082	0.247
CLV_PCSK_KEX2_1	196	198	PF00082	0.159

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z0	Leptomonas seymouri	61%	99%
A0A3S7WPK6	Leishmania donovani	87%	100%
A0A422NM25	Trypanosoma rangeli	39%	97%
A4HT02	Leishmania infantum	87%	100%
C9ZTN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
E9AKY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIW6	Leishmania major	85%	100%
V5B816	Trypanosoma cruzi	36%	97%

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