TNase-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Staphylococcal nuclease homologue, putative

Species:

Leishmania braziliensis

UniProt:

E9AI24_LEIBR

TriTrypDb:

LbrM.06.1060 , LBRM2903_060017900

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AI24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI24

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0005488	binding	1	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.327
CLV_PCSK_KEX2_1	101	103	PF00082	0.224
CLV_PCSK_KEX2_1	169	171	PF00082	0.544
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.224
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.517
CLV_PCSK_SKI1_1	174	178	PF00082	0.671
CLV_Separin_Metazoa	151	155	PF03568	0.224
DEG_APCC_DBOX_1	56	64	PF00400	0.422
DOC_CYCLIN_RxL_1	101	115	PF00134	0.373
DOC_MAPK_gen_1	101	111	PF00069	0.341
DOC_MAPK_gen_1	55	63	PF00069	0.408
DOC_MAPK_HePTP_8	48	60	PF00069	0.586
DOC_MAPK_MEF2A_6	51	60	PF00069	0.671
DOC_PP1_RVXF_1	105	112	PF00149	0.224
DOC_PP4_FxxP_1	138	141	PF00568	0.422
DOC_USP7_MATH_1	13	17	PF00917	0.727
DOC_USP7_MATH_1	141	145	PF00917	0.425
DOC_USP7_MATH_1	29	33	PF00917	0.439
DOC_WW_Pin1_4	137	142	PF00397	0.429
DOC_WW_Pin1_4	212	217	PF00397	0.653
LIG_BIR_III_2	28	32	PF00653	0.661
LIG_BRCT_BRCA1_1	22	26	PF00533	0.616
LIG_Clathr_ClatBox_1	60	64	PF01394	0.365
LIG_FHA_1	15	21	PF00498	0.527
LIG_FHA_1	201	207	PF00498	0.656
LIG_FHA_1	45	51	PF00498	0.486
LIG_FHA_2	47	53	PF00498	0.606
LIG_HCF-1_HBM_1	40	43	PF13415	0.542
LIG_Integrin_RGD_1	98	100	PF01839	0.224
LIG_LIR_Apic_2	137	141	PF02991	0.422
LIG_LIR_Gen_1	103	113	PF02991	0.304
LIG_LIR_Gen_1	122	131	PF02991	0.176
LIG_LIR_Gen_1	91	100	PF02991	0.370
LIG_LIR_Nem_3	103	108	PF02991	0.202
LIG_LIR_Nem_3	122	126	PF02991	0.176
LIG_LIR_Nem_3	91	96	PF02991	0.344
LIG_SH2_CRK	105	109	PF00017	0.394
LIG_SH2_STAP1	74	78	PF00017	0.381
LIG_SH2_STAT5	81	84	PF00017	0.330
LIG_SH3_3	111	117	PF00018	0.365
LIG_SUMO_SIM_par_1	46	52	PF11976	0.508
LIG_WRC_WIRS_1	135	140	PF05994	0.422
MOD_CDC14_SPxK_1	215	218	PF00782	0.639
MOD_CDK_SPxK_1	212	218	PF00069	0.640
MOD_CK1_1	115	121	PF00069	0.422
MOD_CK2_1	13	19	PF00069	0.501
MOD_CK2_1	29	35	PF00069	0.720
MOD_CK2_1	46	52	PF00069	0.568
MOD_GlcNHglycan	117	120	PF01048	0.381
MOD_GlcNHglycan	203	206	PF01048	0.738
MOD_GSK3_1	137	144	PF00069	0.402
MOD_GSK3_1	185	192	PF00069	0.582
MOD_GSK3_1	208	215	PF00069	0.581
MOD_GSK3_1	9	16	PF00069	0.674
MOD_N-GLC_1	88	93	PF02516	0.224
MOD_N-GLC_2	3	5	PF02516	0.711
MOD_NEK2_1	1	6	PF00069	0.625
MOD_NEK2_1	193	198	PF00069	0.542
MOD_NEK2_2	134	139	PF00069	0.450
MOD_NMyristoyl	1	7	PF02799	0.597
MOD_PIKK_1	176	182	PF00454	0.448
MOD_Plk_1	35	41	PF00069	0.622
MOD_Plk_1	88	94	PF00069	0.224
MOD_Plk_2-3	35	41	PF00069	0.510
MOD_Plk_2-3	46	52	PF00069	0.529
MOD_Plk_4	134	140	PF00069	0.449
MOD_Plk_4	88	94	PF00069	0.244
MOD_ProDKin_1	137	143	PF00069	0.429
MOD_ProDKin_1	212	218	PF00069	0.658
MOD_SUMO_rev_2	16	23	PF00179	0.483
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.301
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.354
TRG_ENDOCYTIC_2	105	108	PF00928	0.352
TRG_ER_diArg_1	167	170	PF00400	0.702
TRG_ER_diArg_1	55	58	PF00400	0.614
TRG_NES_CRM1_1	28	40	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K0	Leptomonas seymouri	54%	100%
A0A0S4IY10	Bodo saltans	31%	92%
A0A1X0NDZ2	Trypanosomatidae	44%	100%
A0A1X0NKT8	Trypanosomatidae	43%	100%
A0A3S7WPM0	Leishmania donovani	73%	100%
A4HT00	Leishmania infantum	73%	100%
E9AKY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QIW8	Leishmania major	73%	100%
Q5HHM4	Staphylococcus aureus (strain COL)	29%	98%
Q6GB41	Staphylococcus aureus (strain MSSA476)	29%	98%
Q6GIK1	Staphylococcus aureus (strain MRSA252)	29%	98%
Q7A6P2	Staphylococcus aureus (strain N315)	29%	98%
Q8NXI6	Staphylococcus aureus (strain MW2)	29%	98%
Q99VJ0	Staphylococcus aureus (strain Mu50 / ATCC 700699)	29%	98%