Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

E9AI23_LEIBR

TriTrypDb:

LbrM.06.0971 , LBRM2903_060016700

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AI23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.296
CLV_C14_Caspase3-7	77	81	PF00656	0.526
CLV_C14_Caspase3-7	96	100	PF00656	0.602
CLV_NRD_NRD_1	72	74	PF00675	0.431
CLV_PCSK_KEX2_1	72	74	PF00082	0.369
CLV_PCSK_SKI1_1	65	69	PF00082	0.335
DOC_MAPK_gen_1	48	57	PF00069	0.539
DOC_USP7_MATH_1	36	40	PF00917	0.315
DOC_WW_Pin1_4	101	106	PF00397	0.679
DOC_WW_Pin1_4	114	119	PF00397	0.588
LIG_14-3-3_CanoR_1	50	56	PF00244	0.494
LIG_BRCT_BRCA1_1	131	135	PF00533	0.233
LIG_FHA_1	27	33	PF00498	0.276
LIG_FHA_1	52	58	PF00498	0.586
LIG_FHA_1	66	72	PF00498	0.586
LIG_FHA_2	94	100	PF00498	0.653
LIG_LIR_Gen_1	5	14	PF02991	0.233
LIG_LIR_Nem_3	39	43	PF02991	0.326
LIG_LIR_Nem_3	5	9	PF02991	0.233
LIG_NRBOX	13	19	PF00104	0.250
LIG_SH2_STAT5	146	149	PF00017	0.412
LIG_SH2_STAT5	3	6	PF00017	0.615
LIG_SH2_STAT5	51	54	PF00017	0.567
LIG_SH2_STAT5	56	59	PF00017	0.578
LIG_SH3_1	115	121	PF00018	0.477
LIG_SH3_3	103	109	PF00018	0.673
LIG_SH3_3	115	121	PF00018	0.464
LIG_SH3_3	6	12	PF00018	0.395
LIG_SUMO_SIM_par_1	10	16	PF11976	0.250
LIG_WRC_WIRS_1	3	8	PF05994	0.418
LIG_WW_3	108	112	PF00397	0.690
MOD_CK1_1	104	110	PF00069	0.712
MOD_GlcNHglycan	137	140	PF01048	0.412
MOD_GlcNHglycan	40	43	PF01048	0.308
MOD_GlcNHglycan	9	12	PF01048	0.279
MOD_GSK3_1	129	136	PF00069	0.439
MOD_GSK3_1	18	25	PF00069	0.337
MOD_GSK3_1	51	58	PF00069	0.578
MOD_NEK2_1	129	134	PF00069	0.315
MOD_NEK2_1	13	18	PF00069	0.283
MOD_NEK2_1	135	140	PF00069	0.315
MOD_NEK2_1	28	33	PF00069	0.306
MOD_NEK2_1	7	12	PF00069	0.346
MOD_NEK2_2	51	56	PF00069	0.490
MOD_PIKK_1	104	110	PF00454	0.582
MOD_PKB_1	63	71	PF00069	0.513
MOD_Plk_4	129	135	PF00069	0.227
MOD_Plk_4	13	19	PF00069	0.328
MOD_Plk_4	28	34	PF00069	0.335
MOD_Plk_4	51	57	PF00069	0.492
MOD_ProDKin_1	101	107	PF00069	0.674
MOD_ProDKin_1	114	120	PF00069	0.585
MOD_SUMO_rev_2	97	103	PF00179	0.608
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.233
TRG_ENDOCYTIC_2	3	6	PF00928	0.517
TRG_ER_diArg_1	47	50	PF00400	0.530
TRG_ER_diArg_1	71	73	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL5	Leptomonas seymouri	44%	100%
A0A3S7WPM7	Leishmania donovani	60%	100%
A4HSZ1	Leishmania infantum	61%	100%
E9AKX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4QIX7	Leishmania major	60%	97%