LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
E9AI22_LEIBR
TriTrypDb:
LbrM.06.0430 , LBRM2903_060009900 * , LBRM2903_060010000 *
Length:
566

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AI22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AI22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 331 335 PF00656 0.579
CLV_C14_Caspase3-7 463 467 PF00656 0.551
CLV_C14_Caspase3-7 477 481 PF00656 0.538
CLV_NRD_NRD_1 208 210 PF00675 0.587
CLV_NRD_NRD_1 278 280 PF00675 0.569
CLV_NRD_NRD_1 380 382 PF00675 0.838
CLV_NRD_NRD_1 424 426 PF00675 0.835
CLV_NRD_NRD_1 512 514 PF00675 0.800
CLV_NRD_NRD_1 521 523 PF00675 0.610
CLV_NRD_NRD_1 529 531 PF00675 0.537
CLV_NRD_NRD_1 561 563 PF00675 0.623
CLV_NRD_NRD_1 70 72 PF00675 0.637
CLV_NRD_NRD_1 93 95 PF00675 0.546
CLV_PCSK_KEX2_1 207 209 PF00082 0.587
CLV_PCSK_KEX2_1 267 269 PF00082 0.840
CLV_PCSK_KEX2_1 278 280 PF00082 0.655
CLV_PCSK_KEX2_1 380 382 PF00082 0.838
CLV_PCSK_KEX2_1 424 426 PF00082 0.835
CLV_PCSK_KEX2_1 511 513 PF00082 0.868
CLV_PCSK_KEX2_1 521 523 PF00082 0.661
CLV_PCSK_KEX2_1 561 563 PF00082 0.569
CLV_PCSK_KEX2_1 70 72 PF00082 0.701
CLV_PCSK_PC1ET2_1 267 269 PF00082 0.840
CLV_PCSK_PC1ET2_1 511 513 PF00082 0.868
CLV_PCSK_PC7_1 508 514 PF00082 0.858
CLV_PCSK_SKI1_1 288 292 PF00082 0.576
CLV_PCSK_SKI1_1 508 512 PF00082 0.588
CLV_PCSK_SKI1_1 530 534 PF00082 0.647
DEG_SCF_FBW7_1 357 364 PF00400 0.568
DOC_ANK_TNKS_1 416 423 PF00023 0.572
DOC_CKS1_1 369 374 PF01111 0.567
DOC_CYCLIN_RxL_1 285 295 PF00134 0.568
DOC_MAPK_gen_1 224 234 PF00069 0.573
DOC_MAPK_gen_1 267 274 PF00069 0.840
DOC_MAPK_gen_1 350 359 PF00069 0.839
DOC_MAPK_gen_1 430 440 PF00069 0.555
DOC_MAPK_gen_1 488 499 PF00069 0.550
DOC_MAPK_gen_1 521 528 PF00069 0.553
DOC_MAPK_gen_1 9 18 PF00069 0.532
DOC_MAPK_MEF2A_6 300 308 PF00069 0.567
DOC_MAPK_MEF2A_6 492 499 PF00069 0.551
DOC_PP1_RVXF_1 379 386 PF00149 0.564
DOC_USP7_MATH_1 166 170 PF00917 0.776
DOC_USP7_MATH_1 180 184 PF00917 0.592
DOC_USP7_MATH_1 188 192 PF00917 0.574
DOC_USP7_MATH_1 21 25 PF00917 0.553
DOC_USP7_MATH_1 266 270 PF00917 0.840
DOC_USP7_MATH_1 407 411 PF00917 0.766
DOC_USP7_MATH_1 428 432 PF00917 0.687
DOC_USP7_MATH_1 461 465 PF00917 0.687
DOC_USP7_MATH_1 532 536 PF00917 0.539
DOC_USP7_MATH_2 57 63 PF00917 0.656
DOC_WW_Pin1_4 134 139 PF00397 0.474
DOC_WW_Pin1_4 211 216 PF00397 0.755
DOC_WW_Pin1_4 256 261 PF00397 0.660
DOC_WW_Pin1_4 295 300 PF00397 0.649
DOC_WW_Pin1_4 341 346 PF00397 0.653
DOC_WW_Pin1_4 357 362 PF00397 0.599
DOC_WW_Pin1_4 368 373 PF00397 0.561
DOC_WW_Pin1_4 385 390 PF00397 0.672
DOC_WW_Pin1_4 45 50 PF00397 0.814
DOC_WW_Pin1_4 482 487 PF00397 0.580
DOC_WW_Pin1_4 491 496 PF00397 0.521
DOC_WW_Pin1_4 53 58 PF00397 0.666
LIG_14-3-3_CanoR_1 11 17 PF00244 0.651
LIG_14-3-3_CanoR_1 278 284 PF00244 0.832
LIG_14-3-3_CanoR_1 300 308 PF00244 0.567
LIG_14-3-3_CanoR_1 393 401 PF00244 0.838
LIG_14-3-3_CanoR_1 40 47 PF00244 0.672
LIG_14-3-3_CanoR_1 413 421 PF00244 0.510
LIG_14-3-3_CanoR_1 435 441 PF00244 0.596
LIG_APCC_ABBA_1 190 195 PF00400 0.536
LIG_Clathr_ClatBox_1 290 294 PF01394 0.571
LIG_deltaCOP1_diTrp_1 101 109 PF00928 0.645
LIG_FHA_1 13 19 PF00498 0.766
LIG_FHA_1 156 162 PF00498 0.512
LIG_FHA_1 187 193 PF00498 0.534
LIG_FHA_1 278 284 PF00498 0.564
LIG_FHA_1 323 329 PF00498 0.679
LIG_FHA_1 372 378 PF00498 0.639
LIG_FHA_1 385 391 PF00498 0.521
LIG_FHA_1 477 483 PF00498 0.584
LIG_FHA_1 58 64 PF00498 0.563
LIG_FHA_2 314 320 PF00498 0.618
LIG_FHA_2 334 340 PF00498 0.522
LIG_FHA_2 461 467 PF00498 0.547
LIG_FHA_2 75 81 PF00498 0.433
LIG_LIR_Gen_1 494 500 PF02991 0.815
LIG_LIR_Nem_3 453 458 PF02991 0.526
LIG_LIR_Nem_3 494 499 PF02991 0.815
LIG_LRP6_Inhibitor_1 5 11 PF00058 0.513
LIG_PCNA_yPIPBox_3 557 565 PF02747 0.562
LIG_SH2_GRB2like 458 461 PF00017 0.535
LIG_SH2_SRC 458 461 PF00017 0.803
LIG_SH2_SRC 496 499 PF00017 0.551
LIG_SH2_STAP1 121 125 PF00017 0.499
LIG_SH2_STAT3 110 113 PF00017 0.629
LIG_SH2_STAT5 110 113 PF00017 0.629
LIG_SH2_STAT5 437 440 PF00017 0.559
LIG_SH2_STAT5 458 461 PF00017 0.803
LIG_SH2_STAT5 496 499 PF00017 0.819
LIG_SH2_STAT5 527 530 PF00017 0.713
LIG_SH2_STAT5 53 56 PF00017 0.801
LIG_SH3_3 13 19 PF00018 0.766
LIG_SH3_3 260 266 PF00018 0.577
LIG_SH3_3 280 286 PF00018 0.672
LIG_SH3_3 337 343 PF00018 0.632
LIG_SH3_3 46 52 PF00018 0.536
LIG_SUMO_SIM_par_1 289 295 PF11976 0.571
LIG_SUMO_SIM_par_1 325 331 PF11976 0.716
LIG_UBA3_1 1 9 PF00899 0.520
MOD_CDC14_SPxK_1 485 488 PF00782 0.567
MOD_CDK_SPK_2 295 300 PF00069 0.555
MOD_CDK_SPK_2 45 50 PF00069 0.814
MOD_CDK_SPxK_1 256 262 PF00069 0.662
MOD_CDK_SPxK_1 482 488 PF00069 0.577
MOD_CDK_SPxxK_3 211 218 PF00069 0.592
MOD_CDK_SPxxK_3 482 489 PF00069 0.575
MOD_CK1_1 12 18 PF00069 0.608
MOD_CK1_1 181 187 PF00069 0.647
MOD_CK1_1 214 220 PF00069 0.800
MOD_CK1_1 31 37 PF00069 0.714
MOD_CK1_1 313 319 PF00069 0.737
MOD_CK1_1 402 408 PF00069 0.589
MOD_CK1_1 445 451 PF00069 0.527
MOD_CK1_1 464 470 PF00069 0.503
MOD_CK1_1 476 482 PF00069 0.545
MOD_CK1_1 502 508 PF00069 0.631
MOD_CK1_1 514 520 PF00069 0.759
MOD_CK1_1 552 558 PF00069 0.789
MOD_CK1_1 62 68 PF00069 0.551
MOD_CK2_1 313 319 PF00069 0.537
MOD_CK2_1 333 339 PF00069 0.525
MOD_CK2_1 53 59 PF00069 0.796
MOD_CK2_1 85 91 PF00069 0.461
MOD_Cter_Amidation 276 279 PF01082 0.572
MOD_Cter_Amidation 422 425 PF01082 0.796
MOD_GlcNHglycan 161 164 PF01048 0.656
MOD_GlcNHglycan 183 186 PF01048 0.622
MOD_GlcNHglycan 23 26 PF01048 0.827
MOD_GlcNHglycan 237 240 PF01048 0.697
MOD_GlcNHglycan 301 304 PF01048 0.565
MOD_GlcNHglycan 31 34 PF01048 0.702
MOD_GlcNHglycan 36 39 PF01048 0.610
MOD_GlcNHglycan 361 364 PF01048 0.594
MOD_GlcNHglycan 390 393 PF01048 0.759
MOD_GlcNHglycan 395 398 PF01048 0.749
MOD_GlcNHglycan 404 407 PF01048 0.598
MOD_GlcNHglycan 409 413 PF01048 0.515
MOD_GlcNHglycan 414 417 PF01048 0.527
MOD_GlcNHglycan 444 447 PF01048 0.792
MOD_GlcNHglycan 466 469 PF01048 0.698
MOD_GlcNHglycan 476 479 PF01048 0.812
MOD_GlcNHglycan 501 504 PF01048 0.819
MOD_GlcNHglycan 513 516 PF01048 0.641
MOD_GlcNHglycan 535 538 PF01048 0.571
MOD_GlcNHglycan 541 544 PF01048 0.659
MOD_GlcNHglycan 64 67 PF01048 0.523
MOD_GSK3_1 137 144 PF00069 0.691
MOD_GSK3_1 155 162 PF00069 0.513
MOD_GSK3_1 166 173 PF00069 0.730
MOD_GSK3_1 235 242 PF00069 0.606
MOD_GSK3_1 29 36 PF00069 0.766
MOD_GSK3_1 295 302 PF00069 0.694
MOD_GSK3_1 355 362 PF00069 0.755
MOD_GSK3_1 384 391 PF00069 0.659
MOD_GSK3_1 408 415 PF00069 0.601
MOD_GSK3_1 436 443 PF00069 0.779
MOD_GSK3_1 460 467 PF00069 0.600
MOD_GSK3_1 513 520 PF00069 0.817
MOD_GSK3_1 53 60 PF00069 0.621
MOD_GSK3_1 548 555 PF00069 0.784
MOD_N-GLC_1 234 239 PF02516 0.653
MOD_N-GLC_1 29 34 PF02516 0.790
MOD_N-GLC_1 334 339 PF02516 0.588
MOD_N-GLC_1 459 464 PF02516 0.657
MOD_NEK2_1 234 239 PF00069 0.554
MOD_NEK2_1 29 34 PF00069 0.790
MOD_NEK2_1 322 327 PF00069 0.535
MOD_NEK2_1 373 378 PF00069 0.606
MOD_NEK2_1 438 443 PF00069 0.794
MOD_NEK2_1 459 464 PF00069 0.550
MOD_NEK2_1 539 544 PF00069 0.561
MOD_NEK2_1 58 63 PF00069 0.510
MOD_NEK2_2 188 193 PF00069 0.535
MOD_PK_1 279 285 PF00069 0.563
MOD_PKA_1 511 517 PF00069 0.856
MOD_PKA_2 277 283 PF00069 0.832
MOD_PKA_2 299 305 PF00069 0.642
MOD_PKA_2 313 319 PF00069 0.761
MOD_PKA_2 39 45 PF00069 0.694
MOD_PKA_2 392 398 PF00069 0.691
MOD_PKA_2 399 405 PF00069 0.683
MOD_PKA_2 412 418 PF00069 0.652
MOD_PKA_2 464 470 PF00069 0.582
MOD_PKA_2 511 517 PF00069 0.856
MOD_Plk_1 555 561 PF00069 0.560
MOD_Plk_1 58 64 PF00069 0.771
MOD_Plk_2-3 74 80 PF00069 0.533
MOD_Plk_4 188 194 PF00069 0.533
MOD_Plk_4 199 205 PF00069 0.525
MOD_Plk_4 74 80 PF00069 0.533
MOD_ProDKin_1 134 140 PF00069 0.475
MOD_ProDKin_1 211 217 PF00069 0.757
MOD_ProDKin_1 256 262 PF00069 0.662
MOD_ProDKin_1 295 301 PF00069 0.650
MOD_ProDKin_1 341 347 PF00069 0.653
MOD_ProDKin_1 357 363 PF00069 0.599
MOD_ProDKin_1 368 374 PF00069 0.560
MOD_ProDKin_1 385 391 PF00069 0.674
MOD_ProDKin_1 45 51 PF00069 0.810
MOD_ProDKin_1 482 488 PF00069 0.577
MOD_ProDKin_1 491 497 PF00069 0.521
MOD_ProDKin_1 53 59 PF00069 0.664
TRG_DiLeu_BaLyEn_6 342 347 PF01217 0.593
TRG_ENDOCYTIC_2 437 440 PF00928 0.826
TRG_ENDOCYTIC_2 496 499 PF00928 0.819
TRG_ER_diArg_1 207 209 PF00400 0.780
TRG_ER_diArg_1 349 352 PF00400 0.583
TRG_ER_diArg_1 379 381 PF00400 0.807
TRG_ER_diArg_1 433 436 PF00400 0.595
TRG_ER_diArg_1 560 562 PF00400 0.568
TRG_NES_CRM1_1 367 382 PF08389 0.566
TRG_NLS_Bipartite_1 512 534 PF00514 0.561
TRG_NLS_MonoExtN_4 508 515 PF00514 0.857
TRG_Pf-PMV_PEXEL_1 126 130 PF00026 0.546
TRG_Pf-PMV_PEXEL_1 94 98 PF00026 0.647

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WPD6 Leishmania donovani 59% 99%
A4HST4 Leishmania infantum 59% 99%
E9AKS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
Q4QJ36 Leishmania major 59% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS